Nancy Y Lee

Nancy Y Lee

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Nancy Y Lee

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Patterns of Radiotherapy Use and Outcomes in Head and Neck Soft-Tissue Sarcoma in a National Cohort.

Laryngoscope 2020 Jan 20;130(1):120-127. Epub 2019 Mar 20.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

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http://dx.doi.org/10.1002/lary.27901DOI Listing
January 2020

Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer.

Cancer 2020 Jan 8;126(2):444-452. Epub 2019 Oct 8.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/cncr.32548DOI Listing
January 2020

Optimal mass transport kinetic modeling for head and neck DCE-MRI: Initial analysis.

Magn Reson Med 2019 12 4;82(6):2314-2325. Epub 2019 Jul 4.

Computer Science and Applied Mathematics & Statistics, Stony Brook University, Stony Brook, New York.

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http://dx.doi.org/10.1002/mrm.27897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716991PMC
December 2019

Outcomes of surgery and postoperative radiation therapy in managing medullary thyroid carcinoma.

J Surg Oncol 2019 Nov 16. Epub 2019 Nov 16.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/jso.25761DOI Listing
November 2019

Predicting radiation dosimetric distribution in different regions of the jaw in patients receiving radiotherapy for squamous cell carcinoma of the tonsil.

Head Neck 2019 10 5;41(10):3604-3611. Epub 2019 Aug 5.

Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/hed.25883DOI Listing
October 2019

Human papillomavirus 16 promotes microhomology-mediated end-joining.

Proc Natl Acad Sci U S A 2019 Oct 7;116(43):21573-21579. Epub 2019 Oct 7.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1906120116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815166PMC
October 2019

Endoscopic Resection Followed by Proton Therapy With Pencil Beam Scanning for Skull Base Tumors.

Laryngoscope 2019 06 12;129(6):1313-1317. Epub 2018 Sep 12.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

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http://dx.doi.org/10.1002/lary.27512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414275PMC
June 2019

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.

Hum Pathol 2019 Jun 1;88:66-77. Epub 2019 Apr 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.humpath.2019.03.004DOI Listing
June 2019

Reducing the Radiation Therapy Dose Prescription for Elective Treatment Areas in Human Papillomavirus-Associated Oropharyngeal Carcinoma Being Treated With Primary Chemoradiotherapy at Memorial Sloan Kettering Cancer Center.

Pract Radiat Oncol 2019 Mar 14;9(2):98-101. Epub 2018 Nov 14.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2018.10.015DOI Listing
March 2019

JAVELIN Head and Neck 100: a Phase III trial of avelumab and chemoradiation for locally advanced head and neck cancer.

Authors:
Yao Yu Nancy Y Lee

Future Oncol 2019 Mar 21;15(7):687-694. Epub 2018 Nov 21.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.2217/fon-2018-0405DOI Listing
March 2019

Comparing Kadish, TNM, and the modified Dulguerov staging systems for esthesioneuroblastoma.

J Surg Oncol 2019 Jan 22;119(1):130-142. Epub 2018 Nov 22.

Department of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/jso.25293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352736PMC
January 2019

Image-based Data Mining to Probe Dosimetric Correlates of Radiation-induced Trismus.

Int J Radiat Oncol Biol Phys 2018 11 1;102(4):1330-1338. Epub 2018 Jun 1.

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.ijrobp.2018.05.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620778PMC
November 2018

Long-term quality of life in older patients with HPV-related oropharyngeal cancer.

Head Neck 2018 11 13;40(11):2321-2328. Epub 2018 Nov 13.

Head and Neck Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://doi.wiley.com/10.1002/hed.25159
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http://dx.doi.org/10.1002/hed.25159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681446PMC
November 2018

Characteristics of Radiotherapy Trials Compared With Other Oncological Clinical Trials in the Past 10 Years.

JAMA Oncol 2018 08;4(8):1073-1079

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, China.

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2018.0887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143047PMC
August 2018

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer.

Nat Commun 2018 08 17;9(1):3292. Epub 2018 Aug 17.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1038/s41467-018-05228-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098043PMC
August 2018

Head and neck cancers associated with exposure to the September 11, 2001 World Trade Center terrorist attacks.

Int J Cancer 2018 06 10;142(12):2485-2490. Epub 2018 Feb 10.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.

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http://dx.doi.org/10.1002/ijc.31277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908749PMC
June 2018

Patterns of recurrence in oral tongue cancer with perineural invasion.

Head Neck 2018 06 9;40(6):1287-1295. Epub 2018 Mar 9.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/hed.25110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980694PMC
June 2018

Proton Therapy for Head and Neck Cancer.

Curr Treat Options Oncol 2018 05 9;19(6):28. Epub 2018 May 9.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1250 1st Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s11864-018-0546-9DOI Listing
May 2018

A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer.

Int J Radiat Oncol Biol Phys 2018 03 24;100(3):595-605. Epub 2017 Apr 24.

Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; Division of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.04.017DOI Listing
March 2018

Facility Volume and Survival in Nasopharyngeal Carcinoma.

Int J Radiat Oncol Biol Phys 2018 02 28;100(2):408-417. Epub 2017 Sep 28.

Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California; Department of Medical Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.09.038DOI Listing
February 2018

Proton Therapy for Head and Neck Cancers.

Semin Radiat Oncol 2018 01;28(1):53-63

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.semradonc.2017.08.004DOI Listing
January 2018

Monitoring early response to chemoradiotherapy with F-FMISO dynamic PET in head and neck cancer.

Eur J Nucl Med Mol Imaging 2017 Sep 24;44(10):1682-1691. Epub 2017 May 24.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s00259-017-3720-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563902PMC
September 2017

Patterns of Care in Adjuvant Therapy for Resected Oral Cavity Squamous Cell Cancer in Elderly Patients.

Int J Radiat Oncol Biol Phys 2017 07 2;98(4):758-766. Epub 2017 Feb 2.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.01.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240349PMC
July 2017

Re-Irradiation Therapy for Locally Recurrent Head and Neck Cancer: A National Survey of Practice Patterns.

Cancer Invest 2017 Jul 24;35(6):393-402. Epub 2017 Apr 24.

a Department of Radiation Oncology, David Geffen School of Medicine , University of California Los Angeles , Los Angeles , CA , USA.

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http://dx.doi.org/10.1080/07357907.2017.1310222DOI Listing
July 2017

Predictive modeling of outcomes following definitive chemoradiotherapy for oropharyngeal cancer based on FDG-PET image characteristics.

Phys Med Biol 2017 Jul 12;62(13):5327-5343. Epub 2017 Jun 12.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States of America.

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http://dx.doi.org/10.1088/1361-6560/aa73ccDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729737PMC
July 2017

Impact of concomitant chemoradiation on survival for patients with T1-2N1 head and neck cancer.

Cancer 2017 05 21;123(9):1555-1565. Epub 2016 Dec 21.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1002/cncr.30508DOI Listing
May 2017

Proton Radiation Therapy for Local Control in a Case of Osteosarcoma of the Neck.

Int J Part Ther 2017 14;3(3):421-428. Epub 2017 Mar 14.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.14338/IJPT-16-00015.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871607PMC
March 2017

Dose-volume factors correlating with trismus following chemoradiation for head and neck cancer.

Acta Oncol 2016 29;55(1):99-104. Epub 2015 Apr 29.

b Department of Radiation Oncology , Memorial Sloan Kettering Cancer Center , New York , New York , USA.

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http://dx.doi.org/10.3109/0284186X.2015.1037864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784420PMC
December 2016

Incidence of Oropharyngeal Cancer Among Elderly Patients in the United States.

JAMA Oncol 2016 Dec;2(12):1617-1623

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California4Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1001/jamaoncol.2016.1804DOI Listing
December 2016

Impact of Flap Reconstruction on Radiotoxicity After Salvage Surgery and Reirradiation for Recurrent Head and Neck Cancer.

Ann Surg Oncol 2016 12 9;23(Suppl 5):850-857. Epub 2016 Aug 9.

Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1245/s10434-016-5492-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271365PMC
December 2016

Comparison of mean radiation dose and dosimetric distribution to tooth-bearing regions of the mandible associated with proton beam radiation therapy and intensity-modulated radiation therapy for ipsilateral head and neck tumor.

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Nov 19;122(5):566-571. Epub 2016 Jul 19.

Attending, Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oooo.2016.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279063PMC
November 2016

High-dose hypofractionated radiotherapy is effective and safe for tumors in the head-and-neck.

Oral Oncol 2016 09 12;60:74-80. Epub 2016 Jul 12.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2016.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524568PMC
September 2016

Patterns of regional and distant metastasis in esthesioneuroblastoma.

Laryngoscope 2016 07 10;126(7):1556-61. Epub 2016 Feb 10.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

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http://dx.doi.org/10.1002/lary.25862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914404PMC
July 2016

Employment and return to work following chemoradiation in patient with HPV-related oropharyngeal cancer.

Cancers Head Neck 2016 3;1. Epub 2016 Jun 3.

1Head and Neck Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, #1459, New York, NY 10065 USA.

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http://dx.doi.org/10.1186/s41199-016-0002-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457145PMC
June 2016

Proton Beam Reirradiation for Recurrent Head and Neck Cancer: Multi-institutional Report on Feasibility and Early Outcomes.

Int J Radiat Oncol Biol Phys 2016 May 17;95(1):386-95. Epub 2016 Feb 17.

Memorial Sloan Kettering Cancer Center, Radiation Oncology, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2016.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997784PMC
May 2016

Trends in chemoradiation use in elderly patients with head and neck cancer: Changing treatment patterns with cetuximab.

Head Neck 2016 04 26;38 Suppl 1:E165-71. Epub 2015 Jun 26.

Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/hed.23961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970459PMC
April 2016

Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations.

Clin Cancer Res 2016 Apr 20;22(8):2009-19. Epub 2015 Nov 20.

Memorial Sloan Kettering Cancer Center, Human Oncology and Pathogenesis Program, New York, New York. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870591PMC
April 2016

Intensity-modulated radiotherapy for head and neck surgeons.

Head Neck 2016 04 26;38 Suppl 1:E2368-73. Epub 2015 Dec 26.

Department of Clinical and Translational Oncology, Institute of Molecular and Oncological Medicine of Asturias Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1002/hed.24338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024779PMC
April 2016

The Influence of Diabetes Mellitus and Metformin on Distant Metastases in Oropharyngeal Cancer: A Multicenter Study.

Int J Radiat Oncol Biol Phys 2016 Mar 11;94(3):523-531. Epub 2015 Nov 11.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1016/j.ijrobp.2015.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993040PMC
March 2016

Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent.

Sci Rep 2016 Feb 22;6:21371. Epub 2016 Feb 22.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/srep21371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761964PMC
February 2016

Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer.

World J Radiol 2016 Jan;8(1):90-7

Jacobus FA Jansen, Department of Radiology, Maastricht University Medical Center, 6211 LK Maastricht, the Netherlands.

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http://dx.doi.org/10.4329/wjr.v8.i1.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731352PMC
January 2016

Elective versus Therapeutic Neck Dissection in Oral Cancer.

N Engl J Med 2015 12;373(25):2475-6

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http://dx.doi.org/10.1056/NEJMc1511351DOI Listing
December 2015

Irradiation for locoregionally recurrent, never-irradiated oral cavity cancers.

Head Neck 2015 Nov 28;37(11):1633-41. Epub 2014 Aug 28.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/hed.23806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973396PMC
November 2015

Treatment-related toxicities in older adults with head and neck cancer: A population-based analysis.

Cancer 2015 Jun 27;121(12):2083-9. Epub 2015 Feb 27.

Center for Health Policy and Outcomes, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://doi.wiley.com/10.1002/cncr.29262
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http://dx.doi.org/10.1002/cncr.29262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018230PMC
June 2015

Dorsal vagal complex of the brainstem: Conformal avoidance to reduce nausea. In regard to Monroe et al.

Pract Radiat Oncol 2015 Mar-Apr;5(2):e57

Department of Radiation Oncology, Columbia University, New York, New York.

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http://dx.doi.org/10.1016/j.prro.2014.08.013DOI Listing
May 2015

Efficacy of skin-directed therapy for cutaneous metastases from advanced cancer: a meta-analysis.

J Clin Oncol 2014 Oct 25;32(28):3144-55. Epub 2014 Aug 25.

Daniel E. Spratt, Antonio DeRosa, Nancy Y. Lee, Mario E. Lacoutre, and Christopher A. Barker, Memorial Sloan-Kettering Cancer Center; Elizabeth A. Gordon Spratt, New York University Langone Medical Center, New York; and Shenhong Wu, Stony Brook University Cancer Center, Stony Brook, NY.

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http://dx.doi.org/10.1200/JCO.2014.55.4634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979225PMC
October 2014

External beam radiotherapy with or without concurrent chemotherapy in advanced or recurrent non-anaplastic non-medullary thyroid cancer.

J Surg Oncol 2014 Sep 24;110(4):375-82. Epub 2014 Jun 24.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1002/jso.23656DOI Listing
September 2014

Locally advanced and unresectable cutaneous squamous cell carcinoma: outcomes of concurrent cetuximab and radiotherapy.

J Skin Cancer 2014 21;2014:284582. Epub 2014 Jul 21.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 22, New York, NY 10065, USA.

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http://dx.doi.org/10.1155/2014/284582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129159PMC
August 2014

Estimate of the impact of FDG-avidity on the dose required for head and neck radiotherapy local control.

Radiother Oncol 2014 Jun 12;111(3):340-7. Epub 2014 May 12.

Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2014.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822492PMC
June 2014

A nomogram to predict loco-regional control after re-irradiation for head and neck cancer.

Radiother Oncol 2014 Jun 30;111(3):382-7. Epub 2014 Jun 30.

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, United States. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125394PMC
June 2014

A phase 1 study of everolimus + weekly cisplatin + intensity modulated radiation therapy in head-and-neck cancer.

Int J Radiat Oncol Biol Phys 2013 Nov;87(3):479-86

Department of Medicine, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1016/j.ijrobp.2013.06.2043DOI Listing
November 2013

Pathologically determined tumor volume vs pathologic T stage in the prediction of outcome after surgical treatment of oropharyngeal squamous cell carcinoma.

JAMA Otolaryngol Head Neck Surg 2013 Nov;139(11):1151-5

Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1001/jamaoto.2013.4973DOI Listing
November 2013

Concurrent radiotherapy and ipilimumab immunotherapy for patients with melanoma.

Cancer Immunol Res 2013 Aug 25;1(2):92-8. Epub 2013 Jul 25.

Authors' Affiliations: Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682550PMC
August 2013