Nancy Tsou

Nancy Tsou

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Nancy Tsou

Nancy Tsou

Publications by authors named "Nancy Tsou"

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34Publications

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Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

Bioorg Med Chem Lett 2009 Apr 9;19(8):2125-8. Epub 2009 Mar 9.

Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Quebec, Canada.

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http://dx.doi.org/10.1016/j.bmcl.2009.03.010DOI Listing
April 2009

Diastereoselective Friedel-Crafts alkylation of indoles with chiral alpha-phenyl benzylic cations. Asymmetric synthesis of anti-1,1,2-triarylalkanes.

Org Lett 2008 Jul 19;10(14):3037-40. Epub 2008 Jun 19.

Process Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1021/ol800858cDOI Listing
July 2008

Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation.

J Am Chem Soc 2008 Jun 8;130(22):7060-6. Epub 2008 May 8.

Natural Products Chemistry, Infectious Diseases, and Process Research, Merck Research Laboratories, Merck and Company, P.O. Box 2000, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1021/ja711209pDOI Listing
June 2008

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

Bioorg Med Chem Lett 2008 Apr 10;18(8):2696-700. Epub 2008 Mar 10.

Department of Medicinal Chemistry, Merck Frosst Canada & Co., 16711 Trans Canada Hwy, Kirkland, Que., Canada.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.015DOI Listing
April 2008

Preparation of 2,5,7-trithiabicyclo[2.2.1]heptane from 1,2-bis-triisopropylsilanylsulfanyl alkenes.

Org Lett 2006 Jan;8(1):59-61

Merck Frosst Canada, Inc., Autoroute Transcanadienne, Kirkland, Québec.

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http://dx.doi.org/10.1021/ol0524858DOI Listing
January 2006

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

Bioorg Med Chem Lett 2005 Nov;15(21):4741-4

Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-Dorval, Que., Canada H9R 4P8.

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http://dx.doi.org/10.1016/j.bmcl.2005.07.071DOI Listing
November 2005

Cyclic sulfamide gamma-secretase inhibitors.

Bioorg Med Chem Lett 2005 Oct;15(19):4212-6

Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.

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http://dx.doi.org/10.1016/j.bmcl.2005.06.084DOI Listing
October 2005

Aryl sulfones: a new class of gamma-secretase inhibitors.

Bioorg Med Chem Lett 2005 May;15(10):2685-8

Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.

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http://dx.doi.org/10.1016/j.bmcl.2004.12.017DOI Listing
May 2005

Demonstrating the synergy of synthetic, mechanistic, and computational studies in a regioselective aniline synthesis.

J Org Chem 2004 Feb;69(4):1298-308

Department of Process Research, Merck & Co., Inc., PO Box 2000, Rahway, New Jersey 07065-0900, USA.

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http://dx.doi.org/10.1021/jo035677uDOI Listing
February 2004

Asymmetric synthesis of alpha,alpha-difluoro-beta-amino acid derivatives from enantiomerically pure N-tert-butylsulfinimines.

J Org Chem 2002 Nov;67(23):8276-9

Merck Research Laboratories, West Point, Pennsylvania 19486, and Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1021/jo0259313DOI Listing
November 2002

Crystallization-induced diastereoselection: asymmetric synthesis of substance P inhibitors.

Chemistry 2002 Mar;8(6):1372-6

Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1002/1521-3765(20020315)8:6<1372::aid-chem1372>3.0.co;2-6DOI Listing
March 2002

Studies on the Dimerization of 2-Benzylidene-1-indanone.

J Org Chem 1997 Jun;62(13):4339-4342

Merck Research Laboratories, Department of Molecular Design and Diversity, P.O. Box 2000 (RY50-105), Rahway, New Jersey 07065-0900.

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http://dx.doi.org/10.1021/jo970402yDOI Listing
June 1997