Nancy Speck

Nancy Speck

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Nancy Speck

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Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis.

Stem Cell Reports 2020 Feb 16;14(2):285-299. Epub 2020 Jan 16.

Department of Pediatrics, Section of Hematology/Oncology/BMT University of Colorado, Denver/Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pharmacology, University of Colorado, Denver/Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013201PMC
February 2020

Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells.

Cell Rep 2019 Dec;29(12):4200-4211.e7

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.065DOI Listing
December 2019

Macrophages Fertilize the Soil to Promote Hematopoietic Cell Growth.

Immunity 2019 06;50(6):1342-1344

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193023
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http://dx.doi.org/10.1016/j.immuni.2019.05.017DOI Listing
June 2019

RUNX1 and the endothelial origin of blood.

Exp Hematol 2018 12 31;68:2-9. Epub 2018 Oct 31.

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X183087
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http://dx.doi.org/10.1016/j.exphem.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494457PMC
December 2018

A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells.

J Vis Exp 2018 08 22(138). Epub 2018 Aug 22.

Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania;

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https://www.jove.com/video/56855/a-western-blotting-protocol
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http://dx.doi.org/10.3791/56855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231698PMC
August 2018

Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells only during early embryogenesis.

Development 2018 01 29;145(2). Epub 2018 Jan 29.

Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1242/dev.158162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825840PMC
January 2018

Mutations in Inherited and Sporadic Leukemia.

Front Cell Dev Biol 2017 20;5:111. Epub 2017 Dec 20.

Department of Cell and Developmental Biology, Perelman School of Medicine, Abramson Family Cancer Research Institute, Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fcell.2017.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742424PMC
December 2017

deficiency delays leukemogenesis in mice induced by .

Blood 2017 11 10;130(22):2431-2442. Epub 2017 Oct 10.

Oncogenesis and Development Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2017-04-780106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709785PMC
November 2017

The Role of Runx1 in Embryonic Blood Cell Formation.

Adv Exp Med Biol 2017 ;962:47-64

Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19103, USA.

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http://dx.doi.org/10.1007/978-981-10-3233-2_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813695PMC
September 2017

Twist1 regulates embryonic hematopoietic differentiation through binding to and promoter regions.

Blood Adv 2017 Sep 31;1(20):1672-1681. Epub 2017 Aug 31.

Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1182/bloodadvances.2017006056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728333PMC
September 2017

Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites.

Dev Dyn 2016 10 17;245(10):1011-28. Epub 2016 Aug 17.

Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/dvdy.24430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801748PMC
October 2016

Stress Can Be a Good Thing for Blood Formation.

Authors:
Nancy A Speck

Cell Stem Cell 2016 09;19(3):279-80

Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813687PMC
September 2016

Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos.

Dev Biol 2016 07 20;415(1):111-121. Epub 2016 Apr 20.

Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810923PMC
July 2016

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.

Elife 2015 Oct 13;4:e07780. Epub 2015 Oct 13.

Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.

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http://dx.doi.org/10.7554/eLife.07780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714971PMC
October 2015

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.

Cell Stem Cell 2015 Aug 9;17(2):165-77. Epub 2015 Jul 9.

Abramson Family Cancer Research Institute, Institute for Regenerative Medicine and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530029PMC
August 2015

The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.

J Biol Chem 2015 Mar 20;290(12):7416-25. Epub 2015 Jan 20.

From the Arthritis and Tissue Degeneration Program, Hospital for Special Surgery and the Departments of Medicine and of Physiology, Biophysics and Systems Biology, Weill Cornell Medical College, New York, New York 10021,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.603753
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http://dx.doi.org/10.1074/jbc.M114.603753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367251PMC
March 2015

Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche.

Cell 2015 Jan;160(1-2):241-52

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02138, USA; Chemical Biology Program, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346256PMC
January 2015

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.

Genes Dev 2014 Dec 13;28(23):2597-612. Epub 2014 Nov 13.

Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19014, USA;

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http://dx.doi.org/10.1101/gad.253302.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248291PMC
December 2014

Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation.

Free Radic Biol Med 2014 May 12;70:255-64. Epub 2014 Mar 12.

Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, D-24118 Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.02.025DOI Listing
May 2014

Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder.

Blood 2014 May 27;123(19):2968-77. Epub 2014 Mar 27.

Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO; and.

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http://dx.doi.org/10.1182/blood-2013-11-539643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014839PMC
May 2014

Gata2 is required for HSC generation and survival.

J Exp Med 2013 Dec 2;210(13):2843-50. Epub 2013 Dec 2.

Erasmus Medical Center, Erasmus Stem Cell Institute, 3000 CA Rotterdam, Netherlands.

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http://dx.doi.org/10.1084/jem.20130751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865477PMC
December 2013

Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.

Development 2013 Sep 7;140(18):3765-76. Epub 2013 Aug 7.

Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1242/dev.094961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754475PMC
September 2013

Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.

Blood 2013 May 20;121(18):3714-7. Epub 2013 Feb 20.

Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1182/blood-2012-11-465641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643768PMC
May 2013

The expression of Sox17 identifies and regulates haemogenic endothelium.

Nat Cell Biol 2013 May 21;15(5):502-10. Epub 2013 Apr 21.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1038/ncb2724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011511PMC
May 2013

Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.

J Bone Miner Res 2012 Jul;27(7):1585-97

Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06034, USA.

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http://dx.doi.org/10.1002/jbmr.1601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377839PMC
July 2012

Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.

J Biol Chem 2012 Jul 21;287(28):23678-89. Epub 2012 May 21.

Department of Dermatology, Christian-Albrecht University Kiel, 24098 Kiel, Germany.

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http://dx.doi.org/10.1074/jbc.M112.362756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390642PMC
July 2012

Tyrosyl phosphorylation toggles a Runx1 switch.

Genes Dev 2012 Jul;26(14):1520-6

Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1101/gad.198051.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404380PMC
July 2012

Runx1 loss minimally impacts long-term hematopoietic stem cells.

PLoS One 2011 1;6(12):e28430. Epub 2011 Dec 1.

Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028430PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228772PMC
May 2012

RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.

Crit Rev Oncog 2011 ;16(1-2):77-91

Department of Internal Medicine, Division of Hematology-Oncology and the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248792PMC
http://dx.doi.org/10.1615/critrevoncog.v16.i1-2.80DOI Listing
February 2012

Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos.

Nat Protoc 2012 Feb 9;7(3):421-31. Epub 2012 Feb 9.

Department of Cell Biology, Erasmus Medical Center Stem Cell Institute, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/nprot.2011.441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629302PMC
February 2012

Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.

Cell Stem Cell 2011 Dec;9(6):541-52

Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091100483
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http://dx.doi.org/10.1016/j.stem.2011.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576591PMC
December 2011

Hematopoietic stem cell emergence in the conceptus and the role of Runx1.

Int J Dev Biol 2010 ;54(6-7):1151-63

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://www.intjdevbiol.com/paper.php?doi=103106gs
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http://dx.doi.org/10.1387/ijdb.103106gsDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512753PMC
February 2011

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model.

Blood 2010 Nov 5;116(22):4612-20. Epub 2010 Aug 5.

Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1182/blood-2010-03-276998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996118PMC
November 2010

PAF is in the cabal of MLL1-interacting proteins that promote leukemia.

Cancer Cell 2010 Jun;17(6):531-2

Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.05.019DOI Listing
June 2010

Visualizing blood cell emergence from aortic endothelium.

Cell Stem Cell 2010 Apr;6(4):289-90

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.stem.2010.03.007DOI Listing
April 2010

DNA specificity determinants associate with distinct transcription factor functions.

PLoS Genet 2009 Dec 18;5(12):e1000778. Epub 2009 Dec 18.

Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787013PMC
December 2009

Conditional Cre/LoxP strategies for the study of hematopoietic stem cell formation.

Blood Cells Mol Dis 2009 Jul-Aug;43(1):6-11. Epub 2009 Feb 28.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bcmd.2009.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723839PMC
September 2009

The role of CBFbeta in AML1-ETO's activity.

Blood 2009 Sep;114(13):2849-50

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http://dx.doi.org/10.1182/blood-2009-07-231233DOI Listing
September 2009

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

Blood 2009 Apr 9;113(15):3558-67. Epub 2009 Feb 9.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1182/blood-2008-06-161307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668852PMC
April 2009

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter.

Nature 2009 Feb 7;457(7231):887-91. Epub 2009 Jan 7.

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1038/nature07619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744041PMC
February 2009

A MENage à Trois in leukemia.

Cancer Cell 2008 Jul;14(1):3-5

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.06.009DOI Listing
July 2008

Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.

Cell Cycle 2008 Mar 1;7(5):586-91. Epub 2008 Jan 1.

Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892629PMC
http://dx.doi.org/10.4161/cc.7.5.5549DOI Listing
March 2008

Of lineage and legacy: the development of mammalian hematopoietic stem cells.

Nat Immunol 2008 Feb;9(2):129-36

Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ni1560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696344PMC
February 2008

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Nat Genet 2008 Jan 11;40(1):51-60. Epub 2007 Nov 11.

Hematology/Oncology Division, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ng.2007.7DOI Listing
January 2008

A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails.

BMC Med Genet 2007 Dec 31;8:82. Epub 2007 Dec 31.

The prenatal diagnostic Center of Wenzhou City, Department of genetics of Wenzhou No2 Hospital, Wenzhou, China.

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http://dx.doi.org/10.1186/1471-2350-8-82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241583PMC
December 2007

The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential.

Development 2006 Nov;133(21):4183-92

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1242/dev.02596DOI Listing
November 2006

Runx1 function in hematopoiesis is required in cells that express Tek.

Blood 2006 Jan 20;107(1):106-10. Epub 2005 Sep 20.

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1182/blood-2005-05-1955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895353PMC
January 2006

Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma.

Blood 2005 Nov 28;106(10):3621-4. Epub 2005 Jul 28.

Genetics and Molecular Biology Branch and Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2005-04-1447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459843PMC
November 2005

Telepsychiatry program for rural victims of domestic violence.

Telemed J E Health 2005 Oct;11(5):567-73

The University of Texas Medical Branch, Galveston, Texas, USA.

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http://dx.doi.org/10.1089/tmj.2005.11.567DOI Listing
October 2005

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

Blood 2005 Jul 22;106(2):494-504. Epub 2005 Mar 22.

Division of Hematology and Department of Pathology, Brigham and Women's Hospital, 1 Blackfan Circle, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2004-08-3280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895175PMC
July 2005

Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells.

Stem Cells 2004 ;22(2):158-68

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA. (Current address for Dr. de Bruijn) MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

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http://doi.wiley.com/10.1634/stemcells.22-2-158
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http://dx.doi.org/10.1634/stemcells.22-2-158DOI Listing
November 2004

Possible roles of Runx1 and Sox9 in incipient intramembranous ossification.

J Bone Miner Res 2004 Oct 3;19(10):1671-7. Epub 2004 Aug 3.

Department of Orthodontics, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.

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http://dx.doi.org/10.1359/JBMR.040801DOI Listing
October 2004

CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.

Nat Struct Mol Biol 2004 Sep 22;11(9):901-6. Epub 2004 Aug 22.

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22906, USA.

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http://dx.doi.org/10.1038/nsmb819DOI Listing
September 2004

Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.

Blood Cells Mol Dis 2003 Mar-Apr;30(2):147-56

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/s1079-9796(03)00022-6DOI Listing
August 2004

Nomenclature for Runt-related (RUNX) proteins.

Oncogene 2004 May;23(24):4209-10

Molecular and Cell Biology and Oncology Research Institute, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore.

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http://www.nature.com/articles/1207758
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http://dx.doi.org/10.1038/sj.onc.1207758DOI Listing
May 2004

Core-binding factors in hematopoiesis and immune function.

Oncogene 2004 May;23(24):4238-48

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1038/sj.onc.1207763DOI Listing
May 2004

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

J Biol Chem 2003 Aug 13;278(35):33088-96. Epub 2003 Jun 13.

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1074/jbc.M303973200DOI Listing
August 2003

Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo.

J Cell Physiol 2003 Aug;196(2):301-11

Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655-0106, USA.

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http://dx.doi.org/10.1002/jcp.10316DOI Listing
August 2003

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.

Nat Genet 2002 Dec 18;32(4):645-9. Epub 2002 Nov 18.

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1038/ng1049DOI Listing
December 2002

Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis.

Nat Struct Biol 2002 Sep;9(9):674-9

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1038/nsb831DOI Listing
September 2002

Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.

Blood 2002 Jul;100(2):458-66

Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2001-12-0321DOI Listing
July 2002

Core-binding factors in haematopoiesis and leukaemia.

Nat Rev Cancer 2002 Jul;2(7):502-13

Department of Biochemisty, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1038/nrc840DOI Listing
July 2002