Publications by authors named "Nancy Ratner"

100Publications

Brain-wide structural and functional disruption in mice with oligodendrocyte-specific deletion is rescued by inhibition of nitric oxide synthase.

Proc Natl Acad Sci U S A 2020 Sep 24;117(36):22506-22513. Epub 2020 Aug 24.

Department of Neuroscience, Rappaport Faculty of Medicine and Institute, Technion-Israel Institute of Technology, 3525422 Haifa, Israel;

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http://dx.doi.org/10.1073/pnas.2008391117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486714PMC
September 2020

Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST.

Cancer Res 2020 Aug 19. Epub 2020 Aug 19.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1429DOI Listing
August 2020

After loss in Schwann cells, inflammation drives neurofibroma formation.

Neurooncol Adv 2020 Jul 22;2(Suppl 1):i23-i32. Epub 2019 Nov 22.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1093/noajnl/vdz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317060PMC
July 2020

A molecular basis for neurofibroma-associated skeletal manifestations in NF1.

Genet Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Molecular and Human Genetics and Orthopaedic Surgery, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41436-020-0885-3DOI Listing
June 2020

Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis.

Cell Rep 2020 Apr;31(2):107513

Division of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.03.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213061PMC
April 2020

Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas.

Am J Cancer Res 2020 1;10(3):856-869. Epub 2020 Mar 1.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136923PMC
March 2020

NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.

Acta Neuropathol 2020 01 29;139(1):157-174. Epub 2019 Oct 29.

Department of Experimental Hematology and Cancer Biology, Cincinati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinanti School of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1007/s00401-019-02086-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243727PMC
January 2020

RUNX represses to drive neurofibromagenesis.

Sci Adv 2019 04 24;5(4):eaau8389. Epub 2019 Apr 24.

Cincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1126/sciadv.aau8389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482019PMC
April 2019

Proximity biotinylation identifies a set of conformation-specific interactions between Merlin and cell junction proteins.

Sci Signal 2019 04 23;12(578). Epub 2019 Apr 23.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1126/scisignal.aau8749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631321PMC
April 2019

iGEAK: an interactive gene expression analysis kit for seamless workflow using the R/shiny platform.

BMC Genomics 2019 Mar 6;20(1):177. Epub 2019 Mar 6.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1186/s12864-019-5548-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404331PMC
March 2019

Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1172/jci.insight.98601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413799PMC
February 2019

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma.

Oncogene 2019 04 12;38(15):2876-2884. Epub 2018 Dec 12.

Department of Pediatrics, University of Cincinnati College of Medicine, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, 3333 Burnet Ave., Cincinnati, OH, 45229-0713, USA.

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http://dx.doi.org/10.1038/s41388-018-0600-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461477PMC
April 2019

Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1.

Acta Neuropathol Commun 2018 11 23;6(1):127. Epub 2018 Nov 23.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, 3333 Burnet Ave., ML 7017, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1186/s40478-018-0635-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251093PMC
November 2018

Malignant peripheral nerve sheath tumor: Transformation in a patient with neurofibromatosis type 2.

Pediatr Blood Cancer 2019 02 8;66(2):e27520. Epub 2018 Nov 8.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.27520DOI Listing
February 2019

Defective transcription elongation in a subset of cancers confers immunotherapy resistance.

Nat Commun 2018 10 23;9(1):4410. Epub 2018 Oct 23.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, 45229, OH, USA.

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http://www.nature.com/articles/s41467-018-06810-0
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http://dx.doi.org/10.1038/s41467-018-06810-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199328PMC
October 2018

Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells.

Oncotarget 2018 Mar 18;9(22):15860-15875. Epub 2017 Jul 18.

Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.

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http://dx.doi.org/10.18632/oncotarget.19335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882303PMC
March 2018

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Cancer Cell 2018 02;33(2):292-308.e7

Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813693PMC
February 2018

Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy.

Oncotarget 2017 Oct 30;8(47):82037-82048. Epub 2017 May 30.

Division of Hematology, Oncology, Blood and Marrow Transplant, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.

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http://dx.doi.org/10.18632/oncotarget.18301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669868PMC
October 2017

Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.

J Natl Cancer Inst 2017 08;109(8)

Rare Tumor Initiative, Laboratory of Pathology, and Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC; Department of Neurology, Johns Hopkins Hospital, Baltimore, MD; Neurofibromatosis Center, Department of Neurology Guy's Hospital London, London, UK; Department of Neurology, Washington University School of Medicine, St. Louis, MO; Department of Human Genetics, University of Leuven, Leuven, Belgium; Hunstman Cancer Institute, University of Utah, Salt Lake City, UT; Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH; Bill and Melinda Gates Foundation, Seattle, WA; Children's Tumor Foundation, New York, NY; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

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http://dx.doi.org/10.1093/jnci/djx124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057517PMC
August 2017

Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior.

Cell Rep 2017 04;19(3):545-557

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173045
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http://dx.doi.org/10.1016/j.celrep.2017.03.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828008PMC
April 2017

An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system.

Sci Rep 2017 03 3;7:43315. Epub 2017 Mar 3.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1038/srep43315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335359PMC
March 2017

Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.

N Engl J Med 2016 12;375(26):2550-2560

From the Center for Cancer Research, Pediatric Oncology Branch, Bethesda (E.D., A. Baldwin, L.J.M., P. Whitcomb, S.M., R.E., P. Wolters, J.T., J.G., A.J.S., A.G., B.C.W.) and the Cancer Therapy Evaluation Program, Shady Grove (A.L.D.), National Cancer Institute, and the National Heart, Lung, and Blood Institute (A. Brofferio), Bethesda, National Institutes of Health, and the Food and Drug Administration, Silver Spring (L.J.M., R.E.) - all in Maryland; the Division of Oncology, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (M.J.F., J.B.B.); Children's National Health System, Washington, DC (A.K.); and Cincinnati Children's Hospital, Cincinnati (B.W., L.E.A.-S., T.A.R., J.W., E.S., N.R.).

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http://dx.doi.org/10.1056/NEJMoa1605943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508592PMC
December 2016

CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin.

Oncotarget 2016 Aug;7(33):53191-53203

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.18632/oncotarget.10668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288178PMC
August 2016

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.

EBioMedicine 2016 Jul 4;9:110-119. Epub 2016 Jun 4.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229-0713, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972548PMC
July 2016

The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.

Ann Neurol 2016 07 30;80(1):13-23. Epub 2016 Apr 30.

Department of Pediatrics, University of Rochester Medical Center, Rochester, NY.

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http://dx.doi.org/10.1002/ana.24659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419586PMC
July 2016

Runx1: a new driver in neurofibromagenesis.

Oncoscience 2015 17;2(11):904-5. Epub 2015 Nov 17.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675781PMC
http://dx.doi.org/10.18632/oncoscience.266DOI Listing
December 2015

Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.

Neuro Oncol 2015 Dec 26;17(12):1599-608. Epub 2015 Jun 26.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, Ohio, USA (A.V.P., N.R.); Division of Oncology, Cincinnati Children's Hospital, Cincinnati, Ohio, USA (B.D.); Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (G.J.); Assistant Director for Compliance, Office of Intramural Research, National Institute of Health (M.C.C.).

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http://dx.doi.org/10.1093/neuonc/nov076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633928PMC
December 2015

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.

Pediatr Blood Cancer 2015 Oct 22;62(10):1709-16. Epub 2015 Apr 22.

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.25546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546559PMC
October 2015

A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor.

Nat Rev Cancer 2015 May 16;15(5):290-301. Epub 2015 Apr 16.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://www.nature.com/articles/nrc3911
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http://dx.doi.org/10.1038/nrc3911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822336PMC
May 2015

Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells.

BMC Genomics 2014 Sep 28;15:821. Epub 2014 Sep 28.

Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1186/1471-2164-15-821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190347PMC
September 2014

The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.

Nat Commun 2014 Sep 26;5:4993. Epub 2014 Sep 26.

Department of Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1038/ncomms5993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431623PMC
September 2014

Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.

Am J Pathol 2014 Jul 13;184(7):2082-98. Epub 2014 May 13.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota; Brain Tumor Program, University of Minnesota, Minneapolis, Minnesota; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1016/j.ajpath.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076465PMC
July 2014

The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.

J Neurosci 2014 Mar;34(10):3767-78

Divisions of Experimental Hematology and Cancer Biology, Molecular Cardiovascular Biology, Oncology, and Developmental Biology and Neurosurgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, and Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri Columbia, Columbia, Missouri 65211.

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http://dx.doi.org/10.1523/JNEUROSCI.3515-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942589PMC
March 2014

The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.

J Neurosci 2013 Nov;33(46):17967-75

Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, Department of Molecular, Virology, Immunology, and Medical Genetics, and Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine The Ohio State University, Columbus, Ohio 43210.

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http://dx.doi.org/10.1523/JNEUROSCI.0766-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828453PMC
November 2013

Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature.

Cell Rep 2013 Sep 12;4(6):1197-212. Epub 2013 Sep 12.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982616PMC
September 2013

Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling.

Glia 2013 Nov 6;61(11):1906-21. Epub 2013 Sep 6.

Division of Experimental Hematology and Cancer Biology, Department of Pediatrics, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/glia.22567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447142PMC
November 2013

Interweaving the strands: β-catenin, an HIV co-receptor, and Schwann cell tumors.

Cancer Cell 2013 Mar;23(3):269-71

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635484PMC
March 2013

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

Sarcoma 2012 18;2012:620834. Epub 2012 Dec 18.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA ; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA ; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA ; Brain Tumor Program, University of Minnesota, Minneapolis, MN 55455, USA ; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

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http://www.hindawi.com/journals/sarcoma/2012/620834/
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http://dx.doi.org/10.1155/2012/620834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539440PMC
January 2013

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.

J Clin Invest 2013 Jan 10;123(1):340-7. Epub 2012 Dec 10.

Children’s Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, 3333 Burnet Ave., M.L.C. 7013, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1172/JCI60578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533264PMC
January 2013

Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.

J Neurosci 2012 Nov;32(48):17251-61

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2461-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601465PMC
November 2012

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.

Acta Neuropathol 2013 Jan 26;125(1):159-68. Epub 2012 Oct 26.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1007/s00401-012-1056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547628PMC
January 2013

Neurofibromatosis type 1: modeling CNS dysfunction.

J Neurosci 2012 Oct;32(41):14087-93

Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3242-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477849PMC
October 2012

In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1.

Cancer Res 2012 Oct 23;72(20):5317-27. Epub 2012 Aug 23.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227504PMC
October 2012

Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target.

Clin Cancer Res 2012 Sep 18;18(18):5020-30. Epub 2012 Jul 18.

Divisions of Experimental Hematology and Cancer Biology, Oncology, and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902639PMC
September 2012

Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment.

Clin Cancer Res 2011 12 31;17(24):7563-73. Epub 2011 Oct 31.

Departments of Bone and Soft Tissue Tumor, Pathology, and Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Tianjin, China.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-1707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243813PMC
December 2011

Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.

Mol Cancer Ther 2011 Sep 22;10(9):1740-50. Epub 2011 Jun 22.

Department of Pharmacology and Toxicology, Norris Cotton Cancer Center, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170489PMC
September 2011

R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.

J Biol Chem 2011 Jul 13;286(27):24068-78. Epub 2011 May 13.

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.226951
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http://dx.doi.org/10.1074/jbc.M111.226951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129188PMC
July 2011

Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation.

Cancer Res 2011 Jul 6;71(13):4675-85. Epub 2011 May 6.

Cincinnati Children's Hospital Medical Center; Hoxworth Blood Center, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464476PMC
July 2011

Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging.

Pediatr Blood Cancer 2012 Feb 11;58(2):173-80. Epub 2011 Feb 11.

Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1002/pbc.23015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128176PMC
February 2012

Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.

Clin Cancer Res 2010 Oct 25;16(20):5048-57. Epub 2010 Aug 25.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837895PMC
October 2010

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

Cell Stem Cell 2008 Dec;3(6):658-69

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.stem.2008.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487385PMC
December 2008

How does the Schwann cell lineage form tumors in NF1?

Glia 2008 Nov;56(14):1590-605

Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0017, USA.

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http://dx.doi.org/10.1002/glia.20776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652636PMC
November 2008

Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve.

Neuron Glia Biol 2007 Aug;3(3):233-44

1Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, 3333 Burnet Avenue, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.

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http://dx.doi.org/10.1017/S1740925X08000021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561270PMC
August 2007

Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.

Cancer Cell 2008 Feb;13(2):105-16

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846699PMC
February 2008

Schwann cell preparation from single mouse embryos: analyses of neurofibromin function in Schwann cells.

Methods Enzymol 2006 ;407:22-33

Department of Pediatrics, Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)07003-5DOI Listing
June 2008

Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.

J Neurosci 2006 Mar;26(13):3390-5

Division of Experimental Hematology, Cincinnati Children's Hospital Research Foundation, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4865-05.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673872PMC
March 2006

Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors.

J Neurosci 2005 Nov;25(48):11092-106

Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2981-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725641PMC
November 2005

Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants.

Pediatr Blood Cancer 2006 Jun;46(7):745-54

Division of Hematology/Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/pbc.20565DOI Listing
June 2006

Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.

Cancer Cell 2005 Jan;7(1):65-75

Departments of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854500PMC
January 2005

Mechanisms and roles of axon-Schwann cell interactions.

J Neurosci 2004 Oct;24(42):9250-60

Division of Neuroscience, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3649-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730082PMC
October 2004

Activation of the tumor suppressor merlin modulates its interaction with lipid rafts.

Cancer Res 2004 Apr;64(8):2717-24

Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-3798DOI Listing
April 2004