Dr. Nancy Maurya, PhD

Dr. Nancy Maurya

PhD

GWALIOR, Madhya Pradesh | India

Dr. Nancy Maurya, PhD

Dr. Nancy Maurya

PhD
Metrics

11

Publications

391

Profile Views

44

Reads

6

PubMed Central Citations

Education
Dec 2017
IBRI, Noida
3 Months Certificate program in Bioinformatics
May 2016
JNU, New Delhi
PhD
Experience
Jun 2017
MP-SET 2017
May 2016
Assistant Professor (Contractual)
Academic and Research
Sep 2014
ICMR-Senior Research Fellow
Sep 2014
ICMR-Senior Research Fellow
Sep 2011
ICMR-Junior Research Fellow
Jun 2009
CSIR-UGC-JRF-NET
Top co-authors
Ilora Ghosh
Ilora Ghosh

Jawaharlal Nehru University

3
Nupur Rani Agarwal
Nupur Rani Agarwal

Laboratory # 103

2
Kasturi Mukhopadhyay
Kasturi Mukhopadhyay

Jawaharlal Nehru University

1
Jogendra Singh Pawar
Jogendra Singh Pawar

Laboratory # 103

1
Vivek T Natarajan
Vivek T Natarajan

CSIR-Institute of Genomics and Integrative Biology

1
Shivangi Khanna
Shivangi Khanna

CSIR-Institute of Genomics and Integrative Biology

1
Seema Joshi
Seema Joshi

University of Delhi

1
Sana Mumtaz
Sana Mumtaz

Antimicrobial Research Laboratory

1
Bharath Kumar Velmurugan
Bharath Kumar Velmurugan

Changhua Christian Hospital

1
Jyotsna Singh
Jyotsna Singh

CSIR-Indian Institute of Toxicology Research

1

Publications

11Publications

44Reads

6PubMed Central Citations

Therapeutic applications of cannabinoids.

Chem Biol Interact 2018 Sep 21;293:77-88. Epub 2018 Jul 21.

Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam. Electronic address:

View Article
September 2018
15 Reads
2.58 Impact Factor

Therapeutic applications of cannabinoids

Maurya N, Velmurugan BK. Therapeutic applications of cannabinoids. Chembioint. Volume 293, 25 September 2018, Pages 77-88. doi: 10.1016/j.cbi.2018.07.018. [Epub ahead of print]

Chemico-Biological Interactions

The psychoactive property of cannabinoids is well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use for medical and research purposes are restricted in various countries. However, their utility as medications should not be overshadowed by its negative physiological activities. This review article is focused on the therapeutic potential and applications of phytocannabinoids and endocannabinoids. We further highlights their mode of action, overall effects on physiology, various in vitro and in vivo studies that have been done so far and the extent to which these compounds can be useful in different disease conditions such as cancer, Alzheimer's disease, multiple sclerosis, pain, inflammation, glaucoma and many others. Thus, this work is an attempt to make the readers understand the positive implications of these compounds and indicates the significant developments of utilizing cannabinoids as therapeutic agents.

View Article
July 2018
5 Reads

Neuro-pathological Implications of β-Amyloid Protein: An Update

Nancy Maurya, Nupur Rani Agarwal, Neuro-pathological Implications of β-Amyloid Protein: An Update, P

Proceedings of the nature research society

β-Amyloid protein has been extensively and mostly exclusively associated with Alzheimer’s Disease (AD) since past many years. Its relation to other neuro-pathologies is still elusive. The present work begins with the review of AD connection of β-Amyloid protein and further looks at various studies that establish its role in other neuro-pathological disorders like glaucoma and Parkinson’s Disease (PD). It further searches for the possibility of its involvement in neuroblastoma and brain tumors. Only recent and/or context relevant studies have been included.

View Article
June 2018
8 Reads

Low Sugar Diet: A New Tool in War Against Tumorigenesis

Nupur Rani Agarwal, Nancy Maura. Proceedings of the Nature Research Society, 2, 02009 (2018). doi: 10.11605/j.pnrs.201802009

Proceedings of the nature research society

Cancer is a metabolic disease. Their typical characteristic is high consumption of glucose as these cells mostly have defective mitochondria. They primarily derive energy through aerobic glycolysis even in presence of abundant oxygen. Cancer cells thus are heavily dependent on ample and continuous availability of glucose for growth, proliferation and invasion. These cells adopt various strategies to satisfy their high demand for sugar which includes modification in signalling pathways and abnormally high expression of glucose transporters. Glucose uptake is favoured by alteration in PI3K-Akt-mTOR pathway. High glucose condition creates conducive environment for cancer cells to flourish. The H+ ion secreted as by-product of glycolysis helps in invasion and metastasis. Other by products of glycolysis which includes ATP, NADP and NADPH also aids in growth of cancer cells. Glucose restriction puts break on speedy multiplying tumor cells as unlike normal cells of the body they are unable to metabolize any other source of fuel. Lower glucose level induces changes in level of cleaved caspase 3, Bcl-2, p53 and p21 which prompts senescence and apoptosis in rapidly proliferating tumor cells. Various strategies can be employed to cut down glucose accessibility to cancer cells such as inhibition of glucose transporters, adoption of keto diet. Combining glucose restriction with either chemo or radiotherapy increases their effectiveness; lower CHO levels also provide protection to normal healthy cells of the body against toxic effect of anti-carcinogens. Carbohydrate restriction is a non- toxic, easily impeccable, economical and safe tactic which may be utilized as weapon in war against cancer.

View Article
June 2018
5 Reads

Experimental Assessment of Combined Antimicrobial Effect of Lactic Acid Bacteria and Clove Oil against Escherichia coli.

Authors:
Nancy Maurya

Nancy Maurya. Experimental Assessment of Combined Antimicrobial Effect of Lactic Acid Bacteria and C

Journal of Pharmaceutical, Chemical and Biological Sciences

There has been an increasing threat to the efficacy of antibiotics as more and more pathogens are developing anti-microbial drug resistance. Alternatives are required to be developed for therapeutic purposes so that use of antibiotics can be restricted and their activity can be conserved. The present study is based on the use of combination of Lactic acid bacteria and clove oil against one of the commonest entero- and uro-pathogen, E.coli in order to check the anti-microbial activity of the two in a synergistic way. This study is an attempt to look for the possibility of increased anti-microbial activity of lactic acid bacteria and clove oil against E.coli, when they are used in combination

View Article
October 2017
11 Reads

Lactobacilli and clove essential oil against menace of E.coli: a possible solution for antibiotic resistance

Maurya N*, Shrivastav A. Lactobacilli and clove essential oil against menace of E.coli: a possible s

World Journal of Pharmaceutical Research

E.coli is one of the most common diarrheagenic gram negative bacteria also known to cause urinary tract infections. Treatment of its infection has become more problematic due to development and dissemination of its antibiotic resistant pathotypes. This review focuses on lactobacilli and clove essential oil as alternatives that have been found effective in treatment of E.coli with their reported modes and degree of action. A combined treatment of both lactobacilli and clove essential oil under optimized conditions for their highest possible activities in presence of each other can be a new regime to decrease dependency on conventional antibiotics and thus, control rising antimicrobial resistance.

View Article
August 2017
11 Reads

Enhanced Cationic Charge is a Key Factor in Promoting Staphylocidal Activity of α-Melanocyte Stimulating Hormone via Selective Lipid Affinity.

Sci Rep 2016 08 16;6:31492. Epub 2016 Aug 16.

Antimicrobial Research Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi-110067, India.

View Article
August 2016
11 Reads
3 PubMed Central Citations(source)
5.08 Impact Factor

A combined approach against tumorigenesis using glucose deprivation and mitochondrial complex 1 inhibition by rotenone.

Cell Biol Int 2016 Jul 19;40(7):821-31. Epub 2016 May 19.

Biochemistry and Environmental Toxicology, , Laboratory # 103, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

View Article
July 2016
11 Reads
3 PubMed Central Citations(source)
1.93 Impact Factor

Low-dose rotenone exposure induces early senescence leading to late apoptotic signaling cascade in human trabecular meshwork (HTM) cell line: An in vitro glaucoma model.

Cell Biol Int 2016 Jan 19;40(1):107-20. Epub 2015 Nov 19.

Biochemistry and Environmental Toxicology, Laboratory # 103, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

View Article
January 2016
7 Reads
1.93 Impact Factor

Differential Response by Rotenone on Human Trabecular Meshwork and HeLa Cell Lines

Maurya N, Agarwal NR, Ghosh I. Differential Response by Rotenone on Human Trabecular Meshwork and He

Research and Reviews: Journal of Toxicology (RRJoT)

Cellular response towards a particular stress condition is dependent on a number of factors including genetic makeup, microenvironmental factors, nutrient availability etc. Cells under same stress condition respond differentially and may exhibit pro-apoptotic or anti-apoptotic behavior. Two quite different cell lines—the cancerous cells of HeLa and the Human Trabecular Meshwork (HTM) cell line with very different microenvironmental requirements behave very differently towards oxidative insult due to rotenone. Study of their differential behavior revealed more susceptibility of HeLa cells in comparison to HTM cells. This clearly supports the therapeutic utility of rotenone against cancerous growth.

View Article
August 2015
6 Reads

Rotenone Beyond Just An Insecticide: A Review

Ghosh I, Maurya N, Agarwal NR. Rotenone Beyond Just An Insecticide: A Review. Research and Reviews:

Research and Reviews: Journal of Toxicology (RRJoT)

Pesticides have received the most attention due to their global application and widespread implications on human health. In recent years, both epidemiological and toxicological studies have provided evidence that pesticides have the potential to act as toxicants contributing to the development of pathogenesis such as neuronal degenerations as well as may be utilized to induce signalling for reversal, suppress or prevent carcinogenic progression. Rotenone, an isoflavones naturally found in the roots and stems of several plants, is used as a broad-spectrum pesticide. Surprisingly, being a known toxicant, rotenone is used in organic food farming, based on its label as a natural product. Highly lipophilic, it easily crosses the cellular membrane without depending on a transmembrane protein. Once inside the cell, it accumulates at mitochondrial complex I where it is known to inhibit the transfer of electrons and increases reactive oxygen species (ROS) production, causing oxidative damage to DNA and proteins. More recently, rotenone was also shown to inhibit proteosome activity and catalyze the degradation of ubiquitin tagged proteins which may be implicated in pathogenesis of diseases. Numerous plant derived flavonoids compounds, with mitochondrial electron transport chain interrupter, such as rotenone, are currently used by cancer patients as dietary supplements to complement chemotherapy. Excess generation of ROS and its involvement in down-regulation of cellular proliferation by rotenone may be significant in chemotherapeutic assistance in prolonged treatment of tumourigenesis in future.

View Article
July 2014
6 Reads
Top co-authors
Ilora Ghosh
Ilora Ghosh

Jawaharlal Nehru University

3
Nupur Rani Agarwal
Nupur Rani Agarwal

Laboratory # 103

2
Kasturi Mukhopadhyay
Kasturi Mukhopadhyay

Jawaharlal Nehru University

1
Jogendra Singh Pawar
Jogendra Singh Pawar

Laboratory # 103

1
Vivek T Natarajan
Vivek T Natarajan

CSIR-Institute of Genomics and Integrative Biology

1
Shivangi Khanna
Shivangi Khanna

CSIR-Institute of Genomics and Integrative Biology

1
Seema Joshi
Seema Joshi

University of Delhi

1
Sana Mumtaz
Sana Mumtaz

Antimicrobial Research Laboratory

1
Bharath Kumar Velmurugan
Bharath Kumar Velmurugan

Changhua Christian Hospital

1
Jyotsna Singh
Jyotsna Singh

CSIR-Indian Institute of Toxicology Research

1