Publications by authors named "Nancy J Philp"

41Publications

Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion.

FASEB J 2020 Apr 28;34(4):5401-5419. Epub 2020 Feb 28.

Department of Pathology, Anatomy, & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1096/fj.201902961RDOI Listing
April 2020

The cell biology of the retinal pigment epithelium.

Prog Retin Eye Res 2020 Feb 24:100846. Epub 2020 Feb 24.

Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.preteyeres.2020.100846DOI Listing
February 2020

New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity.

iScience 2019 Dec 26;22:507-518. Epub 2019 Nov 26.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.11.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920289PMC
December 2019

Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

Int J Mol Sci 2019 Feb 11;20(3). Epub 2019 Feb 11.

. Department of Therapeutics, Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France.

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http://dx.doi.org/10.3390/ijms20030762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387069PMC
February 2019

Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells.

Am J Physiol Cell Physiol 2019 01 21;316(1):C121-C133. Epub 2018 Nov 21.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1152/ajpcell.00410.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383144PMC
January 2019

Impact of MCT1 Haploinsufficiency on the Mouse Retina.

Adv Exp Med Biol 2018 ;1074:375-380

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-3-319-75402-4_46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708593PMC
May 2019

Deletion of GLUT1 in mouse lens epithelium leads to cataract formation.

Exp Eye Res 2018 07 28;172:45-53. Epub 2018 Mar 28.

Department of Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2018.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716165PMC
July 2018

Phagocytosis-dependent ketogenesis in retinal pigment epithelium.

J Biol Chem 2017 05 16;292(19):8038-8047. Epub 2017 Mar 16.

From the Department of Biochemistry, School of Dental Medicine (SDM), University of Pennsylvania, Philadelphia, Pennsylvania 19104 and

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http://dx.doi.org/10.1074/jbc.M116.770784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427279PMC
May 2017

Plasma membrane protein polarity and trafficking in RPE cells: past, present and future.

Exp Eye Res 2014 Sep;126:5-15

Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, 1300 York Ave, New York, NY 100652, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2014.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502961PMC
September 2014

Cell culture of retinal pigment epithelium: Special Issue.

Exp Eye Res 2014 Sep;126:1-4

Thomas Jefferson University, Department of Pathology, Anatomy, and Cell Biology, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2014.07.010DOI Listing
September 2014

Cultured primary human fetal retinal pigment epithelium (hfRPE) as a model for evaluating RPE metabolism.

Exp Eye Res 2014 Sep 28;126:77-84. Epub 2014 Jan 28.

Thomas Jefferson University, Dept. of Pathology, Anatomy, & Cell Biology, 1020 Locust Street, Rm315, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345411PMC
September 2014

The SLC16A family of monocarboxylate transporters (MCTs)--physiology and function in cellular metabolism, pH homeostasis, and fluid transport.

Curr Top Membr 2012 ;70:275-311

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/B978-0-12-394316-3.00009-0DOI Listing
April 2013

Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression.

J Biol Chem 2012 Jun 20;287(24):20491-503. Epub 2012 Apr 20.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M112.354761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370234PMC
June 2012

Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane.

Invest Ophthalmol Vis Sci 2011 Aug 29;52(9):6774-84. Epub 2011 Aug 29.

Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1167/iovs.10-6579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176021PMC
August 2011

Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy.

Exp Eye Res 2011 Oct 12;93(4):413-23. Epub 2011 Jun 12.

Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, United States.

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http://dx.doi.org/10.1016/j.exer.2011.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202648PMC
October 2011

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion.

J Clin Invest 2010 Sep 2;120(9):3377-88. Epub 2010 Aug 2.

Department of Medicine, University of Chicago, Chicago, Illinois, USA.

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http://www.jci.org/articles/view/42113
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http://dx.doi.org/10.1172/JCI42113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929715PMC
September 2010

The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.

Kidney Int 2010 Aug 9;78(4):382-8. Epub 2010 Jun 9.

Department of Ophthalmology, Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1038/ki.2010.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684398PMC
August 2010

Modulation of MCT3 expression during wound healing of the retinal pigment epithelium.

Invest Ophthalmol Vis Sci 2010 Oct 26;51(10):5343-50. Epub 2010 May 26.

Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1167/iovs.09-5028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066603PMC
October 2010

Evidence for a homodimeric structure of human monocarboxylate transporter 8.

Endocrinology 2009 Nov 24;150(11):5163-70. Epub 2009 Sep 24.

Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/en.2009-0699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213760PMC
November 2009

Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration.

Am J Physiol Cell Physiol 2009 Mar 10;296(3):C414-21. Epub 2008 Dec 10.

Dept. of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Thomas Jefferson Univ., 1020 Locust St., Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajpcell.00430.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660264PMC
March 2009

Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping.

Dev Dyn 2008 Dec;237(12):3577-90

Department of Pediatrics, USF/ACH-Children's Research Institute, St. Petersburg, Florida 33701, USA.

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http://dx.doi.org/10.1002/dvdy.21645DOI Listing
December 2008

Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium.

Mol Vis 2008 Aug 4;14:1414-28. Epub 2008 Aug 4.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493022PMC
August 2008

Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice.

Am J Physiol Cell Physiol 2008 Aug 4;295(2):C451-7. Epub 2008 Jun 4.

F.M. Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1152/ajpcell.00124.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518420PMC
August 2008

Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium.

J Comp Neurol 2007 Nov;505(2):166-76

F.M. Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/cne.21489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144860PMC
November 2007

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

Cancer Res 2007 May;67(9):4182-9

Department of Pathology, Anatomy and Cell Biology and Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3184DOI Listing
May 2007

Monocarboxylate transporter expression in the spontaneous hypertensive rat: effect of stroke.

J Neurosci Res 2005 Jan 1-15;79(1-2):139-45

Department of Neural and Behavioral Sciences, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1002/jnr.20312DOI Listing
March 2005

MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells.

Am J Physiol Endocrinol Metab 2003 Dec;285(6):E1223-9

Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1152/ajpendo.00172.2003DOI Listing
December 2003

Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.

Invest Ophthalmol Vis Sci 2003 Apr;44(4):1716-21

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1167/iovs.02-0287DOI Listing
April 2003

Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse.

Invest Ophthalmol Vis Sci 2003 Mar;44(3):1305-11

Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1167/iovs.02-0552DOI Listing
March 2003