Nancy E Hynes

Nancy E Hynes

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Nancy E Hynes

Nancy E Hynes

Publications by authors named "Nancy E Hynes"

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Ret Receptor Has Distinct Alterations and Functions in Breast Cancer.

J Mammary Gland Biol Neoplasia 2020 Mar 21;25(1):13-26. Epub 2020 Feb 21.

CONICET-UBA, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Ciudad Universitaria, C1428EGA CABA, Buenos Aires, Argentina.

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http://dx.doi.org/10.1007/s10911-020-09445-4DOI Listing
March 2020

Chronic expression of wild-type Ret receptor in the mammary gland induces luminal tumors that are sensitive to Ret inhibition.

Oncogene 2018 07 26;37(29):4046-4054. Epub 2018 Apr 26.

Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41388-018-0235-yDOI Listing
July 2018

Renal Memo1 Differentially Regulates the Expression of Vitamin D-Dependent Distal Renal Tubular Calcium Transporters.

Front Physiol 2018 9;9:874. Epub 2018 Jul 9.

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.3389/fphys.2018.00874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046545PMC
July 2018

Breast Cancer Patients Have Greatly Benefited from the Progress in Molecular Oncology.

PLoS Biol 2016 Sep 29;14(9):e2000314. Epub 2016 Sep 29.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.2000314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042426PMC
September 2016

Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.

Oncotarget 2016 Aug;7(35):56170-56182

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.18632/oncotarget.10856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302904PMC
August 2016

MEMO1 drives cranial endochondral ossification and palatogenesis.

Dev Biol 2016 07 31;415(2):278-295. Epub 2015 Dec 31.

Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.ydbio.2015.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914435PMC
July 2016

ErbB2: From an EGFR Relative to a Central Target for Cancer Therapy.

Authors:
Nancy E Hynes

Cancer Res 2016 07;76(13):3659-62

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1356DOI Listing
July 2016

Targeting a Novel ER/HOXB7 Signaling Loop in Tamoxifen-Resistant Breast Cancer.

Cancer Discov 2015 Sep;5(9):909-11

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0871DOI Listing
September 2015

Cancer: Staying together on the road to metastasis.

Nature 2014 Oct;514(7522):309-10

Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/514309aDOI Listing
October 2014

EGF receptor family: twisting targets for improved cancer therapies.

Growth Factors 2014 Apr 18;32(2):74-81. Epub 2014 Mar 18.

The Walter & Eliza Hall Institute of Medical Research, Burgess Lab Structural Biology , Parkville , Australia .

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http://dx.doi.org/10.3109/08977194.2014.896355DOI Listing
April 2014

Loss of Memo, a novel FGFR regulator, results in reduced lifespan.

FASEB J 2014 Jan 20;28(1):327-36. Epub 2013 Sep 20.

1Mechanisms of Cancer, Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1096/fj.13-228320DOI Listing
January 2014

Signalling change: signal transduction through the decades.

Nat Rev Mol Cell Biol 2013 Jun 2;14(6):393-8. Epub 2013 May 2.

Friedrich Miescher Institute for Biomedical Research, and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1038/nrm3581DOI Listing
June 2013

The 14-3-3σ tumor suppressor has multiple functions in ErbB2-induced breast cancer.

Cancer Discov 2012 Jan;2(1):19-22

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-11-0317DOI Listing
January 2012

P-Rex1, a guanine exchange factor that is overexpressed in breast cancer, is a convergence node for ErbB and CXCR4 signaling.

Mol Cell 2011 Jan;41(1):5-7

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.molcel.2010.12.024DOI Listing
January 2011

Unfavorable drug interactions in targeted breast cancer therapy.

Cancer Cell 2010 Nov;18(5):401-2

Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Str. 42, D-60596 Frankfurt am Main, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108100042
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http://dx.doi.org/10.1016/j.ccr.2010.10.027DOI Listing
November 2010

Mammary gland growth factors: roles in normal development and in cancer.

Cold Spring Harb Perspect Biol 2010 Aug 16;2(8):a003186. Epub 2010 Jun 16.

Friedrich Miescher Institute for Biomedical Research, Maulbeerestrasse 66, CH-4058 Basel, Switzerland.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a003186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908768PMC
August 2010

Potential for targeting the fibroblast growth factor receptors in breast cancer.

Cancer Res 2010 Jul 22;70(13):5199-202. Epub 2010 Jun 22.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-10-0918DOI Listing
July 2010

Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis.

Cancer Res 2010 May 11;70(10):4151-62. Epub 2010 May 11.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4479DOI Listing
May 2010

Key signalling nodes in mammary gland development and cancer: Myc.

Breast Cancer Res 2009 ;11(5):210

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1186/bcr2406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790850PMC
March 2010

WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth.

Breast Cancer Res 2009 27;11(3):R32. Epub 2009 May 27.

Friedrich Miescher Institute for Biomedical Research (Part of the Novartis Research Foundation), Basel, Switzerland.

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http://dx.doi.org/10.1186/bcr2317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716500PMC
January 2010

c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland.

BMC Biol 2009 Sep 28;7:63. Epub 2009 Sep 28.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1186/1741-7007-7-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761394PMC
September 2009

Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways.

Biochem Biophys Res Commun 2009 Aug 10;386(3):449-54. Epub 2009 Jun 10.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bbrc.2009.06.033DOI Listing
August 2009

ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation.

Clin Cancer Res 2009 Jun 19;15(11):3733-9. Epub 2009 May 19.

Department of Anatomy and Structural Biology and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859965PMC
June 2009

PI3K inhibition overcomes trastuzumab resistance: blockade of ErbB2/ErbB3 is not always enough.

Cancer Cell 2009 May;15(5):353-5

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4059 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ccr.2009.04.004DOI Listing
May 2009

ErbB receptors and signaling pathways in cancer.

Curr Opin Cell Biol 2009 Apr 7;21(2):177-84. Epub 2009 Feb 7.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ceb.2008.12.010DOI Listing
April 2009

Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration.

J Cell Sci 2009 Mar 17;122(Pt 6):787-97. Epub 2009 Feb 17.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1242/jcs.032094DOI Listing
March 2009

Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site.

J Biol Chem 2008 Feb 28;283(5):2734-40. Epub 2007 Nov 28.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.

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http://www.jbc.org/content/283/5/2734.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M703523200
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http://dx.doi.org/10.1074/jbc.M703523200DOI Listing
February 2008

Targeting ERBB receptors in cancer.

Authors:
Nancy E Hynes

Recent Results Cancer Res 2007 ;172:45-57

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1007/978-3-540-31209-3_4DOI Listing
July 2007

Novel c-MYC target genes mediate differential effects on cell proliferation and migration.

EMBO Rep 2007 Jan 8;8(1):70-6. Epub 2006 Dec 8.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/sj.embor.7400849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796762PMC
January 2007

Targeting ADAMS and ERBBs in lung cancer.

Cancer Cell 2006 Jul;10(1):7-11

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ccr.2006.06.012DOI Listing
July 2006

Therapeutic targeting of signal transduction pathways and proteins in breast cancer.

J Mammary Gland Biol Neoplasia 2006 Jan;11(1):1-2

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://link.springer.com/10.1007/s10911-006-9007-3
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http://dx.doi.org/10.1007/s10911-006-9007-3DOI Listing
January 2006

The mTOR pathway in breast cancer.

J Mammary Gland Biol Neoplasia 2006 Jan;11(1):53-61

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1007/s10911-006-9012-6DOI Listing
January 2006

Receptor tyrosine kinases as therapeutic targets in cancer.

Authors:
Nancy E Hynes

Discov Med 2005 Oct;5(29):483-8

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4059 Basel, Switzerland.

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October 2005

ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.

J Biol Chem 2005 Jun 29;280(25):24175-80. Epub 2005 Apr 29.

Department of Biochemistry, Tulane University Health Sciences Center, Tulane Cancer Center, New Orleans, Louisiana 70112-2669, USA.

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http://dx.doi.org/10.1074/jbc.M414044200DOI Listing
June 2005

ERBB receptors and cancer: the complexity of targeted inhibitors.

Nat Rev Cancer 2005 May;5(5):341-54

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://www.nature.com/articles/nrc1609
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http://dx.doi.org/10.1038/nrc1609DOI Listing
May 2005

Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation.

J Biol Chem 2004 Nov 17;279(48):50004-11. Epub 2004 Sep 17.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M404252200DOI Listing
November 2004

TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity.

J Biol Chem 2004 Sep 30;279(37):38787-96. Epub 2004 Jun 30.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH-4058, Switzerland.

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http://dx.doi.org/10.1074/jbc.M312581200DOI Listing
September 2004

Memo mediates ErbB2-driven cell motility.

Nat Cell Biol 2004 Jun 23;6(6):515-22. Epub 2004 May 23.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/ncb1134DOI Listing
June 2004

ErbB receptors: directing key signaling networks throughout life.

Annu Rev Pharmacol Toxicol 2004 ;44:195-217

Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.

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http://www.annualreviews.org/doi/10.1146/annurev.pharmtox.44
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http://dx.doi.org/10.1146/annurev.pharmtox.44.101802.121440DOI Listing
May 2004

A new therapeutic antibody masks ErbB2 to its partners.

Cancer Cell 2004 Apr;5(4):299-301

Friedrich Miescher Institute of the Novartis Research Foundation, P.O. Box 2543, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/s1535-6108(04)00088-1DOI Listing
April 2004

Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins.

Oncogene 2004 Apr;23(20):3501-8

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://www.nature.com/articles/1207331
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http://dx.doi.org/10.1038/sj.onc.1207331DOI Listing
April 2004

ErbB1 and prostate cancer: ErbB1 activity is essential for androgen-induced proliferation and protection from the apoptotic effects of LY294002.

Prostate 2003 Jul;56(2):142-9

Department of Clinical Biochemistry-AKH, Aarhus University Hospital, Aarhus C, Denmark.

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http://dx.doi.org/10.1002/pros.10245DOI Listing
July 2003

Tenascin-C blocks cell-cycle progression of anchorage-dependent fibroblasts on fibronectin through inhibition of syndecan-4.

Oncogene 2003 Jun;22(25):3917-26

Friedrich Miescher Institute for Biomedical Research, Novartis Forschungsstiftung, PO Box 2543, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1038/sj.onc.1206618DOI Listing
June 2003

BAD: a good therapeutic target?

Breast Cancer Res 2003 18;5(1):27-30. Epub 2002 Oct 18.

Friedrich Miescher Institute, Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154131PMC
http://dx.doi.org/10.1186/bcr552DOI Listing
May 2003

Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.

J Cell Biol 2003 May 5;161(3):583-92. Epub 2003 May 5.

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1083/jcb.200212066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172951PMC
May 2003

Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor.

Oncogene 2003 Mar;22(10):1557-67

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, D-co596 Frankfourt an Main, Germany.

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http://dx.doi.org/10.1038/sj.onc.1206299DOI Listing
March 2003

The ErbB receptors and their role in cancer progression.

Exp Cell Res 2003 Mar;284(1):99-110

Friedrich Miescher Institute, PO Box 2543, 4002, Basel, Switzerland.

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http://dx.doi.org/10.1016/s0014-4827(02)00099-xDOI Listing
March 2003

Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers.

Mol Biol Cell 2002 Nov;13(11):4029-44

Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, Department of Medicine and McGill Centre for Translational Research in Cancer, McGill University, Montreal, Quebec, H3T 1E2, Canada.

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http://dx.doi.org/10.1091/mbc.e02-02-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133612PMC
November 2002

Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells.

Oncogene 2002 Jul;21(29):4567-76

Department of Hematology/Oncology, UCSF San Francisco and Buck Institute, Novato, California 94945, USA.

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http://dx.doi.org/10.1038/sj.onc.1205555DOI Listing
July 2002

The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides.

Cancer Res 2002 Jun;62(11):3151-8

Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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June 2002