Nancy A Thornberry

Nancy A Thornberry

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Nancy A Thornberry

Nancy A Thornberry

Publications by authors named "Nancy A Thornberry"

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US immigration order strikes against biotech.

Authors:
Jeremy M Levin Steven H Holtzman John Maraganore Paul J Hastings Ron Cohen Bassil Dahiyat Julian Adams Chris Adams Brett Ahrens Jeff Albers Mara G Aspinall James E Audia Martin Babler Peter Barrett Zoe Barry Nessan Bermingham Stephen Bloch Robert I Blum Paul B Bolno Michael W Bonney Bruce Booth Daniel M Bradbury Steven K Brauer Brook Byers Pablo J Cagnoni Brian M Cali Isaac Ciechanover Chip Clark Michael D Clayman Jeff L Cleland Paula Cobb Ron Cooper Mark G Currie John Diekman Eric L Dobmeier Doug Doerfler Elizabeth Lr Donley Deborah Dunsire Matthew During Jens W Eckstein Eric Elenko Neil A Exter Jonathan J Fleming Gregory J Flesher Jean-Francois Formela Robert Forrester Cedric Francois Heather Franklin Mason W Freeman Howard Furst Leonard Patrick Gage Nicholas Galakatos Brian M Gallagher James A Geraghty Simba Gill David V Goeddel Mark A Goldsmith Maxine Gowen Vikas Goyal Tom Graney David Grayzel Barry Greene Paul Grint J C Gutierrez-Ramos Bill Haney Tuan Ha-Ngoc Tim Harris Faheem Hasnain Yujiro Steve Hata Peter Hecht Leslie Henshaw Rich Heyman Herve Hoppenot H Robert Horvitz Thomas E Hughes Wende S Hutton Stephen T Isaacs Annalisa Jenkins Jeff Jonker Jeff Kaplan Perry Karsen Jeb Keiper Jean Kim Jeff Kindler Rachel King Vanessa King Nina Kjellson Scott Koenig Gerhard Koenig Peter Kolchinsky Paul Laikind Robert Bob Langer John J Lee Jonathan S Leff Bruce A Leicher Nick Leschly Andrew Levin Mark Levin Arnold J Levine Alan Levy David R Liu Harvey F Lodish Uri Lopatin Ted W Love Guy Macdonald Gail J Maderis Ankit Mahadevia Nagesh K Mahanthappa Joel F Martin Alex Martin W Eddie Martucci James G McArthur Corey M McCann Sean A McCarthy C Geoffrey McDonough John Mendlein Larry Miller Diego Miralles Kenneth I Moch Bob More Andrew G Myers Michael A Narachi Amir Nashat Wendy Nelson William J Newell Bernat Olle John E Osborn Julia C Owens Atul Pande Stelios Papadopoulos H Stewart Parker Kush M Parmar Matthew R Patterson Steve M Paul Rob Perez Matthew Perry Cary G Pfeffer Mike Powell Mark Pruzanski Dennis J Purcell Amit Rakhit Kartik Ramamoorthi William Rastetter Adrian Ad Rawcliffe Laurence E Reid Ron C Renaud Jason P Rhodes William J Rieflin Chad Robins Scott M Rocklage Michael Rosenblatt Jonathan G Rosin William J Rutter Saurabh Saha Camille Samuels Vicki L Sato George Scangos John A Scarlett David Schenkein Stuart L Schreiber Andrew Schwab Paul Sekhri Rajeev Shah Thomas Shenk Clay B Siegall Nick J Simon Nancy Simonian Jeff Stein Michael Su Mary T Szela Marco Taglietti Nina Tandon Henri Termeer Nancy A Thornberry Martin Tolar Richard Ulevitch Akshay K Vaishnaw Anne VanLent Martin Varsavsky George P Vlasuk Michel Vounatsos Samuel G Waksal Neil Warma Ryan J Watts Yaron Werber Christoph Westphal Wendell Wierenga Doug E Williams Lewis Rusty Williams Kleanthis G Xanthopoulos Daphne Zohar Sandford Sandy Zweifach

Nat Biotechnol 2017 03;35(3):204-206

Nuvelution Pharmaceuticals, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nbt.3824DOI Listing
March 2017

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.

Mol Endocrinol 2015 Sep 28;29(9):1243-53. Epub 2015 Jul 28.

Departments of Metabolic Disorders-Diabetes (J.S., Y.F., N.A.T., A.D.H., Y.-P.Z.) and Target Validation (J.L., H.H.Z.) and Laboratory of Animal Research (X.S.), Merck Research Laboratories, Rahway, New Jersey 07065; Department of Biochemistry (M.P.K., M.R., M.S., A.D.A.), University of Wisconsin, Madison, Wisconsin 53076; Sarah W. Stedman Nutrition and Metabolism Center (H.E.H., C.B.N.), Duke University Medical Center, Durham, North Carolina 27704; and Department of Surgery/Transplant (Y.W.), University of Illinois at Chicago, Chicago, Illinois 60612.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2014-1335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552436PMC
September 2015

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.

J Med Chem 2014 Apr 2;57(8):3205-12. Epub 2014 Apr 2.

Department of Discovery Chemistry, ‡Department of Metabolic Disorders, §Department of Pharmacology, ∥Department of Drug Metabolism, ⊥Basic Pharmaceutical Sciences, and #Department of Safety Assessment and Animal Resources, Merck & Co., Inc. , Whitehouse Station, New Jersey 08889, United States.

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http://dx.doi.org/10.1021/jm401992eDOI Listing
April 2014

Glucagon-like peptide 1-based drugs and pancreatic safety.

JAMA Intern Med 2013 Oct;173(19):1842-3

Merck Sharp & Dohme Corporation, Whitehouse Station, New Jersey.

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http://dx.doi.org/10.1001/jamainternmed.2013.8138DOI Listing
October 2013

Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

Endocrinology 2011 Nov 30;152(11):4106-15. Epub 2011 Aug 30.

Department of Diabetes and Obesity, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-1440DOI Listing
November 2011

A model selection approach for expression quantitative trait loci (eQTL) mapping.

Genetics 2011 Feb 29;187(2):611-21. Epub 2010 Nov 29.

Department of Statistics, University of Wisconsin, Madison, Wisconsin 53726, USA.

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http://dx.doi.org/10.1534/genetics.110.122796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030500PMC
February 2011

Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.

Bioorg Med Chem Lett 2009 Aug 6;19(15):4097-101. Epub 2009 Jun 6.

Department of Medicinal Chemistry, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.06.011DOI Listing
August 2009

Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4).

Best Pract Res Clin Endocrinol Metab 2009 Aug;23(4):479-86

Department of Metabolic Disorders, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.beem.2009.03.004DOI Listing
August 2009

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.

Bioorg Med Chem Lett 2008 Jul 20;18(13):3706-10. Epub 2008 May 20.

Research Laboratories, Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.05.061DOI Listing
July 2008

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

Bioorg Med Chem Lett 2007 Nov 19;17(21):5853-7. Epub 2007 Aug 19.

Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.08.030DOI Listing
November 2007

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.

Bioorg Med Chem Lett 2007 Aug 2;17(16):4579-83. Epub 2007 Jun 2.

Merck Research Laboratories, Department of Medicinal Chemistry, PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.05.087DOI Listing
August 2007

Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Curr Top Med Chem 2007 ;7(6):557-68

Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.2174/156802607780091028DOI Listing
May 2007

Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.

Bioorg Med Chem Lett 2007 Apr 24;17(7):1903-7. Epub 2007 Jan 24.

Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.01.039DOI Listing
April 2007

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

J Biol Chem 2007 Feb 19;282(7):4545-52. Epub 2006 Dec 19.

Departments of Medicine, Cell Biology, and Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1074/jbc.M606564200DOI Listing
February 2007

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.

Bioorg Med Chem Lett 2005 May;15(10):2533-6

Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.03.055DOI Listing
May 2005

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Bioorg Med Chem Lett 2004 Mar;14(5):1265-8

Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2003.12.040DOI Listing
March 2004

Nicotinyl aspartyl ketones as inhibitors of caspase-3.

Bioorg Med Chem Lett 2003 Jul;13(13):2137-40

Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., Pointe-Claire-Dorval, H9R 4P8, Quebec, Canada.

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http://dx.doi.org/10.1016/s0960-894x(03)00390-1DOI Listing
July 2003

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance.

Proc Natl Acad Sci U S A 2003 May 14;100(11):6825-30. Epub 2003 May 14.

Department of Metabolic Disorders and Molecular Endocrinology, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1073/pnas.0631828100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164531PMC
May 2003

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.

Biochem J 2003 Apr;371(Pt 2):525-32

Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1042/BJ20021643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223300PMC
April 2003

Apoptosis. Life and death decisions.

Science 2003 Jan;299(5604):214-5

Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Montreal, Quebec HLH 3LI, Canada.

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http://dx.doi.org/10.1126/science.1081274DOI Listing
January 2003

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.

Bioorg Med Chem Lett 2002 Aug;12(16):2197-200

Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0960-894x(02)00363-3DOI Listing
August 2002