Nan-Sheng Li

Nan-Sheng Li

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Nan-Sheng Li

Nan-Sheng Li

Publications by authors named "Nan-Sheng Li"

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The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base p.

Biochemistry 2020 May 24;59(17):1665-1671. Epub 2020 Apr 24.

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/acs.biochem.9b01047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260706PMC
May 2020

Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme.

Nat Chem 2020 Feb 20;12(2):193-201. Epub 2020 Jan 20.

Laboratory for Biomolecular Simulation Research, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

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http://dx.doi.org/10.1038/s41557-019-0391-xDOI Listing
February 2020

Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers.

Eur J Med Chem 2019 Dec 1;184:111746. Epub 2019 Oct 1.

Ben May Cancer Research Institute, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874713PMC
December 2019

Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.

J Am Chem Soc 2019 05 2;141(19):7865-7875. Epub 2019 May 2.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex , The University of Dundee , Dow Street , Dundee DD1 5EH , U.K.

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http://dx.doi.org/10.1021/jacs.9b02141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523996PMC
May 2019

Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.

Biochemistry 2018 06 17;57(25):3465-3472. Epub 2018 May 17.

Department of Biochemistry and Molecular Biology and Department of Chemistry , University of Chicago , 929 East 57th Street , Chicago , Illinois 60637 , United States.

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http://dx.doi.org/10.1021/acs.biochem.8b00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693346PMC
June 2018

Synthesis of 5'-Thio-3'-O-ribonucleoside Phosphoramidites.

J Org Chem 2017 12 31;82(23):12003-12013. Epub 2017 Oct 31.

Department of Biochemistry & Molecular Biology and Department of Chemistry, University of Chicago , 929 East 57th Street, Chicago, Illinois 60637, United States.

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http://dx.doi.org/10.1021/acs.joc.7b01484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557410PMC
December 2017

Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.

J Mol Biol 2016 10 2;428(20):4100-4114. Epub 2016 Sep 2.

Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178103PMC
October 2016

Efficient Synthetic Approach to Linear Dasatinib-DNA Conjugates by Click Chemistry.

Bioconjug Chem 2016 Oct 6;27(10):2575-2579. Epub 2016 Oct 6.

Department of Biochemistry & Molecular Biology and ‡Department of Chemistry, University of Chicago , 929 East 57th Street, Chicago, Illinois 60637, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00557DOI Listing
October 2016

Drug conjugated nanoparticles activated by cancer cell specific mRNA.

Oncotarget 2016 Jun;7(25):38243-38256

Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.18632/oncotarget.9430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122386PMC
June 2016

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.

J Immunol 2016 Feb 11;196(4):1933-42. Epub 2016 Jan 11.

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637; Committee on Immunology, University of Chicago, Chicago, IL 60637;

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http://dx.doi.org/10.4049/jimmunol.1502202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744554PMC
February 2016

Heavy atom labeled nucleotides for measurement of kinetic isotope effects.

Biochim Biophys Acta 2015 Nov 27;1854(11):1737-45. Epub 2015 Mar 27.

Department of Chemistry, University of Chicago, Chicago, IL, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2015.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584197PMC
November 2015

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.

Structure 2015 Sep 30;23(9):1678-1691. Epub 2015 Jul 30.

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57(th) Street, GCIS W219, Chicago, IL 60637, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851429PMC
http://dx.doi.org/10.1016/j.str.2015.06.024DOI Listing
September 2015

Synthesis of 2'-O-photocaged ribonucleoside phosphoramidites.

Nucleosides Nucleotides Nucleic Acids 2015 ;34(2):114-29

a Department of Biochemistry & Molecular Biology and Department of Chemistry , University of Chicago , Chicago , Illinois , United States.

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http://dx.doi.org/10.1080/15257770.2014.965256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461471PMC
July 2015

Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.

J Am Chem Soc 2015 Jul 14;137(28):8973-82. Epub 2015 Jul 14.

§Department of Biochemistry and Center for Proteomics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States.

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http://dx.doi.org/10.1021/jacs.5b01189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758122PMC
July 2015

Spinach RNA aptamer detects lead(II) with high selectivity.

Chem Commun (Camb) 2015 May;51(43):9034-7

Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1039/c5cc01526jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755583PMC
May 2015

Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.

Proc Natl Acad Sci U S A 2014 Oct 8;111(43):E4648-57. Epub 2014 Oct 8.

Departments of Biochemistry and Molecular Biology and Committee on Immunology, University of Chicago, Chicago, IL 60637;

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http://dx.doi.org/10.1073/pnas.1408549111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217448PMC
October 2014

A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.

Nat Chem Biol 2014 Aug 22;10(8):686-91. Epub 2014 Jun 22.

1] Department of Chemistry, University of Chicago, Chicago, Illinois, USA. [2] Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nchembio.1561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104137PMC
August 2014

Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis.

J Org Chem 2014 Apr 31;79(8):3647-52. Epub 2014 Mar 31.

Department of Biochemistry & Molecular Biology, ‡Department of Chemistry, and §Department of Molecular Genetics & Cell Biology, University of Chicago , Chicago, Illinois 60637, United States.

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http://dx.doi.org/10.1021/jo4028374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203407PMC
April 2014

RNA catalyses nuclear pre-mRNA splicing.

Nature 2013 Nov 6;503(7475):229-34. Epub 2013 Nov 6.

1] Graduate Program in Cell and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA [2] Department of Molecular Genetics and Cell Biology, Cummings Life Sciences Center, 920 East 58th Street, The University of Chicago, Chicago, Illinois 60637, USA [3].

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http://dx.doi.org/10.1038/nature12734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666680PMC
November 2013

Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage.

J Biol Chem 2013 Oct 22;288(40):29206-14. Epub 2013 Aug 22.

From the Department of Biochemistry and Molecular Biology and.

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http://dx.doi.org/10.1074/jbc.M113.508028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790019PMC
October 2013

Highly stereocontrolled total synthesis of β-D-mannosyl phosphomycoketide: a natural product from Mycobacterium tuberculosis.

J Org Chem 2013 Jun 11;78(12):5970-86. Epub 2013 Jun 11.

Department of Biochemistry and Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States.

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http://dx.doi.org/10.1021/jo4006602DOI Listing
June 2013

Automated solid-phase synthesis of RNA oligonucleotides containing a nonbridging phosphorodithioate linkage via phosphorothioamidites.

J Org Chem 2012 Nov 25;77(21):9889-92. Epub 2012 Oct 25.

Department of Biochemistry & Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States.

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http://dx.doi.org/10.1021/jo301834pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500914PMC
November 2012

General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.

J Am Chem Soc 2012 Oct 25;134(40):16717-24. Epub 2012 Sep 25.

Cancer Research UK, Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1021/ja3067429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707309PMC
October 2012

Efficient synthesis of 2'-C-α-aminomethyl-2'-deoxynucleosides.

Chem Commun (Camb) 2012 Sep 26;48(70):8754-6. Epub 2012 Jul 26.

Department of Biochemistry & Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1039/c2cc34556kDOI Listing
September 2012

Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding.

RNA 2012 Jun 26;18(6):1123-41. Epub 2012 Apr 26.

The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1261/rna.028738.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358636PMC
June 2012

Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage.

Acc Chem Res 2011 Dec 1;44(12):1257-69. Epub 2011 Sep 1.

Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/ar200131tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243799PMC
December 2011

Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.

Proc Natl Acad Sci U S A 2011 May 25;108(19):7751-6. Epub 2011 Apr 25.

Department of Biochemistry and Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1102294108
Publisher Site
http://dx.doi.org/10.1073/pnas.1102294108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093456PMC
May 2011

A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage.

Nucleic Acids Res 2011 Mar 9;39(5):e31. Epub 2010 Dec 9.

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E. 57th Street, Room W406, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/nar/gkq1265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061073PMC
March 2011

Sin resolvase catalytic activity and oligomerization state are tightly coupled.

J Mol Biol 2010 Nov 22;404(1):16-33. Epub 2010 Sep 22.

Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.08.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976518PMC
November 2010

Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.

Proc Natl Acad Sci U S A 2010 Jun 14;107(26):11751-6. Epub 2010 Jun 14.

Cancer Research United Kingdom Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1004255107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900685PMC
June 2010

Synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites for probing cytosine function in RNA.

J Org Chem 2009 Nov;74(21):8021-30

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/jo9016919DOI Listing
November 2009

Synthesis of 2'-C-beta-methyl-2'-deoxyguanosine.

J Org Chem 2009 Mar;74(5):2227-30

Howard Hughes Medical Institute, Department of Biochemistry & Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/jo802666kDOI Listing
March 2009

Efficient chemical synthesis of AppDNA by adenylation of immobilized DNA-5'-monophosphate.

Org Lett 2009 Mar;11(5):1067-70

Department of Biochemistry & Molecular Biology, The University of Chicago, 929 East 57th Street, MC 1028, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/ol802815gDOI Listing
March 2009

Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.

Bioorg Med Chem 2008 May 27;16(10):5754-60. Epub 2008 Mar 27.

Howard Hughes Medical Institute, Department of Biochemistry & Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.03.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664738PMC
May 2008

The mechanism of RNA strand scission: an experimental measure of the Brønsted coefficient, beta nuc.

Angew Chem Int Ed Engl 2007 ;46(20):3714-7

Howard Hughes Medical Institute, Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1002/anie.200605124DOI Listing
August 2007

Efficient synthesis of methyl 3,5-di-O-benzyl-alpha-D-ribofuranoside and application to the synthesis of 2'-C-beta-alkoxymethyluridines.

Org Lett 2007 Aug 13;9(16):3009-12. Epub 2007 Jul 13.

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/ol071075bDOI Listing
August 2007

Synthesis of 2'-C-alpha-(hydroxyalkyl) and 2'-C-alpha-alkylcytidine phosphoramidites: analogues for probing solvent interactions with RNA.

J Org Chem 2007 Feb;72(4):1198-210

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1021/jo062002tDOI Listing
February 2007

Efficient synthesis of 2'-C-beta-methylguanosine.

J Org Chem 2006 May;71(10):4018-20

Howard Hughes Medical Institute, Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/jo0602165DOI Listing
May 2006

Synthesis of the phosphoramidite derivatives of 2'-deoxy-2'-C-alpha-methylcytidine and 2'-deoxy-2'-C-alpha-hydroxymethylcytidine: analogues for chemical dissection of RNA's 2'-hydroxyl group.

J Org Chem 2004 Jul;69(14):4751-9

Department of Biochemistry and Molecular Biology, University of Chicago, 5841 South Maryland Avenue, MC 1028, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/jo0495337DOI Listing
July 2004

A packing-density metric for exploring the interior of folded RNA molecules.

Angew Chem Int Ed Engl 2004 Jun;43(23):3033-7

Howard Hughes Medical Institute, The University of Chicago, Department of Biochemistry and Molecular Biology, 5841 S. Maryland Avenue, MC1028, Chicago, Il 60637, USA.

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http://dx.doi.org/10.1002/anie.200353575DOI Listing
June 2004

New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis.

Chem Biol 2004 Feb;11(2):237-46

Department of Biochemistry and Molecular Biology, The University of Chicago, 5841 South Maryland Avenue, MC1028, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.chembiol.2004.02.011DOI Listing
February 2004

Synthesis of the phosphoramidite derivative of 2'-deoxy-2'-C-beta-methylcytidine.

J Org Chem 2003 Aug;68(17):6799-802

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Chicago, 5841 South Maryland Avenue, MC 1028, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1021/jo034263yDOI Listing
August 2003

Synthesis of (E)-1-Aryl-1-alkenes via a Novel BF(3).OEt(2)-Catalyzed Aldol-Grob Reaction Sequence.

J Org Chem 1999 Apr;64(9):3157-3161

Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, Tennessee 37996-1600.

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http://dx.doi.org/10.1021/jo9822784DOI Listing
April 1999