Publications by authors named "Nan Ye"

69 Publications

Correction to: Admission fasting plasma glucose is associated with in-hospital outcomes in patients with acute coronary syndrome and diabetes: findings from the improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project.

BMC Cardiovasc Disord 2021 Jul 22;21(1):349. Epub 2021 Jul 22.

Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, No. 2 Anzhen Street, Chao yang District, Beijing, 100029, PR China.

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http://dx.doi.org/10.1186/s12872-021-02118-yDOI Listing
July 2021

The association between atrial fibrillation and in-hospital outcomes in chronic kidney disease patients with acute coronary syndrome: findings from the improving care for cardiovascular disease in China-acute coronary syndrome (CCC-ACS) project.

BMC Cardiovasc Disord 2021 Jul 17;21(1):345. Epub 2021 Jul 17.

Renal Division, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Street, Chao yang District, Beijing, 100029, People's Republic of China.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia in patients with chronic kidney disease (CKD) and acute coronary syndrome (ACS). This study aimed to explore the frequency and impact of AF on clinical outcomes in CKD patients with ACS.

Methods: CKD inpatients with ACS between November 2014 and December 2018 were included based on the improving care for cardiovascular disease in China-ACS (CCC-ACS) project. Included patients were divided into an AF group and a non-AF group according to the discharge diagnosis. Multivariable logistic regression was used to adjust for potential confounders.

Results: A total of 16,533 CKD patients with ACS were included. A total of 1418 (8.6%) patients had clinically recognized AF during hospitalization, 654 of whom had an eGFR of 45 to < 60 ml/min/1.73 m, and 764 had an estimated glomerular filtration rate (eGFR) < 45 ml/min/1.73 m. Compared with the non-AF group, the AF group had a higher risk of in-hospital mortality [OR 1.250; 95% CI (1.001-1.560), P = 0.049] and major adverse cardiovascular events (MACEs) [OR 1.361; 95% CI (1.197-1.547), P < 0.001]. We also found that compared with patients with eGFR 45 to < 60 ml/min/1.73 m, patients with eGFR < 45 ml/min/1.73 m had a 1.512-fold increased risk of mortality and a 1.435-fold increased risk of MACEs.

Conclusions: AF was a risk factor affecting the short-term prognosis of ACS patients in the CKD population. Furthermore, the lower the eGFR, the higher the risk of in-hospital mortality and MACEs in CKD patients with ACS.

Trial Registry: Clinicaltrial.gov, NCT02306616. Registered 29 November 2014, https://clinicaltrials.gov/ct2/show/NCT02306616?term=NCT02306616&draw=2&rank=1.
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http://dx.doi.org/10.1186/s12872-021-02125-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285806PMC
July 2021

Microwave Radiometry at Frequencies From 500 to 1400 MHz: An Emerging Technology for Earth Observations.

IEEE J Sel Top Appl Earth Obs Remote Sens 2021 14;14:4894-4914. Epub 2021 Apr 14.

NASA Jet Propulsion Laboratory, Pasadena, CA 91109 USA.

Microwave radiometry has provided valuable spaceborne observations of Earth's geophysical properties for decades. The recent SMOS, Aquarius, and SMAP satellites have demonstrated the value of measurements at 1400 MHz for observing surface soil moisture, sea surface salinity, sea ice thickness, soil freeze/thaw state, and other geophysical variables. However, the information obtained is limited by penetration through the subsurface at 1400 MHz and by a reduced sensitivity to surface salinity in cold or wind-roughened waters. Recent airborne experiments have shown the potential of brightness temperature measurements from 500-1400 MHz to address these limitations by enabling sensing of soil moisture and sea ice thickness to greater depths, sensing of temperature deep within ice sheets, improved sensing of sea salinity in cold waters, and enhanced sensitivity to soil moisture under vegetation canopies. However, the absence of significant spectrum reserved for passive microwave measurements in the 500-1400 MHz band requires both an opportunistic sensing strategy and systems for reducing the impact of radio-frequency interference. Here, we summarize the potential advantages and applications of 500-1400 MHz microwave radiometry for Earth observation and review recent experiments and demonstrations of these concepts. We also describe the remaining questions and challenges to be addressed in advancing to future spaceborne operation of this technology along with recommendations for future research activities.
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http://dx.doi.org/10.1109/jstars.2021.3073286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244653PMC
April 2021

Protective effects and mechanism of coenzyme Q10 and vitamin C on doxorubicin-induced gastric mucosal injury and effects of intestinal flora.

Korean J Physiol Pharmacol 2021 Jul;25(4):261-272

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China.

Doxorubicin (Dox) is widely used to the treatment of cancer, however, it could cause damage to gastric mucosa. To investigate the protective effects and related mechanisms of coenzyme Q10 (CoQ10) and vitamin C (VC) on Dox-induced gastric mucosal injury, we presented the survey of the 4 groups of the rats with different conditions. The results showed Dox treatment significantly induced GES-1 apoptosis, but preconditioning in GES-1 cells with VC or CoQ10 significantly inhibited the Dox-induced decrease and other harm effects, including the expression and of IκKβ, IκBα, NF-κB/p65 and tumor necrosis factor (TNF-α) in GES-1 cells. Moreover, high-throughput sequencing results showed Dox treatment increased the number of harmful gut microbes, and CoQ10 and VC treatment inhibited this effect. CoQ10 and VC treatment inhibits Dox-induced gastric mucosal injury by inhibiting the activation of the IkKB/IκBα/NF-κB/p65/TNF-α pathway, promoting anti-inflammatory effects of gastric tissue and regulating the composition of the intestinal flora.
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http://dx.doi.org/10.4196/kjpp.2021.25.4.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255120PMC
July 2021

Self-assembly of propeller-shaped amphiphilic molecules: control over the supramolecular morphology and photoproperties of their aggregates.

Soft Matter 2021 Jul;17(27):6661-6668

Department of Chemistry, National Demonstration Centre for Experimental Chemistry Education, Yanbian University, Yanji 133002, China.

The aggregation-induced emission (AIE) effect is an important feature for luminescence studies, which can offer a broader range of applications for fluorescent materials. Herein, we report the morphological control and photoproperties of amphipathic propeller-shaped rod-coil molecules based on a benzene-1,3,5-tricarboxamide (BTA) unit, which restricts the intramolecular rotation and leads to the AIE effect during the self-assembly process. Investigations on the assembly of these molecules have revealed that tetragonal perforated lamella, hexagonal columnar, body-centered tetragonal micellar, and hexagonal close-packed nanostructures were spontaneously formed in the solid-state. In the solution-state, these molecules assemble into nanosheet-like aggregates, bowl-like objects, and spherical nanoparticles, respectively. The morphology of the molecular aggregates can be controlled by modifying the molecular chain length or introducing lateral methyl groups in the coil chain. Notably, these molecular assemblies exhibit strong AIE phenomena in a mixed THF/H2O solution and can be used as smart soft materials due to the restriction of their intramolecular motion.
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http://dx.doi.org/10.1039/d1sm00661dDOI Listing
July 2021

In-hospital acute kidney injury and atrial fibrillation: incidence, risk factors, and outcome.

Ren Fail 2021 Dec;43(1):949-957

Division of Nepphrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: The incidence and the risk factors of in-hospitalized acute kidney injury (AKI) in patients hospitalized for atrial fibrillation (AF) were unclear.

Methods: The Improving Care for Cardiovascular Disease in China-AF (CCC-AF) project is an ongoing registry and quality improvement project, with 240 hospitals recruited across China. We selected 4527 patients hospitalized for AF registered in the CCC-AF from January 2015 to January 2019. Patients were divided into the AKI and non-AKI groups according to the changes in serum creatinine levels during hospitalization.

Results: Among the 4527 patients, the incidence of AKI was 8.0% (361/4527). Multivariate logistic analysis results indicated that the incidence of in-hospital AKI in patients with AF on admission was 2.6 times higher than that in patients with sinus rhythm (OR 2.60, 95% CI 1.77-3.81). Age (per 10-year increase, OR 1.22, 95% CI 1.07-1.38), atrial flutter/atrial tachycardia on admission (OR 2.16, 95% CI 1.12-4.15), diuretics therapy before admission (OR 1.48, 95% CI 1.07-2.04) and baseline hemoglobin (per 20 g/L decrease, OR 1.21, 95% CI 1.10-1.32) were independent risk factors for in-hospital AKI. β blockers therapy given before admission (OR 0.67, 95% CI 0.51-0.87) and non-warfarin therapy during hospitalization (OR 0.71, 95% CI 0.53-0.96) were associated with a decreased risk of in-hospital AKI. After adjustment for confounders, in-hospital AKI was associated with a 34% increase in risk of major adverse cardiovascular (OR 1.34, 95% CI 1.02-1.90,  = 0.023).

Conclusions: Clinicians should pay attention to the monitoring and prevention of in-hospital AKI to improve the prognosis of patients with AF.
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http://dx.doi.org/10.1080/0886022X.2021.1939049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218696PMC
December 2021

Survey of in-silico prediction of anticancer peptides.

Authors:
Nan Ye

Curr Top Med Chem 2021 Jun 11. Epub 2021 Jun 11.

School of Finance and Economics, Xinyang Agriculture and Forestry University, Xinyang 464000, China.

Cancer is one of the major causes of death among human beings. Traditional treatments of cancer kill cancerous cells and negatively affect normal cells. The side effects and high medical costs prevent effective treatment. Recently, anticancer peptides have become potential therapeutic agents that are expected to assist the traditional treatments. Compared with the conventional wet-lab experiments, computation-based methods provide a promising sight for high-throughput identification of peptides that has an anticancer activity. We summarize the current available database of anticancer peptides/proteins. We survey 21 recently published in-silico methods that aim to accurately predict anticancer peptides. More specifically, we focus on the benchmark datasets, feature construction and feature selection, machine learning algorithms, assessment criteria, comparison of different methods, and publically available predictors. Finally, we propose several recommendations concerning the future development of database of anticancer peptides, and the methods that are used to predict anticancer peptides.
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http://dx.doi.org/10.2174/1568026621666210612030536DOI Listing
June 2021

Prophylactic dialysis improves short-term clinical outcome in patients with non-dialysis-dependent chronic kidney disease undergoing cardiac surgery: a meta-analysis of randomized controlled trials.

Coron Artery Dis 2021 Jul 26. Epub 2021 Jul 26.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R.China.

Background: Several studies have reported that prophylactic dialysis can reduce the mortality of non-dialysis-dependent chronic kidney disease (CKD) patients after cardiac surgery. However, the results of complications in these randomized controlled trials (RCTs) were not consistent. We aimed to perform a meta-analysis to systematically evaluate the effect of prophylactic dialysis in these non-dialysis-dependent CKD patients.

Methods: We systematically searched Medline, Embase, Cochrane's Library and other online sources for related RCTs. Effects of prophylactic dialysis on the incidence of 30 days' mortality and postoperative complications were analyzed.

Results: Four RCTs comprising 395 patients were included, all of them treated by coronary artery bypass grafting. Treatment of preoperative and intraoperative prophylactic dialysis significantly reduced the rate of 30-day all-cause mortality (risk ratio [RR]: 0.27, 95% confidence interval [CI], 0.13-0.58, P < 0.001, I2 = 0%) and the incidence of pulmonary complications (RR: 0.39, 95% CI, 0.20-0.77, P = 0.007, I2 = 0%), low cardiac output (RR: 0.29, 95% CI, 0.09-0.99, P = 0.05, I2 = 0%), and acute kidney injury (RR: 0.19, 95% CI: 0.07-0.52, P = 0.001, I2 = 0%). However, there were no statistically significant differences between the dialysis group and the control group in gastrointestinal bleeding, sepsis or multiple organ failure, wound infection, arrhythmia, transient neurologic deficit, stroke and re-exploration for bleeding.

Conclusion: Prophylactic dialysis can improve the 30-day clinical outcomes of non-dialysis-dependent CKD patients undergoing cardiac surgery, it was associated with the 30-day mortality benefit and led to a decrease in the incidence of pulmonary complications, as well as low cardiac output, and acute kidney injury.
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http://dx.doi.org/10.1097/MCA.0000000000001080DOI Listing
July 2021

MicroRNA-29b-3p Inhibits the Migration and Invasion of Gastric Cancer Cells by Regulating the Autophagy-Associated Protein MAZ.

Onco Targets Ther 2021 18;14:3239-3249. Epub 2021 May 18.

School of Chemical Engineering and Technology, Tianjin University, Tianjin, the People's Republic of China.

Purpose: The purpose of this study was to investigate the relationship between microRNA-29b-3p (miR-29b-3p) and myc-associated zinc finger protein (MAZ) expression and the effects of this interaction on the proliferation, migration, and invasion of gastric cancer cells.

Methods: qPCR and Western blots were used to detect the expression of miR-29b-3p and MAZ. The dual luciferase reporter gene system was used to explore whether MAZ is the target of miR-29b-3p. Cell function experiments and a mouse tumorigenesis model were used to determine the effects of miR-29b-3p overexpression and MAZ depletion on proliferation, migration, and invasion in gastric cancer cell lines and on tumor growth.

Results: The expression level of miR-29b-3p was low and the expression level of MAZ was high in gastric cancer cells compared with normal human gastric mucosal epithelial cells. MAZ was the target gene of miR-29b-3p. The upregulation of miR-29b-3p reduces the expression of MAZ. Overexpression of miR-29b-3p and downregulation of MAZ inhibited the proliferation and migration of cancer cells and induced apoptosis by controlling the expression of autophagy-related proteins. MiR-29b-3p mimics inhibit tumor growth in mice.

Conclusion: MiR-29b-3p inhibits the migration and invasion of gastric cancer cells by regulating the autophagy-related protein MAZ.
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http://dx.doi.org/10.2147/OTT.S274215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140921PMC
May 2021

Scalable Preparation of Ultrathin Graphene-Reinforced Copper Composite Foils with High Mechanical Properties and Excellent Heat Dissipation.

ACS Appl Mater Interfaces 2021 May 28;13(18):21714-21723. Epub 2021 Apr 28.

School of Materials Science and Engineering, Nanchang University, Nanchang 330031, China.

As an important basic material of electronic equipment, copper (Cu) foils should have a small thickness, good mechanical properties, and excellent thermal conductivity. However, preparing an ultrathin Cu foil with good properties remains challenging. Herein, we report an electroless deposition (ELD) strategy for the facile and scalable preparation of an ultrathin freestanding nickel-coated graphene (NCG)/Cu composite foil in a short time of 25 min. The NCG can significantly improve the mechanical and physical properties of composite foils. Experimental results reveal that the NCG/Cu composite foil manifests the best performance when the NCG concentration in an ELD bath was 30 mg/L. The composite foil evidenced a thickness of 1.1 μm, a high tensile strength of 338.7 MPa, and a high thermal conductivity of 431.2 W/mK. Compared with the pure Cu foil, both bending times and elastic modulus are increased by 298.1 and 737.3%, respectively. Remarkably, the composite foil has excellent heat dissipation performance, showing enormous potential as a heat sink material. This work proposes a new method for manufacturing the ultrathin graphene-reinforced Cu composite foil with high performance for numerous applications.
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http://dx.doi.org/10.1021/acsami.1c01519DOI Listing
May 2021

Investigation of Obesity-Alleviation Effect of on Mice Fed with a High-Fat Diet through Metabolomics Revealed Enhanced Decomposition and Inhibition of Accumulation of Lipids.

J Proteome Res 2021 05 15;20(5):2714-2724. Epub 2021 Apr 15.

Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 88 Keyuan South Road, Hi-Tech Zone, Chengdu 610041, China.

The metabolic and bioactivity effects of () in obesity treatment were studied in mice fed with a high-fat diet using a metabolomics approach. Aqueous extracts of were obtained via grinding, dissolving, and freeze-drying. The hepatic steatosis effect of was characterized by hematoxylin and eosin histological staining. External performance of the obesity-alleviation effect was monitored by measuring body and food weight. In addition, the metabolomics analysis of the -mice interaction system was performed using the established platform combining liquid chromatography-tandem mass spectrometry with statistical analysis. The presence and spatial distribution patterns of differential molecules were further evaluated through desorption electrospray ionization-mass spectrometry imaging. The results showed that played a vital role in downregulating lipid accumulation (especially triacylglycerols) and fatty acids biosynthesis together with enhanced lipid decomposition and healing in Bagg albino mice. During such a process, mainly induced metabolomic alterations of amino acids, organic acids, phospholipids, and glycerolipids. Moreover, under the experimental concentrations, induced more fluctuations of aqueous-soluble metabolites in the plasma and lipids in the liver than in the kidneys. This study provides an advanced alternative to traditional -based studies for evaluating the metabolic effects and bioactivity of through metabolomics technology, revealing potential technological improvement and clinical application.
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http://dx.doi.org/10.1021/acs.jproteome.1c00015DOI Listing
May 2021

Influence of Pulse Current Forward-Reverse Duty Cycle on Structure and Performance of Electroplated W-Cu Composite Coatings.

Materials (Basel) 2021 Mar 5;14(5). Epub 2021 Mar 5.

School of Materials Science and Engineering, Nanchang University, No. 999, Xuefu Avenue, Nanchang 330031, China.

Tungsten-copper (W-Cu) composites are widely used as electrical contact materials, resistance welding, electrical discharge machining (EDM), and plasma electrode materials due to their excellent arc erosion resistance, fusion welding resistance, high strength, and superior hardness. However, the traditional preparation methods pay little attention to the compactness and microstructural uniformity of W-Cu composites. Herein, W-Cu composite coatings are prepared by pulse electroplating using nano-W powder as raw material and the influence of forward-reverse duty cycle of pulse current on the structure and mechanical properties is systematically investigated. Moreover, the densification mechanism of the W-Cu composite coating is analyzed from the viewpoints of forward-pulse plating and reverse-pulse plating. At the current density () of 2 A/dm, frequency () of 1500 Hz, forward duty cycle () of 40% and reverse duty cycle () of 10%, the W-Cu composite coating rendered a uniform microstructure and compact structure, resulting in a hardness of 127 HV and electrical conductivity of 53.7 MS/m.
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http://dx.doi.org/10.3390/ma14051233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961998PMC
March 2021

Abnormality in coronary slow flow phenomenon detected by nailfold microcirculation microanalysis.

Chin Med J (Engl) 2021 03 17;134(11):1370-1372. Epub 2021 Mar 17.

Department of Cardiology, Jinshan Hospital of Fudan University, Shanghai 201508, China.

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http://dx.doi.org/10.1097/CM9.0000000000001437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183737PMC
March 2021

Blood Pressure Effects of Canagliflozin and Clinical Outcomes in Type 2 Diabetes and Chronic Kidney Disease: Insights From the CREDENCE Trial.

Circulation 2021 May 8;143(18):1735-1749. Epub 2021 Feb 8.

The George Institute for Global Health (N.Y., M.J.J., M.O., C.H., A.E.S., C.A., B.N., D.C.W., G.L.D.T., V.P., B.L.N.), University of New South Wales, Sydney, Australia.

Background: People with type 2 diabetes and chronic kidney disease experience a high burden of hypertension, but the magnitude and consistency of blood pressure (BP) lowering with canagliflozin in this population are uncertain. Whether the effects of canagliflozin on kidney and cardiovascular outcomes vary by baseline BP or BP-lowering therapy is also unknown.

Methods: The CREDENCE trial (Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation) randomized people with type 2 diabetes and chronic kidney disease to canagliflozin or placebo. In a post hoc analysis, we investigated the effect of canagliflozin on systolic BP across subgroups defined by baseline systolic BP, number of BP-lowering drug classes, and history of apparent treatment-resistant hypertension (BP ≥130/80 mm Hg while receiving ≥3 classes of BP-lowering drugs, including a diuretic). We also assessed whether effects on clinical outcomes differed across these subgroups.

Results: The trial included 4401 participants, of whom 3361 (76.4%) had baseline systolic BP ≥130 mm Hg, and 1371 (31.2%) had resistant hypertension. By week 3, canagliflozin reduced systolic BP by 3.50 mm Hg (95% CI, -4.27 to -2.72), an effect maintained over the duration of the trial, with similar reductions across BP and BP-lowering therapy subgroups (all interaction ≥0.05). Canagliflozin also reduced the need for initiation of additional BP-lowering agents during the trial (hazard ratio, 0.68 [95% CI, 0.61-0.75]). The effect of canagliflozin on kidney failure, doubling of serum creatinine, or death caused by kidney or cardiovascular disease (hazard ratio, 0.70 [95% CI, 0.59-0.82]) was consistent across BP and BP-lowering therapy subgroups (all interaction ≥0.35), as were effects on other key kidney, cardiovascular, and safety outcomes.

Conclusions: In people with type 2 diabetes and chronic kidney disease, canagliflozin lowers systolic BP across all BP-defined subgroups and reduces the need for additional BP-lowering agents. These findings support use of canagliflozin for end-organ protection and as an adjunct BP-lowering therapy in people with chronic kidney disease. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791.
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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.048740DOI Listing
May 2021

[Causes of and risk factors for failure in catheter removal after transurethral resection of the prostate].

Zhonghua Nan Ke Xue 2020 Mar;26(3):250-253

Department of Urology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.

Objective: To find the causes of the failure in the first catheter removal (CR) after transurethral resection of the prostate (TURP) and the related risk factors.

Methods: We collected the clinical data on 285 BPH patients treated by TURP from June 2015 to May 2018. We divided the cases into a successful CR (SCR) and a failed CR (FCR) group and investigated the risk factors for the first CR after TURP by multivariate logistic regression analysis.

Results: CR was successfully performed in 246 and failed in 39 of the 285 cases. In the FCR group, post-CR urinary retention occurred in 15 cases immediately after, severe urinary tract irritation in 13, massive gross hematuria in 7 and urinary incontinence in 4 within 1 month. Multivariate logistic regression analysis showed that the independent risk factors for CR failure included IPSS (OR = 5.106, P = 0.013), preoperative urinary tract infection (OR = 3.835, P = 0.041), prostate volume (OR = 4.160, P = 0.011) and catheter compression time (OR = 4.051, P = 0.017).

Conclusions: The common causes of the failure in catheter removal after TURP included early postoperative urinary retention, urinary infection, secondary hematuria and urinary incontinence.
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March 2020

A Study of Potential SARS-CoV-2 Antiviral Drugs and Preliminary Research of Their Molecular Mechanism, Based on Anti-SARS-CoV Drug Screening and Molecular Dynamics Simulation.

J Comput Biol 2020 Dec 1. Epub 2020 Dec 1.

School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China.

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http://dx.doi.org/10.1089/cmb.2020.0112DOI Listing
December 2020

Formation Mechanism of High-Purity TiAlN Powders under Microwave Sintering.

Materials (Basel) 2020 Nov 26;13(23). Epub 2020 Nov 26.

School of Material Science and Engineering, Nanchang University, No. 999, Xuefu Avenue, Nanchang 330031, China.

In the present study, high-purity ternary-phase nitride (TiAlN) powders were synthesized through microwave sintering using TiH, Al, and TiN powders as raw materials. X-ray diffraction (XRD), differential scanning calorimetry (DSC), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) were adopted to characterize the as-prepared powders. It was found that the TiAlN powder prepared by the microwave sintering of the 1TiH/1.15Al/1TiN mixture at 1250 °C for 30 min manifested great purity (96.68%) with uniform grain size distribution. The formation mechanism of TiAlN occurred in four stages. The solid-phase reaction of Ti/Al and Ti/TiN took place below the melting point of aluminum and formed TiAl and TiN phases, which were the main intermediates in TiAlN formation. Therefore, the present work puts forward a favorable method for the preparation of high-purity TiAlN powders.
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http://dx.doi.org/10.3390/ma13235356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728301PMC
November 2020

Association between the serotonin transporter linked polymorphic region and lifelong premature ejaculation: An updated meta-analysis of case-control studies.

Medicine (Baltimore) 2020 Oct;99(41):e22169

Department of Urology, the Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Previous studies on the association between serotonin transporter linked polymorphic region (5-HTTLPR) polymorphism and premature ejaculation (PE) have led to inconsistent results. The purpose of the present meta-analysis was to examine whether 5-HTTLPR polymorphism is associated with PE susceptibility.All eligible studies were searched and acquired from PubMed, Embase, Science Direct, CNKI, and Wanfang databases according to inclusion and exclusion criteria. Odds ratios (ORs) with 95% confidence intervals (CIs) were computed to assess the strength of the association between 5-HTTLPR polymorphism and PE. In addition, heterogeneity test, publication bias and sensitivity analysis were also conducted.Firstly, the association were observed in 8 studies (L vs S: OR = 0.74, 95% CI = 0.63-0.87; LL vs SS: OR = 0.61, 95% CI = 0.44-0.83; SL vs SS: OR = 0.73, 95% CI = 0.55-0.96; LL + SL vs SS: OR = 0.67, 95% CI = 0.52-0.86; LL vs SL + SS: OR = 0.72, 95% CI = 0.55-0.92). When the 2 studies not in Hardy-Weinberg equilibrium (HWE) were omitted, a positive association could only be observed between the 5-HTTLPR polymorphism and PE in allele contrast model (L vs S: OR = 0.81, 95% CI = 0.67-0.98). In the stratified analysis by subgroup, significantly associations were also found between PE and 5-HTTLPR polymorphism in Caucasians but not Asians (L vs S: OR = 0.79, 95% CI = 0.63-0.98; LL + SL vs SS: OR = 0.67, 95% CI = 0.46-0.96).Our meta-analysis demonstrated that the 5-HTTLPR polymorphism was associated with the susceptibility to PE in the Caucasian population. Compared with S allele, L allele is likely to be less susceptible to PE.
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http://dx.doi.org/10.1097/MD.0000000000022169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544385PMC
October 2020

Admission fasting plasma glucose is associated with in-hospital outcomes in patients with acute coronary syndrome and diabetes: findings from the improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project.

BMC Cardiovasc Disord 2020 08 20;20(1):380. Epub 2020 Aug 20.

Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, No. 2 Anzhen Street, Chao yang District, Beijing, 100029, PR China.

Background: The discrepancy between glycosylated hemoglobin (HbA) and fasting plasma glucose (FPG) in clinical practice may be related to factors such as acute stress, renal dysfunction, and anemia, and its relationship with in-hospital outcomes is uncertain. The aim of this study was to investigate the association between the type of discrepancy between HbA and FPG and in-hospital outcomes in patients with acute coronary syndrome (ACS) and diabetes.

Methods: The Improving Care for Cardiovascular Disease in China - Acute Coronary Syndrome (CCC-ACS) project is a national, hospital-based quality improvement project with an ongoing database. Patients with ACS, diabetes and complete HbA and FPG values at admission were included. The consistent group included patients with HbA < 6.5% and FPG < 7.0 mmol/L or HbA ≥ 6.5% and FPG ≥ 7.0 mmol/L. The discrepancy group included patients with HbA ≥ 6.5% and FPG < 7.0 mmol/L (increased HbA group) or HbA < 6.5% and FPG ≥ 7.0 mmol/L (increased FBG group).

Results: A total of 7762 patients were included in this study. The numbers of patients in the consistent and discrepancy groups were 5490 and 2272 respectively. In the discrepancy group, increased HbA accounted for 77.5% of discrepancies, and increased FPG accounted for 22.5% of discrepancies. After adjusting for confounders, patients in the increased FPG group had a 1.6-fold increased risk of heart failure (OR, 1.62; 95% CI, 1.08-2.44), a 1.6-fold increased risk of composite cardiovascular death and heart failure (OR, 1.63; 95% CI, 1.09-2.43), and a 1.6-fold increased risk of composite major adverse cardiovascular and cerebrovascular events (MACCEs) and heart failure (OR, 1.56; 95% CI, 1.08-2.24) compared to patients in the increased HbA group.

Conclusions: Patients with an increased FPG but normal HbA had a higher risk of in-hospital adverse outcomes than those with increased HbA but normal FPG. This result may indicate that when HbA and FPG are inconsistent in patients with ACS and diabetes, the increased FPG that may be caused by stress hyperglycemia may have a more substantial adverse effect than increased HbA, which may be caused by chronic hyperglycemia. These high-risk patients should be given more attention and closer monitoring in clinical practice.

Trial Registry: Clinicaltrial.gov , NCT02306616 . Registered 29 November 2014.
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http://dx.doi.org/10.1186/s12872-020-01662-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441713PMC
August 2020

Ghrelin promotes the osteogenic differentiation of rMSCs via miR-206 and the ERK1/2 pathway.

Cytotechnology 2020 Oct 22;72(5):707-713. Epub 2020 Jul 22.

Department of Cervical Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University, Muslims Camp Square Road No 1, Hohhot, China.

Objective: Mesenchymal stem cells (MSCs) can differentiate into chondroblasts, adipocytes, or osteoblasts under appropriate stimulation. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), stimulates growth hormone (GH) secretion and exerts both orexigenic and adipogenic effects. The ERK1/2 signaling pathway is known to trigger osteogenic differentiation of rabbit bone marrow-derived mesenchymal stromal cells. In the present study, the function of miR-206 in the ghrelin-mediated osteogenic differentiation of rabbit bone marrow-derived mesenchymal stromal cells (rMSCs) was explored.

Methods: The expression of miR-206 was detected by qPCR, and phosphorylated ERK1/2 and the protein expression levels of ALP, RUNX2, and Osterix were assessed by western blotting.

Results: Ghrelin inhibited the expression of miR-206 to promote the osteogenic differentiation of rMSCs. Moreover, ghrelin increased the phosphorylation of ERK1/2, while overexpression of miR-206 suppressed ERK1/2 phosphorylation, indicating that miR-206 can regulate the ERK1/2 pathway. Further, inhibition of ERK1/2 had no influence on miR-206 expression; however, the phosphorylation of ERK1/2 was decreased, and the protein expression levels of ALP, RUNX2, and Osterix were downregulated.

Conclusions: Ghrelin promotes the osteogenic differentiation of rMSCs via miR-206 and the ERK1/2 pathway.
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http://dx.doi.org/10.1007/s10616-020-00413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548014PMC
October 2020

Quantifying the spreading resistance of an anisotropic thin film conductor.

Sci Rep 2020 Jun 30;10(1):10633. Epub 2020 Jun 30.

National Institute of Advanced Industrial Science and Technology (AIST), AIST Tsukuba Central 5, Higashi 1-1-1, Tsukuba, Ibaraki, 305-8565, Japan.

Recently, highly anisotropic conductors, such as multilayer graphene, have been attracting much attention. The local resistivity can be determined by measuring the contact resistance; however, the theoretical expressions of contact resistance have been developed for isotropic slabs but have not been well developed for highly anisotropic film conductors. We obtain theoretical expressions of the spreading resistance below the circular contact for a highly anisotropic film on a bulk slab. The film spreading resistance of isotropic conductors deviates from the bulk spreading resistance when the film thickness is smaller than the contact radius. Nevertheless, the spreading resistance of anisotropic conducting films can be approximated by that of the bulk slabs even when the film thickness is smaller than the contact radius if the in-plane electrical conductivity is larger than the out-of-plane electrical conductivity. Owing to the high in-plane conductivity, the spreading resistance of anisotropic bulk conductors can be lowered from that predicted by the Holm's equation obtained using the out-of-plane conductivity and the contact radius. We show that these characteristics are beneficial to use the highly anisotropic film as a cover layer when the in-plane conductivity of the film is high and the conductivity of the base slab is low.
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http://dx.doi.org/10.1038/s41598-020-66739-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326967PMC
June 2020

Electroless Deposition of Automatically Shedded Thin Copper Foils.

ACS Appl Mater Interfaces 2020 Jun 10;12(25):28831-28839. Epub 2020 Jun 10.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Textiles, Donghua University, Shanghai 201620, China.

Electroless deposition (ELD) is a process widely used for the production of thin metal films, but stripping the films from the substrate remains challenging. Here, we report a low-cost ELD method for the large-scale production of freestanding copper (Cu) foils in a short time of 25-55 min. By atomizing a thin (<100 nm) sacrificial layer of chitosan with weak glycosyl bonds and a high degree of deacetylation on the glass substrate, the chitosan is completely decomposed in the process of Cu-deposition, producing automatically shedded Cu foils with varied thicknesses from 746 nm to 8.33 μm and high elastic modulus. When used as battery current collectors, the thin Cu foils with enhanced adhesive fastness and contact areas greatly enhance the capacity and rate capability of graphite anodes. Compared with the commercial Cu current collectors, both the battery capacity and energy density are increased by 429.6 and 484.1%, respectively. The reported approach can be extended for fabricating other metal foils such as nickel with properties appealing for applications.
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http://dx.doi.org/10.1021/acsami.0c05987DOI Listing
June 2020

SMRT sequencing revealed to be an effective method for ADTKD-MUC1 diagnosis through follow-up analysis of a Chinese family.

Sci Rep 2020 05 25;10(1):8616. Epub 2020 May 25.

Division of Nephrology, Beijing AnZhen Hospital, Capital Medical University, Beijing, 100029, China.

We reported a large Chinese family diagnosed with autosomal dominant tubulointerstitial kidney disease caused by MUC1 mutation (ADTKD-MUC1). Cytosine duplication within a string of 7 cytosines in the variable-number tandem repeats (VNTR) region of the MUC1 gene was detected by long-read single-molecule real-time (SMRT) sequencing. MUC1 frameshift protein (MUC1fs) was found to be expressed in renal tubules and urinary exfoliated cells by pathological examination. The family, which consisted of 5 generations including 137 individuals, was followed for 5 years. Genetic testing was performed in thirty-four individuals, 17 of whom carried MUC1 mutations. The ADTKD-MUC1-affected individuals had an elevated incidence of hyperuricaemia without gout attack. Within five years, higher baseline levels of urinary α1-microglobulin were detected in affected individuals with rapidly progressing renal failure than in affected individuals with stable renal function, and the increases manifested even before increases in serum creatinine. This study demonstrates that SMRT sequencing is an effective method for the identification of MUC1 mutations. The pathological examination of MUC1fs expression in renal tissue and urinary exfoliated cells can contribute to early screening of family members suspected to be affected. It is suggested that affected individuals with elevated urinary α1-microglobulin levels should be closely monitored for renal function.
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http://dx.doi.org/10.1038/s41598-020-65491-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248079PMC
May 2020

Heterogeneous photodiodes on silicon nitride waveguides.

Opt Express 2020 May;28(10):14824-14830

Heterogeneous integration through low-temperature die bonding is a promising technique to enable high-performance III-V photodetectors on the silicon nitride (SiN) photonic platform. Here we demonstrate InGaAs/InP modified uni-traveling carrier photodiodes on SiN waveguides with 20 nA dark current, 20 GHz bandwidth, and record-high external (internal) responsivities of 0.8 A/W (0.94 A/W) and 0.33 A/W (0.83 A/W) at 1550 nm and 1064 nm, respectively. Open eye diagrams at 40 Gbit/s are demonstrated. Balanced photodiodes of this type reach 10 GHz bandwidth with over 40 dB common mode rejection ratio.
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http://dx.doi.org/10.1364/OE.387939DOI Listing
May 2020

High fidelity underwater wireless optical communication with a phase-conjugated frame structure.

Appl Opt 2020 May;59(13):4000-4007

In this paper, the influence factors of phase noise are first analyzed in detail and verified by experiments, and its principle is theoretically derived. Besides, we propose a novel, to the best of our knowledge, frame structure for m-quadrature amplitude modulation-orthogonal frequency division multiplexing (m-QAM-OFDM) in underwater wireless optical communication. The frame structure contains OFDM signals and their phase-conjugated signals. At the receiving end, by the simple superposition of phase-conjugated symbols, the noise suppression can be achieved. The feasibility is experimentally demonstrated by transmitting m-QAM-OFDM signal in different modulation formats and scenarios. The results show that bit error rate performance can be significantly improved, and there is also a significant increase in transmission capacity compared to the traditional phase-conjugated method. Moreover, the proposed frame structure can provide a robust and simple compromise between transmission capacity and distance.
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http://dx.doi.org/10.1364/AO.388536DOI Listing
May 2020

Corrigendum: Critical Role of Alternative M2 Skewing in miR-155 Deletion-Mediated Protection of Colitis.

Front Immunol 2019;10:3153. Epub 2020 Feb 13.

Institute of Immunology, PLA, Army Medical University, Chongqing, China.

[This corrects the article DOI: 10.3389/fimmu.2018.00904.].
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http://dx.doi.org/10.3389/fimmu.2019.03153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031493PMC
February 2020

Effect of nephrology follow-up on long-term outcomes in patients with acute kidney injury: A systematic review and meta-analysis.

Nephrology (Carlton) 2020 Aug 18;25(8):607-615. Epub 2020 Feb 18.

The Renal and Metabolic Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Aim: Acute kidney injury (AKI) is associated with poor short-term and long-term clinical outcomes. The role of nephrology follow-up in post-AKI management remains uncertain.

Methods: A systematic review and meta-analysis were performed examining all randomized controlled trials and observational studies assessing the effect of nephrology follow-up on patients' clinical outcomes. The primary outcome was all-cause mortality. The secondary outcomes were renal outcomes, which were defined as a composite of requirement of permanent dialysis and recurrent AKI. Pooled analysis was performed using a random-effect model.

Results: We identified six studies (8972 patients, mean follow-up of 49 months). Five were retrospective cohort studies and one was a prospective cohort study. Risk of bias was a concern with all studied. Only four studies reported primary and/or secondary outcomes and were included. Compared with patients without nephrology follow-up, patients with nephrology follow-up had significantly reduced mortality by 22% (three studies, 3240 patients, relative risk [RR] = 0.78, 95% confidence interval [CI] = 0.70-0.88, I = 0.0%). Nephrology follow-up did not improve composite renal outcomes with high heterogeneity due to significant differences in reported renal outcomes and follow-up period (two studies, 2537 patients, RR = 1.72, 95% CI = 0.49-6.05, I = 90.1%).

Conclusion: Current evidence from observational studies is biased. It suggests long-term survival benefits with post-discharge nephrology follow-up in AKI patients. However, due to its low quality, such evidence is only hypothesis-generating. Nonetheless, it provides a rationale for future randomized controlled trials of nephrology follow-up in AKI patients. SUMMARY AT A GLANCE The present meta-analysis assessed the effect of nephrology follow-up on patients' clinical outcomes, and suggested long-term survival benefits in acute kidney injury (AKI) survivors. Although the study inherently comprises potential risks of bias due to paucity of available data, the results provide a rationale for future randomized controlled trials.
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http://dx.doi.org/10.1111/nep.13698DOI Listing
August 2020

Analysis of the relationship between MIR155HG variants and gastric Cancer susceptibility.

BMC Gastroenterol 2020 Jan 20;20(1):17. Epub 2020 Jan 20.

Department of gastroenterology, First Affiliate Hospital of Xi'an JiaoTong University, #227 West Yanta Road, Xi'an, 710061, Shaanxi Province, China.

Background: Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer risk.

Materials & Methods: A total of 506 gastric cancer patients and 500 healthy controls were enrolled in this study. Genotypes were examined with the MassARRAY platform and data management and analysis were conducted with the Typer Software. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated with logistic regression adjusting for age and gender to evaluate the associations between SNPs with gastric cancer in genetic model analysis.

Results: The "CC" genotype of rs4143370 decreased the risk of gastric cancer in genotype model (p = 0.020) and recessive model (p = 0.018). Inversely, the "CC" genotype of rs1893650 increased the risk of gastric cancer in genotype model (p = 0.023) and recessive model (p = 0.014). Stratified analysis showed that rs11911469 was associated with an increased risk of gastric cancer only among the male group in the dominant model (p = 0.039) and additive model (p = 0.030). The haplotype analysis showed a strong linkage disequilibrium among these six SNPs (rs4143370, rs77699734, rs11911469, rs1893650, rs34904192 and rs928883).

Conclusion: This study confirmed the relationship between SNPs of MIR155HG and the gastric cancer risk among the Chinese Han population. Our data may provide a new perspective to understand the aetiology of gastric cancer.
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http://dx.doi.org/10.1186/s12876-020-1169-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972026PMC
January 2020

Intestinal Injury in Heat Stroke.

J Emerg Med 2019 Dec 7;57(6):791-797. Epub 2019 Nov 7.

Department of Military Biosafety, Army Medical University, Third Military Medical University, Chongqing, China.

Background: Heat stroke is a life-threatening syndrome that is characterized by its severe clinical symptoms, rapid progression, and high rate of mortality. Recently, research has indicated that a dysfunctional intestinal epithelia barrier plays an important role in the pathophysiology of heat stroke. Protecting the intestines from heat stress had been identified as a potentially effective treatment for patients with heat stroke and may reduce the innate immune response caused by endotoxins in circulation.

Objectives: The aim of this review is to discuss this key event in heat stroke and to describe the mechanism during progression.

Discussion: Direct injuries and secondary impairments of the intestine induced by heat stress are discussed; recent studies that refer to intestine-specific prevention and treatment in heat stroke and heat stress-induced injuries are also summarized.

Conclusions: A more detailed pathogenesis of heat stroke needs to be elucidated so that potentially effective means of treatment and prevention of heat stroke can be developed and studied.
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http://dx.doi.org/10.1016/j.jemermed.2019.08.033DOI Listing
December 2019
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