Publications by authors named "Najib M El-Sayed"

69Publications

Draft Genome Sequence of Pseudomonas aeruginosa Strain PA14-UM.

Microbiol Resour Announc 2020 Nov 12;9(46). Epub 2020 Nov 12.

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.

View Article and Find Full Text PDF
November 2020

The transition of M-CSF-derived human macrophages to a growth-promoting phenotype.

Blood Adv 2020 Nov;4(21):5460-5472

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD; and.

View Article and Find Full Text PDF
November 2020

Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis.

PLoS Negl Trop Dis 2019 03 7;13(3):e0007152. Epub 2019 Mar 7.

Department of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, MD United States of America.

View Article and Find Full Text PDF
March 2019

Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival.

J Immunol 2019 04 4;202(8):2348-2359. Epub 2019 Mar 4.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742;

View Article and Find Full Text PDF
April 2019

Glucose Levels Alter the Mga Virulence Regulon in the Group A Streptococcus.

Sci Rep 2018 03 21;8(1):4971. Epub 2018 Mar 21.

Department of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park (UMCP), College Park, Maryland, USA.

View Article and Find Full Text PDF
March 2018

Intrinsic DNA curvature in trypanosomes.

BMC Res Notes 2017 Nov 9;10(1):585. Epub 2017 Nov 9.

Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la Republica, 11400, Montevideo, Uruguay.

View Article and Find Full Text PDF
November 2017

Genome-wide discovery of novel M1T1 group A streptococcal determinants important for fitness and virulence during soft-tissue infection.

PLoS Pathog 2017 Aug 23;13(8):e1006584. Epub 2017 Aug 23.

Department of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, United States of America.

View Article and Find Full Text PDF
August 2017

The Transcriptome of Developmental Stages in Their Natural Sand Fly Vector.

mBio 2017 04 4;8(2). Epub 2017 Apr 4.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

View Article and Find Full Text PDF
April 2017

The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of .

mBio 2017 03 7;8(2). Epub 2017 Mar 7.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA

View Article and Find Full Text PDF
March 2017

The Transcriptional Regulator CpsY Is Important for Innate Immune Evasion in Streptococcus pyogenes.

Infect Immun 2017 03 23;85(3). Epub 2017 Feb 23.

Department of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA

View Article and Find Full Text PDF
March 2017

Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion.

PLoS Negl Trop Dis 2016 09 15;10(9):e0004992. Epub 2016 Sep 15.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America.

View Article and Find Full Text PDF
September 2016

Comparative Transcriptome Profiling of Human Foreskin Fibroblasts Infected with the Sylvio and Y Strains of Trypanosoma cruzi.

PLoS One 2016 9;11(8):e0159197. Epub 2016 Aug 9.

Department of Cell Biology and Molecular Genetics, College of Computational, Mathematical and Natural Science, University of Maryland, College Park, Maryland, United States of America.

View Article and Find Full Text PDF
July 2017

Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

mBio 2016 05 10;7(3). Epub 2016 May 10.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA

View Article and Find Full Text PDF
May 2016

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection.

PLoS Pathog 2016 Apr 5;12(4):e1005511. Epub 2016 Apr 5.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.

View Article and Find Full Text PDF
April 2016

The fruRBA Operon Is Necessary for Group A Streptococcal Growth in Fructose and for Resistance to Neutrophil Killing during Growth in Whole Human Blood.

Infect Immun 2016 Apr 24;84(4):1016-1031. Epub 2016 Mar 24.

Department of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA

View Article and Find Full Text PDF
April 2016

Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions.

BMC Genomics 2015 Dec 29;16:1108. Epub 2015 Dec 29.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.

View Article and Find Full Text PDF
December 2015

Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation.

Nucleic Acids Res 2015 Aug 6;43(14):6799-813. Epub 2015 Jul 6.

Department of Cell Biology and Molecular Genetics, 3128 Bioscience Research Building, University of Maryland, College Park, MD 20742, USA Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA

View Article and Find Full Text PDF
August 2015

The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.

J Leukoc Biol 2015 Sep 5;98(3):395-407. Epub 2015 Jun 5.

*Department of Cell Biology and Molecular Genetics and Maryland Pathogen Research Institute and Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA

View Article and Find Full Text PDF
September 2015

Genomic analysis of sequence-dependent DNA curvature in Leishmania.

PLoS One 2013 30;8(4):e63068. Epub 2013 Apr 30.

Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Montevideo, Uruguay.

View Article and Find Full Text PDF
November 2013

Transcript expression analysis of putative Trypanosoma brucei GPI-anchored surface proteins during development in the tsetse and mammalian hosts.

PLoS Negl Trop Dis 2012 19;6(6):e1708. Epub 2012 Jun 19.

Division of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, USA.

View Article and Find Full Text PDF
September 2012

The genome and its implications.

Adv Parasitol 2011 ;75:209-30

Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

View Article and Find Full Text PDF
December 2011

Identification of Schistosoma mansoni microRNAs.

BMC Genomics 2011 Jan 19;12:47. Epub 2011 Jan 19.

Graduate Program in Bioinformatics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

View Article and Find Full Text PDF
January 2011

Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans.

PLoS Genet 2010 Jul 29;6(7):e1001044. Epub 2010 Jul 29.

Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, United States of America.

View Article and Find Full Text PDF
July 2010

The Alveolate Perkinsus marinus: biological insights from EST gene discovery.

BMC Genomics 2010 Apr 7;11:228. Epub 2010 Apr 7.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA.

View Article and Find Full Text PDF
April 2010

Assessing student understanding of host pathogen interactions using a concept inventory.

J Microbiol Biol Educ 2009 17;10(1):43-50. Epub 2009 Dec 17.

Department of Cell Biology and Molecular Genetics, College of Chemical and Life Sciences, University of Maryland, College Park, Maryland 20742.

View Article and Find Full Text PDF
May 2013

Role of transposable elements in trypanosomatids.

Microbes Infect 2008 May 21;10(6):575-81. Epub 2008 Feb 21.

Laboratoire de Résonance Magnétique des Systèmes Biologiques, Université Victor Segalen Bordeaux 2, UMR-5536 CNRS, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.

View Article and Find Full Text PDF
May 2008

Sequence diversity and evolution of multigene families in Trypanosoma cruzi.

Mol Biochem Parasitol 2008 Jan 6;157(1):65-72. Epub 2007 Oct 6.

Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

View Article and Find Full Text PDF
January 2008

Schistosoma mansoni genome: closing in on a final gene set.

Exp Parasitol 2007 Nov 21;117(3):225-8. Epub 2007 Jun 21.

The J.C. Venter Institute, Rockville, MD 20850, USA.

View Article and Find Full Text PDF
November 2007

Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni.

BMC Genomics 2007 Jun 20;8:181. Epub 2007 Jun 20.

Laboratório de Genética Bioquímica, Departmento de Imunologia e Bioquímica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

View Article and Find Full Text PDF
June 2007

New Trypanosoma cruzi repeated element that shows site specificity for insertion.

Eukaryot Cell 2007 Jul 25;6(7):1228-38. Epub 2007 May 25.

Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, UNIFESP, Rua Botucatu, São Paulo, Brazil.

View Article and Find Full Text PDF
July 2007

The expression of a plant-type ferredoxin redox system provides molecular evidence for a plastid in the early dinoflagellate Perkinsus marinus.

Protist 2007 Jan 22;158(1):119-30. Epub 2006 Nov 22.

FB Biologie/Parasitologie, Philipps-Universität Marburg, 35032 Marburg, Germany.

View Article and Find Full Text PDF
January 2007

Cofactor-independent phosphoglycerate mutase is an essential gene in procyclic form Trypanosoma brucei.

Parasitol Res 2007 Mar 6;100(4):887-92. Epub 2006 Oct 6.

The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.

View Article and Find Full Text PDF
March 2007

Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region.

BMC Genomics 2006 Mar 22;7:60. Epub 2006 Mar 22.

Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles 90095, USA.

View Article and Find Full Text PDF
March 2006

The genetic map and comparative analysis with the physical map of Trypanosoma brucei.

Nucleic Acids Res 2005 27;33(21):6688-93. Epub 2005 Nov 27.

Wellcome Centre for Molecular Parasitology, Anderson College Complex, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, UK.

View Article and Find Full Text PDF
December 2005

The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion.

Mol Biol Evol 2006 Feb 2;23(2):411-20. Epub 2005 Nov 2.

Laboratoire de Génomique Fonctionnelle des Trypanosomatides, UMR-5162 Centre National de la Recherche Scientifique, Université Victor Segalen Bordeaux 2, Bordeaux Cedex, France.

View Article and Find Full Text PDF
February 2006

Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements.

Mol Biochem Parasitol 2006 Feb 10;145(2):158-70. Epub 2005 Oct 10.

Laboratoire de Génomique Fonctionnelle Des Trypanosomatides, Université Victor Segalen Bordeaux 2, UMR-5162 CNRS, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France.

View Article and Find Full Text PDF
February 2006

The genome of the African trypanosome Trypanosoma brucei.

Authors:
Matthew Berriman Elodie Ghedin Christiane Hertz-Fowler Gaëlle Blandin Hubert Renauld Daniella C Bartholomeu Nicola J Lennard Elisabet Caler Nancy E Hamlin Brian Haas Ulrike Böhme Linda Hannick Martin A Aslett Joshua Shallom Lucio Marcello Lihua Hou Bill Wickstead U Cecilia M Alsmark Claire Arrowsmith Rebecca J Atkin Andrew J Barron Frederic Bringaud Karen Brooks Mark Carrington Inna Cherevach Tracey-Jane Chillingworth Carol Churcher Louise N Clark Craig H Corton Ann Cronin Rob M Davies Jonathon Doggett Appolinaire Djikeng Tamara Feldblyum Mark C Field Audrey Fraser Ian Goodhead Zahra Hance David Harper Barbara R Harris Heidi Hauser Jessica Hostetler Al Ivens Kay Jagels David Johnson Justin Johnson Kristine Jones Arnaud X Kerhornou Hean Koo Natasha Larke Scott Landfear Christopher Larkin Vanessa Leech Alexandra Line Angela Lord Annette Macleod Paul J Mooney Sharon Moule David M A Martin Gareth W Morgan Karen Mungall Halina Norbertczak Doug Ormond Grace Pai Chris S Peacock Jeremy Peterson Michael A Quail Ester Rabbinowitsch Marie-Adele Rajandream Chris Reitter Steven L Salzberg Mandy Sanders Seth Schobel Sarah Sharp Mark Simmonds Anjana J Simpson Luke Tallon C Michael R Turner Andrew Tait Adrian R Tivey Susan Van Aken Danielle Walker David Wanless Shiliang Wang Brian White Owen White Sally Whitehead John Woodward Jennifer Wortman Mark D Adams T Martin Embley Keith Gull Elisabetta Ullu J David Barry Alan H Fairlamb Fred Opperdoes Barclay G Barrell John E Donelson Neil Hall Claire M Fraser Sara E Melville Najib M El-Sayed

Science 2005 Jul;309(5733):416-22

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.

View Article and Find Full Text PDF
July 2005

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

Science 2005 Jul;309(5733):409-15

Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA.

View Article and Find Full Text PDF
July 2005

Promoter architecture and response to a positive regulator of archaeal transcription.

Mol Microbiol 2005 May;56(3):625-37

Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0634, USA.

View Article and Find Full Text PDF
May 2005

Sequencing strategies for parasite genomes.

Methods Mol Biol 2004 ;270:1-16

Department of Parsite Genomics, The Institute for Genomic Research, Rockville, MD, USA.

View Article and Find Full Text PDF
July 2004

Advances in schistosome genomics.

Trends Parasitol 2004 Apr;20(4):154-7

Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

View Article and Find Full Text PDF
April 2004

The ingi and RIME non-LTR retrotransposons are not randomly distributed in the genome of Trypanosoma brucei.

Mol Biol Evol 2004 Mar 23;21(3):520-8. Epub 2003 Dec 23.

Laboratoire de Génomique Fonctionnelle des Trypanosomatides, UMR-5162 CNRS, Université Victor Segalen Bordeaux II, Bordeaux, France.

View Article and Find Full Text PDF
March 2004

Trypanosoma cruzi: RNA structure and post-transcriptional control of tubulin gene expression.

Exp Parasitol 2002 Nov-Dec;102(3-4):123-33

Departamento de Bioquímica e Imunologia, ICB, da Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-010, Brazil.

View Article and Find Full Text PDF
July 2003

Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi.

Mol Biochem Parasitol 2002 Sep-Oct;124(1-2):73-8

Laboratoire de Parasitologie Moléculaire, Université Victor Segalen Bordeaux II, UMR-5016 CNRS, 146 rue Léo Saignat, Bordeaux, France.

View Article and Find Full Text PDF
January 2003

Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray.

Mol Biochem Parasitol 2002 Aug;123(2):115-23

Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 506, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
August 2002