Nael Nadif Kasri

Nael Nadif Kasri

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Nael Nadif Kasri

Nael Nadif Kasri

Publications by authors named "Nael Nadif Kasri"

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Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.

Cell Rep 2020 Jan;30(1):173-186.e6

Department of Cognitive Neuroscience, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, 6525 HR Nijmegen, the Netherlands; Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.002DOI Listing
January 2020

Modeling Psychiatric Diseases with Induced Pluripotent Stem Cells.

Adv Exp Med Biol 2019 ;1192:297-312

Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/978-981-32-9721-0_15DOI Listing
November 2019

Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia.

Genet Med 2019 08 4;21(8):1790-1796. Epub 2019 Jan 4.

Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1038/s41436-018-0415-8DOI Listing
August 2019

ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility.

Nucleic Acids Res 2019 06;47(11):5587-5602

Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkz273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582315PMC
June 2019

Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release.

Brain Struct Funct 2018 Dec 5;223(9):4211-4226. Epub 2018 Sep 5.

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboudumc, 6525 HR, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00429-018-1746-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267273PMC
December 2018

Basolateral amygdala noradrenergic activity is required for enhancement of object recognition memory by histone deacetylase inhibition in the anterior insular cortex.

Neuropharmacology 2018 10 18;141:32-41. Epub 2018 Aug 18.

Dept. Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183053
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http://dx.doi.org/10.1016/j.neuropharm.2018.08.018DOI Listing
October 2018

The promise of induced pluripotent stem cells for neurodevelopmental disorders.

Prog Neuropsychopharmacol Biol Psychiatry 2018 06 8;84(Pt B):382-391. Epub 2017 Nov 8.

Department of Human Genetics, Department of Cognitive Neuroscience, Radboudumc, 6500 HB, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2017.11.009DOI Listing
June 2018

Connecting the dots in mental illness: The synapse as the intersection of brain function and disease.

Prog Neuropsychopharmacol Biol Psychiatry 2018 06;84(Pt B):305

Florey Institute of Neuroscience and Mental Health, Florey Department of Neuroscience, University of Melbourne, Parkville Victoria Australia.

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http://dx.doi.org/10.1016/j.pnpbp.2018.03.025DOI Listing
June 2018

Inhibitory control of the excitatory/inhibitory balance in psychiatric disorders.

F1000Res 2018 8;7:23. Epub 2018 Jan 8.

Department of Human Genetics & Department of Cognitive Neuroscience, Radboudumc, Geert Grooteplein 10, Box 9101, 6500 HB Nijmegen, Netherlands.

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http://dx.doi.org/10.12688/f1000research.12155.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760969PMC
January 2018

Integrated transcriptional analysis unveils the dynamics of cellular differentiation in the developing mouse hippocampus.

Sci Rep 2017 12 22;7(1):18073. Epub 2017 Dec 22.

Radboud University, Department of Molecular Biology, Faculty of Science, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-18287-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741714PMC
December 2017

Epigenetic Etiology of Intellectual Disability.

J Neurosci 2017 11;37(45):10773-10782

Instituto de Neurociencias, Molecular Neurobiology Unit, s/n 03550, San Juan de Alicante, Alicante, Spain

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1840-1
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http://dx.doi.org/10.1523/JNEUROSCI.1840-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678009PMC
November 2017

Basal ryanodine receptor activity suppresses autophagic flux.

Biochem Pharmacol 2017 05 18;132:133-142. Epub 2017 Mar 18.

KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.03.011DOI Listing
May 2017

The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function.

Prog Neuropsychopharmacol Biol Psychiatry 2017 02 27;73:109-118. Epub 2016 Feb 27.

Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, The Netherlands; Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002268PMC
February 2017

Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays.

J Vis Exp 2017 01 8(119). Epub 2017 Jan 8.

Department of Cognitive Neurosciences, Radboudumc; Donders Institute for Brain, Cognition and Behaviour, Radboud University; Department of Human Genetics, Radboudumc;

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http://dx.doi.org/10.3791/54900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407693PMC
January 2017

The Multifarious Hippocampal Functions of MicroRNA-137.

Neuroscientist 2016 10 22;22(5):440-6. Epub 2015 Sep 22.

Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, Netherlands Department of Human Genetics, Radboud University Medical Centre, Nijmegen, Netherlands

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http://dx.doi.org/10.1177/1073858415608356DOI Listing
October 2016

Increased GABA receptor signaling in a rat model for schizophrenia.

Sci Rep 2016 Sep 30;6:34240. Epub 2016 Sep 30.

Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University, Nijmegen, the Netherlands.

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http://www.nature.com/articles/srep34240
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043235PMC
http://dx.doi.org/10.1038/srep34240DOI Listing
September 2016

Extraction, Identification, and Quantification of Histones from Small Quantities of Specific Brain Tissue.

Curr Protoc Neurosci 2016 07 1;76:4.38.1-4.38.20. Epub 2016 Jul 1.

Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/cpns.11DOI Listing
July 2016

Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling.

Neuron 2016 07 30;91(2):341-55. Epub 2016 Jun 30.

Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, the Netherlands; Department of Human Genetics, Radboudumc, 6500 HB Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.06.003DOI Listing
July 2016

Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies.

Stem Cell Rev Rep 2016 Feb;12(1):54-72

Department of Cognitive Neuroscience, Radboudumc, Nijmegen, 6500, HB, The Netherlands.

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http://dx.doi.org/10.1007/s12015-015-9622-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720703PMC
February 2016

The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a.

Neurobiol Learn Mem 2015 Oct 2;124:88-96. Epub 2015 Jul 2.

Department of Cognitive Neuroscience, Radboudumc, 6500 HB Nijmegen, The Netherlands; Department of Human Genetics, Radboudumc, 6500 HB Nijmegen, The Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2015.06.013DOI Listing
October 2015

MicroRNA-137 Controls AMPA-Receptor-Mediated Transmission and mGluR-Dependent LTD.

Cell Rep 2015 Jun 18;11(12):1876-84. Epub 2015 Jun 18.

Department of Neuroinformatics, Radboud University Nijmegen, 6525 HP Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, 6525 AJ Nijmegen, the Netherlands. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)00576-8.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471500576
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http://dx.doi.org/10.1016/j.celrep.2015.05.040DOI Listing
June 2015

Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models.

J Neurosci 2015 May;35(19):7349-64

Department of Neurobiology, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, FIN 70210, Finland, Turku Centre for Biotechnology, Åbo Akademi University and University of Turku, Turku, FIN 20521, Finland

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http://dx.doi.org/10.1523/JNEUROSCI.0037-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705433PMC
May 2015

Homozygous SLC6A17 mutations cause autosomal-recessive intellectual disability with progressive tremor, speech impairment, and behavioral problems.

Am J Hum Genet 2015 Mar 19;96(3):386-96. Epub 2015 Feb 19.

Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen 6500 HB, the Netherlands; Department of Cognitive Neurosciences, Donders Institute for Brain, Cognition, and Behavior, Radboud university medical center, Nijmegen 6500 HB, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375531PMC
March 2015

Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.

Mol Brain 2015 Jan 9;8. Epub 2015 Jan 9.

Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, Nijmegen, 6500, HB, The Netherlands.

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http://dx.doi.org/10.1186/s13041-014-0092-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304614PMC
January 2015

Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.

J Med Genet 2014 Jul 8;51(7):487-94. Epub 2014 May 8.

Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands Nijmegen Centre for Molecular Life Sciences, Institute for Genetic and Metabolic Diseases, Radboud university medical center, Nijmegen, The Netherlands.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2013-102182
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http://dx.doi.org/10.1136/jmedgenet-2013-102182DOI Listing
July 2014

Bcl-2 binds to and inhibits ryanodine receptors.

J Cell Sci 2014 Jun 24;127(Pt 12):2782-92. Epub 2014 Apr 24.

KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, B-3000 Leuven, Belgium

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http://dx.doi.org/10.1242/jcs.150011DOI Listing
June 2014

Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice.

Dev Biol 2014 Feb 19;386(2):395-407. Epub 2013 Dec 19.

Department of Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands; Department of Cognitive Neurosciences, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ydbio.2013.12.016DOI Listing
February 2014

Rho GTPase signaling at the synapse: implications for intellectual disability.

Exp Cell Res 2013 Sep 14;319(15):2368-74. Epub 2013 Jun 14.

Donders Institute for Brain Cognition and Behavior, Radboud University Nijmegen Medical Center, Department Cognitive Neuroscience, the Netherlands.

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http://dx.doi.org/10.1016/j.yexcr.2013.05.033DOI Listing
September 2013

The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.

Curr Biol 2009 Jul 28;19(13):1133-9. Epub 2009 May 28.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York, NY 11724, USA.

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http://dx.doi.org/10.1016/j.cub.2009.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711225PMC
July 2009

Rho-linked genes and neurological disorders.

Pflugers Arch 2008 Feb 15;455(5):787-97. Epub 2007 Nov 15.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Demerec Building, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1007/s00424-007-0385-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515081PMC
February 2008

Binding of IRBIT to the IP3 receptor: determinants and functional effects.

Biochem Biophys Res Commun 2006 Apr 28;343(1):49-56. Epub 2006 Feb 28.

Laboratorium voor Fysiologie, Katholieke Universiteit Leuven Campus Gasthuisberg O/N1, Leuven, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X060042
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http://dx.doi.org/10.1016/j.bbrc.2006.02.119DOI Listing
April 2006

Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor.

J Biol Chem 2006 Mar 12;281(13):8332-8. Epub 2006 Jan 12.

Laboratorium voor Fysiologie, K. U. Leuven Campus Gasthuisberg, O/N Herestraat 49/802, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M510971200DOI Listing
March 2006

Calmodulin and calcium-release channels.

Biol Res 2004 ;37(4):577-82

Laboratorium voor Fysiologie, K.U. Leuven Campus Gasthuisberg O/N, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.4067/s0716-97602004000400011DOI Listing
October 2005

Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells.

Mol Pharmacol 2005 Jul 25;68(1):241-50. Epub 2005 Apr 25.

Laboratorium voor Fysiologie, Katholieke Universiteit Leuven Campus Gasthuisberg Herestraat 49/802, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1124/mol.105.013045DOI Listing
July 2005

Regulation of the phosphorylation of the inositol 1,4,5-trisphosphate receptor by protein kinase C.

Biochem Biophys Res Commun 2004 Jul;319(3):888-93

Laboratory of Physiology, K.U. Leuven Campus Gasthuisberg O/N, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbrc.2004.05.071DOI Listing
July 2004

A novel Ca2+-induced Ca2+ release mechanism in A7r5 cells regulated by calmodulin-like proteins.

J Biol Chem 2003 Jul 13;278(30):27548-55. Epub 2003 May 13.

Laboratorium voor Fysiologie, K.U. Leuven Campus Gasthuisberg O/N, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M302026200DOI Listing
July 2003

The role of calmodulin for inositol 1,4,5-trisphosphate receptor function.

Biochim Biophys Acta 2002 Nov;1600(1-2):19-31

Laboratorium voor Fysiologie, K.U.Leuven Campus Gasthuisberg O/N, Herestraat 49, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.1016/s1570-9639(02)00440-5DOI Listing
November 2002

Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism.

J Biol Chem 2002 Sep 16;277(38):35061-70. Epub 2002 Jul 16.

Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA.

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http://dx.doi.org/10.1074/jbc.M202928200DOI Listing
September 2002

Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor.

Biochem J 2002 Jul;365(Pt 1):269-77

Laboratorium voor Fysiologie, Katholieke Universiteit Leuven Campus Gasthuisberg O/N, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1042/BJ20020144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222651PMC
July 2002