Nadia Messaddeq

Nadia Messaddeq

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Nadia Messaddeq

Publications by authors named "Nadia Messaddeq"

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In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies.

Exp Eye Res 2019 09 11;186:107721. Epub 2019 Jul 11.

INSERM, Laboratoire de Génétique Médicale, UMR_U1112, Ciliopathies Modeling and Associated Therapies Team (CMAT), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut de Génétique Médicale D'Alsace (IGMA), Université de Strasbourg, 11 Rues Humann, Bâtiment 3, 67085, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2019.107721DOI Listing
September 2019

STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice.

Hum Mol Genet 2019 05;28(10):1579-1593

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Inserm, CNRS, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1093/hmg/ddy446DOI Listing
May 2019

Phagocytosis by Sertoli Cells: Analysis of Main Phagocytosis Steps by Confocal and Electron Microscopy.

Methods Mol Biol 2018 ;1748:85-101

Laboratoire Signalisation et Transports Ioniques Membranaires, Université de Poitiers/CNRS, Poitiers, France.

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http://link.springer.com/10.1007/978-1-4939-7698-0_8
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http://dx.doi.org/10.1007/978-1-4939-7698-0_8DOI Listing
February 2019

Pickering nano-emulsion as a nanocarrier for pH-triggered drug release.

Int J Pharm 2018 Oct 31;549(1-2):299-305. Epub 2018 Jul 31.

Université de Strasbourg, Faculté de pharmacie, Laboratoire de Conception et d'Application de molécules Bioactives, Equipe de pharmacie biogalénique, 74 route du Rhin, B.P. 60024, 67401 Illkirch cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2018.07.066DOI Listing
October 2018

Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle.

PLoS One 2018 15;13(3):e0193882. Epub 2018 Mar 15.

CSGA, AgroSup Dijon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université de Bourgogne Franche-Comté, 9E Boulevard Jeanne d'Arc, Dijon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193882PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854349PMC
June 2018

Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in Mice.

Mol Ther 2018 04 14;26(4):1082-1092. Epub 2018 Feb 14.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch 67400, France; INSERM U964, Illkirch 67400, France; CNRS UMR7104, Illkirch 67400, France; Strasbourg University, Illkirch 67400, France. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080128PMC
April 2018

The MTM1-UBQLN2-HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle.

Nat Cell Biol 2018 02 22;20(2):198-210. Epub 2018 Jan 22.

Department of Translational Medicine and Neurogenetics, IGBMC, Illkirch, France.

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http://dx.doi.org/10.1038/s41556-017-0024-9DOI Listing
February 2018

A new formulation of poly(MAOTIB) nanoparticles as an efficient contrast agent for in vivo X-ray imaging.

Acta Biomater 2018 01 9;66:200-212. Epub 2017 Nov 9.

Université de Strasbourg, CNRS, CAMB UMR 7199, F-67000 Strasbourg, France.

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http://dx.doi.org/10.1016/j.actbio.2017.11.011DOI Listing
January 2018

The histone code reader Spin1 controls skeletal muscle development.

Cell Death Dis 2017 11 23;8(11):e3173. Epub 2017 Nov 23.

Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacher Str. 66, Freiburg, Germany.

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http://dx.doi.org/10.1038/cddis.2017.468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775400PMC
November 2017

Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice.

Nat Commun 2017 06 7;8:15661. Epub 2017 Jun 7.

Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch 67404, France.

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http://dx.doi.org/10.1038/ncomms15661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467247PMC
June 2017

ISCA1 is essential for mitochondrial FeS biogenesis in vivo.

Nat Commun 2017 05 11;8:15124. Epub 2017 May 11.

IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics Department, 67404 Illkirch, France.

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http://dx.doi.org/10.1038/ncomms15124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437272PMC
May 2017

Well-organized spheroids as a new platform to examine cell interaction and behaviour during organ development.

Cell Tissue Res 2016 Dec 6;366(3):601-615. Epub 2016 Sep 6.

INSERM (French National Institute of Health and Medical Research), "Osteoarticular and Dental Regenerative Nanomedicine" laboratory, UMR 1109, Faculté de Médecine, FMTS, F-67085, Strasbourg Cedex, France.

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http://dx.doi.org/10.1007/s00441-016-2487-6DOI Listing
December 2016

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.

Hum Mol Genet 2016 10 4;25(19):4170-4185. Epub 2016 Aug 4.

Laboratoire Signalisation et Transports Ioniques Membranaires, Université de Poitiers/CNRS, 1 rue Georges Bonnet, F-86022 Poitiers, France

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http://dx.doi.org/10.1093/hmg/ddw251DOI Listing
October 2016

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.

Cell Rep 2016 10;17(4):1008-1021

Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany; BIOSS Centre of Biological Signalling Studies, Albert Ludwigs University, 79106 Freiburg, Germany; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Standort Freiburg, 79108 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081406PMC
October 2016

One-step synthesis of iron oxide polypyrrole nanoparticles encapsulating ketoprofen as model of hydrophobic drug.

Int J Pharm 2016 Jul 7;508(1-2):61-70. Epub 2016 May 7.

University of Strasbourg, Faculty of Pharmacy, 74 route du Rhin 67401 Illkirch Cedex, France; CNRS UMR 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, University of Strasbourg, route du Rhin No. 74, F-67401 Illkirch Cedex, France.

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http://dx.doi.org/10.1016/j.ijpharm.2016.04.073DOI Listing
July 2016

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.

Sci Rep 2016 05 6;6:25658. Epub 2016 May 6.

Roche Pharma Research and Early Development (pRED), Neurodegeneration and Regeneration, Roche Innovation Center Basel, Switzerland.

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http://dx.doi.org/10.1038/srep25658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858719PMC
May 2016

Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.

Sci Rep 2016 05 6;6:25541. Epub 2016 May 6.

CNRS, Université de Strasbourg, UMR7242, Ecole Supérieure de Biotechnologie de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1038/srep25541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858698PMC
May 2016

Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch.

Sci Rep 2016 04 29;6:25140. Epub 2016 Apr 29.

Department of Functional Genomics and Cancer, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC)/ CNRS UMR 7104/ INSERM U 964/ Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1038/srep25140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850390PMC
April 2016

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Hum Mol Genet 2015 Dec 16;24(23):6736-55. Epub 2015 Sep 16.

Institut Clinique de la Souris, PHENOMIN, GIE CERBM, 1 rue Laurent Fries, 67404 Illkirch, France, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, Centre National de la Recherche Scientifique, UMR7104, Illkirch, France, Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France and Université de Strasbourg, Illkirch, France

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http://dx.doi.org/10.1093/hmg/ddv380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634377PMC
December 2015

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.

Nat Commun 2015 Dec 17;6:10210. Epub 2015 Dec 17.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique UMR 7104, Institut National de la Santé et de la Recherche Médicale U964, Université de Strasbourg, 67400 Illkirch, France.

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http://dx.doi.org/10.1038/ncomms10210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703903PMC
December 2015

Microfluidic conceived Trojan microcarriers for oral delivery of nanoparticles.

Int J Pharm 2015 Sep 23;493(1-2):7-15. Epub 2015 Jun 23.

Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France.

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http://dx.doi.org/10.1016/j.ijpharm.2015.06.028DOI Listing
September 2015

A novel function of Huntingtin in the cilium and retinal ciliopathy in Huntington's disease mice.

Neurobiol Dis 2015 Aug 16;80:15-28. Epub 2015 May 16.

Institute of Genetics and Molecular and Cellular Biology, 67404 Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, 67404 Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, 67404 Illkirch, France; Université de Strasbourg, 67000 Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.05.008DOI Listing
August 2015

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.

Cell Rep 2015 Jun 4;11(10):1564-76. Epub 2015 Jun 4.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, 67404 Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, 67404 Illkirch, France; Université de Strasbourg, 67404 Illkirch, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.010DOI Listing
June 2015

Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.

PLoS Genet 2015 Mar 24;11(3):e1005062. Epub 2015 Mar 24.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France; Institut Clinique de la Souris, PHENOMIN, GIE CERBM, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1005062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372517PMC
March 2015

Microfluidic conceived drug loaded Janus particles in side-by-side capillaries device.

Int J Pharm 2014 Oct 19;473(1-2):239-49. Epub 2014 Jun 19.

Laboratory of Design and Application of Bioactive Molecules (CAMB), Faculty of Pharmacy, University of Strasbourg (UdS), Strasbourg, France.

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http://dx.doi.org/10.1016/j.ijpharm.2014.06.035DOI Listing
October 2014

Biodistribution of X-ray iodinated contrast agent in nano-emulsions is controlled by the chemical nature of the oily core.

ACS Nano 2014 Oct 10;8(10):10537-50. Epub 2014 Oct 10.

University of Strasbourg, Faculty of Pharmacy , 74 route du Rhin, 67401 Illkirch Cedex, France.

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http://dx.doi.org/10.1021/nn503973zDOI Listing
October 2014

Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity.

PLoS One 2013 4;8(12):e81175. Epub 2013 Dec 4.

Institute of Research and Biotechnology of Strasbourg, Centre national de la recherche scientifique, UMR7242, University of Strasbourg, Medalis/Labex, Drug Discovery Center, Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081175PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852222PMC
September 2014

Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia.

Nat Med 2014 May 6;20(5):542-7. Epub 2014 Apr 6.

1] Départment de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France. [2] INSERM, U596, Illkirch, France. [3] CNRS, UMR7104, Illkirch, France. [4] Université de Strasbourg, Strasbourg, France. [5] Collège de France, Chaire de génétique humaine, Illkirch, France.

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http://dx.doi.org/10.1038/nm.3510DOI Listing
May 2014

Poly-ε-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography.

Biomaterials 2014 Mar 3;35(9):2981-6. Epub 2014 Jan 3.

University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, 67401 Illkirch, France.

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http://dx.doi.org/10.1016/j.biomaterials.2013.12.032DOI Listing
March 2014

Prokineticin receptor-1 is a new regulator of endothelial insulin uptake and capillary formation to control insulin sensitivity and cardiovascular and kidney functions.

J Am Heart Assoc 2013 Oct 23;2(5):e000411. Epub 2013 Oct 23.

CNRS, Université de Strasbourg, UMR7242, Ecole Supérieure de Biotechnologie de Strasbourg, and Medalis/Labex, Drug Discovery Center, Illkirch, France.

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http://dx.doi.org/10.1161/JAHA.113.000411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835255PMC
October 2013

Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.

FASEB J 2013 Aug 21;27(8):3384-94. Epub 2013 May 21.

Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.

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http://dx.doi.org/10.1096/fj.12-220947DOI Listing
August 2013

Retinoic acid deficiency impairs the vestibular function.

J Neurosci 2013 Mar;33(13):5856-66

IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), BP 10142, Illkirch F-67404, France.

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http://dx.doi.org/10.1523/JNEUROSCI.4618-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705067PMC
March 2013

Iodinated α-tocopherol nano-emulsions as non-toxic contrast agents for preclinical X-ray imaging.

Biomaterials 2013 Jan 16;34(2):481-91. Epub 2012 Oct 16.

University of Strasbourg, Faculty of Pharmacy, Illkirch, France.

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http://dx.doi.org/10.1016/j.biomaterials.2012.09.026DOI Listing
January 2013

Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models.

Dis Model Mech 2012 Nov 24;5(6):852-9. Epub 2012 May 24.

Department of Pediatrics, Taubman Medical Research Institute, University of Michigan Medical Center, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1242/dmm.009746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484867PMC
November 2012

Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich's ataxia.

Dis Model Mech 2012 Nov 26;5(6):860-9. Epub 2012 Jun 26.

Translational Medecine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France.

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http://dx.doi.org/10.1242/dmm.009829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484868PMC
November 2012

Primary T-tubule and autophagy defects in the phosphoinositide phosphatase Jumpy/MTMR14 knockout mice muscle.

Adv Biol Regul 2012 Jan;52(1):98-107

Department of Translational Medicine and Neurogenetics, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), 1, rue Laurent Fries, BP10142, 67404 Illkirch, France.

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http://linkinghub.elsevier.com/retrieve/pii/S006525711100055
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http://dx.doi.org/10.1016/j.advenzreg.2011.09.007DOI Listing
January 2012

Microencapsulation of nanoemulsions: novel Trojan particles for bioactive lipid molecule delivery.

Int J Nanomedicine 2011 24;6:1313-25. Epub 2011 Jun 24.

University of Strasbourg, Faculty of Pharmacy, UMR CNRS 7199 Laboratory of Conception and Application of Bioactive Molecules (Biogalenic Pharmacy team), Illkirch, France.

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http://www.dovepress.com/microencapsulation-of-nanoemulsions
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http://dx.doi.org/10.2147/IJN.S20353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133523PMC
November 2011

Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation.

Eur J Cell Biol 2011 Feb-Mar;90(2-3):270-7. Epub 2010 Oct 20.

Institut de génétique et de biologie moléculaire et cellulaire, Department of Cell Biology and Development, CNRS UdS UMR7104, Inserm U964, Illkirch, France.

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http://dx.doi.org/10.1016/j.ejcb.2010.09.003DOI Listing
July 2011

Cell death after high-LET irradiation in orthotopic human hepatocellular carcinoma in vivo.

In Vivo 2011 Jan-Feb;25(1):1-9

EA-3430, Université de Strasbourg, Centre Régional de Lutte contre le Cancer Paul Strauss, 3 rue de la porte de l'Hôpital, 67065 Strasbourg, France.

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May 2011

Genetic inactivation of prokineticin receptor-1 leads to heart and kidney disorders.

Arterioscler Thromb Vasc Biol 2011 Apr 27;31(4):842-50. Epub 2011 Jan 27.

Centre National de la Recherche Scientifique, Université de Strasbourg, UMR 7242, Ecole Supérieure de Biotechnologie de Strasbourg, Illkirch, France.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.110.222323
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http://dx.doi.org/10.1161/ATVBAHA.110.222323DOI Listing
April 2011

Overproduction of delta-endotoxins by sporeless Bacillus thuringiensis mutants obtained by nitrous acid mutagenesis.

Curr Microbiol 2011 Jan 20;62(1):38-43. Epub 2010 May 20.

Laboratory of Biopesticides, Centre of Biotechnology of Sfax, P.O. Box 1177, 3018, Sfax, Tunisia.

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http://dx.doi.org/10.1007/s00284-010-9670-xDOI Listing
January 2011

Polyglutamine toxicity induces rod photoreceptor division, morphological transformation or death in spinocerebellar ataxia 7 mouse retina.

Neurobiol Dis 2010 Oct 18;40(1):311-24. Epub 2010 Jun 18.

Department of Neurobiology and Genetics, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR 7104-CNRS/INSERM/UdS, BP10142, 67404 Illkirch Cédex, France.

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http://linkinghub.elsevier.com/retrieve/pii/S096999611000201
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http://dx.doi.org/10.1016/j.nbd.2010.06.005DOI Listing
October 2010

Myocytic androgen receptor controls the strength but not the mass of limb muscles.

Proc Natl Acad Sci U S A 2010 Aug 26;107(32):14327-32. Epub 2010 Jul 26.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale U964, Université de Strasbourg, Collège de France, 67404 Illkirch, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1009536107
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http://dx.doi.org/10.1073/pnas.1009536107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922552PMC
August 2010

Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.

Am J Physiol Heart Circ Physiol 2010 Mar 18;298(3):H844-52. Epub 2009 Dec 18.

Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, Centre National de la Recherche Scientifique, Université de Strasbourg, Illkirch, France.

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http://www.physiology.org/doi/10.1152/ajpheart.00898.2009
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http://dx.doi.org/10.1152/ajpheart.00898.2009DOI Listing
March 2010

T-tubule disorganization and defective excitation-contraction coupling in muscle fibers lacking myotubularin lipid phosphatase.

Proc Natl Acad Sci U S A 2009 Nov 21;106(44):18763-8. Epub 2009 Oct 21.

Department of Neurobiology and Genetics, and Imaging Center-Electron Microscopy, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7104, Université Louis Pasteur, Collège de France, 67404 Illkirch, France.

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http://dx.doi.org/10.1073/pnas.0900705106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773964PMC
November 2009

Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia.

Biochim Biophys Acta 2009 Feb 24;1792(2):140-7. Epub 2008 Nov 24.

INSERM U781-Université Paris Descartes-Hôpital Necker-Enfants Malades-149 rue de Sèvres-75015, Paris, France.

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http://linkinghub.elsevier.com/retrieve/pii/S092544390800229
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http://dx.doi.org/10.1016/j.bbadis.2008.11.010DOI Listing
February 2009

Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation.

Proc Natl Acad Sci U S A 2009 Feb 3;106(6):1820-5. Epub 2009 Feb 3.

Laboratoire Physiopathologie des Syndromes Rares Héréditaires, AVENIR-Inserm, EA3949, Faculté de Médecine de Strasbourg, Université Louis Pasteur, 11 rue Humann, 67085 Strasbourg, France.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0812518106
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http://dx.doi.org/10.1073/pnas.0812518106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635307PMC
February 2009

Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage.

Cardiovasc Res 2009 Jan 20;81(1):28-37. Epub 2008 Sep 20.

CNRS/ULP, UMR 7175-LC1, Ecole Supérieure de Biotechnologie de Strasbourg, Bld. Sébastien Brandt BP. 10413, F-67412 Illkirch, France.

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http://dx.doi.org/10.1093/cvr/cvn251DOI Listing
January 2009

Liver receptor homolog 1 is essential for ovulation.

Genes Dev 2008 Jul;22(14):1871-6

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch, France.

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http://dx.doi.org/10.1101/gad.472008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492734PMC
July 2008

Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation.

Arterioscler Thromb Vasc Biol 2008 May;28(5):841-9

Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur-Strasbourg I, Ecole Supérieure de Biotechnologie de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1161/ATVBAHA.108.162404DOI Listing
May 2008

The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.

FASEB J 2007 Sep 18;21(11):2980-93. Epub 2007 Apr 18.

UMR 7175/CNRS/Universite Strasbourg I, Ecole Supérieure de Biotechnologie de Strasbourg, Bld. Sébastien Brandt BP. 10413, F-67412 Illkirch, France.

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http://www.fasebj.org/doi/10.1096/fj.07-8116com
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http://dx.doi.org/10.1096/fj.07-8116comDOI Listing
September 2007

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.

Proc Natl Acad Sci U S A 2007 Jun 7;104(25):10703-8. Epub 2007 Jun 7.

Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université Louis Pasteur, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0611568104
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http://dx.doi.org/10.1073/pnas.0611568104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1965576PMC
June 2007

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.

J Invest Dermatol 2007 May 15;127(5):1250-60. Epub 2007 Feb 15.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS UMR7104; INSERM U596; ULP, Collège de France), Illkirch, Strasbourg, France.

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http://dx.doi.org/10.1038/sj.jid.5700672DOI Listing
May 2007

Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cells.

Differentiation 2006 Dec;74(9-10):661-8

Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 du CNRS, U. 596 de l'INSERM, Université Louis Pasteur, Cedex, CU de Strasbourg, France.

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http://dx.doi.org/10.1111/j.1432-0436.2006.00094.xDOI Listing
December 2006

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.

Genes Dev 2006 Jun;20(11):1525-38

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut Clinique de la Souris (ICS), CNRS/INSERM/ULP, Collège de France, 67404 Illkirch Cedex, CU de Strasbourg, France.

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http://www.genesdev.org/cgi/doi/10.1101/gad.368706
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http://dx.doi.org/10.1101/gad.368706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475764PMC
June 2006

Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification.

Nat Genet 2006 Jan 27;38(1):112-7. Epub 2005 Nov 27.

Telethon Institute of Genetics and Medicine, via P. Castellino 111, 80131 Naples, Italy.

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http://www.nature.com/articles/ng1684
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January 2006

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.

Nature 2006 Jan 8;439(7075):484-9. Epub 2006 Jan 8.

Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 Rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1038/nature04330DOI Listing
January 2006

Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1.

Biol Cell 2005 Oct;97(10):787-98

CNRS IEM FRE2815, Institut de Transgénose, 3B rue de la Férollerie, 45071 Orleans cedex 2, France.

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http://dx.doi.org/10.1042/BC20040525DOI Listing
October 2005

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

Proc Natl Acad Sci U S A 2005 Oct 30;102(41):14795-800. Epub 2005 Sep 30.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut Clinique de la Souris (ICS), Collège de France, BP10142, 1 Rue Laurent Fries, Illkirch 67404, CU de Strasbourg, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0507385102
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http://dx.doi.org/10.1073/pnas.0507385102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253602PMC
October 2005

TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis.

Dev Biol 2005 Sep;285(1):28-37

Department of Physiological Genetics of Nuclear Signaling, UMR 7104, B.P. 10142-67404, ILLKIRCH, C.U. de Strasbourg, France.

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http://dx.doi.org/10.1016/j.ydbio.2005.05.043DOI Listing
September 2005

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Proc Natl Acad Sci U S A 2004 Mar 16;101(13):4543-7. Epub 2004 Mar 16.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, BP10142, 1 Rue Laurent Fries, 67404 Illkirch, France.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0400356101
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http://dx.doi.org/10.1073/pnas.0400356101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384783PMC
March 2004

Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling.

FASEB J 2003 Jul 8;17(10):1373-5. Epub 2003 May 8.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université L. Pasteur de Strasbourg, BP 10142, 67404 Illkirch Cedex, France.

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http://www.fasebj.org/doi/10.1096/fj.02-1122fje
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July 2003

Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy.

Circulation 2003 Jul 16;107(25):3223-9. Epub 2003 Jun 16.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Strasbourg, Illkirch, France.

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https://www.ahajournals.org/doi/10.1161/01.CIR.0000074224.57
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http://dx.doi.org/10.1161/01.CIR.0000074224.57016.01DOI Listing
July 2003

The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice.

Proc Natl Acad Sci U S A 2002 Nov 21;99(23):15060-5. Epub 2002 Oct 21.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur Strasbourg, 67404 Illkirch Cedex, France.

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http://dx.doi.org/10.1073/pnas.212498399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524320PMC
November 2002

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.

EMBO J 2002 Jul;21(13):3402-13

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France.

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http://emboj.embopress.org/cgi/doi/10.1093/emboj/cdf331
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http://dx.doi.org/10.1093/emboj/cdf331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125394PMC
July 2002