Publications by authors named "Nader Aboul-Fettouh"

14 Publications

  • Page 1 of 1

Immunotherapy and Systemic Treatment of Cutaneous Squamous Cell Carcinoma.

Dermatol Pract Concept 2021 Nov 1;11(Suppl 2):e2021169S. Epub 2021 Oct 1.

Departments of Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cutaneous squamous cell carcinomas (cSCC) represent one of the most diagnosed non-melanoma skin cancers and its incidence is increasing globally. Whereas early stage and low risk cSCC is typically treated with surgery, and in some cases other localized therapeutic modalities, locally advanced or metastatic cSCC is a cause of significant morbidity and mortality that requires a different approach to therapy. Therapeutic attempts at treating advanced cSCC include a multi-disciplinary approach with considerations for surgery, radiation, and systemic therapies. In this review, we will discuss the various systemic therapies that have been trialed for advanced cSCC, beginning with the early cytotoxic and platinum-based agents as well as their corresponding limitations. We will then review the targeted approaches using EGFR inhibitors prior to discussing the more recent immunotherapeutics that have shown good tumor responses in this often-lethal disease.
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http://dx.doi.org/10.5826/dpc.11S2a169SDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609954PMC
November 2021

Use of PD-1 Inhibitors in the Treatment of Advanced Basal Cell Carcinoma.

Dermatol Surg 2021 11;47(11):1511-1512

Departments of Dermatology and Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1097/DSS.0000000000003207DOI Listing
November 2021

PD-1 inhibitors for cutaneous squamous cell carcinoma: A meta-analysis.

Australas J Dermatol 2022 Feb 26;63(1):36-42. Epub 2021 Oct 26.

Departments of Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PD-1 inhibitors are immunotherapeutic agents used in the treatment of advanced cutaneous squamous cell carcinoma (cSCC). This study aimed to determine the pooled objective response and disease control rates of patients with advanced cSCC treated with PD-1 inhibitors. Pubmed, Cochrane Library and EMBASE databases were searched up to 1 January 2021 to include eligible articles. Objective response rate (ORR) and disease control rate (DCR) were pooled and analysed. Subgroup analysis of the odds ratio (OR) for ORR for patients by PD-L1 tumour proportion score (TPS) was performed. Seven articles including a total of 453 patients were identified and included. Pooled estimate of ORR was 44% (95% CI: 39-49%, I  = 23.7%) and of DCR was 66% (95% CI: 57-74%, I  = 68.2%). Pooled odds ratio of ORR for patients by PD-L1 TPS was 2.81 (95% CI: 1.22-6.51, I  = 0.0%). These results were derived from single-arm studies, some of which were retrospective. No head-to-head trials comparing PD-1 inhibitors have been reported. We present aggregate estimates of ORR and DCR for patients with advanced cSCC treated with PD-1 inhibitors, as well as subgroup analysis for ORR for patients by PD-L1 TPS.
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http://dx.doi.org/10.1111/ajd.13733DOI Listing
February 2022

The Navicular Graft for Reconstructing Deep Alar Defects.

Cureus 2021 Jul 27;13(7):e16657. Epub 2021 Jul 27.

Dermatology, MD Anderson Cancer Center, Houston, USA.

The reconstruction of deep nasal ala defects can be challenging. The often thick, sebaceous skin of the nose provides structural support helping maintain the ala shape and nasal patency; loss of this support may result in ala deformity and nasal vestibule collapse. Traditional full-thickness skin grafts of deep alar defects may result in depressed scars. We present a variation of the full-thickness skin graft to repair deeper alar defects, sculpting the graft into a boat-shaped or "navicular" form. This allows for sufficient volume restoration and good cosmesis while avoiding more extensive surgical repairs of the nasal ala. The navicular graft offers several advantages: the avoidance of more extensive procedures involving cartilage grafts and/or flaps, appropriate color/texture match, and volume restoration without pitting, notching, or retraction of nasal structures. In addition, no struts or bolsters are needed.
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http://dx.doi.org/10.7759/cureus.16657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388222PMC
July 2021

Intracavitary Foam Sclerotherapy in Dissecting Cellulitis of the Scalp.

Dermatol Surg 2021 09;47(9):1317-1319

Texas Surgical Dermatology PA, Spring, Texas.

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http://dx.doi.org/10.1097/DSS.0000000000003035DOI Listing
September 2021

Do Not Mess With Tattoos? Mohs Micrographic Surgery for Basal Cell Carcinoma Within the State of Texas.

Dermatol Surg 2021 09;47(9):1273-1275

Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1097/DSS.0000000000003087DOI Listing
September 2021

3-Color Mohs Mapping Method to Uniquely Stain up to 6 Specimens.

Dermatol Surg 2021 08;47(8):1107-1108

Department of Dermatology, University of Texas Health Science Center, Houston, Texas.

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http://dx.doi.org/10.1097/DSS.0000000000002951DOI Listing
August 2021

Retiform Purpura as a Sign of Necrotizing Cellulitis in an Immunocompetent Boy.

Pediatr Emerg Care 2020 Nov;36(11):e646-e648

From the Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX.

Severe group A streptococcus (GAS) infections, particularly necrotizing soft tissue infections (NSTIs), have been associated with the development of streptococcal toxic-shock syndrome (STSS), a systemic illness caused by GAS-derived toxins. Traditional physical examination findings in NSTIs include skin necrosis, crepitus, and hemorrhagic bullae. However, these findings are limited in sensitivity and additional clinical markers may aid in making an early diagnosis of NSTI. We present a case of a superficial infection, specifically GAS necrotizing cellulitis, complicated by STSS in a healthy boy with an associated skin finding of retiform purpura that aided in early diagnosis of a NSTI.
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http://dx.doi.org/10.1097/PEC.0000000000002251DOI Listing
November 2020

CreLite: An optogenetically controlled Cre/loxP system using red light.

Dev Dyn 2020 11 31;249(11):1394-1403. Epub 2020 Aug 31.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Precise manipulation of gene expression with temporal and spatial control is essential for functional analysis and determining cell lineage relationships in complex biological systems. The cyclic recombinase (Cre)-loxP system is commonly used for gene manipulation at desired times and places. However, specificity is dependent on the availability of tissue- or cell-specific regulatory elements used in combination with Cre. Here, we present CreLite, an optogenetically controlled Cre system using red light in developing zebrafish embryos.

Results: Cre activity is disabled by splitting Cre and fusing with the Arabidopsis thaliana red light-inducible binding partners, PhyB and PIF6. Upon red light illumination, the PhyB-CreC and PIF6-CreN fusion proteins come together in the presence of the cofactor phycocyanobilin (PCB) to restore Cre activity. Red light exposure of zebrafish embryos harboring a Cre-dependent multicolor fluorescent protein reporter injected with CreLite mRNAs and PCB resulted in Cre activity as measured by the generation of multispectral cell labeling in several different tissues.

Conclusions: Our data show that CreLite can be used for gene manipulations in whole embryos or small groups of cells at different developmental stages, and suggests CreLite may also be useful for temporal and spatial control of gene expression in cell culture, ex vivo organ culture, and other animal models.
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http://dx.doi.org/10.1002/dvdy.232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931845PMC
November 2020

Readability and Quality of Online Patient Education Material on Websites of Breast Imaging Centers.

J Am Coll Radiol 2020 Oct 16;17(10):1245-1251. Epub 2020 May 16.

Department of Radiology, UT Southwestern Medical Center, Dallas, Texas.

Objectives: The purpose of this study was to assess the readability and quality of patient information regarding mammography, tomosynthesis, and breast density on the websites of ACR-designated mammography Breast Imaging Centers of Excellence (BICOEs) in the United States.

Materials And Methods: In this institutional review board-exempt study, websites of mammography BICOEs were identified by state. Websites were assessed for presence of patient education material on screening mammography, tomosynthesis, and breast density. This material was then assessed for readability using five well-established readability metrics (Flesch-Kincaid Reading Ease Index, Flesch-Kincaid Grade Level, Gunning-Fog Score, Coleman-Liau Index, and Simple Measure of Gobbledygook Index) and for quality using the DISCERN instrument.

Results: We identified 1,482 BICOE centers, of which 1,451 (98%) had websites; 79% (1,156 of 1,451) of websites had information on screening mammography, 45% (657 of 1,451) on tomosynthesis, and 16% (228 of 1,451) on breast density. Readability analysis showed that the overall average grade level of patient information was 12.4. Average readability grade levels by tested indexes were Flesch-Kincaid Grade Level of 11.5, Gunning-Fog Score of 14.1, Coleman-Liau Index of 14.1, and Simple Measure of Gobbledygook Index of 10.9. The average Flesch-Kincaid Reading Ease score was 45, with 0 being the most difficult and 100 being the easiest text to read. The overall DISCERN score nationally was 2.61 of 5 (with 5 representing the highest quality).

Conclusions: Although most BICOEs have patient education material on their websites regarding mammography and some have information regarding tomosynthesis and breast density, the average readability grade level of this material is more than double the nationally recommended readability grade level of 6 for health care information. Additionally, the overall quality of this material is relatively low per established quality metrics.
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http://dx.doi.org/10.1016/j.jacr.2020.04.016DOI Listing
October 2020

Aggressive squamous cell carcinoma in a patient on the Janus kinase inhibitor ruxolitinib.

JAAD Case Rep 2018 Jun 30;4(5):455-457. Epub 2018 Apr 30.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031591PMC
June 2018

Patient satisfaction and preference for absorbable versus nonabsorbable sutures for linear repairs.

J Am Acad Dermatol 2018 Sep 10;79(3):561-562. Epub 2018 Feb 10.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.02.020DOI Listing
September 2018

The majority of patients presenting with vitiligo have a clinical sign of activity.

J Am Acad Dermatol 2017 10;77(4):774-775

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2017.05.027DOI Listing
October 2017
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