Nadege Loäec

Nadege Loäec

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Nadege Loäec

Nadege Loäec

Publications by authors named "Nadege Loäec"

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[]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors.

Molecules 2019 Nov 13;24(22). Epub 2019 Nov 13.

Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.

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http://dx.doi.org/10.3390/molecules24224090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891749PMC
November 2019

Novel cationic bis(acylhydrazones) as modulators of Epstein-Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA.

Eur J Med Chem 2019 Sep 23;178:13-29. Epub 2019 May 23.

CNRS UMR9187, INSERM U1196, Institut Curie, PSL Research University, 91405, Orsay, France; CNRS UMR9187, INSERM U1196, Université Paris Sud, Université Paris-Saclay, 91405, Orsay, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.05.042DOI Listing
September 2019

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

PLoS One 2018 3;13(5):e0196761. Epub 2018 May 3.

Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196761PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933782PMC
August 2018

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

Molecules 2018 Jan 24;23(2). Epub 2018 Jan 24.

Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.

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http://dx.doi.org/10.3390/molecules23020064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017736PMC
January 2018

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.

Mol Inform 2017 04 21;36(4). Epub 2016 Dec 21.

Technische Universität Dortmund, Fakultät für Chemie und chemische Biologie, Otto-Hahn-Straße 6, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1002/minf.201600123DOI Listing
April 2017

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.

Eur J Med Chem 2017 Jan 22;125:696-709. Epub 2016 Sep 22.

ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.09.064DOI Listing
January 2017

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.

Bioorg Med Chem Lett 2016 09 16;26(17):4327-9. Epub 2016 Jul 16.

Université Clermont Auvergne, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, F-63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, F-63178 Aubière, France. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.07.032DOI Listing
September 2016

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.

Eur J Med Chem 2016 Aug 5;118:170-7. Epub 2016 Apr 5.

Université Clermont Auvergne, Université Blaise Pascal, Institut de Chimie de Clermont-Ferrand, BP 10448, F-63000 Clermont-Ferrand, France; CNRS, UMR 6296, ICCF, F-63178 Aubière, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.04.004DOI Listing
August 2016

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms.

Bioorg Med Chem 2016 08 13;24(16):3790-800. Epub 2016 Jun 13.

Technische Universität Braunschweig, Institut für Medizinische und Pharmazeutische Chemie, Beethovenstraße 55, D-38106 Braunschweig, Germany; Technische Universität Braunschweig, Center of Pharmaceutical Engineering (PVZ), Franz-Liszt-Straße 35A, D-38106 Braunschweig, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896163044
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http://dx.doi.org/10.1016/j.bmc.2016.06.023DOI Listing
August 2016

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.

Molecules 2016 Apr 30;21(5). Epub 2016 Apr 30.

Normandie Univ; Uni Rouen; INSA; CNRS, COBRA, UMR 6014, 76000 Rouen, France.

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http://dx.doi.org/10.3390/molecules21050578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273584PMC
April 2016

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

J Med Chem 2015 Apr 23;58(7):3131-43. Epub 2015 Mar 23.

†Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.

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http://dx.doi.org/10.1021/jm501994dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506206PMC
April 2015

Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

Mar Drugs 2015 Apr 28;13(5):2617-28. Epub 2015 Apr 28.

Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.

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http://dx.doi.org/10.3390/md13052617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446597PMC
April 2015

Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors.

Eur J Med Chem 2015 Mar 23;92:124-34. Epub 2014 Dec 23.

Normandie Univ, COBRA, UMR 6014 & FR 3038; Univ Rouen; INSA Rouen; CNRS, Bâtiment IRCOF, 1 rue Tesnière, 76821 Mont St Aignan Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.12.038DOI Listing
March 2015

Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis.

Neuro Oncol 2014 Nov 2;16(11):1484-98. Epub 2014 Jun 2.

Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, Astrocyte and Vascular Niche, Biomedical Research Institute (IRIB), PRES Normandy, TC2N network, University of Rouen, Mont-Saint-Aignan, France (M.J., C.L., L.D., M.-T.S., V.L., P.G., H.C.); Neuro-oncology department, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France (C.M., J.H.); Lyon Neuroscience Research Center INSERM U1028/CNRS UMR 5292, Lyon, France (C.M., J.H.); University of Claude Bernard - Lyon 1, Villeurbanne, France (C.M., J.H.); Institut de Chimie et Biochimie Moléculaires et Supramoléculaires UMR 5246, University of Claude Bernard - Lyon 1, Villeurbanne, France (F.L., G.L., B.J., N.L.); Protein Phosphorylation & Human Disease Group & USR3151, Station Biologique, Roscoff, France (N.L., L.M.); ManRos Therapeutics, Roscoff, France (L.M.).

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http://dx.doi.org/10.1093/neuonc/nou102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201071PMC
November 2014

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I.

Molecules 2014 Sep 29;19(10):15546-71. Epub 2014 Sep 29.

Normandie Université, Laboratoire C.O.B.R.A., UMR 6014 and FR 3038; Université de Rouen; INSA de Rouen; CNRS, Bâtiment I.R.C.O.F. rue Tesnière, Mont-Saint-Aignan F-76821, France.

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http://dx.doi.org/10.3390/molecules191015546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270991PMC
September 2014

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.

Eur J Med Chem 2014 Aug 11;83:274-83. Epub 2014 Jun 11.

Technische Universität Braunschweig, Institut für Medizinische und Pharmazeutische Chemie, Beethovenstraße 55, D-38106 Braunschweig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.06.020DOI Listing
August 2014

Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.

J Nat Prod 2014 May 5;77(5):1117-22. Epub 2014 May 5.

Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, LabEx CEBA , 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1021/np400856hDOI Listing
May 2014

Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.

Bioorg Med Chem Lett 2013 Dec 17;23(24):6784-8. Epub 2013 Oct 17.

Normandie Univ, COBRA, UMR 6014 & FR 3038; Univ Rouen; INSA Rouen; CNRS, Bâtiment IRCOF, 1 rue Tesnière, 76821 Mont St Aignan Cedex, France.

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http://dx.doi.org/10.1016/j.bmcl.2013.10.019DOI Listing
December 2013

Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.

J Med Chem 2013 Sep 13;56(18):7289-301. Epub 2013 Sep 13.

Division of Chemistry and Materials Sciences, Graduate School of Engineering, Nagasaki University , 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.

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http://dx.doi.org/10.1021/jm400719yDOI Listing
September 2013

Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.

Eur J Med Chem 2013 Jan 24;59:283-95. Epub 2012 Nov 24.

Université de Rouen, Laboratoire de Chimie Organique et Bio-organique, Réactivité et Analyse (C.O.B.R.A.), CNRS UMR 6014 & FR3038, Institut de Recherche en Chimie Organique Fine (I.R.C.O.F.) rue Tesnière, 76130 Mont Saint-Aignan, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.11.030DOI Listing
January 2013

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.

Eur J Med Chem 2012 Dec 16;58:171-83. Epub 2012 Oct 16.

Université de Rouen, Laboratoire de Chimie Organique et Bio-organique, Réactivité et Analyse, CNRS UMR 6014 & FR3038, Institut de Recherche en Chimie Organique Fine rue Tesnière, 76130 Mont Saint-Aignan, France.

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http://linkinghub.elsevier.com/retrieve/pii/S022352341200609
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http://dx.doi.org/10.1016/j.ejmech.2012.10.006DOI Listing
December 2012