Publications by authors named "Nabil M Yousif"

3 Publications

  • Page 1 of 1

New pyrimidinone and fused pyrimidinone derivatives as potential anticancer chemotherapeutics.

Arch Pharm (Weinheim) 2012 Sep 6;345(9):729-38. Epub 2012 Jun 6.

National Research Center, Photochemistry Department, Dokki, Cairo, Egypt.

A series of novel substituted pyrimidinones and fused pyrimidinones (compounds 3-18) were synthesized starting with oxiranylmethanone 2. The in vitro cytotoxicity against a human breast adenocarcinoma (MCF-7) cell line was investigated and most of the tested compounds showed potent cytotoxic activity against the MCF-7 cell line comparable to the activity of the commonly used anticancer drug cisplatin. Treatment of MCF-7 cells with increasing doses (2, 5, 10, and 20 µg/mL) of the tested compounds revealed that the activity of superoxide dismutase and the level of hydrogen peroxide were significantly increased, while the activities of catalase and glutathione peroxidase and the levels of reduced glutathione were significantly lowered compared with control MCF-7 cells. In general, derivatives 11 and 16 revealed the highest anticancer activity among the tested compounds.
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http://dx.doi.org/10.1002/ardp.201200119DOI Listing
September 2012

Antimicrobial activity of new 2,4-disubstituted thiazolidinone derivatives.

Z Naturforsch C J Biosci 2009 Nov-Dec;64(11-12):785-9

Photochemistry Department, National Research Center, El Dokki, Cairo, Egypt.

A number of new disubstituted 2,5-thiazolidinone derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes). They displayed different degrees of antimicrobial activities or inhibitory actions.
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http://dx.doi.org/10.1515/znc-2009-11-1205DOI Listing
April 2010

Conversion of 3-arylazo-5-phenyl-2(3H)-furanones into other heterocycles of anticipated biological activity.

Arch Pharm (Weinheim) 2007 Jun;340(6):315-9

Photochemistry Department, National Research Centre, Dokki, Giza, Egypt.

3-arylazo-5-phenyl-2(3H)-furanones 3 were prepared and converted into a variety of heterocyclic systems of synthetic and biological importance. Hydrazine hydrate reacted with furanones as nucleophiles and gave the corresponding acid hydrazides 4. The latter products were used as starting materials for the synthesis of 1,3,4-oxadiazoles 6, 9, and the 1,2,4-triazoles 8. Evaluation of the antiviral activity of selected compounds obtained was performed using two viruses: HAV and HSV-1. Some of the tested compounds showed promising activities.
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http://dx.doi.org/10.1002/ardp.200700043DOI Listing
June 2007