Dr. Nabeel P M, B Tech, MS, PhD - HTIC - IIT Madras - Research Scientist

Dr. Nabeel P M

B Tech, MS, PhD

HTIC - IIT Madras

Research Scientist

Chennai, Tamil Nadu | India

Main Specialties: Advanced Heart Failure & Transplant Cardiology, Cardiovascular Disease, Public Health, Statistics, Vascular & Interventional Radiology, Vascular Surgery

Additional Specialties: Cardiovascular research

ORCID logohttps://orcid.org/0000-0001-7280-0048


Top Author

Dr. Nabeel P M, B Tech, MS, PhD - HTIC - IIT Madras - Research Scientist

Dr. Nabeel P M

B Tech, MS, PhD

Introduction

Nabeel was born in Malappuram, Kerala, India in 1991. He received B.Tech. degree in Electrical and Electronics Engineering from the Government Engineering College Barton Hill, Trivandrum, Kerala University, India, in 2012. M.S. and the Ph.D. dual degree in Biomedical Instrumentation from Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
He is currently a researcher of the cardiovascular division at Healthcare Technology Innovation Centre (HTIC), a Research and Development Centre of IIT Madras. His doctoral research involved investigating novel biophysical models of the human cardiovascular system and developing intelligent technologies for noninvasive, cuffless and calibration-free measurement of arterial blood pressure. Two patents were filed based on his doctoral research, on the methods and systems for non-invasive, cuffless, and calibration-free evaluation of blood pressure. He was awarded Institute Research Award 2018-19 for the best Ph.D. research in IIT Madras. His research interests include cardiovascular engineering, biomedical instrumentation, medical sensor design, system development and signal processing for biomedical applications, biophysics, and mathematical modeling and simulation of the human physiological systems.

Primary Affiliation: HTIC - IIT Madras - Chennai, Tamil Nadu , India

Specialties:

Additional Specialties:

Research Interests:


View Dr. Nabeel P M’s Resume / CV

Education

Jul 2013 - May 2019
Indian Institute of Technology Madras
Ph.D
Biomedical Instrumentation
Jun 2008 - Apr 2012
Government Engineering College Barton Hill
B. Tech.
Electrical and Electronics Engineering

Experience

Jun 2013 - Apr 2019
Institute Research Award 2018-19, Indian Institute of Technology Madras.
Researcher
Invention of calibration-free cuffless central arterial blood pressure monitor
Jun 2018
Best paper award at the 2018 Russian German Conference in Aachen Germany.
Author
Paper: Variation in local pulse wave velocity over the cardiac cycle: in-vivo validation using dual-MPG arterial compliance probe
Sep 2017
Clinical validation of Bi-modal arterial compliance probe for calibration-free cuffless blood pressure estimation.
Investigator
Study center: Ramakrishna Medical Centre, Woriyur, Trichy, India
Feb 2016
Indo-US Grand Challenge Initiative [Phase II] – Affordable blood pressure technologies for low resource settings, A joint NIH USA and SERB-DST India funding program.
Researcher
Project: Arterial compliance probe for cuff-less blood pressure measurement, Duration: 2016 – 2017.
Apr 2014
Indo-US Grand Challenge Initiative [Phase I] – Affordable blood pressure technologies for low resource settings, A joint NIH USA and SERB-DST India funding program.
Researcher
Project: Arterial compliance probe for cuff-less blood pressure measurement, Duration: 2016 – 2017.
Jul 2013
Healthcare Technology Innovation Centre
Researcher
Cardiovascular Science

Publications

39Publications

243Reads

153Profile Views

5PubMed Central Citations

Novel Geometric Representation for One-Dimensional Model of Arterial Blood Pulse Wave Propagation.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

http://europepmc.org/abstract/med/31945948

View Article
July 2019
2 Reads

Multimodal Image-Free Ultrasound Technique for Evaluation of Arterial Viscoelastic Properties: A Feasibility Study.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

http://europepmc.org/abstract/med/31946990

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July 2019
3 Reads

Continuous Assessment of Carotid Diameter using an Accelerometer Patch Probe for Ambulatory Arterial Stiffness Monitoring.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

http://europepmc.org/abstract/med/31946991

View Article
July 2019
1 Read

Accelerometric patch probe for carotid local pulse wave velocity measurement: design, development, and in-vivo experimental validation

Biomed Phys Eng Express, 2019. DOI: 10.1088/2057-1976/ab1a82.

Biomedical Physics and Engineering Express

Objective: In this work, we demonstrate an accelerometric patch probe and associated measurement system for local pulse wave velocity (PWV) measurement and its application in cuffless blood pressure (BP) measurement. Approach: The proposed system consists of dual accelerometric patch probe to capture acceleration plethysmography (APG) signals from the carotid artery. The probe was integrated to an application-specific analog front-end circuitry with negligible inter-channel delay and a data acquisition module. Real-time signal processing and local PWV evaluation were performed using custom software. The functionality of the developed system and the relationship between local PWV and reference BP parameters were experimentally validated by multiple in-vivo studies on a cohort of 26 subjects. Inter- and intra-subject BP-local pulse transit time (PTT) models were developed and used for cuffless BP measurement. Further, the reliability of the proposed method in long-term BP monitoring was validated by performing a study over a week. Main results: Reliability of the proposed novel approach for local PWV measurement using APG signals has been demonstrated. Measured baseline carotid local PWV values were in the range of 3 – 4.2 m/s, with high reproducibility (R = 0.94) and with an inter-beat variation range of 2.61 % – 15.5 %. Mean local PTT versus brachial systolic, diastolic, and mean arterial BP obtained from both sitting and standing posture correlated well with an R-value > 0.8. Beat-by-beat BP parameters and local PWV during the post-exercise recovery of each individual yielded statistically significant intra-subject trends. Cuffless BP estimation with intra-subject BP-local PTT models results in more reliable assessments of BP parameters than inter-subject models. The developed BP prediction models found to be reliable over a period of one week with a root-mean-square error ≤ 1.7 mmHg. Significance: A non-invasive cost-effective system for continuous monitoring central aortic BP parameters and local arterial stiffness indices.

View Article
April 2019
5 Reads

Arterial compliance probe for cuffless evaluation of carotid pulse pressure.

PLoS One 2018 16;13(8):e0202480. Epub 2018 Aug 16.

Healthcare Technology Innovation Centre, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202480PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095577PMC
February 2019
8 Reads
3.234 Impact Factor

Live demonstration of ARTSENS® Pen-an image-free ultrasound device for automated evaluation of vascular stiffness

J. Joseph, P. M. Nabeel, M. I. Shah, V. Raj Kiran and M. Sivaprakasam, “Live demonstration of ARTSENS® Pen-an image-free ultrasound device for automated evaluation of vascular stiffness,” IEEE Sensors, New Delhi, India, 2018, pp. 1-1.

Proceedings of IEEE Sensors

Ultrasound-based techniques for non-invasive assessment of arterial stiffness - the earliest detectable manifestation of cardiovascular conditions, has gained significant attention over the years. State-of-the-art techniques use imaging systems for measuring carotid artery stiffness or rely on carotid-femoral pulse wave velocity to evaluate vascular stiffness. These techniques are expensive, require expertise to operate and are not suitable for field deployment. In this context, we developed ARTSENS® - an ultrasound technology for image-free, noninvasive, automated evaluation of vascular stiffness amenable for field use. The latest version of this novel technology, ARTSENS® Pen is proposed for a live demonstration in the IEEE SENSORS 2018 Conference.

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December 2018
3 Reads

Bi-Modal Arterial Compliance Probe for Calibration-Free Cuffless Blood Pressure Estimation.

IEEE Trans Biomed Eng 2018 11 20;65(11):2392-2404. Epub 2018 Aug 20.

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http://dx.doi.org/10.1109/TBME.2018.2866332DOI Listing
November 2018
6 Reads
2.350 Impact Factor

An in-vivo study on intra-day variations in vascular stiffness using ARTSENS Pen

V. Raj Kiran, P. M. Nabeel, J. Joseph, S. Venkatramanan, M. I. Shah, and M. Sivaprakasam, “An in-vivo study on intra-day variations in vascular stiffness using ARTSENS Pen,” in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018, pp. 4575–4578.

Proceedings of 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

This work presents investigations on intraday variations in arterial stiffness. For this purpose, an in-vivo study was conducted on five subjects over a duration of five consecutive days. Five stiffness index (β) measurements were obtained per day for each individual. Our clinically validated ARTSENS device was used to perform fully automated reliable stiffness measurements on the carotid artery. For each measurement, two trials were performed and averaged. These trials were observed to be repeatable with the coefficient of variation <; 0.72%. For each day, one measurement that was performed immediately after the lunch was subject to intervention due to the consumed food, which significantly (p <; 0.001) deviated from the mean baseline β of the day. Such significant deviations were not observed for the rest measurements that were performed in the absence of an intervention. Two subjects who consumed caffeinated beverages during the lunch exhibited an increment in β measurement (taken immediately after lunch) as compared to mean baseline β of the day. Further, there was no significant (p = 0.97) difference between the mean baseline β measured over a day and the mean baseline β measured over the entire course of the study. Results obtained from the present study demonstrated that the arterial stiffness does not vary significantly over a short period but varies progressively. However, significant temporary variations in stiffness could be observed due to dietary interventions.

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October 2018
5 Reads

Vascular wall stiffness indices detection using an accelerometer-based system

2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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August 2018
4 Reads

Measurement of arterial Young’s elastic modulus using ARTSENS Pen

V. Raj Kiran, P. M. Nabeel, J. Joseph, M. I. Shah, and M. Sivaprakasam, “Measurement of arterial Young’s elastic modulus using ARTSENS Pen,” in IEEE International Symposium on Medical Measurements and Applications (MeMeA), Rome, Italy, 2018, pp. 1–6.

Proceedings of IEEE International Symposium on Medical Measurements and Applications (MeMeA)

Arterial Young's modulus (Y) is an important elastic property of the artery that quantifies the material stiffness. Several studies have demonstrated that the quantitative values of Y and its standard deviation could be potentially used as an independent predictor of coronary heart diseases. For reliable measurements of Y, accurate measurements of arterial diameter and wall thickness are required. Conventionally these arterial dimensions are measured by imaging systems that are not a viable option for large-scale screening due to their form factor and a high degree of complexity. In this work, we present a portable image-free ultrasound modality - ARTSENS Pen for measurement of Y. ARTSENS is an extensively validated technology that is capable of providing clinical standard measurements of arterial dimensions and stiffness. In this present work, we have demonstrated the capability of the ARTSENS to make accurate and repeatable measurements of Y. The performance of the device is validated through an in-vivo study on 15 subjects. The ARTSENS measurements of Y were repeatable over continuous cardiac cycles for all the recruited subjects (beat-to-beat variation < 6 %). The mean of Y measured for all the subjects was $262.8\pm 99$ kPa. The accuracy of the system was evaluated by a comparative analysis against a reference B-mode imaging modality. Regression analysis of the data showed that the Y measurements that were taken by ARTSENS significantly correlated (r = 0.90, p < 0.001) to the reference system measurements. Bland Altman analysis indicated a strong degree of agreement between measurements taken by the two devices, with an insignificant difference (p = 0.32).

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August 2018
2 Reads

Carotid local pulse wave velocity measurement using dual element accelerometric patch probe

R. Arathy, P. M. Nabeel, J. Joseph, and M. Sivaprakasam, “Carotid local pulse wave velocity measurement using dual element accelerometric patch probe,” in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2018, pp. 4571–4574.

Proceedings of 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

 In this work, we demonstrate an accelerometric patch probe with two microelectromechanical accelerometer sensors for local pulse wave velocity (PWV) measurement from the carotid artery. Dual acceleration plethysmogram (APG) signals were acquired from a small section of the artery by keeping the sensors at 32 mm apart. A custom analog front-end circuit (inter-channel delay

View Article
July 2018
1 Read

Local pulse wave velocity and cuffless blood pressure assessment using ARTSENS

P. M. Nabeel, V. Raj Kiran, J. Joseph, and M. Sivaprakasam, “Local pulse wave velocity and cuffless blood pressure assessment using ARTSENS,” in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Seogwipo, 2018, p. 1.

Proceedings of 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

We present a unimodal arterial compliance probe for cuffless evaluation of blood pressure (BP) parameters using ARTSENS® technology. The proposed technique could evaluate BP parameters using simultaneously measured arterial dimensions, local pulse wave velocity (PWV), and their variations over the cardiac cycle, without any calibration procedure. An in-vivo study was conducted on five healthy subjects using a prototype system to validate the proposed approach. Local PWV and arterial dimension were evaluated from the carotid artery in a beat-by-beat manner. RMSE in carotid BP measurements was less than 10.5 mmHg, illustrating the reliability of the proposed calibration-free cuffless BP evaluation technique.

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July 2018
5 Reads

Evaluation of local pulse wave velocity using an image free ultrasound technique

2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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June 2018
3 Reads

Non-invasive assessment of local pulse wave velocity as function of arterial pressure

2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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June 2018
4 Reads

Single-source PPG-based local pulse wave velocity measurement: a potential cuffless blood pressure estimation technique.

Physiol Meas 2017 Nov 30;38(12):2122-2140. Epub 2017 Nov 30.

Department of Electrical Engineering, Indian Institute of Technology (IIT) Madras, Chennai, India.

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http://dx.doi.org/10.1088/1361-6579/aa9550DOI Listing
November 2017
38 Reads
4 Citations
1.810 Impact Factor

A Magnetic Plethysmograph Probe for Local Pulse Wave Velocity Measurement.

IEEE Trans Biomed Circuits Syst 2017 10 29;11(5):1065-1076. Epub 2017 Aug 29.

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http://dx.doi.org/10.1109/TBCAS.2017.2733622DOI Listing
October 2017
112 Reads
1 Citation
2.482 Impact Factor

Cuffless blood pressure measurement using ultrasound and dual photoplethysmograph transducer

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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September 2017
5 Reads

Brachial artery stiffness estimation using ARTSENS.

Conf Proc IEEE Eng Med Biol Soc 2017 07;2017:262-265

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http://dx.doi.org/10.1109/EMBC.2017.8036812DOI Listing
July 2017
13 Reads

An accelerometer probe for local pulse wave velocity measurement

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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July 2017
6 Reads

Brachial artery stiffness estimation using ARTSENS

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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July 2017
3 Reads

Measurement of carotid blood pressure and local pulse wave velocity changes during cuff induced hyperemia

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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July 2017
2 Reads

Experimental validation of dual PPG local pulse wave velocity probe

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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July 2017
4 Reads

Arterial compliance probe for calibration free pulse pressure measurement

2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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August 2016
5 Reads

Arterial compliance probe for local blood pulse wave velocity measurement.

Conf Proc IEEE Eng Med Biol Soc 2015 08;2015:5712-5

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http://dx.doi.org/10.1109/EMBC.2015.7319689DOI Listing
August 2015
4 Reads

Top co-authors

Jayaraj Joseph
Jayaraj Joseph

Indian Institute of Technology

9
Mohanasankar Sivaprakasam
Mohanasankar Sivaprakasam

University of California at Santa Cruz

9
Nabeel P M
Nabeel P M

HTIC - IIT Madras

3