Publications by authors named "N Vogt"

277 Publications

Why the Rationale for Canine Vaccination Is Unpersuasive.

Front Vet Sci 2021 11;8:719060. Epub 2021 Aug 11.

Department of Philosophy, King's College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fvets.2021.719060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385313PMC
August 2021

Atomic force microscopy in super-resolution.

Authors:
Nina Vogt

Nat Methods 2021 08;18(8):859

Nature Methods, .

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http://dx.doi.org/10.1038/s41592-021-01246-9DOI Listing
August 2021

Effects of simvastatin on white matter integrity in healthy middle-aged adults.

Ann Clin Transl Neurol 2021 08 18;8(8):1656-1667. Epub 2021 Jul 18.

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Background: The brain is the most cholesterol-rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol-lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol-rich brain white matter (WM) is largely unknown.

Methods: We used longitudinal neuroimaging data acquired from 73 healthy, cognitively unimpaired, statin-naïve, middle-aged adults during an 18-month randomized controlled trial of simvastatin 40 mg daily (n = 35) or matching placebo (n = 38). ANCOVA models (covariates: age, sex, APOE-ɛ4) tested the effect of treatment group on percent change in WM, gray matter (GM), and WM hyperintensity (WMH) neuroimaging measures at each study visit. Mediation analysis tested the indirect effects of simvastatin on WM microstructure through change in serum total cholesterol levels.

Results: At 18 months, the simvastatin group showed a significant preservation in global WM fractional anisotropy (β = 0.88%, 95% CI 0.27 to 1.50, P = 0.005), radial diffusivity (β = -1.10%, 95% CI -2.13 to -0.06, P = 0.039), and WM volume (β = 0.72%, 95% CI 0.13 to 1.32, P = 0.018) relative to the placebo group. There was no significant effect of simvastatin on GM or WMH volume. Change in serum total cholesterol mediated approximately 30% of the effect of simvastatin on WM microstructure.

Conclusions: Simvastatin treatment in healthy, middle-aged adults resulted in preserved WM microstructure and volume at 18 months. The partial mediation by serum cholesterol reduction suggests both peripheral and central mechanisms. Future studies are needed to determine whether these effects persist and translate to cognitive outcomes.

Trial Registration: NCT00939822 (ClinicalTrials.gov).
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http://dx.doi.org/10.1002/acn3.51421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351379PMC
August 2021

How accurate is the determination of equilibrium structures for van der Waals complexes? The dimer NO⋯CO as an example.

J Chem Phys 2021 May;154(19):194302

Departamento de Química Física y Química Inorgánica, Facultad de Ciencias - I.U. CINQUIMA, Universidad de Valladolid, Paseo de Belén, 7, 47011 Valladolid, Spain.

Plausible methods for accurate determination of equilibrium structures of intermolecular clusters have been assessed for the van der Waals dimer NO⋯CO. In order to assure a large initial dataset of rotational parameters, we first measured the microwave spectra of the NO⋯CO and NO⋯CO isotopologs, expanding previous measurements. Then, an anharmonic force field was calculated ab initio and a semi-experimental equilibrium structure was determined. The dimer structure was also calculated at the coupled-cluster level of theory using very large basis sets with diffuse functions and counterpoise correction. It was found that the contributions of the diffuse functions and the counterpoise correction are not additive and do not compensate each other although they have almost the same value but opposite signs. The semi-experimental and ab initio structures were found to be in fair agreement, with the equilibrium distance between the centers of mass of both monomers being 3.825(13) Å and the intermolecular bond length r(C⋯O) = 3.300(9) Å. In this case, the mass-dependent method did not permit us to determine reliable intermolecular parameters. The combination of experimental rotational constants and results of ab initio calculations thus proves to be very sensitive to examine the accuracy of structural determinations in intermolecular clusters, offering insight into other aggregates.
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http://dx.doi.org/10.1063/5.0048603DOI Listing
May 2021

Optogenetic silencing at synaptic terminals.

Authors:
Nina Vogt

Nat Methods 2021 07;18(7):712

Nature Methods, .

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http://dx.doi.org/10.1038/s41592-021-01212-5DOI Listing
July 2021
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