Publications by authors named "N Ramachandran"

121 Publications

A comparison of two pulp revascularization techniques using platelet-rich plasma and whole blood clot.

J Conserv Dent 2020 Nov-Dec;23(6):637-643. Epub 2021 Feb 11.

Department of Conservative Dentistry and Endodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India.

Aim: The aim of this preliminary study was to compare outcomes of two regenerative endodontic protocols in necrotic teeth with open apices.

Methodology: Forty teeth with open apices in patients with an age range of 15-54 were randomly distributed in two groups: group 1, with whole blood clot in the canal (=20) and group 2, whole blood with Platelet rich plasma (PRP) in the canal (=20). Clinical and radiological follow up assessments were undertaken over a period ranging from 6 months to one year. Radiographic Root Area (RRA) was measured using the freeware ImageJ. Statistical analysis was performed using the independent samples t test and the Chi-squared test, the significance level was set at p=0.05.

Results: There was no difference in the percentage change in RRA between the PRP group and whole blood-clot + PRP group.

Conclusion: Whole blood clot and PRP are comparable on the grounds of percentage change in RRA and there is no statistically significant difference between the two in a follow-up period of up to one year.
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http://dx.doi.org/10.4103/JCD.JCD_221_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095687PMC
February 2021

Impact of the first surge of the COVID-19 pandemic on a tertiary referral centre for kidney cancer.

BJU Int 2021 May 8. Epub 2021 May 8.

Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.

Objective: To analyse the impact of the COVID-19 pandemic on a centralized specialist kidney cancer care pathway.

Materials And Methods: We conducted a retrospective analysis of patient and pathway characteristics including prioritization strategies at the Specialist Centre for Kidney Cancer located at the Royal Free London NHS Foundation Trust (RFH) before and during the surge of COVID-19.

Results: On 18 March 2020 all elective surgery was halted at RFH to redeploy resources and staff for the COVID-19 surge. Prioritizing of patients according to European Association of Urology guidance was introduced. Clinics and the specialist multidisciplinary team (SMDT) meetings were maintained with physical distancing, kidney surgery was moved to a COVID-protected site, and infection prevention measurements were enforced. During the 7 weeks of lockdown (23 March to 10 May 2020), 234 cases were discussed at the SMDT meetings, 53% compared to the 446 cases discussed in the 7 weeks pre-lockdown. The reduction in referrals was more pronounced for small and asymptomatic renal masses. Of 62 low-priority cancer patients, 27 (43.5%) were deferred. Only one (4%) COVID-19 infection occurred postoperatively, and the patient made a full recovery. No increase in clinical or pathological upstaging could be detected in patients who underwent deferred surgery compared to pre-COVID practice.

Conclusion: The first surge of the COVID-19 pandemic severely impacted diagnosis, referral and treatment of kidney cancer at a tertiary referral centre. With a policy of prioritization and COVID-protected pathways, capacity for time-sensitive oncological interventions was maintained and no immediate clinical harm was observed.
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http://dx.doi.org/10.1111/bju.15441DOI Listing
May 2021

Semen quality and total microbial load: An association study in important Indian Goat breeds during different seasons.

Andrologia 2021 May 25;53(4):e13995. Epub 2021 Feb 25.

Bioenergetics and Environmental Sciences Division, ICAR-National Institute of Animal Nutrition and Physiology (ICAR-NIANP), Bengaluru, Karnataka, India.

The invasion of the male urogenital tract by microorganisms, and its subsequent effects on sperm fertilising ability, has not been well discussed in bucks. The present study was conducted to assess the bacterial load in fresh semen of the 2-6 years old bucks. For conducting the experiment, semen ejaculates from 18 bucks (6 from each breed namely Jakhrana, Jamunapari and Barbari) were used. We collected 5 ejaculates from each buck in each season (Summer-April to June, Rainy-July to Sept and Winter-November to January). Semen was collected with the artificial vagina (AV) method, and separate AV was used for each buck every time. The semen collection frequency was once in a week. Immediately after initial evaluation, collected semen samples were transferred to the microbiology laboratory of the institute. Thereafter, the semen samples were subjected to bacteriological examination to assess the microbial load. The results of the current study indicate that the microbial load in the semen was significantly (p < 0.05) higher in the Jamunapari bucks and in aged bucks. Bacteriospermia in different seasons was not significantly varied; however, nonsignificant increase in microbial load during the rainy season was observed. Overall, the average bacterial load in the semen of Jamunapari, Barbari and Jakhrana bucks was found 540.50 ± 55.88 CFU/ml, 391.81 ± 46.33CFU/ml and 388.93 ± 44.71 CFU/ml respectively. No significant difference in bacterial counts in the subsequent ejaculates among bucks was observed. Moreover, correlation analysis revealed that the proportions of motility, viability, plasma membrane integrity and acrosomal integrity were negatively influenced by the increased bacterial contamination of buck semen.
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http://dx.doi.org/10.1111/and.13995DOI Listing
May 2021

Mixed acinar and macrocystic ductal prostatic adenocarcinoma.

Lancet Oncol 2021 01;22(1):e37

Department of Urology, University College London Hospital NHS Foundation Trust, London, UK; Division of Surgery & Interventional Science, University College London, London, UK.

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http://dx.doi.org/10.1016/S1470-2045(20)30435-6DOI Listing
January 2021

Does the Mode of Conception Influence Early Postpartum Depression? A Prospective Comparative Study from South India.

Indian J Psychol Med 2020 Nov 20;42(6):525-529. Epub 2020 Jul 20.

Dept. of Community Medicine, Aarupadai Veedu Medical College & Hospital, Puducherry, India.

Background: Besides infertility, the treatment associated with it is potentially related to psychological stress to mothers. This study was conducted to know whether the mode of conception has any association with early postpartum depression.

Method: A prospective cohort study was conducted on postnatal mothers at a tertiary care hospital from January to June 2019. The study participants were divided into two groups: postnatal mothers who delivered following spontaneous conception and assisted conception. Basic sociodemographic and obstetric details were collected. Postnatal depression assessment was done at the end of first and sixth week after delivery on all the mothers by using the Edinburgh Postnatal Depression Scale (EPDS).

Results: In total, 110 subjects (55 in each group) were included in the study. The primary outcome measured was the presence of postpartum depression (EPDS score ≥10). The mean (±SD) age of the participants was 29 ± 6.4 years. The sociodemographic profiles of the two groups were comparable except for mean age, mode of delivery, socioeconomic status, prepregnancy body mass index -the group differences in these variables were statistically significant (P ≤ 0.05). There was no significant difference in the EPDS scores at one week or six weeks of postpartum among the two groups. Comparison of EPDS score among the two groups by Fisher's exact test showed that those mothers with a past history of depression were more likely to have postpartum depression immediately after delivery.

Conclusion: Mode of conception was not associated with an increase in postpartum depression among women who underwent infertility treatment.
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http://dx.doi.org/10.1177/0253717620928439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735233PMC
November 2020