Publications by authors named "N O Abashidze"

13 Publications

Racial and Ethnic Disparities in the Use of Prostate Magnetic Resonance Imaging Following an Elevated Prostate-Specific Antigen Test.

JAMA Netw Open 2021 11 1;4(11):e2132388. Epub 2021 Nov 1.

Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia.

Importance: Prostate cancer screening and diagnosis exhibit known racial and ethnic disparities. Whether these disparities persist in prostate magnetic resonance imaging (MRI) utilization after elevated prostate-specific antigen (PSA) results is poorly understood.

Objective: To assess potential racial and ethnic disparities in prostate MRI utilization following elevated PSA results.

Design, Setting, And Participants: This cohort study of 794 809 insured US men was drawn from deidentified medical claims between January 2011 and December 2017 obtained from a commercial claims database. Eligible participants were aged 40 years and older and received a single PSA result and no prior PSA screening or prostate MRI claims. Analysis was performed in January 2021.

Main Outcomes And Measures: Multivariable logistic regression was used to examine associations between elevated PSA results and follow-up prostate MRI. For patients receiving prostate MRI, multivariable regressions were estimated for the time between PSA and subsequent prostate MRI. PSA thresholds explored included PSA levels above 2.5 ng/mL, 4 ng/mL, and 10 ng/mL. Analyses were stratified by race, ethnicity, and age.

Results: Of 794 809 participants, 51 500 (6.5%) had PSA levels above 4 ng/mL; of these, 1524 (3.0%) underwent prostate MRI within 180 days. In this sample, mean (SD) age was 59.8 (11.3) years (range 40-89 years); 31 350 (3.9%) were Asian, 75 935 (9.6%) were Black, 107 956 (13.6%) were Hispanic, and 455 214 (57.3%) were White. Compared with White patients, Black patients with PSA levels above 4 ng/mL and 10 ng/mL were 24.1% (odds ratio [OR], 0.78; 95% CI, 0.65-0.89) and 35.0% (OR, 0.65; 95% CI, 0.50-0.85) less likely to undergo subsequent prostate MRI, respectively. Asian patients with PSA levels higher than 4 ng/mL (OR, 0.76; 95% CI, 0.58-0.99) and Hispanic patients with PSA levels above 10 ng/mL (OR, 0.77; 95% CI, 0.59-0.99) were also less likely to undergo subsequent prostate MRI compared with White patients. Black patients between ages 65 and 74 years with PSA above 4 ng/mL and 10 ng/mL were 23.6% (OR, 0.76; 95% CI, 0.64-0.91) and 43.9% (OR, 0.56; 95% CI, 0.35-0.91) less likely to undergo MRI, respectively. Race and ethnicity were not significantly associated with mean time between PSA and MRI.

Conclusions And Relevance: Among men with elevated PSA results, racial and ethnic disparities were evident in subsequent prostate MRI utilization and were more pronounced at higher PSA thresholds. Further research is needed to better understand and mitigate physician decision-making biases and other potential sources of disparities in prostate cancer diagnosis and management.
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http://dx.doi.org/10.1001/jamanetworkopen.2021.32388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576586PMC
November 2021

[STUDY OF ANTIVIRAL AND IMMUNECORRECTIVE EFFECTS OF LAZOLEX IN PATIENTS WITH RECURRENT HERPETIC STOMATITIS].

Georgian Med News 2020 Oct(307):73-78

Tbilisi State Medical University, Department of periodontal and oral mucosa diseases; Georgian-German Implantation Center Hbi-DentImplant; Dental Clinic Davident; V.Bakhutashvili Institute of Medical Biotechnology, Tbilisi; Batumi Shota Rustaveli State University; Georgia.

At present, our country continues intensive research to find and introduce into practice new natural medicinal preparations made from ecologically clean endemic plants of Georgia. An example of such studies in the Iveria-Pharma company is the domestic drug Lazolex (extract of the pericarpium of an unripe walnut), which has passed the necessary preclinical tests and began to be used in the clinic as an antiherpetic agent. On healthy volunteers, we found positive immunotropic effects of Lazolex. Therefore, we considered it necessary to study the antiviral effect of the drug and its immunomodulatory properties in a clinical setting, specifically in chronic herpetic stomatitis. First of all, it was shown that the state of the patients' immune system was in a clear correlation with the severity of the herpes process, i.e. the most severe immunosuppression was recorded in patients with severe stomatitis. The double effect of the drug is to significantly increase the results of antiviral treatment and immunorehabilitation of patients. As a result of a parallel study of Zovirax and Lazolex, a high clinical activity of both drugs was recorded. However, the presence of pronounced immuno-corrective properties in Lazolex manifested itself in an improvement in the quality of patient treatment: active tissue regeneration and a significant decrease in the timing of exacerbation of local herpetic lesions, an increase in the duration of remission. Conducted clinical, laboratory and immunological studies allow us to recommend Lazolex for active use in dental practice for viral diseases.
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October 2020

[Oral cavity features in patients suffering from osteogenesis imperfecta].

Georgian Med News 2011 Apr(193):34-41

Osteogenesis Imperfecta (OI) is a rare hereditary connective tissue disorder. This pathology is characterized by disruption of biosynthesis of Type I collagen, and production of limited amount of defective and imperfect collagens. This causes decrease in bone mass of human body, bones become fragile and brittle, resulting in unreasonable multiple fractures. Reportedly, number of patients with OI ranges between 32-38 in Georgia. However, exact number of patients, including children and their parents, is unknown. Dentinogenesis Imperfecta (DI; DGI) and skeletal malocclusion occupy special place in varied spectrum of OI clinical symptoms. We studied 14 patients: 9 women (64.3%), 5 men (35.7%) and divided them in three age groups: I - 2.5-6 years - period of primary dentition (28.6%), II - 6-14 years - period of changing teeth dentition (35.7%) and III - above 14 years - period of permanent dentition (35.7%). 28.5% of screened patients had one of the symptoms of DI, such as tooth discoloration. Discoloration of primary teeth was revealed in 4 patients (primary dentition). Another symptom of DI, such as early abrasion, was detected in 5 patients i.e. 35.71%. This was divided in the following manner: I age group - 3 cases, II and III age groups - 1-1 cases. It was also observed that early abrasion of primary teeth prevails over permanent. One of DI's radiographic symptoms, such as peculiar form of teeth crown and root, was revealed in 21.4% or in 3 patients, 2 of whom had bulbous crown, and the third one deformed (curved) root. Peculiar characteristics of DI, such as increased constriction of the coronal-radicular junction, obliterated pulp chamber, short and narrow roots, were not observed in the patients examined. Interesting characteristic of DI, such as periapical destruction of intact tooth root, was revealed in the form of bone defect in 7.1% of those examined (1 patient). Therefore, out of examined 14 patients with OI - DI had 6 patients or 42.85% of cases. Also, interesting observation was revealed - DI is more common in primary teeth (66.66%) than in permanent (33.33%). Radiographic examination - orthopantomography - revealed secondary osteoporosis of jaw bones in 100% of cases. Mucous tissue of examined patients is within normal range. Among examined patients, 1 case of adenty, 1 case of retention and 1 case of overcomplex tooth were revealed. According to current literature, it is unknown whether there is a lgical relationship between adenty, retention, overcomplex teeth and OI. This will be defined by future research.
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April 2011

[Comparative estimation of laser devices in complex treatment of oral cavity mucous membrane diseases].

Georgian Med News 2009 May(170):27-9

The aim of the study was to compare laser devices "Optodan" and portative laser "Baure" in complex treatment of oral cavity mucous membrane diseases. We studied 90 patients: 54 female (60,0+/-0,77%) and 36 (30,0+/-0,7%) men from 18 to 45 years old. All patients had different forms of oral mucosal diseases: Stomatitis aphtosa chronica recidiva had 36 patients (28,9+/-0,9%); Erythema exudativum multiforme - 10 patients (6,7+/-1,5%), Candidosis angulitis - 26 patients (17,8+/-1,46%), Lichen ruber planus ulceroza - 4 patients (4,44+/-1,03%), Trauma mechanicum acutium - 12 patients (11,06+/-2,8%), Stomatitis herpetica - 28 patients (31,1+/-1,48%). All the patients were practically healthy and had no contraindications for physiotherapy. Before treatment to all patients had been recommended means of individual hygiene and several recommendations. The patients were divided into two groups. Every group consisted of 45 patients. 13 patients with Stomatitis aphtosa chronica recidiva, 14 - Stomatitis herpetica, 3 - Erythema exudativum multiforme, 8 - Candidosis angulitis, 2 - Lichen ruber planus ulceroza, 5 - Trauma mechanicum acutium. All the patients underwent symptomatic treatment according to the form and gravity of disease. Patients in a first group in addition had laserotherapy with a laser device "Optodan". Patients in a second group underwent laserotherapy with a portative device (Baurer). The positive results were achieved in both groups, though the first group patients mentioned considerable reduce of pain right after procedures. Our research proved the high effectiveness of laserotherapy in complex treatment of oral cavity mucous membrane diseases. Treatment with device "Optodan" is the most preferable.
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May 2009

[Root canal treatment at pulpitis, periodontitis using ultrasound].

Georgian Med News 2009 May(170):24-6

The aim of our research was the clinical estimation of ultrasound efficiency during root canal treatment at pulpitis, periodontitis. 446 root canals of 164 single and multi-rooted teeth were used for this study. Teeth were treated and monitored for 3 months, 6 months, 9 months, 1 year, 1,5 year, 2 year. All teeth with periapical destructive changes had periapical destructive lesions in x-ray imaging. Patients were divided into two groups. Endodontic treatment of first group combined mechanical and chemical processing with ultrasound divise Pieson Master-400, Endosonore profiles, sodium hypochlorite (NAOCI) +canal lubricant (EDTA). In a second group we used the traditional layout of treatment pulpitis end periodontitis. According to our results, in a first group the X-ray improvement was - after 3 months in I group in 53 (64,6+/-0,7%) patients, in the II group - 44 (53,65+/-2,3%); after 6 months in the I group - 59 (71,9+/-2,2%), in the II group - 56 (68,29+/-0,54%); after 9 months in the I group - 62 (75,6+/-0,56%), in the II group - 56 (68,29+/-0,54%); after 1 year in the I group - 70 (85,36+/-0,18%), in the II group - 63 (76,83+/-0,53%); after 1,5 year in the I group - 76 (92,68+/-2,8%), in the II group - 65 (79,26+/-0,5%); after 2 years in the I group - 77 (93,9+/-2,7%), in the II group - 65 (79,27+/-2,11%). We can conclude, that the ultrasound preparation of the root canal leads us to the considerable lowering of complication of endodontic treatment, though doesn't guarantee their complete absence. In the end we can resume that the usage of ultrasound preparation during endodontic treatment considerably exceed the effectiveness of chemical irrigation of root canal. That is because of its bactericide effect, opening and cleaning root canal system, creation favorable conditions for hermetic filling of root canal after removal of smear line.
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May 2009
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