Publications by authors named "N M Yaacob"

107 Publications

Mitochondrial DNA sequence of the horseshoe crab .

Mitochondrial DNA B Resour 2021 May 23;6(6):1710-1714. Epub 2021 May 23.

Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia.

This paper reports on the complete mitochondrial (mt) genome of a horseshoe crab, (), in Kuala Kemaman, Terengganu, Malaysia. Whole-genome sequencing of hemocyte DNA was performed with Illumina HiSeq system and the generated reads were assembled with ABySS 2.1.5 and reassembled using mitoZ against and , resulting in a contig of 15 Kb. Phylogenetic analysis of the assembled mt genome suggests that the is closely related to than to
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http://dx.doi.org/10.1080/23802359.2021.1930213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158250PMC
May 2021

Survival and Characteristics of Bladder Cancer: Analysis of the Malaysian National Cancer Registry.

Int J Environ Res Public Health 2021 05 14;18(10). Epub 2021 May 14.

Malaysian National Cancer Registry Department, National Cancer Institute, Ministry of Health Malaysia, Putrajaya 62250, Malaysia.

Background: Bladder cancer ranked ninth of principal male cancer in Malaysia. This study aimed to evaluate the clinical characteristics and survival of bladder cancer patients in Malaysia.

Methods: A retrospective cohort study was conducted by obtaining records in the Malaysian National Cancer Registry. Patients aged 15 years old and above with diagnosis date between 2007 and 2011 were included. Death was updated until 31 December 2016. Five-year observed survival and median survival time were determined by the life table method and Kaplan-Meier estimate method.

Results: Among 1828 cases, the mean (SD) age of diagnosis was 64.9 (12.5) years. The patients were predominantly men (78.7%), Malay ethnicity (49.4%) and transitional cell carcinoma (78.2%). Only 14.8% of patients were at stage I. The overall five-year observed survival and median survival time was 36.9% (95% CI: 34.6, 39.1) and 27.3 months (95% CI: 23.6, 31.0). The highest five-year observed survival recorded at stage I (67.6%, 95% CI: 62.0, 73.3) and markedly worsen at stage II (34.3%, 95% CI: 27.9, 40.8), III (25.7%, 95% CI: 18.7, 32.6) and IV (12.2%, 95% CI: 8.1, 16.3).

Conclusions: Survival of bladder cancer patients in Malaysia was lower with advancing stage. The cancer control programme should be enhanced to improve survival.
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http://dx.doi.org/10.3390/ijerph18105237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156894PMC
May 2021

Net survival differences of breast cancer between stages at diagnosis and age groups in the east coast region of West Malaysia: a retrospective cohort study.

BMJ Open 2021 05 18;11(5):e043642. Epub 2021 May 18.

Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia - Kampus Kesihatan, Kubang Kerian, Malaysia.

Objective: Estimation of the net survival of breast cancer helps in assessing breast cancer burden at a population level. Thus, this study aims to estimate the net survival of breast cancer at different cancer staging and age at diagnosis in the east coast region of West Malaysia.

Setting: Kelantan, Malaysia.

Participants: All breast cancer cases diagnosed in 2007 and 2011 identified from Kelantan Cancer Registry.

Design: This retrospective cohort study used a relative survival approach to estimate the net survival of patients with breast cancer. Thus, two data were needed; breast cancer data from Kelantan Cancer Registry and general population mortality data for Kelantan population.

Primary And Secondary Outcome Measures: Net survival according to stage and age group at diagnosis at 1, 3 and 5 years following diagnosis.

Results: The highest net survival was observed among stage I and II breast cancer cases, while the lowest net survival was observed among stage IV breast cancer cases. In term of age at diagnosis, breast cancer cases aged 65 and older had the best net survival compared with the other age groups.

Conclusion: The age at diagnosis had a minimal impact on the net survival compared with the stage at diagnosis. The finding of this study is applicable to other populations with similar breast cancer profile.
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http://dx.doi.org/10.1136/bmjopen-2020-043642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130742PMC
May 2021

Assessment of Aqueous Extraction Methods on Extractable Organic Matter and Hydrophobic/Hydrophilic Fractions of Virgin Forest Soils.

Molecules 2021 Apr 23;26(9). Epub 2021 Apr 23.

Faculty of Education & Graduate School of Engineering, Soka University, 1-236 Tangi-Machi, Hachioji-Shi 192-8577, Tokyo, Japan.

The assessment of water-extractable organic matter using an autoclave can provide useful information on physical, chemical, and biological changes within the soil. The present study used virgin forest soils from Chini Forest Reserve, Langkawi Island, and Kenyir Forest Reserve (Malaysia), extracted using different extraction methods. The dissolved organic carbon (DOC), total dissolved nitrogen (TDN), total dissolved phosphorus (TDP), and ammonium-nitrate content were higher in the autoclave treatments, up to 3.0, 1.3, 1.2, and 1.4 times more than by natural extraction (extracted for 24 h at room temperature). Overall, the highest extractable DOC, TDN, TDP, ammonium and nitrate could be seen under autoclaved conditions 121 °C 2×, up to 146.74 mg C/L, 8.97 mg N/L, 0.23 mg P/L, 5.43 mg N mg/L and 3.47 N mg/L, respectively. The soil extracts became slightly acidic with a higher temperature and longer duration. Similar trends were observed in the humic and nonhumic substances, where different types of soil extract treatments influenced the concentrations of the fractions. Different soil extraction methods can provide further details, thus widening the application of soil extracts, especially in microbes.
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http://dx.doi.org/10.3390/molecules26092480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123026PMC
April 2021

A Randomized Controlled Trial Comparing Two Doses of Caffeine for Apnoea in Prematurity.

Int J Environ Res Public Health 2021 04 23;18(9). Epub 2021 Apr 23.

Department of Paediatrics, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.

Caffeine is the most commonly used methyl xanthine for the prevention of apnoea in prematurity, but the ideal dose was uncertain, until now. This study compared two doses of caffeine for the prevention of apnoea in prematurity. A clinical trial was conducted on 78 preterm infants ≤32 weeks in Neonatal Intensive Care Unit. They were randomly allocated to receive the intervention (loading 40 mg/kg/day and maintenance of 20 mg/kg/day) or the control (loading 20 mg/kg/day and maintenance of 10 mg/kg/day) dose of caffeine. The primary outcome of the study was the frequency and total days of apnoea per duration of treatment for both groups. The frequency of apnoea ranged from zero to fourteen in the intervention group and zero to twelve in the control group. There was no statistically significant difference between the groups, with a -value of 0.839. The number of days of apnoea was also similar between both groups, with a -value of 0.928. There was also no significant difference in adverse events between both regimens. This study did not support the use of higher doses of caffeine as a prevention for apnoea in prematurity.
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http://dx.doi.org/10.3390/ijerph18094509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123071PMC
April 2021