Publications by authors named "N L Chernaya"

7 Publications

[Therapy of perinatal brain injury outcomes: results of a multicenter double-blind placebo-controlled randomized study of tenoten for children (liquid dosage form)].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(7. Vyp. 2):33-39

Kazan State Medical University, Kazan, Russia.

Objective: To evaluate the efficacy and safety of tenoten for children (a novel liquid pediatric formulation) in the treatment of perinatal brain injury (PBI) outcomes.

Material And Methods: The multicenter double-blind placebo-controlled randomized trial enrolled 184 children (aged 29 days-9 months) with the total score 12-27 according to Djurba-Mastukova scale and the level of physical development 25-75 centiles. Patients were randomized into tenoten (10 drops per day) and placebo groups. Treatment period was 12 weeks ± 5 days. Percentage of patients with ≥4 points improvement according to Djurba-Mastukova scale (responder rate) was used as a primary efficacy endpoint.

Results And Conclusion: Patients in the tenoten group had a significant result on primary efficacy endpoint: 77.5% of participants responded to therapy (p=0.02 vs. placebo). In addition, the safety of tenoten for children in the treatment of PBI outcomes is shown. Tenoten for children (a novel liquid pediatric formulation) has been shown to be an effective medication in treatment of PBI outcomes that helps to achieve therapeutic results with minimal side-effects, good tolerability and the high level of adherence to therapy.
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http://dx.doi.org/10.17116/hirurgia20190715DOI Listing
November 2019

[Endovascular and surgical treatment of a patient with traumatic rupture of the aorta and hepatic artery].

Angiol Sosud Khir 2016 ;22(1):176-81

Department of Roentgenosurgical Methods of Diagnosis and Treatment, Scientific Research Institute of Emergency Ambulance Care named after N.V. Sklifosovsky, Moscow, Russia.

Traumatic rupture of the aorta is the second most common cause of death in closed chest injury. The latest findings of autopsy showed that 80% of lethal outcomes in aortic injury occur in the prehospital period. Taking into consideration the incidence and high rate of death prior to the diagnosis stage, aortic rupture in closed thoracic injury is an important problem. Due to the characteristic mechanism of the development (during sharp deceleration of the body) this type of traumatic lesion of the aorta became known as "deceleration syndrome". The most vulnerable to tension aortic portion is its neck where the mobile part of the thoracic aorta is connected to the fixed arch in the place of the arterial ligament attachment. Open surgical intervention in patients with severe closed chest injury (often concomitant injury) is associated with high mortality and complications. Currently endovascular prosthetic repair of the aorta is a method of choice at the primary stage of treatment of patients with aortic injury. In this article we present a rare case report of concomitant lesion of large vessels (the descending aortic portion and proper hepatic artery) in a patient with severe concomitant injury, as well as peculiarities of diagnosis and combined treatment (endovascular prosthetic repair of the aorta and hepatic artery with an aotovein).
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September 2016

[Endovascular treatment of post-traumatic arteriovenous fistulae].

Khirurgiia (Mosk) 2015 (7):34-40

N.V. Sklifosovskiy Research Institute for Emergency Care, Department of Health, Moscow, Russia.

Aim: To summarize the experience of endovascular treatment of traumatic arteriovenous fistulae.

Material And Methods: Endovascular interventions for arteriovenous fistulae of different locations were applied in 16 patients aged 19 to 83 years (mean 50.4±14.3) in A.V. Vishnevskiy Institute of Surgery from 2003 to 2014. Among causes there were stab wounds, gunshot wounds, blunt trauma, iatrogenic. Different endovascular methods including stenting with self-opening and balloon-expanding stent-grafts, embolic coils and occluders implantation were used.

Results: Pain syndrome, disorders of support function and trophic changes were observed in patients with arteriovenous fistulae more localized more distal than lower one third of the thigh. More proximally located arteriovenous fistulae regardless of their diameter resulted severe heart failure and portal hypertension. Angiographic and clinical success was achieved in 100% of cases. Manifestations of heart failure and portal hypertension disappeared in all patients after endovascular interventions. Also support function restored, pain and trophic disorders were cured.

Conclusion: Arteriovenous fistulae regardless of their size, location and time of existence must be dissociated. Prolonged arteriovenous shunting leads to severe heart failure. Current technologies and tools used in endovascular interventions provide reliable dissociation of arteriovenous fistulae even in case of difficult anatomical features.
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http://dx.doi.org/10.17116/hirurgia2015734-40DOI Listing
September 2015

Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy.

World J Gastrointest Surg 2013 Mar;5(3):51-61

Vyacheslav I Egorov, Ostroumov 14 City Hospital, Department of Surgical Oncology, Sechenov First State Medical University, 117997 Moscow, Russia.

Reported here are two cases of a modified Appleby operation for borderline resectable ductal adenocarcinoma of the pancreatic body, in one of which a R0 distal resection was attended to by excision, not only of the celiac axis, but also of the common and left hepatic arteries in the presence of arterial anatomic variation Michels, type VIIIb. The possibility and avenues of the maintenance of the blood supply to the left hepatic lobe after surgical aggression of this kind are demonstrated employing computed tomography (CT) and 3-D CT angiography. Furthermore, both cases highlight all important worrisome aspects of pancreatic cancer resectability prediction.
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http://dx.doi.org/10.4240/wjgs.v5.i3.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615305PMC
March 2013

[Resistance of Antarctic microorganisms to UV radiation].

Mikrobiol Z 2011 May-Jun;73(3):3-8

The paper deals with the samples of microorganisms isolated from biofilms of encrustation of 11 stationary points of monitoring on the vertical rock of biogeographical testing ground (island Galindez, Antarctic Region). They are presented by morphologically various forms of bacteria (n x 10(7) cells in 1g of sample), yeast (n x 10(5)) and fungi (n x 10(4)-10(6)). Threshold and lethal UV dozes for isolated monocultures of the Antarctic microorganisms are determined. The threshold doze of UV radiation which is a measure of ability of a cell to reparation of DNA damages for bacteria was 40-70 J/m2. The lethal UV doze (LD99.99) for bacteria varied within the limits of 200-480 J/m2, for yeast of 700-1200 J/m2. Both pigmented and not pigmented bacteria were resistant to UV radiation. As a rule, Gram-positive bacteria were more resistant to UV than Gram-negative ones. It is shown, that resistance of investigated Antarctic rocky microorganisms to UV radiation is their genetically stable characteristic.
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September 2011
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