Publications by authors named "N Khachapuridze"

30 Publications

INFLAMMATION IN CHILDHOOD EPILEPSY SYNDROMES.

Georgian Med News 2021 Mar(312):88-92

Tbilisi State Medical University, Department of Paediatric Neurology, Georgia.

Epilepsy is one of the most common neurological disorder affecting up to 1% of the world population. It is a heterogeneous disorder and includes genetic, structural, metabolic causes, sometimes reason is unknown. In recent 20 years inflammation has been considered as a possible etiologic factor in angiogenesis and epileptogenesis in experimental models but there is still lack of evidence if inflammation could be seen in clinical cases of children with different forms of epilepsy. Epileptic encephalopathies are the group of epilepsies when seizure itself can cause severe cognitive and behavioral abnormalities. Besides seizures occurring in epileptic encephalopathies prone to be highly resistant to medication. Thus any etiological factor contributing to epileptogenesis could have high clinical relevance in modern epileptology. The aim of our research was to study the pro-inflammatory cytokines in different forms of epilepsy in children. We have assessed 56 children from 0-16 years of age. 20 were included in control group (Group 1), 20 children with resolved seizures were involved in study group (Group 2a) and 16 children with resistant seizures were identified as group 2b. The concentration of the following pro-inflammatory cytokines was assessed in blood serum: VCAM-1, CCL2, CCL3, CCL11 as well as a correlation between concentration and seizure repetition rate was also studied. All pro-inflammatory markers were within normal range in controls as well as in both study groups except CCL11. The concentration of CCL11 was elevated in group 2b. Thus we could hypothesize that inflammation could contribute to etiology of resistant epilepsies including epileptic encephalopathies. This evidence could serve as very significant information for pharmaceutical industry for future development of anti-inflammatory medicines as add on therapy with antiepileptic drugs for treatment of drug resistant epilepsies.
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March 2021

[MODERN ISSUES OF KALCIPHEROL INFLUENCE ON CHILDREN AND ADULTS' HEALTH (REVIEW)].

Georgian Med News 2021 Mar(312):82-87

Tbilisi State Medical University, Department of Peadiatric Neurology; Iashvili Children's Central Hospital, Tbilisi, Georgia.

The purpose of this review is study of literature for the development of biological effect of Kalcipherol (D vitamin group) on children population. Different factors seem, that D- vitamin deficiency disbalance elevated, children specifically negative effect, which have a major impact on health, growth and development of infants, children and adolescents. Vitamin D and calcium deficiencies are preventable global public health problems in pediatric medicine. The laboratory assessment of vitamin D (calcidiol-25(OH)D), epidemiological studies assessing the prevalence of vitamin D deficiency, are performed to analyze the relationships between neuropsychological function and mechanisms of toxic effects in the setting of vitamin D.
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March 2021

[MODERN INSUES OF ESSENTIAL TRACE ELEMENTS LEVEL INFLUENCE ON CHILDREN AND ADULTH HEALTH (REVIEW)].

Georgian Med News 2020 May(302):105-108

Tbilisi State Medical University; Center for Mental Health and Prevention of Addiction, Tbilisi, Georgia.

Systematic review article reported that essential trace elements, mainly microelements Copper and Zinc (deficiency and high values concentration disbalance in blood) play significant roles in neurodevelopmental processes and are associated not only with inattention and hyperactivity, impulsivity symptoms among children and adolescents in the most critical active growth and development periods (between 3 and 16 years old). In the same time previous studies have proposed that clinical symptoms are significant associated their levels and positively correlated with cognitive symptomatology as trace bioactive substances. Their functional connectivity is different and is one of the serious problems for clinical pediatric.
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May 2020

[THE CALCIUM-PHOSPHORIC METABOLISM AND DEVELOPMENT OF BONE ORGANIC MATRIX AT CHILDREN AND ADOLESCENTS ON D-AVITAMIN BACKGROUND (REVIEW)].

Georgian Med News 2020 May(302):101-104

Tbilisi State Medical University, Georgia.

The purpose of the review is to study the literature data on the manifestation of D-deficient rickets in children of various age groups. It is shown that the rapid growth of the musculoskeletal system requires timely intake of both macronutrients and vitamin D, its biologically active metabolites. The role of the relationship between the intestines, liver, kidneys and bone tissue in regulating the necessary level of phosphorus-calcium salts in bone tissue, the synthesis of its organic matrix is shown. Modern data on the content of phosphorus, calcium and d vitamin in women's milk during various periods of lactation are presented. It is shown that the prevention of their deficiency should begin already in the antenatal period of the child's development. The article presents prevalence of vitamin D deficiency in children of puberty and pre-puberty age, The hypo Vitamin D status in children with complicated forms orthopedic pathology is descid. The level of vitamin D and calcium-phospharic metabolism are presented summarizing the literature data. Vitamin D availability and vitamin D insufficiency in pediatric clinical practice is analysed, showing high prevalence of vitamin D difficiency in children in the first part of life. Analyses of results demonstrated differences of vitamin D serum concentration in length of age and food additives. Its manifestation, with confusing and wildly differing guidance being change the structure and volume of each components. Vitamin D, calcium-phosphoric deficiencies and osteomalacia are global public health problems in infants, children and adolescents.
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May 2020

[MODERN ISSUES OF D-VITAMIN SIGNIFICANCE IN DEVELOPMENT OF FULERUM-MOVE DEVICES OF INFANTS, CHILDREN AND ADOLESCENTS ( REVIEW)].

Georgian Med News 2020 Feb(299):43-47

Tbilisi State Medical University, Department of Pediatric Neurology; Department of Pediatrics, Georgia.

The purpose of this review is the study of literature for the current data on the metabolism of vitamin D and its role in development of bone tissue in children. The role of the main marker enabling assessing 25(OH)D concentration in the body the reference values has been analyzed. Summarizing the literature data, we may say that vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets and osteomalacia, which have a mayor impact on health of infants, children and adolescents.
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February 2020