Publications by authors named "N J Chao"

426 Publications

Female Sex is Associated with Improved Long-Term Survival Following Allogeneic Hematopoietic Stem Cell Transplant.

Transplant Cell Ther 2021 Jun 16. Epub 2021 Jun 16.

Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC. Electronic address:

Background: Life expectancy for long-term survivors of allogeneic hematopoietic stem cell transplant (alloHSCT), defined as those living ≥5 years post-transplant, is significantly lower compared to that of the age-matched general population despite a relatively low primary disease relapse rate >2 years post-transplant. Among several factors, patient sex is increasingly recognized as a prognostic indicator of long-term survival.

Objective: We examined the influence of patient sex and donor-recipient sex matching on overall survival in a landmark analysis of long-term survivors.

Study Design: Using our institutional database supplemented with individual patient record review, we retrospectively investigated the relative influence of recipient sex and donor-recipient sex matching on outcomes of long-term survivors receiving alloHSCT between 1994 - 2014.

Results: Over this 20-year period, 247 met inclusion criteria for analysis; males and females had similar demographic and treatment characteristics. However, significantly more deaths after the 5-year landmark occurred in male recipients. Interestingly, donor sex did not have a significant impact on overall survival in multivariate analysis, and differences in overall survival of donor-recipient sex pairs was driven by recipient sex. In addition to recipient sex, only cGVHD retained significance as a covariate with impact on overall survival in multivariate analysis. Men experienced slightly higher, but non-significant, rates and increased severity of cGVHD, and a greater percentage of cGVHD-related mortality as compared to females.

Conclusion: In this long-term survival analysis of alloHSCT adult patients, one of the only to include follow-up to 15 years, our results show that women survive significantly longer than men irrespective of their age at transplant. This outcome is independent of other common pre-transplant prognostic indicators such as donor sex or performance status at transplant. Inferior survival for males is consistent with survival outcomes described in transplant literature. Gathering evidence suggests a biologic basis for long-term sex-determined outcomes, possibly due to differing rates or severity of cGVHD or sustained alloimmune tolerance in females. Larger studies are warranted to validate these retrospective clinical results.
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http://dx.doi.org/10.1016/j.jtct.2021.06.012DOI Listing
June 2021

Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study.

Front Pharmacol 2021 18;12:672769. Epub 2021 May 18.

Department of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, Med-X Center for Informatics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

The aim of this study was to investigate the correlation between genetic polymorphisms of azathioprine-metabolizing enzymes and adverse reactions of myelosuppression. To this end, a retrospective analysis was performed on 1,419 Chinese patients involving 40 different diseases and 3 genes: (94C>A), (T>C), and (415C>T). Strict inclusion and exclusion criteria were established to collect the relative cases, and the correlation between azathioprine and myelosuppression was evaluated by adverse drug reaction criteria. The mutation rates of the three genes were 29.32, 3.73, and 21.92% and grades I to IV myelosuppression occurred in 54 (9.28%) of the 582 patients who took azathioprine. The highest proportion of myelosuppression was observed in 5 of the 6 (83.33%) patients carrying the (415C>T) TT genotype and 12 of the 102 (11.76%) patients carrying the (415C>T) CT genotype. Only the (415C>T) polymorphism was found to be associated with the adverse effects of azathioprine-induced myelosuppression (odds ratio [OR], 51.818; 95% CI, 5.280-508.556; = 0.001), which suggested that the (415C>T) polymorphism could be an influencing factor of azathioprine-induced myelosuppression in the Chinese population. Epistatic interactions between (94C>A) and (415C>T) affect the occurrence of myelosuppression. Thus, it is recommended that the genotype of (415C>T) and (94C>A) be checked before administration, and azathioprine should be avoided in patients carrying a homozygous (415C>T) mutation. This study is the first to investigate the association between genetic polymorphisms of these three azathioprine-metabolizing enzymes and myelosuppression in a large number of cases with a diverse range of diseases.
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http://dx.doi.org/10.3389/fphar.2021.672769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167793PMC
May 2021

Microblog credibility indicators regarding misinformation of genetically modified food on Weibo.

PLoS One 2021 1;16(6):e0252392. Epub 2021 Jun 1.

Department of Communication, University of California, Davis, CA, United States of America.

The considerable amount of misinformation on social media regarding genetically modified (GM) food will not only hinder public understanding but also mislead the public to make unreasoned decisions. This study discovered a new mechanism of misinformation diffusion in the case of GM food and applied a framework of supervised machine learning to identify effective credibility indicators for the misinformation prediction of GM food. Main indicators are proposed, including user identities involved in spreading information, linguistic styles, and propagation dynamics. Results show that linguistic styles, including sentiment and topics, have the dominant predictive power. In addition, among the user identities, engagement, and extroversion are effective predictors, while reputation has almost no predictive power in this study. Finally, we provide strategies that readers should be aware of when assessing the credibility of online posts and suggest improvements that Weibo can use to avoid rumormongering and enhance the science communication of GM food.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168881PMC
June 2021