Publications by authors named "N Dupin"

395 Publications

Bartonella and Coxiella infections presenting as systemic vasculitis: case series and review of literature.

Rheumatology (Oxford) 2021 Sep 9. Epub 2021 Sep 9.

Département de Médecine Interne, Centre de Référence National pour les maladies auto-immunes systémiques rares, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objectives: Coxiella and Bartonella sp. display particular tropism for endothelial or endocardial tissues and an abnormal host response to infections with induced autoimmunity. We aimed, through a case series combined with a comprehensive literature review, to outline characteristics of Coxiella and Bartonella infections presenting as systemic vasculitis.

Methods: We retrospectively included cases of definite Coxiella and Bartonella infections presenting with vasculitis features and performed a comprehensive literature review.

Results: Six cases of Bartonella infections were added to 18 cases from literature review. Causative pathogens were mainly B. henselae. Bartonella infection mimicked anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis in 83% with PR3-ANCA and presented as cryoglobulinemic vasculitis in 8%. Glomerulonephritis was present in 92%, and 88% had endocarditis. Complement fractions were low in 82% and rheumatoid factor positive in 85%. Kidney biopsies showed cell proliferation, mostly crescentic, with pauci-immune glomerulonephritis in 29%. Outcome was favorable, with the use of antibiotics alone in one third. Five cases of Coxiella infections were added to 16 from literature review. Sixteen had small-vessel vasculitides, mainly cryoglobulinemia vasculitis in 75%. One patient had polyarteritis nodosa-like vasculitis and four large-vessel vasculitis. Outcome was good except for one death. A highly sensitive next generation sequencing analysis on 3 Coxiella and 2 Bartonella-related vasculitides biopsies did not find any bacterial DNA.

Conclusion: Coxiella and Bartonella are both able to induce vasculitis but display distinct vasculitis features. Bartonella mimics PR3-ANCA-associated vasculitis in the setting of endocarditis, whereas Coxiella may induce vasculitis involving all vessel sizes.
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http://dx.doi.org/10.1093/rheumatology/keab691DOI Listing
September 2021

Abdominal metastases from Merkel cell carcinoma: Prevalence and presentation on CT examination in 111 patients.

Diagn Interv Imaging 2021 Aug 28. Epub 2021 Aug 28.

Department of Radiology, Hopital Robert Debré, Université de Reims Champagne-Ardenne, 51100 Reims, France.

Purpose: The purpose of this study was to report the prevalence and imaging features of abdominal metastases from Merkel cell carcinoma (MCC) on computed tomography (CT) examinations.

Materials And Methods: A total of 111 patients with MCC from two institutions were initially identified. Of these, 27 patients (27/111; 24.3%) had abdominal metastases from MCC present on CT examination. There were 19 men and 8 women with a mean age of 75  ± 10.8 (SD) years (age range: 46-92 years). CT examinations were retrospectively reviewed by two radiologists and analyzed quantitatively for the number and dimensions of abdominal metastases from MCC and qualitatively in terms of location, margins, contours, homogeneity, patterns of enhancement, vascular involvement and extension of metastases from MCC.

Results: Fifteen patients (15/27; 56%) had abdominal metastatic disease at initial diagnosis and twelve (12/27; 44%) developed abdominal metastases during the course of the disease. The mean number of locations of abdominal metastases was 2.1 ± 1.12 (SD) (range: 1-5). Abdominal metastases involved abdominal lymph nodes (16/27; 59%), adrenal glands/kidneys/retroperitoneum (14/27; 52%), mesentery/peritoneum (13/27; 48%), liver (7/27; 26%) and pancreas (7/27; 26%). Vascular involvement was found in association with peritoneal/mesenteric metastases in 6/13 (46%) patients with intraperitoneal metastases or in association with abdominal lymph nodes in 4/16 (25%) patients. Ureteral encasement and/or dilatation was found in 4/14 (28%) patients with retroperitoneal metastases and 3/16 (19%) patients with abdominal lymph nodes. Metastases to the liver, pancreas, peritoneum, retroperitoneum and adrenal glands displayed internal enhancement during the arterial phase in 1/2 (50%), 4/5 (80%), 4/7 (57%) and 5/8 (62%) patients for whom arterial phase was available, respectively.

Conclusion: Metastases from MCC have a prevalence of 24.3% on CT examination and may involve a variety of abdominal organs, mainly lymph nodes, peritoneal and retroperitoneal structures, but also the liver and pancreas. CT features of abdominal metastases from MCC include hypervascularity during the arterial phase of enhancement and eventually vascular and ureteral involvement.
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http://dx.doi.org/10.1016/j.diii.2021.08.002DOI Listing
August 2021

Is ceftriaxone similarly effective to benzylpenicillin in neurosyphilis? - Authors' reply.

Lancet Infect Dis 2021 09;21(9):1207-1208

Service de Dermatologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, (AP-HP), Paris, France; Centre National de Référence de la Syphilis, Institut Cochin, Unité Inserm U1016, Université de Paris, Paris 75014, France. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(21)00466-7DOI Listing
September 2021

Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report.

Acta Derm Venereol 2021 Aug 16. Epub 2021 Aug 16.

Department of Dermatology, Hôpital Cochin, AP-HP, AP-HP Centre-Université de Paris, 89 rue d'Assas, FR-75006 Paris, France.

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http://dx.doi.org/10.2340/00015555-3888DOI Listing
August 2021

Rare cutaneous adverse effects of COVID-19 vaccines: a case series and review of the literature.

J Eur Acad Dermatol Venereol 2021 Aug 7. Epub 2021 Aug 7.

Department of Dermatology, Hôpital Cochin, AP-HP, AP-HP.Centre-Université de Paris, Paris, France.

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http://dx.doi.org/10.1111/jdv.17578DOI Listing
August 2021
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