Publications by authors named "Myriam Gorospe"

100Publications

Practical guide for circular RNA analysis: Steps, tips, and resources.

Wiley Interdiscip Rev RNA 2020 Oct 28:e1633. Epub 2020 Oct 28.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/wrna.1633DOI Listing
October 2020

Translational control during cellular senescence.

Mol Cell Biol 2020 Oct 19. Epub 2020 Oct 19.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA 21042.

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http://dx.doi.org/10.1128/MCB.00512-20DOI Listing
October 2020

Circular RNAs in Blood Malignancies.

Front Mol Biosci 2020 26;7:109. Epub 2020 Jun 26.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fmolb.2020.00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333357PMC
June 2020

Hepatic HuR modulates lipid homeostasis in response to high-fat diet.

Nat Commun 2020 06 16;11(1):3067. Epub 2020 Jun 16.

Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.

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http://dx.doi.org/10.1038/s41467-020-16918-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298042PMC
June 2020

Regulation of senescence traits by MAPKs.

Geroscience 2020 04 16;42(2):397-408. Epub 2020 Apr 16.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s11357-020-00183-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205942PMC
April 2020

Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging.

Trends Mol Med 2020 04 28;26(4):422-433. Epub 2020 Feb 28.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2020.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152597PMC
April 2020

Survey of senescent cell markers with age in human tissues.

Aging (Albany NY) 2020 03 11;12(5):4052-4066. Epub 2020 Mar 11.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.18632/aging.102903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093180PMC
March 2020

A Circular RNA from the Locus Controls Cell Cycle Progression by Suppressing p53 Levels.

Mol Cell Biol 2020 04 13;40(9). Epub 2020 Apr 13.

Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00473-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156218PMC
April 2020

Interaction between HuR and Modulates Autophagy in the Intestinal Epithelium by Altering ATG16L1 Translation.

Mol Cell Biol 2020 02 27;40(6). Epub 2020 Feb 27.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00492-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048268PMC
February 2020

Long Noncoding RNA H19 Impairs the Intestinal Barrier by Suppressing Autophagy and Lowering Paneth and Goblet Cell Function.

Cell Mol Gastroenterol Hepatol 2020 18;9(4):611-625. Epub 2019 Dec 18.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland; Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078540PMC
December 2019

A novel long noncoding RNA Linc-ASEN represses cellular senescence through multileveled reduction of p21 expression.

Cell Death Differ 2020 Jun 9;27(6):1844-1861. Epub 2019 Dec 9.

Department of Molecular Medicine, and Medical Research Center, Inha University College of Medicine, Incheon, Korea.

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http://dx.doi.org/10.1038/s41418-019-0467-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244501PMC
June 2020

SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.

J Neurosci 2020 01 9;40(3):694-709. Epub 2019 Dec 9.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224,

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http://dx.doi.org/10.1523/JNEUROSCI.1446-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961992PMC
January 2020

Transcriptome signature of cellular senescence.

Nucleic Acids Res 2019 Dec;47(21):11476

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1093/nar/gkz879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868356PMC
December 2019

'RNA circles of influence' in Kaposi sarcoma.

Ann Transl Med 2019 Jul;7(Suppl 3):S109

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.21037/atm.2019.05.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685872PMC
July 2019

Methods for analysis of circular RNAs.

Wiley Interdiscip Rev RNA 2020 01 5;11(1):e1566. Epub 2019 Sep 5.

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1002/wrna.1566DOI Listing
January 2020

Skewed macrophage polarization in aging skeletal muscle.

Aging Cell 2019 12 2;18(6):e13032. Epub 2019 Sep 2.

Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/acel.13032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826159PMC
December 2019

Rolling Circle cDNA Synthesis Uncovers Circular RNA Splice Variants.

Int J Mol Sci 2019 Aug 16;20(16). Epub 2019 Aug 16.

Institute of Life Sciences, Nalco Square, Bhubaneswar 751023, India.

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http://dx.doi.org/10.3390/ijms20163988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721031PMC
August 2019

HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling.

Cardiovasc Res 2020 04;116(5):944-955

>Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.

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http://dx.doi.org/10.1093/cvr/cvz205DOI Listing
April 2020

Transcriptome signature of cellular senescence.

Nucleic Acids Res 2019 08;47(14):7294-7305

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1093/nar/gkz555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698740PMC
August 2019

Correction: Polysome Fractionation to Analyze mRNA Distribution Profiles.

Bio Protoc 2019 Feb;9(3)

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, USA.

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http://dx.doi.org/10.21769/BioProtoc.3176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482963PMC
February 2019

mRNA methylation in cell senescence.

Wiley Interdiscip Rev RNA 2019 11 29;10(6):e1547. Epub 2019 May 29.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1002/wrna.1547DOI Listing
November 2019

RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Localization of TLR2 via Post-transcriptional Control of CNPY3.

Gastroenterology 2019 09 17;157(3):731-743. Epub 2019 May 17.

Cell Biology Group, Department of Surgery, Baltimore, Maryland; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland; Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085194089
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http://dx.doi.org/10.1053/j.gastro.2019.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707881PMC
September 2019

Long noncoding RNAs in intestinal epithelium homeostasis.

Am J Physiol Cell Physiol 2019 07 1;317(1):C93-C100. Epub 2019 May 1.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine , Baltimore, Maryland.

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https://www.physiology.org/doi/10.1152/ajpcell.00092.2019
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http://dx.doi.org/10.1152/ajpcell.00092.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689755PMC
July 2019

NF90 regulation of immune factor expression in response to malaria antigens.

Cell Cycle 2019 Mar - Apr;18(6-7):708-722. Epub 2019 Mar 8.

a Laboratory of Genetics and Genomics , National Institute on Aging Intramural Research Program, National Institutes of Health , Baltimore , MD , USA.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2019.1
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http://dx.doi.org/10.1080/15384101.2019.1580496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464584PMC
April 2020

Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.

Nucleic Acids Res 2019 03;47(5):2472-2486

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/nar/gkz082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412117PMC
March 2019

RPAD (RNase R treatment, polyadenylation, and poly(A)+ RNA depletion) method to isolate highly pure circular RNA.

Methods 2019 02 2;155:41-48. Epub 2018 Nov 2.

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, MD, USA; Institute of Life Sciences, Bhubaneswar, India. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2018.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387848PMC
February 2019

Intracellular RNA-tracking methods.

Open Biol 2018 10 3;8(10). Epub 2018 Oct 3.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA

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http://rsob.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsob.180104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223214PMC
October 2018

Cooperative translational control of polymorphic BAFF by NF90 and miR-15a.

Nucleic Acids Res 2018 12;46(22):12040-12051

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1093/nar/gky866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294513PMC
December 2018

The coding potential of circRNAs.

Aging (Albany NY) 2018 09;10(9):2228-2229

Institute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, India.

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http://www.aging-us.com/article/101554/text
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http://dx.doi.org/10.18632/aging.101554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188482PMC
September 2018

Multi-leveled suppression of p53 function by HuR IncRNPs.

Noncoding RNA Investig 2018 Jan 17;2. Epub 2018 Jan 17.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.21037/ncri.2018.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108584PMC
January 2018

Identifying intronic circRNAs: progress and challenges.

Noncoding RNA Investig 2018 Jun 14;2. Epub 2018 Jun 14.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.21037/ncri.2018.05.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105274PMC
June 2018

GRSF1 suppresses cell senescence.

Aging (Albany NY) 2018 Aug;10(8):1856-1866

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.18632/aging.101516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128438PMC
August 2018

AKTions by Cytoplasmic lncRNA CASC9 Promote Hepatocellular Carcinoma Survival.

Hepatology 2018 11 11;68(5):1675-1677. Epub 2018 Oct 11.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland.

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http://doi.wiley.com/10.1002/hep.30165
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http://dx.doi.org/10.1002/hep.30165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277902PMC
November 2018

Author Correction: HuR regulates telomerase activity through TERC methylation.

Nat Commun 2018 07 10;9(1):2721. Epub 2018 Jul 10.

Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.

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http://dx.doi.org/10.1038/s41467-018-05213-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039521PMC
July 2018

SCAMP4 enhances the senescent cell secretome.

Genes Dev 2018 07;32(13-14):909-914

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.313270.118
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http://dx.doi.org/10.1101/gad.313270.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075036PMC
July 2018

HuR regulates telomerase activity through TERC methylation.

Nat Commun 2018 06 7;9(1):2213. Epub 2018 Jun 7.

Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China.

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http://dx.doi.org/10.1038/s41467-018-04617-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992219PMC
June 2018

Detection and Analysis of Circular RNAs by RT-PCR.

Bio Protoc 2018 Mar;8(6)

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland, USA.

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http://dx.doi.org/10.21769/BioProtoc.2775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891140PMC
March 2018

Regulation of Intestinal Epithelial Barrier Function by Long Noncoding RNA through Interaction with MicroRNA 29b.

Mol Cell Biol 2018 07 14;38(13). Epub 2018 Jun 14.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00010-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002690PMC
July 2018

Stress granules counteract senescence by sequestration of PAI-1.

EMBO Rep 2018 05 28;19(5). Epub 2018 Mar 28.

Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC, Canada

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http://embor.embopress.org/lookup/doi/10.15252/embr.20174472
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http://dx.doi.org/10.15252/embr.201744722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934773PMC
May 2018

α4 Coordinates Small Intestinal Epithelium Homeostasis by Regulating Stability of HuR.

Mol Cell Biol 2018 06 15;38(11). Epub 2018 May 15.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00631-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954190PMC
June 2018

Cytoplasmic functions of long noncoding RNAs.

Wiley Interdiscip Rev RNA 2018 05 8;9(3):e1471. Epub 2018 Mar 8.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1002/wrna.1471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963534PMC
May 2018

Noncoding RNAs in Alzheimer's disease.

Wiley Interdiscip Rev RNA 2018 03 12;9(2). Epub 2018 Jan 12.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1002/wrna.1463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847280PMC
March 2018

Analysis of Circular RNAs Using the Web Tool CircInteractome.

Methods Mol Biol 2018 ;1724:43-56

Laboratory of Genetics and Genomics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://link.springer.com/10.1007/978-1-4939-7562-4_4
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http://dx.doi.org/10.1007/978-1-4939-7562-4_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897125PMC
January 2019

STIM1, but not STIM2, Is the Calcium Sensor Critical for Sweat Secretion.

J Invest Dermatol 2018 03 17;138(3):704-707. Epub 2017 Oct 17.

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1016/j.jid.2017.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828914PMC
March 2018

Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195.

Gastroenterology 2018 02 16;154(3):599-611. Epub 2017 Oct 16.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland; Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811324PMC
February 2018

Senescence-Associated MicroRNAs.

Int Rev Cell Mol Biol 2017 28;334:177-205. Epub 2017 Apr 28.

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.ircmb.2017.03.008DOI Listing
April 2018

RNA-editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA.

FEBS Lett 2017 09 30;591(18):2890-2904. Epub 2017 Aug 30.

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, IL, USA.

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http://dx.doi.org/10.1002/1873-3468.12795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612911PMC
September 2017

Cooperative Repression of Insulin-Like Growth Factor Type 2 Receptor Translation by MicroRNA 195 and RNA-Binding Protein CUGBP1.

Mol Cell Biol 2017 Oct 12;37(19). Epub 2017 Sep 12.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00225-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599715PMC
October 2017

The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.

J Biol Chem 2017 09 6;292(35):14532-14543. Epub 2017 Jul 6.

the Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107,

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http://dx.doi.org/10.1074/jbc.M117.782771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582845PMC
September 2017

Polysome Fractionation to Analyze mRNA Distribution Profiles.

Bio Protoc 2017 Feb;7(3)

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, USA.

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http://dx.doi.org/10.21769/BioProtoc.2126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431591PMC
February 2017

Affinity Pulldown of Biotinylated RNA for Detection of Protein-RNA Complexes.

Bio Protoc 2016 Dec;6(24)

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, USA.

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http://dx.doi.org/10.21769/BioProtoc.2062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431594PMC
December 2016

SASP regulation by noncoding RNA.

Mech Ageing Dev 2017 12 11;168:37-43. Epub 2017 May 11.

Laboratory of Genetics and Genomics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.mad.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681880PMC
December 2017

LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis.

Oncotarget 2017 Jul;8(30):49409-49420

Laboratory of Genetics and Genomics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.18632/oncotarget.17219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564778PMC
July 2017

Overexpression of the Cytokine BAFF and Autoimmunity Risk.

N Engl J Med 2017 04;376(17):1615-1626

From Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato (M.S., V.O., M.L.I., M. Pitzalis, M. Pala, C.S., V.F., M.F., M. Deiana, I.A., E.P., A. Mulas, M.G.P., M. Lobina, S.L., Mara Marongiu, V.S., Michele Marongiu, G.S., F.B., A. Maschio, F.D., M. Dei, F.V., S.O., A.A., M.B.W., A. Meloni, S. Sanna, E.F., M.Z., F.C.), Center for Advanced Studies, Research, and Development in Sardinia, Parco Scientifico e Tecnologico della Sardegna (I.Z., M.F., R.C., G. Cuccuru), Struttura Complessa Disciplina di Ematologia e Centro Trapianto Cellule Staminali Emopoietiche Wilma Deplano, Ospedale Oncologico di Riferimento Regionale Armando Businco (M. Pani), Dipartimento di Sanità Pubblica, Medicina Clinica e Molecolare, Università di Cagliari (E.C., J.F., G. Coghe, L.L., G. Fenu), Azienda Ospedaliera Brotzu, S.C. Neurologia (P.F., M. Melis), Division of Rheumatology, University and University Hospital of Cagliari (M. Piga, A. Mathieu), Department of Medical Sciences M. Aresu, University of Cagliari (D.F., S.D.G., M.G.M.), Azienda Ospedaliera Brotzu, U.S. Gastroenterologia Pediatrica Ospedale Pediatrico Microcitemico A. Cao (M.C.), and Nephrology, Dialysis, and Transplantation Unit, Giuseppe Brotzu Hospital (A.P.), Cagliari, Dipartimento di Scienze Biomediche, Università degli Studi di Sassari (M.F., F.P., F.C.), Unit of Neurology, Department of Clinical and Experimental Medicine, University of Sassari (G. Farina, G.R.), and Servizio Trasfusionale (M.A.S.) and Clinica Medica (A.D.), Azienda Ospedaliero Universitaria di Sassari, Sassari, Neurology B, Department of Neurological, Biomedical, and Movement Sciences, University of Verona, Verona (G. Farina), Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont, Novara (N.B., S.D.), SC Neurologia, Dipartimento di Scienze Mediche, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo (M. Leone), Don C. Gnocchi Foundation IRCCS (F.R.G.), and Referral Center for Systemic Autoimmune Diseases Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico and University of Milan (M. Marchini), Milan, and Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche e Ospedali Riuniti, Ancona (M.G.D.) - all in Italy; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore (M.L.I., M.G., D.S.); the Department of Clinical Neurosciences (M.B., S. Sawcer) and JDRF-Wellcome Trust Diabetes and Inflammation Laboratory, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research (J.A.T.), University of Cambridge, Cambridge, United Kingdom; Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital Solna (I.K., I.L.B., T.O., J.H.), Institute of Environmental Medicine (L.A.) and Institute of Environmental Medicine, Unit of Immunology and Chronic Disease (M.E.A.R.), Karolinska Institute, and Center for Occupational and Environmental Medicine, Stockholm County Council (L.A.), Stockholm; Department of Functional Biology, University of Oviedo, Oviedo (A.S.), Rheumatology Department, Hospital Universitario 12 de Octubre, Madrid (P.E.C.), Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Seville (M.J.C.-P.), Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela (A.G.), and Centro de Genómica e Investigación Oncológica, Pfizer-Universidad de Granada-Junta de Andalucía, Granada (M.E.A.R.) - all in Spain; Department of Human Genetics, University of Chicago, Chicago (J.H.M., J.N.); Centro Hospitalar do Porto-Hospital Santo Antonio and Unit for Multidisciplinary Research in Biomedicine-Unidade Multidisciplinar de Investigação Biomédica, Porto, Portugal (B.M.S.); Departments of Pathology and Genetics, Stanford University, Stanford, CA (S.B.M.); and Center for Statistical Genetics, University of Michigan, Ann Arbor (G.R.A.).

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http://dx.doi.org/10.1056/NEJMoa1610528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605835PMC
April 2017

High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs.

Nucleic Acids Res 2017 Jul;45(12):e116

Laboratory of Genetics and Genomics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499592PMC
July 2017

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.

J Cell Biochem 2017 09 3;118(9):2587-2598. Epub 2017 May 3.

Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, P. R. China.

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http://doi.wiley.com/10.1002/jcb.25957
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509477PMC
September 2017

TIA-1 RRM23 binding and recognition of target oligonucleotides.

Nucleic Acids Res 2017 05;45(8):4944-4957

Monash Biomedicine Discovery Institute, Department of Biochemistry & Molecular Biology, Monash University, Victoria 3800, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416816PMC
May 2017

RNA in extracellular vesicles.

Wiley Interdiscip Rev RNA 2017 07 28;8(4). Epub 2017 Jan 28.

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474163PMC
July 2017

Mitochondrial noncoding RNA transport.

BMB Rep 2017 Apr;50(4):164-174

Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437960PMC
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April 2017

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.

RNA Biol 2017 03 12;14(3):361-369. Epub 2017 Jan 12.

a Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15476286.2017.1279788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367248PMC
March 2017

HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation.

Mol Cell Biol 2017 04 17;37(7). Epub 2017 Mar 17.

Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00574-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359429PMC
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Bioinformatic tools for analysis of CLIP ribonucleoprotein data.

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Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509467PMC
July 2017

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.

Nucleic Acids Res 2017 04;45(7):4021-4035

Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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April 2017

UNRelenting Translation UNRestrains Melanoma Migration.

Cancer Cell 2016 11;30(5):655-657

Laboratory of Genetics and Genomics, National Institute on Aging-IRP, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489341PMC
November 2016

A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA).

Aging (Albany NY) 2016 11;8(11):2971-2987

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.18632/aging.101106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191881PMC
November 2016

RT-qPCR Detection of Senescence-Associated Circular RNAs.

Methods Mol Biol 2017 ;1534:79-87

Laboratory of Genetics and Genomics, National Institute on Aging-Intramural Research Program, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/978-1-4939-6670-7_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669796PMC
January 2018

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.

Free Radic Biol Med 2016 10 8;99:225-233. Epub 2016 Aug 8.

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, 251 Bayview Blvd., Suite 100, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107118PMC
October 2016

Emerging roles and context of circular RNAs.

Wiley Interdiscip Rev RNA 2017 03 9;8(2). Epub 2016 Sep 9.

Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/wrna.1386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315638PMC
March 2017

The long and the short of TRF2 in neurogenesis.

Cell Cycle 2016 Nov 26;15(22):3026-3032. Epub 2016 Aug 26.

a Laboratory of Genetics, National Institute on Aging, National Institutes of Health , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15384101.2016.1222339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134711PMC
November 2016

Identification of neural stem cell differentiation repressor complex Pnky-PTBP1.

Stem Cell Investig 2016 7;3:10. Epub 2016 Apr 7.

Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.21037/sci.2016.03.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923653PMC
June 2016

Posttranslational control of HuR function.

Wiley Interdiscip Rev RNA 2017 01 16;8(1). Epub 2016 Jun 16.

Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://doi.wiley.com/10.1002/wrna.1372
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January 2017

RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF.

RNA Biol 2016 09 10;13(9):837-47. Epub 2016 Jun 10.

b Department of Anatomy , Physiology and Genetics, Uniformed Services University of the Health Sciences , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15476286.2016.1197484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013987PMC
September 2016

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.

Nucleic Acids Res 2016 07 1;44(13):6335-49. Epub 2016 Jun 1.

Genome Instability and Chromatin Remodeling Section, Lab of Genetics, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA

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http://dx.doi.org/10.1093/nar/gkw508DOI Listing
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July 2016

Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.

Biochim Biophys Acta 2016 09 27;1862(9):1558-69. Epub 2016 May 27.

Section of Molecular Neurogenetics, Dept. of Neurology, Building 89, 3rd floor, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany. Electronic address:

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September 2016

Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2.

Cell Rep 2016 05 21;15(5):926-934. Epub 2016 Apr 21.

Laboratory of Genetics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA. Electronic address:

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May 2016

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence.

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