Myles Brown

Myles Brown

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Myles Brown

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Deciphering essential cistromes using genome-wide CRISPR screens.

Proc Natl Acad Sci U S A 2019 Dec 14;116(50):25186-25195. Epub 2019 Nov 14.

Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1908155116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911175PMC
December 2019

Consideration of breast cancer subtype in targeting the androgen receptor.

Pharmacol Ther 2019 08 8;200:135-147. Epub 2019 May 8.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258193007
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http://dx.doi.org/10.1016/j.pharmthera.2019.05.005DOI Listing
August 2019

The Sly Oncogene: FOXA1 Mutations in Prostate Cancer.

Cancer Cell 2019 Aug;36(2):119-121

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.07.005DOI Listing
August 2019

Estrogen receptor signaling is reprogrammed during breast tumorigenesis.

Proc Natl Acad Sci U S A 2019 Jun 20;116(23):11437-11443. Epub 2019 May 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1819155116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561257PMC
June 2019

LLGL2 rescues nutrient stress by promoting leucine uptake in ER breast cancer.

Nature 2019 05 17;569(7755):275-279. Epub 2019 Apr 17.

Department of Medicine, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41586-019-1126-2
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http://dx.doi.org/10.1038/s41586-019-1126-2DOI Listing
May 2019

Pre-diagnostic sex hormone levels and survival among breast cancer patients.

Breast Cancer Res Treat 2019 Apr 2;174(3):749-758. Epub 2019 Jan 2.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s10549-018-05121-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446911PMC
April 2019

Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute.

Nat Protoc 2019 03 1;14(3):756-780. Epub 2019 Feb 1.

Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.

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http://www.nature.com/articles/s41596-018-0113-7
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http://dx.doi.org/10.1038/s41596-018-0113-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862721PMC
March 2019

A Bayesian model for single cell transcript expression analysis on MERFISH data.

Bioinformatics 2019 03;35(6):995-1001

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419903PMC
March 2019

Bag-1L: a promising therapeutic target for androgen receptor-dependent prostate cancer.

J Mol Endocrinol 2019 Mar 1. Epub 2019 Mar 1.

A Cato, Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.

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http://dx.doi.org/10.1530/JME-19-0034DOI Listing
March 2019

Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis.

Nucleic Acids Res 2019 Jan;47(D1):D729-D735

Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

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http://dx.doi.org/10.1093/nar/gky1094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324081PMC
January 2019

Improved design and analysis of CRISPR knockout screens.

Bioinformatics 2018 12;34(23):4095-4101

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247926PMC
December 2018

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

Cancer Cell 2018 12 21;34(6):939-953.e9. Epub 2018 Nov 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183048
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http://dx.doi.org/10.1016/j.ccell.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310147PMC
December 2018

Transcriptional Regulation in Prostate Cancer.

Cold Spring Harb Perspect Med 2018 11 1;8(11). Epub 2018 Nov 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a030437DOI Listing
November 2018

Enhancing Therapy: It's about Time.

Authors:
Myles Brown

Cell 2018 08;174(4):771-772

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.07.037DOI Listing
August 2018

Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies.

Cell Syst 2018 Mar 7;6(3):343-354.e5. Epub 2018 Feb 7.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA; School of Life Science and Technology, Tongji University, Shanghai 200092, China; Department of Statistics, Harvard University, Cambridge, MA 02138, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876130PMC
March 2018

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.

Cancer Cell 2018 02;33(2):173-186.e5

Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA 02210, USA; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02210, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813700PMC
February 2018

Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer.

Cancer Res 2017 11;77(21):e19-e22

Shanghai Key Laboratory of Tuberculosis, Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-0327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826647PMC
November 2017

Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1.

Endocr Relat Cancer 2017 10 15;24(10):T135-T145. Epub 2017 Aug 15.

Department of Medical OncologyDana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1530/ERC-17-0281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609455PMC
October 2017

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

Proc Natl Acad Sci U S A 2017 06 13;114(26):E5207-E5215. Epub 2017 Jun 13.

Division of Molecular and Cellular Oncology, Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1617467114
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http://dx.doi.org/10.1073/pnas.1617467114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495225PMC
June 2017

The Evolving Role of the Estrogen Receptor Mutations in Endocrine Therapy-Resistant Breast Cancer.

Curr Oncol Rep 2017 May;19(5):35

Smith Breast Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11912-017-0591-8DOI Listing
May 2017

Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells.

Proc Natl Acad Sci U S A 2017 03 27;114(11):E2186-E2194. Epub 2017 Feb 27.

Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1615015114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358377PMC
March 2017

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.

Cell Rep 2017 03;18(10):2359-2372

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston 02215, MA, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston 02215, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609449PMC
March 2017

Transcriptional landscape of the human cell cycle.

Proc Natl Acad Sci U S A 2017 03 13;114(13):3473-3478. Epub 2017 Mar 13.

Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada;

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http://dx.doi.org/10.1073/pnas.1617636114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380023PMC
March 2017

A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland.

Lab Anim 2017 Feb 9;51(1):85-88. Epub 2016 Jul 9.

1 Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1177/0023677216640706DOI Listing
February 2017

Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse.

Nucleic Acids Res 2017 01 26;45(D1):D658-D662. Epub 2016 Oct 26.

Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China

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http://dx.doi.org/10.1093/nar/gkw983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210658PMC
January 2017

Targeting transcriptional co-activators in advanced prostate cancer.

Cell Cycle 2016 12 9;15(24):3333-3334. Epub 2016 Sep 9.

c Institute of Oncology Research, Oncology Institute of Southern Switzerland , Bellinzona , Switzerland.

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http://dx.doi.org/10.1080/15384101.2016.1229019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224444PMC
December 2016

Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library.

Nat Biotechnol 2016 Dec 31;34(12):1279-1286. Epub 2016 Oct 31.

Biodynamic Optical Imaging Center (BIOPIC), Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1038/nbt.3715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592164PMC
December 2016

Modeling cis-regulation with a compendium of genome-wide histone H3K27ac profiles.

Genome Res 2016 10 27;26(10):1417-1429. Epub 2016 Jul 27.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1101/gr.201574.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052056PMC
October 2016

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.

Proc Natl Acad Sci U S A 2016 10 6;113(43):E6600-E6609. Epub 2016 Oct 6.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; Department of Medicine, Baylor College of Medicine, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1612835113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087040PMC
October 2016

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

Epigenetic remodeling regulates transcriptional changes between ovarian cancer and benign precursors.

JCI Insight 2016 Aug;1(13)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.87988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017158PMC
August 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.

Cancer Cell 2016 06 26;29(6):846-858. Epub 2016 May 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124371PMC
June 2016

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

Cell Rep 2016 06 9;15(12):2692-704. Epub 2016 Jun 9.

Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094353PMC
June 2016

Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.

Mol Cancer Res 2016 05 10;14(5):470-81. Epub 2016 Mar 10.

Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas. Department of Medicine, Baylor College of Medicine, Houston, Texas. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867274PMC
May 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

High-dimensional genomic data bias correction and data integration using MANCIE.

Nat Commun 2016 Apr 13;7:11305. Epub 2016 Apr 13.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms11305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833864PMC
April 2016

Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer.

Nat Commun 2016 Mar 15;7:10982. Epub 2016 Mar 15.

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms10982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796315PMC
March 2016

How drug resistance takes shape.

Elife 2016 03 24;5. Epub 2016 Mar 24.

Center for Functional Cancer Epigenetics and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States.

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http://dx.doi.org/10.7554/eLife.14973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821798PMC
March 2016

An Integrative Pharmacogenomic Approach Identifies Two-drug Combination Therapies for Personalized Cancer Medicine.

Sci Rep 2016 Feb 26;6:22120. Epub 2016 Feb 26.

School of Life Science and Technology, Tongji University, Shanghai 200092, China.

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http://www.nature.com/articles/srep22120
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http://dx.doi.org/10.1038/srep22120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768263PMC
February 2016

Alcohol Consumption and Risk of Breast Cancer by Tumor Receptor Expression.

Horm Cancer 2015 Dec 18;6(5-6):237-46. Epub 2015 Sep 18.

Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, 715 N Pleasant Street, Amherst, MA, 01003, USA.

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http://dx.doi.org/10.1007/s12672-015-0235-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631632PMC
December 2015

Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR.

Genome Biol 2015 Dec 16;16:281. Epub 2015 Dec 16.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.

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http://liulab.dfci.harvard.edu/publications/GenomeBiol15_281
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http://genomebiology.com/2015/16/1/281
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http://dx.doi.org/10.1186/s13059-015-0843-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699372PMC
December 2015

ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer.

Nat Rev Clin Oncol 2015 Oct 30;12(10):573-83. Epub 2015 Jun 30.

Lester &Sue Smith Breast Center and Dan L. Duncan Cancer Center, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, BCM 600, Houston, TX 77030, USA.

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http://www.nature.com/articles/nrclinonc.2015.117
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http://dx.doi.org/10.1038/nrclinonc.2015.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911210PMC
October 2015

Sequence determinants of improved CRISPR sgRNA design.

Genome Res 2015 Aug 10;25(8):1147-57. Epub 2015 Jun 10.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts 02115, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA;

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http://dx.doi.org/10.1101/gr.191452.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509999PMC
August 2015

Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L.

Nucl Recept Signal 2014 4;12:e005. Epub 2014 Nov 4.

Division of Molecular and Cellular Oncology, Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA (LC, MB) and Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany (AN, ACBC).

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http://dx.doi.org/10.1621/nrs.12005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242288PMC
June 2015

Adult body size and physical activity in relation to risk of breast cancer according to tumor androgen receptor status.

Cancer Epidemiol Biomarkers Prev 2015 Jun 8;24(6):962-8. Epub 2015 Apr 8.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-1429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452447PMC
June 2015

26th Pezcoller symposium: cancers driven by hormones.

Cancer Res 2015 Apr 18;75(7):1177-80. Epub 2015 Mar 18.

Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-14-2902DOI Listing
April 2015

Targeting the androgen receptor in breast cancer.

Curr Oncol Rep 2015 Feb;17(2)

Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.

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http://link.springer.com/10.1007/s11912-014-0427-8
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http://dx.doi.org/10.1007/s11912-014-0427-8DOI Listing
February 2015

Measuring residual estrogen receptor availability during fulvestrant therapy in patients with metastatic breast cancer.

Cancer Discov 2015 Jan 7;5(1):72-81. Epub 2014 Nov 7.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, the Netherlands.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0697DOI Listing
January 2015

Loss of estrogen-regulated microRNA expression increases HER2 signaling and is prognostic of poor outcome in luminal breast cancer.

Cancer Res 2015 Jan 11;75(2):436-45. Epub 2014 Nov 11.

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-1041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297564PMC
January 2015

PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.

Cancer Discov 2014 Dec 24;4(12):1430-47. Epub 2014 Sep 24.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Genetics, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258125PMC
December 2014

Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer.

Cancer Epidemiol Biomarkers Prev 2014 Oct 12;23(10):2027-31. Epub 2014 Jun 12.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184923PMC
October 2014

Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen.

Mol Endocrinol 2014 Aug 3;28(8):1337-51. Epub 2014 Jul 3.

Molecular Cardiology Research Institute (F.K.G., C.S.V., L.I.K., G.R.S.), Tufts Medical Center, Boston, Massachusetts 02111; and Medical Oncology Department (M.W. M.B.), Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/me.2013-1395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116586PMC
August 2014

Refined DNase-seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification.

Nat Methods 2014 Jan 8;11(1):73-78. Epub 2013 Dec 8.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nmeth.2762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018771PMC
January 2014