Muthu K Shanmugam

Muthu K Shanmugam

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Focus on Formononetin: Anticancer Potential and Molecular Targets.

Cancers (Basel) 2019 May 1;11(5). Epub 2019 May 1.

Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA.

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https://www.mdpi.com/2072-6694/11/5/611
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http://dx.doi.org/10.3390/cancers11050611DOI Listing
May 2019

Targeting autophagy using natural compounds for cancer prevention and therapy.

Cancer 2019 Apr 12;125(8):1228-1246. Epub 2019 Feb 12.

Lake Erie College of Osteopathic Medicine, Bradenton, Florida.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.31978
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http://dx.doi.org/10.1002/cncr.31978DOI Listing
April 2019

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

Pharmacol Res 2019 Apr 17;144:192-209. Epub 2019 Apr 17.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.04.004DOI Listing
April 2019

Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor-negative breast cancer cells.

J Cell Biochem 2019 Mar 27;120(3):4504-4513. Epub 2018 Sep 27.

Radiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/jcb.27738DOI Listing
March 2019

Role of Natural Products in Modulating Histone Deacetylases in Cancer.

Molecules 2019 Mar 16;24(6). Epub 2019 Mar 16.

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://dx.doi.org/10.3390/molecules24061047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471757PMC
March 2019

Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model.

Cancers (Basel) 2019 Jan 7;11(1). Epub 2019 Jan 7.

Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://www.mdpi.com/2072-6694/11/1/49
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http://dx.doi.org/10.3390/cancers11010049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356594PMC
January 2019

Role of RNF20 in cancer development and progression - a comprehensive review.

Biosci Rep 2018 08 12;38(4). Epub 2018 Jul 12.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600 Singapore

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http://dx.doi.org/10.1042/BSR20171287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043722PMC
August 2018

Potential role of genipin in cancer therapy.

Pharmacol Res 2018 07 24;133:195-200. Epub 2018 May 24.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.05.007DOI Listing
July 2018

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.

Pharmacol Res 2018 07 21;133:213-214. Epub 2018 May 21.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6009, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183066
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http://dx.doi.org/10.1016/j.phrs.2018.05.004DOI Listing
July 2018

Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.

Biomedicines 2018 Jul 27;6(3). Epub 2018 Jul 27.

Institute of Molecular and Cellular Biology (A*STAR), 61 Biopolis Drive, Singapore 138673, Singapore.

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http://dx.doi.org/10.3390/biomedicines6030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163404PMC
July 2018

Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer.

Curr Vasc Pharmacol 2017 ;15(6):503-519

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6009. Australia.

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http://www.eurekaselect.com/154180/article
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http://dx.doi.org/10.2174/1570161115666170713094319DOI Listing
May 2018

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review.

Nutrients 2018 05 19;10(5). Epub 2018 May 19.

Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, 18301 N. Miami Avenue, Miami, FL 33169, USA.

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http://dx.doi.org/10.3390/nu10050645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986524PMC
May 2018

Corrigendum on "Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer" [Cancer Lett. 363 (1) (2015) 28-36].

Cancer Lett 2018 04 17;420:259. Epub 2018 Jan 17.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA 6845, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.01.003DOI Listing
April 2018

Correction: Role of novel histone modifications in cancer.

Oncotarget 2018 Apr 10;9(27):19460. Epub 2018 Apr 10.

Institute of Molecular and Cell Biology, ASTAR, Biopolis Drive, Proteos, Singapore, Singapore.

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http://dx.doi.org/10.18632/oncotarget.25152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922411PMC
April 2018

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.

Pharmacol Res 2018 03 21;129:357-364. Epub 2017 Nov 21.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.11.023DOI Listing
March 2018

The Application of Embelin for Cancer Prevention and Therapy.

Molecules 2018 03 9;23(3). Epub 2018 Mar 9.

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://dx.doi.org/10.3390/molecules23030621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017120PMC
March 2018

Role of novel histone modifications in cancer.

Oncotarget 2018 Feb 17;9(13):11414-11426. Epub 2017 Dec 17.

Institute of Molecular and Cell Biology, ASTAR, Biopolis Drive, Proteos, Singapore, Singapore.

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http://dx.doi.org/10.18632/oncotarget.23356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834259PMC
February 2018

Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics.

Drug Discov Today 2017 12 5;22(12):1765-1781. Epub 2017 Aug 5.

Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore; National University Cancer Institute, National University Health System, 119074, Singapore; Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA 6102, Australia; Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2017.08.001DOI Listing
December 2017

SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma.

Biosci Rep 2017 Dec 15;37(6). Epub 2017 Dec 15.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore

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http://dx.doi.org/10.1042/BSR20171270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435460PMC
December 2017

The Role of Resveratrol in Cancer Therapy.

Int J Mol Sci 2017 Dec 1;18(12). Epub 2017 Dec 1.

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://dx.doi.org/10.3390/ijms18122589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751192PMC
December 2017

Butein and Its Role in Chronic Diseases.

Adv Exp Med Biol 2016 ;928:419-433

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.

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http://dx.doi.org/10.1007/978-3-319-41334-1_17DOI Listing
June 2017

Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma.

Target Oncol 2017 02;12(1):1-10

Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, 18301 N. Miami Avenue, Miami, FL, 33169, USA.

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http://dx.doi.org/10.1007/s11523-016-0452-7DOI Listing
February 2017

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds.

Semin Cancer Biol 2016 10 30;40-41:35-47. Epub 2016 Mar 30.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Western Australia 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2016.03.005DOI Listing
October 2016

Targeting transcription factor STAT3 for cancer prevention and therapy.

Pharmacol Ther 2016 06 12;162:86-97. Epub 2016 Feb 12.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2015.10.004DOI Listing
June 2016

Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics.

Pharmacol Ther 2016 06 22;162:98-119. Epub 2016 Jan 22.

Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.01.011DOI Listing
June 2016

ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation.

Oncotarget 2016 May;7(19):27007-20

Department of Physiology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore (NUS), Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053628PMC
http://dx.doi.org/10.18632/oncotarget.8875DOI Listing
May 2016

Potential role of targeted therapies in the treatment of triple-negative breast cancer.

Anticancer Drugs 2016 Mar;27(3):147-55

aDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore bSchool of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, Perth, Western Australia, Australia cDepartment of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, Florida, USA.

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http://dx.doi.org/10.1097/CAD.0000000000000328DOI Listing
March 2016

Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs.

Bioorg Med Chem Lett 2016 Feb 10;26(3):1056-1060. Epub 2015 Dec 10.

Department of Studies in Chemistry, Manasagangotri, University of Mysore, Mysore 570006, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.12.026DOI Listing
February 2016

Ageing and the telomere connection: An intimate relationship with inflammation.

Ageing Res Rev 2016 Jan 23;25:55-69. Epub 2015 Nov 23.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, WA, Australia; Memory, Aging and Cognition Centre, National University Health System, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2015.11.006DOI Listing
January 2016

Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model.

Mol Carcinog 2015 Oct 3;54(10):971-85. Epub 2014 May 3.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1002/mc.22166DOI Listing
October 2015

N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma.

ChemMedChem 2015 Sep 21;10(9):1548-58. Epub 2015 Jul 21.

Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543 (Republic of Singapore).

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http://dx.doi.org/10.1002/cmdc.201500235DOI Listing
September 2015

Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer.

Cancer Lett 2015 07 28;363(1):28-36. Epub 2015 Mar 28.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA 6845, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.03.033DOI Listing
July 2015

Analysis of the intricate relationship between chronic inflammation and cancer.

Biochem J 2015 May;468(1):1-15

*Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1042/BJ20141337DOI Listing
May 2015

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3.

Mol Oncol 2015 Apr 5;9(4):818-33. Epub 2015 Jan 5.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Western Australia 6009, Australia. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2014.12.008
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http://dx.doi.org/10.1016/j.molonc.2014.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528777PMC
April 2015

The multifaceted role of curcumin in cancer prevention and treatment.

Molecules 2015 Feb 5;20(2):2728-69. Epub 2015 Feb 5.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.3390/molecules20022728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272781PMC
February 2015

Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence.

Cancer Lett 2014 May 30;346(2):206-16. Epub 2014 Jan 30.

Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004441PMC
May 2014

Role of epigenetics in inflammation-associated diseases.

Subcell Biochem 2013 ;61:627-57

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1007/978-94-007-4525-4_27DOI Listing
February 2014

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.

Cancer Lett 2013 Dec 17;341(2):139-49. Epub 2013 Aug 17.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.canlet.2013.08.023DOI Listing
December 2013

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.

Br J Pharmacol 2013 Oct;170(4):807-21

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Molecular Toxicology Lab, Department of Biotechnology, Bharathiar University, Coimbatore, India.

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http://dx.doi.org/10.1111/bph.12302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799595PMC
October 2013

Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma.

Cancer Prev Res (Phila) 2013 Aug 26;6(8):843-54. Epub 2013 Jun 26.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1158/1940-6207.CAPR-13-0070DOI Listing
August 2013

Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies.

Biochem Pharmacol 2013 Jun 13;85(11):1579-87. Epub 2013 Mar 13.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.bcp.2013.03.006DOI Listing
June 2013

Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer.

Biochem Pharmacol 2012 Nov 27;84(10):1268-76. Epub 2012 Jul 27.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.bcp.2012.07.015DOI Listing
November 2012

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer.

Cancer Lett 2012 Jul 7;320(2):158-70. Epub 2012 Mar 7.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.canlet.2012.02.037DOI Listing
July 2012

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.

Clin Cancer Res 2012 Apr 20;18(8):2220-9. Epub 2012 Feb 20.

Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute of Singapore, National University of Singapore.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2470DOI Listing
April 2012

Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.

Eur J Pharmacol 2012 Mar 20;679(1-3):109-16. Epub 2012 Jan 20.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.

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http://linkinghub.elsevier.com/retrieve/pii/S001429991200051
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http://dx.doi.org/10.1016/j.ejphar.2012.01.002DOI Listing
March 2012

Multifaceted link between cancer and inflammation.

Biosci Rep 2012 Feb;32(1):1-15

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://bioscirep.org/cgi/doi/10.1042/BSR20100136
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http://dx.doi.org/10.1042/BSR20100136DOI Listing
February 2012

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.

Int J Cancer 2011 Oct 20;129(7):1552-63. Epub 2011 Jul 20.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.

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http://dx.doi.org/10.1002/ijc.26120DOI Listing
October 2011

Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer.

Nutr Cancer 2011 ;63(2):161-73

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://www.tandfonline.com/doi/abs/10.1080/01635581.2011.523
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http://dx.doi.org/10.1080/01635581.2011.523502DOI Listing
June 2011

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.

Br J Pharmacol 2011 May;163(2):283-98

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/j.1476-5381.2010.01187.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087132PMC
May 2011

Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.

Cancer Lett 2011 Apr 17;303(1):9-20. Epub 2010 Dec 17.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.canlet.2010.10.025DOI Listing
April 2011

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.

Clin Cancer Res 2011 Mar 3;17(6):1425-39. Epub 2010 Dec 3.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1123DOI Listing
March 2011

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.

Biochem Pharmacol 2010 Nov 10;80(10):1553-62. Epub 2010 Aug 10.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.bcp.2010.07.045DOI Listing
November 2010