Publications by authors named "Mustafa Aksoy"

49 Publications

Evaluation of Inner Ear and Hearing Functions in Lichen Planus Patients.

J Cosmet Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Harran University, Faculty of Medicine, Department of Dermatology, Sanliurfa, Turkey.

Objective: Lichen planus (LP), which affects skin, nails, hair, and mucosal surfaces, is a chronic, autoimmune, andinflammatorydisease, and autoimmune diseases may affect the inner ear. This studyaims to investigate hearing and inner ear functions of the LP patients.

Material And Methods: The present study was formed by 49 patients who were clinically and histopathologically diagnosed with LP and did not receive any treatment. The healthy group consisted of 52 healthy individuals. Pure tone audiometry (PTA) and distortion product otoacoustic emission tests were used in the hearing evaluation.

Results: At frequencies of 1, 2, 4, 6, and 8 kHz in the right ear and 0.5, 1, 2, 4, 6, and 8 kHz in the left ear in PTA, the lichen group's hearing thresholds were higher than the healthy group's.Upon comparing the hearing thresholds of LP patients with oral mucosa involvement and LP patients without oral mucosa involvement, there were significant differences between the groups at 1, 4, and 8 kHz in the right ear and at 0.25, 0.5, 2, 4, 6, and 8 kHz inthe left ear.

Conclusion: Because of the increasing hearing thresholds,we think that hearing and inner ear functions of LP patients, particularly with oral mucosal involvement, are negatively affected.
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http://dx.doi.org/10.1111/jocd.14124DOI Listing
April 2021

Comparison of refractive outcomes using Scheimpflug Holladay equivalent keratometry or IOLMaster 700 keratometry for IOL power calculation.

Int Ophthalmol 2021 Mar 17. Epub 2021 Mar 17.

Department of Ophthalmology, Faculty of Medicine, Başkent University, Ankara, Turkey.

Purpose: This study aims to compare postoperative refractive error results using Pentacam (Oculus Optikgeräte GmbH) Holladay equivalent keratometry readings (EKR) or IOLMaster 700 (Carl Zeiss Meditec AG) keratometry (K) values in IOL power calculation.

Material And Methods: This retrospective study included 54 eyes of 31 patients who underwent cataract surgery. Preoperative biometric measurements of all patients were obtained using IOLMaster 700 followed by Pentacam measurements. IOLMaster 700 K measurements on horizontal (K1) and vertical (K2) axes and EKR measurements on 2 mm (EKR2mm), 3 mm (EKR3mm) and 4.5 mm (EKR4.5 mm) corneal zones were recorded. EKR4.5 mm value and IOLMaster 700 K values were used in Holladay-II, SRK/T, Haigis, and Hoffer-Q formulas to calculate predictive refractive error (PRE). Absolute refractive error (ARE) was calculated as the absolute difference between actual postoperative refractive error (APRE) and PRE values.

Results: Mean age was 72.2 ± 8.3 (51-87) years and mean IOL power was 21.5 ± 2.9 D (18-23 D). There was no significant difference between PRE values when IOLMaster 700 K measurements and EKR4.5 mm K measurements were used in Holladay-II, SRK/T, Haigis, and Hoffer-Q formulas (p = 0.571, p = 0.833, p = 0.165, p = 0.347, respectively). There was no significant difference between APRE and ARE values (p = 0.124). According to mean ARE results, the closest estimate was achieved when the IOLMaster 700 K values were used in the Holladay-II formula (p = 0.271).

Conclusion: IOLMaster 700 K measurement and Pentacam EKR4.5 mm measurements can be used interchangeably. IOLMaster 700 K values yielded the most predictive measurement of the refractive result using the Holladay-II formula.
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http://dx.doi.org/10.1007/s10792-021-01781-6DOI Listing
March 2021

The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study.

Int J Clin Pract 2021 Feb 24:e14114. Epub 2021 Feb 24.

Department of Dermatology, Van Training and Research Hospital, Van, Turkey.

Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients receiving secukinumab treatment for psoriasis vulgaris (PV).

Materials And Methods: In this retrospective study, we evaluated the laboratory results of 40 patients who were followed up with a diagnosis of PV and received secukinumab treatment in three different dermatology clinics between July 2018 and September 2019.

Results: Neutrophil count and leukocyte count were significantly decreased after secukinumab treatment. (P < .001) There was no statistically significant difference between lymphocyte count, platelet count, MPV, NLR and PLR values before treatment and at the 4th month of treatment (P values .230, .065, .110, .915 and .365, respectively).

Conclusion: In conclusion, it can be concluded that parameters such as NLR, PLR and MPV are not suitable parameters for monitoring the effects of secukinumab treatment on inflammation.
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http://dx.doi.org/10.1111/ijcp.14114DOI Listing
February 2021

Evaluation of thiol/disulphide balance in patients with cutaneous leishmaniasis.

Int J Clin Pract 2021 Feb 11:e14087. Epub 2021 Feb 11.

Department of Physiology, Harran University Medical Faculty, Şanlıurfa, Turkey.

Objective: The aim of this study was to evaluate serum thiol disulphide levels in patients with cutaneous leishmaniasis (CL) compared with a healthy control group and to investigate whether thiol/disulphide balance can be used as a new marker of oxidative stress in CL patients.

Material And Methods: This prospective study included 47 patients diagnosed with CL and 46 healthy individuals without any disease. Native thiol, disulphide and total thiol levels were used in plasma. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured.

Results: Disulphide, native thiol disulphide and total thiol disulphide levels were significantly lower in CL patients compared with the control group. However, there was no statistically significant difference between CL patients and the control group in terms of disulphide/native thiol, disulphide/total thiol and native thiol/total thiol values.

Conclusion: Based on the data in our study, it can be said that the use of thiol/disulphide balance as a new oxidative stress marker in CL patients is not appropriate, but studies with a larger number of patients are needed.
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http://dx.doi.org/10.1111/ijcp.14087DOI Listing
February 2021

Retinal nerve fibre layer thickness and choroidal thickness: An evaluation in psoriasis patients.

Int J Clin Pract 2021 Apr 18;75(4):e13904. Epub 2020 Dec 18.

Department of Dermatolog, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey.

Background/objectives: To conduct a comparative study of retinal nerve fibre layer (RNFL) thickness and choroidal thickness of psoriasis patients and healthy volunteers.

Methods: This study included 35 severe psoriasis patients, 35 mild psoriasis patients and 35 healthy individuals. RNFL and choroidal thickness analysis were performed by spectral field optical coherence tomography (SD-OCT). Only patients with psoriasis vulgaris who have not used systemic therapy for the last 3 months were included in the study.

Results: In the severe psoriasis group, the RSLT thickness was found to be statistically significantly thinner and the choroid thickness was thicker than the mild psoriasis and control group (P < .001). There was no significant difference in terms of RNLF and choroid thickness compared to mild psoriasis and the control group (P > .05). The correlation between length of the disease duration, RNFL and choroidal thickness was not significant (P > 0,05).

Conclusion: The increase in choroidal thickness was found to be significant, while with respect to RNFL thickness, a decrease was evident, a possible indicator of damage to microvascular structures in the choroid and ganglion cells, especially in patients with severe psoriasis. Therefore, choroidal and RSLT thickness measurement with OCT device can assist in the detection of damage to psoriasis.
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http://dx.doi.org/10.1111/ijcp.13904DOI Listing
April 2021

Evaluation of inflammatory parameters in patients with cutaneous leishmaniasis.

Dermatol Ther 2021 Jan 7;34(1):e14603. Epub 2020 Dec 7.

Department of Microbiology, Harran University Medical Faculty, Sanlıurfa, Turkey.

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease characterized by various skin lesions that can cause deformities when healed. Our aim in this study is to show the utility of parameters such as neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio (TLR), and mean thrombocyte volume (MTV) as auxiliary laboratory methods in CL patients. About 107 patients who were admitted to our dermatological and venereal diseases outpatient clinic between January 2018 and January 2019 and were diagnosed with CL by microscopic examination and 74 healthy individuals were included in the study. There were no significant differences between the patient and control group in terms of neutrophil counts, leukocyte counts, platelet counts, and NLR values (P values: .271, .053, .263, and .459, respectively). When the TLR and MTV values of patients with CL and those of the healthy controls were compared, it was found that TLR and MTV values were statistically higher in patients with CL (P values of .010 and .044, respectively). Based on these data, NLR was not considered to be a suitable parameter for demonstrating inflammation in CL patients, but TLR and MTV were held to be an appropriate parameter for demonstrating inflammation in CL patients. In addition, we think that the increase in MTV and TLR, can be used as an auxiliary laboratory test in the diagnosis of CL disease.
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http://dx.doi.org/10.1111/dth.14603DOI Listing
January 2021

Choroidal Vascularity Index in Patients with Type-1 Diabetes Mellitus without Diabetic Retinopathy.

Curr Eye Res 2020 Nov 17:1-6. Epub 2020 Nov 17.

Department of Endocrinology and Metabolism, Afyonkarahisar University of Health Sciences , Afyonkarahisar, Turkey.

: This study aims to assess choroidal vascularity index (CVI) and choroidal thickness (CT) in patients diagnosed with type 1 diabetes mellitus (DM) and compare them with healthy control subjects. : This retrospective and cross-sectional study includes 43 patients diagnosed with type 1 DM and 43 healthy age/gender-matched subjects as the control group. Enhanced depth imaging optical coherence tomography (EDI-OCT; Spectralis, Heidelberg Engineering GmbH, Heidelberg, Germany) images of all participants were analyzed. CT measurements of five different points (subfoveal, 500 µm temporal, 1500 µm temporal, 500 µm nasal, and 1500 µm nasal to the fovea) were obtained. Choroid images were divided into luminal (LA) and stromal areas (SA) determined by image binarization method. Choroidal vascularity index (CVI) was defined as the ratio of LA to total choroid area (TCA). The effects of age, HbA1c, fasting plasma glucose, duration of DM, mean blood pressure, intraocular pressure, and axial length measurements on CVI were investigated. : There was no significant difference between any of the CT measurements of the groups (all > .05). There was no significant difference between the groups according to TCA (0.82 ± 0.24 vs. 0.80 ± 0.19; = .065), LA (0.54 ± 0.17 vs. 0.55 ± 0.16; = .123) and SA (0.28 ± 0.06 vs. 0.25 ± 0.07; = .068). However, patients had significantly lower CVI compared to control subjects (66.07 ± 3.19 vs. 68.89 ± 2.85, < .001). Univariate linear regression model revealed that there was a negative correlation between disease duration and CVI (standardized beta coefficient: -0.416, = .006). : According to our findings, reduced CVI may indicate subclinical dysfunction in choroid of patients with type 1 DM.
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http://dx.doi.org/10.1080/02713683.2020.1846755DOI Listing
November 2020

Evaluation of inflammatory parameters in lipoid proteinosis patients.

Dermatol Ther 2020 11 8;33(6):e14495. Epub 2020 Nov 8.

Sanlıurfa Training and Research Hospital, Department of Dermatology, Sanlıurfa, Turkey.

Lipoid proteinosis (LP) is a rare metabolic storage disease characterized by the storage of hyaline-like substances in the skin, mucosa, and many other organs. The aim of this study was to compare the neutrophil/lymphocyte ratio (NLR), platelets/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of LP patients with healthy control group and to determine the usefulness of these parameters in determining the inflammatory status in LP patients. This study included 14 patients who were admitted to our clinic between March 2013 and January 2017 and diagnosed as LP with clinical, radiological, and histopathological examinations with 14 individuals who had no systemic inflammatory disease or malignancy and has a hemogram result. There was no statistically significant difference between the two groups in comparison to the MPV and PLR values of the patients with LP and healthy controls (P values 0.666 and 0.654, respectively). When the NLR values of the patients with LP and healthy controls were compared, it was found that the LP-diagnosed NLR values were statistically higher. (P: 0.019). In conclusion, it can be said that NLR is an appropriate parameter in demonstrating inflammation in LP patients, but PLR and MPV are not a suitable parameter in demonstrating inflammation in LP patients. Prospective studies with more patients are needed.
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http://dx.doi.org/10.1111/dth.14495DOI Listing
November 2020

Atypical and unusual morphological variants of cutaneous leishmaniasis.

Int J Clin Pract 2020 Oct 26:e13730. Epub 2020 Oct 26.

Department of Pathology, Harran University Medical Faculty, Sanliurfa, Turkey.

Objective: Cutaneous leishmaniasis (CL) is a skin disease characterised by prolonged nodulo-ulcerative lesions of the skin that heals with atrophic scar. Clinical features of CL vary depending on the type of parasite and host immune resistance. The aim of this study was to investigate the clinical features of atypical and unusual morphological variants of CL patients diagnosed in our clinic.

Materials And Methods: In this prospective study, 27 CL patients with atypical clinical features among 486 patients admitted to our clinic between July 2018 and September 2019 and diagnosed as CL by slit-skin smear examination or histopathological examination were included.

Results: Of 27 patients, 15 (55.5%) were male and 12 (44.5%) were female. The mean age of the patients was 25.8 ± 7.62 years. Seven (25.9%) patients had lupoid lesions, five (18.6%) patients had eczematoid lesions, four (14.8%) patients had lip lesions, three (11.1%) patients had erysipelas-like lesions, two (7.4%) patients had eyelid lesions, two (7.4%) patients had sporotrichoid lesions, two (7.4%) patients had verrucous lesions, one (3.7%) patient had psoriasiform lesion and one (3.7%) patient had paronychial lesion.

Conclusion: In conclusion, rare clinical forms of CL are presented in this study. It should be kept in mind that CL may have very different clinical features and should be considered in the differential diagnosis of eczema, psoriasis, erysipelas, sporotrichosis, paronychia and verrucous lesions.
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http://dx.doi.org/10.1111/ijcp.13730DOI Listing
October 2020

Microwave Radiometer Instability Due to Infrequent Calibration.

IEEE J Sel Top Appl Earth Obs Remote Sens 2020 ;13

National Aeronautics and Space Administration, Greenbelt, MD 20771 USA.

We directly quantify the effect of infrequent calibration on the stability of microwave radiometer temperature measurements (where a power measurement for the unknown source is acquired at a fixed time, but calibration data are acquired at variable earlier times) with robust and nonrobust implementations of a new metric. Based on our new metric, we also determine a component of uncertainty in a single measurement due to infrequent calibration effects. We apply our metric to experimental data acquired from experimental ground-based calibration data acquired from a NASA millimeter-wave imaging radiometer and a NIST radiometer (Noise Figure Radiometer-NFRad). Based on a stochastic model for the NFRad, we determine the random uncertainty of an empirical prediction model of our stability metric by a Monte Carlo method. For comparison purposes, we also present a secondary metric that quantifies stability for the case where calibration data are acquired at a fixed time, but power measurements for the unknown source are acquired at variable later times.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579836PMC
January 2020

Effects of disease severity on quality of life in patients with psoriasis.

Dermatol Ther 2020 11 27;33(6):e14422. Epub 2020 Oct 27.

Department of Dermatology and Venereology, Medical Faculty, Harran University, Turkey.

Psoriasis is one of the leading dermatological diseases that can result in degradation in quality of life (QOL). We aimed to evaluate the effects of disease severity on QOL in psoriasis patients living in our region. Fifty-nine female and 41 male patients diagnosed with psoriasis were included in the study. The Psoriasis Area Severity Index (PASI) was used to determine disease severity. The Psoriasis Quality of Life Questionnaire (PQLQ) was used to evaluate QOL. The mean PASI score was 14.3 ± 10.1. The PQLQ and subscale scores were not affected by age, marital status, educational status, or age at onset of the disease etc. parameters (P > .05). Additional drug use, joint involvement, and lesion site exposure were found to increase psychosocial negativity scores significantly (P < .05). The mean scores for difficulties in daily life and treatment problems were significantly higher in men than in women (P < .05). There was a positive correlation between PASI scores and PQLQ, PQLQ subgroup scores. We found that QOL decreased with increasing severity of the disease. QOL as well as clinical severity should be considered in the planning and follow-up of psoriasis treatment. To evaluate the QOL, we believe that the PQLQ can be used as demonstrated in our study.
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http://dx.doi.org/10.1111/dth.14422DOI Listing
November 2020

Trace elements and oxidative stress status in patients with psoriasis.

Postepy Dermatol Alergol 2020 Jun 7;37(3):333-339. Epub 2020 Apr 7.

Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.

Introduction: Psoriasis is a common, inflammatory skin disease of which etiopathogenesis is still not explained clearly, however in which trace elements and oxidative stress are considered to play a role.

Aim: To evaluate the serum trace element and oxidative stress levels in patients diagnosed with psoriasis.

Material And Methods: A total of 87 psoriasis patients and 60 healthy subjects were included in the study. Serum sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), selenium (Se), zinc (Zn), copper (Cu) levels, oxidative stress parameters, ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO) and ferroxidase (FOX) activity and an inflammatory marker, C-reactive protein (CRP), were examined in all participants.

Results: IMA, IMA/Albumin (IMA/Alb), CAT, Cu, FOX and CRP levels were found to be significantly higher; Se, Zn and albumin levels were significantly lower in the patient group as compared to the control group. No significant difference was found between groups with regard to Na, K, Ca, P, Mg, Fe and MPO levels.

Conclusions: Some trace element levels and oxidant-antioxidant balance were changed in psoriasis patients.
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http://dx.doi.org/10.5114/ada.2020.94265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394161PMC
June 2020

Analysis of Nonstationary Radiometer Gain Using Ensemble Detection.

IEEE J Sel Top Appl Earth Obs Remote Sens 2020 ;13:2807-2818

University at Albany, State University of New York, Albany, NY 12222 USA.

Radiometer gain is generally a nonstationary random process, even though it is assumed to be strictly or weakly stationary. Since the radiometer gain signal cannot be observed independently, analysis of its nonstationary properties would be challenging. However, using the time series of postgain voltages to form an ensemble set, the radiometer gain may be characterized via radiometer calibration. In this article, the ensemble detection algorithm is presented by which the unknown radiometer gain can be analytically characterized when it is following a Gaussian model (as a strictly stationary process) or a 1st order autoregressive, AR(1) model (as a weakly stationary process). In addition, in a particular radiometer calibration scheme, the nonstationary gain can also be represented as either Gaussian or AR(1) process, and parameters of such an equivalent gain model can be retrieved. However, unlike stationary or weakly stationary gain, retrieved parameters of the Gaussian and AR(1) processes, which describe the nonstationary gain, highly depend on the calibration setup and timings.
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http://dx.doi.org/10.1109/jstars.2020.2993765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393976PMC
January 2020

Peri-operative blood transfusion in elective major surgery: incidence, indications and outcome - an observational multicentre study.

Authors:
Dilek Unal Yesim Senayli Reyhan Polat Donat R Spahn Fevzı Toraman Neslıhan Alkis Alanoglu Zekeriyya Aydinli Bahar Bermede Ahmet Onat Bilgin Hulya Buget Mehmet Coskunfirat Nesil Demir Asli Goren Suna Guner Can Meltem Orhan Mukadder Senturk Mert Tezcan Busra Toprak Huseyin Ilksen Yildirim Guclu Cigdem Abitagaoglu Suheyla Abut Yesim Akdaglı Ekici Arzu Akdas Tekin Esra Akdogan Ali Akin Mine Akovali Nukhet Aksoy Semsi Mustafa Alaygut Ergin Arar Makbule Cavidan Arican Sule Arici Ayse Gulbin Arik Emine Arik Esma Arslan Mahmut Ay Necmiye Aykac Zuhal Ayoglu Hilal Basaran Cumhur Baytas Volkan Bedirli Nurdan Bestas Azize Bigat Zekiye Bilgin Mehmet Ugur Boran Omer Faruk Buyukcoban Sibel Cakar Turhan Sanem Cakmak Meltem Cankaya Baris Capar Ayse Cebeci Zubeyir Cetinkaya Ethemoglu Filiz Banu Cicekci Faruk Colak Alkin Colak Yusuf Ziya Dagli Esra Demir Hafize Fisun Derbent Abdurrahim Dumanlı Ozcan Ayca Ekinci Osman Erdogan Kayhan Gulay Erturk Engin Erus Ipek Esen Tekeli Arzu Gamli Mehmet Gulel Basak Gulgun Gamze Gunduz Emel Gunes Isin Guven Aytac Betul Hacibeyoglu Gulcin Has Selmi Nazan Ilgaz Kocyigit Ozgen Ilksen Egilmez Ayse Iyigun Muzeyyen Kara Inci Karakaya Deniz Karasu Derya Karaveli Arzu Kavas Ayse Duygu Kaya Mensure Kaya Suleyman Kazak Bengisun Zuleyha Keskin Gulsen Kilci Oya Kilic Yeliz Kirdemir Pakize Koc Zeynep Koksal Ceren Kozanhan Betul Kucukguclu Semih Kucukosman Gamze Kupeli Ilke Kurtay Aysun Kurtipek Omer Meco Basak Ceyda Nalbant Burak Okyay Rahsan Dilek Omur Dilek Orak Yavuz Ounde Elif Özayar Esra Ozcelik Menekse Ozden Eyup Sabri Ozer Yetkin Ozgok Aysegul Ozhan Mehmet Ozgur Ozlu Onur Sagir Ozlem Saglik Arzu Sagun Aslinur Sahap Mehmet Sahin Cihan Sahiner Yeliz Salman Nevriye Saracoglu Ayten Saracoglu Kemal Tolga Sarizeybek Hilal Selcuk Sert Gokce Sen Betul Sen Ozlem Sener Elif Bengi Sengul Fatma Isil Silay Emin Subası Ferhunde Dilek Tarikci Kilic Ebru Tas Nilay Tekgul Zeki Tuncel Tekgunduz Sibel Tezcan Keles Gonul Topcu Hulya Tunay Abdurrahman Ugun Fatih Un Canan Unal Petek Unver Suheyla Ural Sedef Gulcin Uzumcugil Filiz Yerebakan Akesen Selcan Yesildal Kadir Yildirim Mustafa Yildiz Altun Aysun Yildiz Munise Yilmaz Erisen Hatice Yilmaz Hakan Yilmaz Mehmet Yuzkat Nureddin

Blood Transfus 2020 07;18(4):261-279

Department of Anaesthesiology and Reanimation, Van Yuzuncu Yil University Medical Faculty Dursun Odabası Medical Center, Van, Turkey.

Background: Patients' demographic and epidemiological characteristics, local variations in clinicians' knowledge and experience and types of surgery can influence peri-operative transfusion practices. Sharing data on transfusion practices and recipients may improve patients' care and implementation of Patient Blood Management (PBM).

Materials And Methods: This was a multicentre, prospective, observational, cross-sectional study that included 61 centres. Clinical and transfusion data of patients undergoing major elective surgery were collected; transfusion predictors and patients' outcomes were analysed.

Results: Of 6,121 patients, 1,579 (25.8%) received a peri-operative transfusion. A total of 5,812 blood components were transfused: red blood cells (RBC), fresh-frozen plasma and platelets in 1,425 (23.3%), 762 (12.4%) and 88 (1.4%) cases, respectively). Pre-operative anaemia was identified in 2,019 (33%) patients. Half of the RBC units were used by patients in the age group 45-69 years. Specific procedures with the highest RBC use were coronary artery bypass grafting (16.9% of all units) and hip arthroplasty (14.9%). Low haemoglobin concentration was the most common indication for intra-operative RBC transfusion (57%) and plasma and platelet transfusions were mostly initiated for acute bleeding (61.3% and 61.1%, respectively). The RBC transfusion rate in study centres varied from 2% to 72%. RBC transfusion was inappropriate in 99% (n=150/151) of pre-operative, 23% (n=211/926) of intra-operative and 43% (n=308/716) of post-operative RBC transfusion episodes. Pre-operative haemoglobin, increased blood loss, open surgery and duration of surgery were the main independent predictors of intra-operative RBC transfusion. Low pre-operative haemoglobin concentration was independently associated with post-operative pulmonary complications.

Conclusions: These findings identified areas for improvement in peri-operative transfusion practice and PBM implementation in Turkey.
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http://dx.doi.org/10.2450/2020.0011-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375885PMC
July 2020

Cutaneous Leishmaniasis due to Three Leishmania Species Among Syrian Refugees in Sanliurfa, Southeastern Turkey.

Acta Parasitol 2020 Dec 16;65(4):936-948. Epub 2020 Jun 16.

Ministry of Health, Health Sciences University, Van Training and Research Hospital, Dermatology Clinic, Van, Turkey.

Sanliurfa, a city in southeastern Turkey, is host to 477,166 Syrian refugees. The incidence of cutaneous leishmaniasis (CL) may be on the rise in areas affected by a refugee crisis, like Sanliurfa; thus, consequently, local uncommon species of Leishmania may be encountered in these regions. This might potentially make diagnosis and treatment more challenging over time. In this study, it was aimed to identify the causative agents of CL in clinical samples. A total of 154 patients (60 Syrian and 94 Turkish) who were diagnosed with CL via microscopical examination and PCR were enrolled this study. All of the samples were analyzed using internal transcribed spacer 1 genes, restriction fragment length polymorphism, DNA-sequencing, and phylogenetic analyses. In this study, Leishmania tropica was determined to be the predominant species in 140 of the patients (90.9%), followed by Leishmania major in 12 patients (7.8%), and Leishmania infantum in 2 patients (1.3%). Of the 94 Turkish patients, 94.7% were infected with L. tropica and 5.3% were infected with L. major, while none were infected with L. infantum. However, of the 60 Syrian patients, 85% were infected with L. tropica, 11.7% were infected with L. major, and 3.3% were infected with L. infantum. There was a significant association between the Leishmania species and the nations (Turkish-Syrian) (P < 0.001). The sequences were numbered from MH347941 to MH347953 and submitted to GenBank. This study confirmed that L. tropica, L. major, and L. infantum coexisted in Sanliurfa. This was the first time that the species L. infantum was reported among recent immigrants from Syria in Sanliurfa. Therefore, it is necessary to discriminate the Leishmania species for diagnosis, treatment, and controlled studies in hyper-endemic regions.
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http://dx.doi.org/10.2478/s11686-020-00227-wDOI Listing
December 2020

Thiol/disulphide balance in patients with psoriasis.

Postepy Dermatol Alergol 2020 Feb 9;37(1):52-55. Epub 2020 Mar 9.

Department of Biochemistry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.

Introduction: Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis.

Aim: To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group.

Material And Methods: Eighty patients with psoriasis and 80 healthy individuals who were age- and gender-matched with these patients were included in this study. Serum native thiol, disulfide and total thiol levels were measured by a new automated method developed by Erel and Neselioglu. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol were calculated.

Results: While there was no statistically significant difference in terms of disulphide levels (SS) between the patient and control groups ( > 0.05), there were significant differences in terms of total thiol and native thiol (SH) levels, SS/SH, SS/total thiol and SH/total thiol ratios between the patient and control groups ( < 0.05). There was a statistically significant relationship between duration of the disease and the disulfide/native thiol ratio ( > 0.05).

Conclusions: In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative stress in the pathogenesis of psoriasis.
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http://dx.doi.org/10.5114/ada.2018.77767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247074PMC
February 2020

Choroidal Thickness After Dexamethasone Implant or Aflibercept in Patients with Diabetic Macular Edema Persistent to Ranibizumab.

J Ocul Pharmacol Ther 2020 10 27;36(8):629-635. Epub 2020 May 27.

Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey.

This study aims to compare subfoveal choroidal thicknesses (SFCTs) after intravitreal dexamethasone (IVD) or intravitreal aflibercept (IVA) treatment in patients with persistent diabetic macular edema (DME) unresponsive to intravitreal ranibizumab (IVR). The study consisted of patients with DME unresponsive to IVR treatment in which 37 were administered 1 dose IVD (group A) and 34 patients who were administered 3 doses of IVA (group B), as well as 35 healthy individuals (group C). Detailed ophthalmological examination and optical coherence tomography parameters of group A and group B, including central retinal thickness and SFCT, were retrospectively evaluated before and after treatment. Results from preinjection, and 1, 2, and 3 months after injection were analyzed. Results of group A and group B were compared within themselves and also compared with group C. SFCT measurements were compared within group A and group B (1 = preinjection; 2 = 1 month postinjection; 3 = 2 months postinjection; 4 = 3 months postinjection). There was significant thinning in SFCT between 1-2, 1-3, 1-4, 2-3, 2-4, and 3-4 time intervals within both group A and group B (both  < 0.001). Comparison of SFCT measurements showed preinjection, 1-, and 2-month values of group A were significantly thicker than those of group C ( < 0.001), whereas there was no significant difference between 3-month values ( = 0.09). Preinjection, 1-, and 2-month values of group B were significantly thicker than those of group C ( < 0.001), whereas there was no significant difference between 3-month values ( = 0.06). Three month follow-up showed thinning in SFCT measurements in patients with persistent DME unresponsive to IVR who were applied IVD or IVA treatment.
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http://dx.doi.org/10.1089/jop.2020.0004DOI Listing
October 2020

Changes in ocular biometric parameters after renal transplantation.

Int Ophthalmol 2020 Sep 15;40(9):2283-2289. Epub 2020 May 15.

Department of General Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey.

Purpose: This study aimed to investigate the changes in postoperative ocular biometric parameters in end-stage renal disease patients who underwent renal transplantation.

Material And Methods: This retrospective study included a total of 33 eyes of 33 patients. The ocular biometric measurements which were evaluated were axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), corneal keratometry (K1 and K2), degree of astigmatism, lens thickness (LT), and intraocular pressure (IOP). Refractive prediction error (RE) was calculated before and after renal transplantation using the same diopter (D) for intraocular lens (IOL) power calculation and evaluated for potential cataract surgery.

Results: The study included 15 male (45%) and 18 female (55%) patients. Mean patient age was 31.55 ± 8.24 (range: 18-49 years). In the comparison of preoperative and 1-month postoperative measurements, there was a statistically significant difference in AL, LT, ACD, and CCT (p < 0.001). There was no statistically significant difference between K1, K2, and astigmatism measurements (p = 0.72; p = 0.35; p = 0.62, respectively). There was no statistically significant difference in RE (p = 0.61-Holladay 2).

Conclusion: While renal transplantation surgery does not lead to significant changes in astigmatism, predicted refractive error, corneal keratometry, or intraocular pressure, it causes significant decrease in axial length, lens thickness, and central corneal thickness and significant increase in anterior chamber depth. However, these changes do not result in significant changes in IOL power calculation in planned cataract surgery.
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http://dx.doi.org/10.1007/s10792-020-01411-7DOI Listing
September 2020

The Diagnostic Ability of Ganglion Cell Complex Thickness-to-Total Retinal Thickness Ratio in Glaucoma in a Caucasian Population

Turk J Ophthalmol 2020 03;50(1):26-30

Başkent University Health Sciences Faculty, Department of Ophthalmology Ankara, Turkey

Objectives: To evaluate the diagnostic accuracy of the macular ganglion cell complex-to-total retinal thickness (G/T) ratio in a Caucasian population.

Materials And Methods: A total of 86 patients were enrolled in this cross-sectional study. Patients were divided into 4 groups: healthy; ocular hypertension; preperimetric glaucoma; and early glaucoma. Macular ganglion cell complex (mGCC) thickness, total retinal thickness, and retinal nerve fiber layer thickness (RNFLT) in one randomly selected eye of each patient were measured with measured with Heidelberg HD spectral domain optical coherence tomography (Heidelberg Engineering, Inc., Heidelberg, Germany). G/T ratio (%) was calculated as (mGCC thickness / total retinal thickness) x100. The ability of each parameter to diagnose glaucoma was examined by area under the receiver operating characteristic curve (AUROC) analysis and sensitivity evaluation at a fixed level of specificity. Unpaired t test was used to compare the measured values between the healthy subjects and the different patient groups.

Results: The study included 9 healthy individuals, 18 patients with ocular hypertension, 28 with preperimetric glaucoma, and 31 with early glaucoma. Total retinal thickness, mGCC thickness, RNFLT, and G/T ratio were highest in the healthy group and decreased progressively in patients with ocular hypertension, preperimetric glaucoma, and early glaucoma. All comparisons between the groups were significant for these parameters (p<0.001 for all). Average RNFLT, average GCC, and total retinal thickness showed consistently higher AUROC than G/T ratio in the differentiation between healthy individuals and patients with ocular hypertension, preperimetric glaucoma, and early glaucoma.

Conclusion: G/T ratio does not contribute to separation of ocular hypertension, preperimetric glaucoma, and early glaucoma patients from the healthy population. Compared to the other parameters investigated, G/T had lower diagnostic value.
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http://dx.doi.org/10.4274/tjo.galenos.2019.19577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086093PMC
March 2020

Neutrophil/Lymphocyte Ratios, Platelet/Lymphocyte Ratios, and Mean Platelet Volume Values in Patients with Measles.

Cureus 2020 Jan 9;12(1):e6607. Epub 2020 Jan 9.

Pediatrics, Harran University, Şanlıurfa, TUR.

Aim: The purpose of this study was to compare neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of patients with measles within the healthy control group and then determine the utility of these parameters for determination of inflammatory situation in patients with measles.

Materials And Method: A total of 51 pediatric patients who had visited Harran University Medical Faculty Pediatrics Clinic between June 2018 and May 2019 and who had been diagnosed with measles after anamnesis, clinical, and serological evaluations were included our study; 49 healthy children who visited our clinic for various reasons and had taken hemogram tests were also added to our study as the control group.

Results: NLR and PLR values were observed higher than the control group for patients diagnosed with measles; however, the difference between the two groups was not statistically significant (p values 0.515 and 0.796, respectively). When MPV values of patients diagnosed with measles and control groups were compared, it was determined that MPV value was statistically lower in patients diagnosed with measles (p: 0.001).

Conclusion: Based on the parameters obtained through our study, it can be said that NLR and PLR are not suitable parameters for proving inflammation in patients with measles but MPV can be used as a convenient parameter for that purpose. However, prospective studies conducted with more patients are needed in this respect.
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http://dx.doi.org/10.7759/cureus.6607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008753PMC
January 2020

Resolution of Idiopathic Intracranial Hypertension Symptoms by Surgery for Obstructive Sleep Apnea in a Pediatric Patient.

J Pediatr Neurosci 2019 Apr-Jun;14(2):110-112

Department of Ophthalmology, Ophthalmology Clinic, Yozgat City Hospital, Yozgat, Turkey.

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http://dx.doi.org/10.4103/jpn.JPN_30_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712914PMC
September 2019

Assessment of autonomic nervous system functions and cardiac rhythms in patients using isotretinoin.

Postepy Dermatol Alergol 2019 Jun 29;36(3):291-294. Epub 2018 Jun 29.

Department of Cardiology, Harran University, Şanlıurfa, Turkey.

Aim: The aim of the study was to analyze the potential effects of isotretinoin, frequently used in the treatment of acne vulgaris these days.

Material And Methods: For this purpose, we used the methods of sympathetic skin response (SSR) electrophysiological analysis and electrocardiographic (ECG) analysis in patients using isotretinoin. Thirty patients who were diagnosed with acne vulgaris and treated with oral isotretinoin with a dose of 0.5 mg/kg for at least 1 month were included in the study. In all patients ECG scanning and SSR analysis were performed both before treatment and 1 month after the start of treatment.

Conclusions: This study is very important because SSR results show that increasing the existing sympathetic activity in acne vulgaris after isotretinoin usage could explain the exacerbation in acne lesions for the first month, and according to the ECG results the medication did not cause cardiac side effects.
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http://dx.doi.org/10.5114/ada.2018.76848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640012PMC
June 2019

ANALYSIS OF NON-STATIONARY RADIOMETER GAIN VIA ENSEMBLE DETECTION.

IEEE Int Geosci Remote Sens Symp Proc 2019 14;2019:8893-8896. Epub 2019 Nov 14.

University at Albany, State University of New York.

Although considered as stationary and Gaussian in general, radiometer gain is usually a fluctuating signal with non-stationary properties. Analyses of such non-stationary features is challenging as the radiometer signal cannot be observed independently. On the other hand, time series of post-gain voltages constitute an ensemble set for the radiometer gain which can be used to characterize the radiometer gain. This paper presents a novel technique called "Ensemble Detection" which can analytically retrieve the standard deviation of stationary Gaussian radiometer gain or find an equivalent stationary Gaussian process which represents the non-stationary radiometer gain under different calibration schemes. It has been found that the equivalent Gaussian process for non-stationary radiometer gain heavily depends on the calibration structure and the observation times of the measurand and the calibration references.
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http://dx.doi.org/10.1109/igarss.2019.8897887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412603PMC
November 2019

Dynamic thiol/disulphide homeostasis in vitiligo patients.

Postepy Dermatol Alergol 2018 Oct 19;35(5):498-501. Epub 2018 Jul 19.

Department of Physiology, Faculty of Medicine, Harran University, Sanlıurfa, Turkey.

Introduction: Vitiligo is an acquired depigmentation disorder with melanocyte destruction.

Aim: To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group.

Material And Methods: Thirty-two patients with vitiligo and 35 healthy individuals were included in the study. Native thiol, disulfide and total thiol levels in plasma were evaluated using a new and automated spectrophotometric method. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured.

Results: There was no statistically significant difference between the two groups when the patient and control groups were compared in terms of thiol/disulphide balance ( > 0.05). There was no statistically significant difference in native thiol, disulphide and total thiol levels for vitiligo when compared with the control group ( > 0.005).

Conclusions: In recent years, there have been numerous studies on the role of oxidative stress in the etiopathogenesis of vitiligo. In this study, we investigated in vitiligo patients whether thiol/disulphide balance is a new oxidative stress marker. The results were compared with a healthy control group. We measured the thiol/disulphide balance by a new method developed by Erel and Neselioglu. The serum thiol/disulphide levels were similar in the vitiligo patients and the control subjects, which indicated that the thiol/disulphide balance was not affected by vitiligo. We are of the opinion that new investigations to determine serum levels of thiol/disulphide may shed light on the possible roles of these molecules in vitiligo.
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http://dx.doi.org/10.5114/ada.2018.72856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232545PMC
October 2018

Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey.

Int J Dermatol 2018 Aug 16;57(8):973-982. Epub 2018 Apr 16.

Department of Dermatology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Background: Cutaneous leishmaniasis (CL) is a vector-born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged.

Objectives: The aim of this study was to develop diagnostic and therapeutic guidelines for the management of CL in Turkey.

Methods: This guideline is a consensus text prepared by 18 experienced CL specialists who have been working for many years in areas where the disease is endemic. The Delphi method was used to determine expert group consensus. Initially, a comprehensive list of items about CL was identified, and consensus was built from feedback provided by expert participants from the preceding rounds.

Results: Evidence-based and expert-based recommendations through diagnostic and therapeutic algorithms according to local availability and conditions are outlined.

Conclusion: Because CL can mimic many other skin diseases, early diagnosis and early treatment are very important to prevent complications and spread of the disease. The fastest and easiest diagnostic method is the leishmanial smear. The most common treatment is the use of local or systemic pentavalent antimony compounds.
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http://dx.doi.org/10.1111/ijd.14002DOI Listing
August 2018

Quality of life in patients with melasma in Turkish women.

Dermatol Reports 2017 Oct 10;9(2):7340. Epub 2017 Oct 10.

Department of Dermatology, Harran University Medical Faculty, Sanliurfa, Turkey.

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http://dx.doi.org/10.4081/dr.2017.7340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806155PMC
October 2017

A Complication after Percutaneous Nephrolithotomy: Anesthesia Mumps.

Anesth Essays Res 2017 Jul-Sep;11(3):794-796

Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Yildirim Beyazit, Ankara, Turkey.

Some surgical procedures performed under moderate and sometimes extreme positions expose patients to nonphysiological changes. Especially, the manipulations of a patient in prone and lateral decubitus position might increase complications. Anesthesia mumps has been reported as one of these complications. It has been found to be rare but known entity associated with patients of all age groups and all surgical positions. We herein describe an early noticed acute case of unilateral anesthesia mumps that developed after endotracheal intubation in prone position in a 54-year-old female. Anesthesia mumps may occur in the immediate postoperative period with no suspicious predisposing factor. The reports of such cases would increase the awareness among anesthesiologists and postoperative caregivers regarding this benign complication.
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http://dx.doi.org/10.4103/0259-1162.204203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594812PMC
September 2017

[Investigation of the prevalence of Trichomonas vaginalis among female Syrian refugees with the complaints of vaginitis aged between 15-49 years].

Mikrobiyol Bul 2016 Oct;50(4):590-597

Harran University Vocational School of Health Services, Medical Laboratory Programme, Medical Microbiology, Sanliurfa, Turkey.

Since the Syrian civil war began in 2011, most of the Syrian refugees have immigrated to Turkey due to its open gate policy and the width of the border. By the end of 2015, it was estimated that there were 2.5 million Syrian refugees in Turkey. Many of the Syrian refugees live in Sanliurfa due to its location on the border with Syria. Trichomonas vaginalis, apart from viral agents is the most common parasite among sexually transmitted infection agents. The aim of this study was to determine the prevalence of T.vaginalis among female married Syrian refugees living outside of the camps in Sanliurfa city center, aged between 15-49 years with complaints of vaginitis. This multi-purpose survey was carried out between February and March of 2015, in collaboration with the United Nations Population Fund and Harran University. This study was approved under the heading of "General Health Status of Female Syrian Refugees" by the Ethics Committee of Harran University Faculty of Medicine. A total of 460 Syrian refugees house were selected using the probability cluster sampling method, with a 95% confidence level and a 5% confidence interval with a design effect. Two women refused to participate in the study, and the response rate was 99.6%. Two Syrian nurses, one laboratory technician, and one interpreter who knew Kurdish and Arabic were hired for the field survey. A structured questionnaire written in Turkish was translated to Arabic and used to collect the sociodemographic data during face to face interviews. According to the questionnaire data, the women with the complaints of vaginal discharge, unusual vaginal bleeding and/or dyspareunia were invited to the Gynecology Department of Harran University Research and Training Hospital for a medical examination. During gynecological examination, swab samples obtained from posterior fornix were evaluated by direct microscopy and Giemsa staining methods for the presence of T.vaginalis trophozoites. Of 458 women who have participated the questionnaire survey, 232 (50.6%) have declared that they had vaginitis complaints. Accordingly, 157 symptomatic and non-pregnant women were invited to the hospital, however only 89 (56.7%) accepted the invitation. T.vaginalis infection was detected in 19 (21.3%) by direct microscopy, and in 32 (36%) by Giemsa staining of the samples taken during the examination of those 89 women (mean age: 31.6 ± 8.7 years). In the gynecological examination, 56.2% (50/89) of the women were clinically diagnosed as vaginitis. A statistically significant association was detected between T.vaginalis positivity and the cases with or without the clinical vaginitis diagnosis (p< 0.001). Our data indicated that the prevalence of T.vaginalis (36%) detected in the female Syrian refugees is higher than the prevalence (3-13%) of our general population, but it is close to the prevalence (40%) in groups with risky behaviors (sex workers). In conclusion, health screening studies and health educations about safe sex life for Syrian refugees would be useful in the prevention of sexually transmitted diseases.
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http://dx.doi.org/10.5578/mb.28173DOI Listing
October 2016

Changes in Anterior Chamber Depth after Phacoemulsification in Pseudoexfoliative Eyes and their Effect on Accuracy of Intraocular Lens Power Calculation.

Turk J Ophthalmol 2016 Dec 1;46(6):255-258. Epub 2016 Dec 1.

Başkent University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

Objectives: To compare anterior chamber depth (ACD) changes after phacoemulsification surgery in patients with pseudoexfoliation syndrome (PEX) and normal patients using an anterior segment imaging method. Another aim of this study was to evaluate the effect of these changes on the accuracy of intraocular lens (IOL) power calculation and postoperative refraction.

Materials And Methods: Twenty-two eyes of 22 patients with PEX and 30 eyes of 30 normal patients who underwent uneventful phacoemulsification surgery and IOL implantation were included in the study. The ACD of all patients was evaluated preoperatively and at 3 months postoperatively with the ALLEGRO Oculyzer (WaveLight® Oculyzer™ II, Alcon, Novartis)-Scheimpflug imaging system.

Results: The postoperative mean ACD values were significantly larger than the preoperative ACD values in both groups (p<0.001 for both groups). The pre- to postoperative change in ACD was 0.46±0.3 mm in the PEX group, which was a larger change than seen in the normal patients (0.12±0.1 mm) (p=0.04). The mean absolute errors (MAE) calculated with different IOL formulas (SRK/T, Haigis, Hoffer and Holladay 1 formulas) were comparable and no statistically significant difference was observed between the two groups (p=0.21).

Conclusion: Phacoemulsification induces more significant ACD changes in patients with PEX compared to normal patients. However, the MAE did not differ significantly between the groups.
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http://dx.doi.org/10.4274/tjo.56659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177780PMC
December 2016

A Case Of Bilateral Acquired Localized Lipoatrophy.

Case Rep Dermatol 2016 May-Aug;8(2):185-8. Epub 2016 Jul 11.

Department of Dermatology, Harran University School of Medicine, Şanliurfa, Turkey.

Lipoatrophy is characterized by inflammation and tissue loss in fatty tissue. This disease may be congenital or acquired, primary or secondary. Secondary lipoatrophy develops with infections, collagen tissue diseases, tumors and drug injections. In this report, we present the case of a 14-year-old female patient who developed lipoatrophy following intramuscular steroid injection to both buttocks.
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http://dx.doi.org/10.1159/000447256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965542PMC
August 2016