Publications by authors named "Musri Musman"

4 Publications

  • Page 1 of 1

Macrophylloflavone: A New Biflavonoid from Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities.

ScientificWorldJournal 2020 12;2020:2983129. Epub 2020 May 12.

Department of Chemistry Education, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.

Investigations of antibacterial, antioxidant, and anti-type 2 diabetes mellitus activities have been carried out on Mart. plant extract fractions. An isolate from a fraction of ethyl acetate extract was characterized with spectroscopic data. A new biflavonoid compound was found to have a skeleton of 5,7,4',5″,7″,3‴,4‴-heptahydroxyflavanone[3-6″] flavones which was named macrophylloflavone (). The compound was evaluated for its antibacterial activity against ATCC 25922 and ATCC 25923 with cephazolin as a positive control, antioxidant assay against 2,2 diphenyl-1-picrylhydrazyl (DPPH) with ascorbic acid as the positive control, and anti-type 2 diabetes mellitus treatment with metformin as a positive control. The biflavonoid compound exhibited a good inhibition for bacteria and free radical DPPH. Furthermore, biflavonoid compound treatment on the diabetic rats suggested its ability to decrease the blood glucose level. This study provided evidence that the plant has antibacterial, antioxidant, and antidiabetic properties.
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March 2021

Toxicity of Barringtonia racemosa (L.) Kernel Extract on Pomacea canaliculata (Ampullariidae).

Musri Musman

Trop Life Sci Res 2010 Dec;21(2):41-50

Department of Marine Science, Coordinatorate of Marine Science and Fishery, Syiah Kuala University, Darussalam-Banda Aceh 23111, Indonesia.

A number of tropical plant species have been recognised as molluscicidal plants, and Barringtonia racemosa (L.) is one of these. The toxicity effects of B. racemosa seed kernel extracts on Pomacea canaliculata were evaluated. The lethal concentration at 50% [LC50 (lower-upper limits)] values, in ppm/48 hours, were 70.71 (41.33-120.97), 94.39 (62.48-142.59), 186.84 (129.21-270.17), and 672.72 (366.57-1234.53) for the extracts withdrawn using dichloromethane (DCM), methanol (MeOH), ethyl acetate (EtOAc), heptane (hp) solvents, respectively at 95% confidence interval (C. I.). All analyses were conducted using Trimmed Spearman-Karber (TSK) program version 1.5. It is assumed that the observed biological effects of the extracts may be due to the saponins and flavonoids present in the seed. The dichloromethanic and methanolic extracts contain saponin and flavonoid substances. Therefore these extracts have shown more potent molluscicidal activity towards the tested organism compared to the remaining extracts. This observed biological activity suggests a promising role for B. racemosa in the control of P. canaliculata.
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December 2010

Spawning seasons of Rasbora tawarensis (Pisces: Cyprinidae) in Lake Laut Tawar, Aceh province, Indonesia.

Reprod Biol Endocrinol 2010 May 18;8:49. Epub 2010 May 18.

School of Biological Sciences Universiti Sains Malaysia, Penang 11800, Malaysia.

Background: Rasbora tawarensis is an endemic freshwater fish in Lake Laut Tawar, Aceh Province, Indonesia. Unfortunately, its status is regarded as critical endangered with populations decreasing in recent years. To date no information on the spawning activities of the fish are available. Therefore, this study provides a contribution to the knowledge on reproductive biology of R. tawarensis especially on spawning seasons as well as basic information for conservation of the species.

Methods: Monthly sampling was conducted from April 2008 to March 2009 by using selective gillnets. The gonadosomatic index, size composition and sex ratio were assessed. The gonadal development was evaluated based on macroscopic and microscopic examinations of the gonads.

Results: The gonadosomatic index (GSI) varied between 6.65 to 18.16 in female and 4.94 to 8.56 for male. GSI of the female R. tawarensis was higher in March, September and December indicating the onset of reproductive seasons, the GSI and oocyte size being directly correlated with gonadal development stages. Although, a greater proportion of mature male than female was detected during the study, the sex ratio showed that the overall number of female was higher than male. The ovaries had multiple oocyte size classes at every stage of gonadal development, thus R. tawarensis can be classified as a group synchronous spawner or a fractional multiple spawner.

Conclusion: The spawning seasons of R. tawarensis were three times a year and September being the peak of the reproductive season and the female was the predominant sex. This species is classified as a group synchronous spawner.
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May 2010

Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp.

J Nat Prod 2002 Oct;65(10):1505-6

Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

An anhydrophytosphingosine named pachastrissamine (3) has been isolated as a cytotoxic principle of a sponge, Pachastrissa sp., and the structure including the absolute configuration determined by spectroscopic and chemical analysis.
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October 2002