Murray Stewart

Murray Stewart

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Murray Stewart

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Clinical and genetic heterogeneity in Melkersson-Rosenthal Syndrome.

Eur J Med Genet 2019 Jun 11;62(6):103536. Epub 2018 Sep 11.

Manchester Centre for Genomic Medicine, Evolution and Genomic Sciences, University of Manchester, Manchester, UK; Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17697212183039
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http://dx.doi.org/10.1016/j.ejmg.2018.09.003DOI Listing
June 2019

Dual inhibitors of LSD1 and spermine oxidase.

Medchemcomm 2019 May 8;10(5):778-790. Epub 2019 Feb 8.

Department of Drug Discovery and Biomedical Sciences , Medical University of South Carolina , 70 President St. , Charleston , SC 29425 , USA . Email:

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http://dx.doi.org/10.1039/c8md00610eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533887PMC
May 2019

Structure-function relationships in the Nab2 polyadenosine-RNA binding Zn finger protein family.

Protein Sci 2019 Mar 16;28(3):513-523. Epub 2019 Jan 16.

MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1002/pro.3565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371209PMC
March 2019

Polyadenylation and nuclear export of mRNAs.

Authors:
Murray Stewart

J Biol Chem 2019 03 25;294(9):2977-2987. Epub 2019 Jan 25.

From the MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom

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http://dx.doi.org/10.1074/jbc.REV118.005594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398137PMC
March 2019

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.

PLoS One 2018 23;13(8):e0202677. Epub 2018 Aug 23.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202677PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107220PMC
February 2019

Polyamine Homeostasis in Snyder-Robinson Syndrome.

Med Sci (Basel) 2018 Dec 7;6(4). Epub 2018 Dec 7.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.3390/medsci6040112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318755PMC
December 2018

Polyamine metabolism and cancer: treatments, challenges and opportunities.

Nat Rev Cancer 2018 11;18(11):681-695

Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1038/s41568-018-0050-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487480PMC
November 2018

Polyamine catabolism and oxidative damage.

J Biol Chem 2018 11 17;293(48):18736-18745. Epub 2018 Oct 17.

From the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.TM118.003337
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http://dx.doi.org/10.1074/jbc.TM118.003337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290137PMC
November 2018

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.

Allergy 2018 10;73(10):2033-2045

Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.

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http://doi.wiley.com/10.1111/all.13472
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http://dx.doi.org/10.1111/all.13472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461714PMC
October 2018

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis.

Gastroenterology 2018 09 23;155(3):668-673. Epub 2018 May 23.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183456
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http://dx.doi.org/10.1053/j.gastro.2018.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120769PMC
September 2018

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy.

Med Sci (Basel) 2017 Dec 18;5(4). Epub 2017 Dec 18.

Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.

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http://www.mdpi.com/2076-3271/5/4/38
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http://dx.doi.org/10.3390/medsci5040038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753667PMC
December 2017

Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.

Int J Oncol 2017 Jun 2;50(6):2011-2023. Epub 2017 May 2.

Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, P.R. China.

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http://dx.doi.org/10.3892/ijo.2017.3979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435328PMC
June 2017

Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex.

Nucleic Acids Res 2017 May;45(9):5577-5585

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/nar/gkx158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435946PMC
May 2017

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

PLoS One 2017 19;12(4):e0175917. Epub 2017 Apr 19.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175917PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396973PMC
April 2017

Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy.

J Control Release 2017 01 23;246:110-119. Epub 2016 Dec 23.

Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258827PMC
January 2017

Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation: A Perfect Combination for Cancer Therapy.

Adv Cancer Res 2016 2;130:55-111. Epub 2016 Mar 2.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S0065230X163000
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http://dx.doi.org/10.1016/bs.acr.2016.01.007DOI Listing
December 2016

Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.

Amino Acids 2016 10 13;48(10):2375-88. Epub 2016 Apr 13.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2215 Garland Avenue, 1030C Medical Research Building IV, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/s00726-016-2231-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042810PMC
October 2016

Targeting polyamine metabolism for cancer therapy and prevention.

Biochem J 2016 10;473(19):2937-53

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Bunting, Blaustein Building, Room 551, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1042/BCJ20160383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711482PMC
October 2016

Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer.

Oncogene 2016 10 4;35(42):5480-5488. Epub 2016 Apr 4.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050049PMC
http://dx.doi.org/10.1038/onc.2016.91DOI Listing
October 2016

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.

J Struct Biol 2016 09 21;195(3):273-281. Epub 2016 Jun 21.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1016/j.jsb.2016.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991853PMC
September 2016

The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region.

J Struct Biol 2016 09 12;195(3):316-324. Epub 2016 Jul 12.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2016.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991852PMC
September 2016

Structural Biology and Regulation of Protein Import into the Nucleus.

J Mol Biol 2016 05 30;428(10 Pt A):2060-90. Epub 2015 Oct 30.

School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.10.023DOI Listing
May 2016

Data Sharing as Part of the Normal Scientific Process: A View from the Pharmaceutical Industry.

PLoS Med 2016 Jan 5;13(1):e1001936. Epub 2016 Jan 5.

Chief Medical Officer GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1001936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701406PMC
January 2016

1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex.

Acta Crystallogr F Struct Biol Commun 2015 Oct 23;71(Pt 10):1318-21. Epub 2015 Sep 23.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.

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http://dx.doi.org/10.1107/S2053230X1501643XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601597PMC
October 2015

Type 2 diabetes mellitus development programs in the new regulatory environment with cardiovascular safety requirements.

Diabetes Metab Syndr Obes 2015 20;8:315-25. Epub 2015 Jul 20.

Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.2147/DMSO.S84005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516202PMC
August 2015

Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.

PLoS One 2014 12;9(11):e110161. Epub 2014 Nov 12.

Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Veterans Affair Medical Center, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110161PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229091PMC
July 2015

Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.

ChemMedChem 2015 Jul 20;10(7):1232-9. Epub 2015 Apr 20.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).

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http://doi.wiley.com/10.1002/cmdc.201500014
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http://dx.doi.org/10.1002/cmdc.201500014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515083PMC
July 2015

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.

Structure 2015 Jul 4;23(7):1246-57. Epub 2015 Jun 4.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509546PMC
July 2015

Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.

Acta Crystallogr F Struct Biol Commun 2015 Jul 27;71(Pt 7):876-88. Epub 2015 Jun 27.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.

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http://dx.doi.org/10.1107/S2053230X15008766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498709PMC
July 2015

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.

Oncogene 2015 Jun 1;34(26):3429-40. Epub 2014 Sep 1.

1] Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA [2] Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA [3] Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA [4] Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.

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http://dx.doi.org/10.1038/onc.2014.273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345146PMC
June 2015

Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface.

Nucleic Acids Res 2015 Feb 23;43(3):1927-36. Epub 2015 Jan 23.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK

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http://dx.doi.org/10.1093/nar/gkv030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330389PMC
February 2015

The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA.

Nucleic Acids Res 2015 Feb 27;43(3):1883-93. Epub 2015 Jan 27.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK

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http://dx.doi.org/10.1093/nar/gkv032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330390PMC
February 2015

Promiscuous binding of Karyopherinβ1 modulates FG nucleoporin barrier function and expedites NTF2 transport kinetics.

Biophys J 2015 Feb;108(4):918-927

Biozentrum and the Swiss Nanoscience Institute, University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.12.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336380PMC
February 2015

Structural biology of the PCI-protein fold.

Bioarchitecture 2012 Jul-Aug;2(4):118-23. Epub 2012 Jul 1.

MRC Laboratory of Molecular Biology; Cambridge, UK.

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http://www.tandfonline.com/doi/abs/10.4161/bioa.21131
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http://dx.doi.org/10.4161/bioa.21131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675071PMC
December 2014

Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro.

Diabetes Care 2014 Aug 4;37(8):2317-25. Epub 2014 Jun 4.

Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, and Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/dc14-0001DOI Listing
August 2014

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export.

Nucleic Acids Res 2014 Jun 4;42(10):6686-97. Epub 2014 Apr 4.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK

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http://dx.doi.org/10.1093/nar/gku252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041426PMC
June 2014

Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP.

Nucleic Acids Res 2014 Apr 7;42(8):5059-71. Epub 2014 Feb 7.

MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK, Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK and Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

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http://dx.doi.org/10.1093/nar/gku095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005691PMC
April 2014

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Amino Acids 2014 Mar 19;46(3):585-94. Epub 2013 Mar 19.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting Blaustein Bldg, Room 551, 1650 Orleans Street, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s00726-013-1485-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692581PMC
March 2014

Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention.

Amino Acids 2014 Mar 15;46(3):511-9. Epub 2013 Jun 15.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Bunting Blaustein Bldg., Room 551, 1650 Orleans Street, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s00726-013-1529-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795954PMC
March 2014

Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers.

Nucleic Acids Res 2014 Jan 25;42(1):672-80. Epub 2013 Sep 25.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1093/nar/gkt876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874189PMC
January 2014

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.

Mol Cancer Ther 2013 Oct 13;12(10):2088-99. Epub 2013 Aug 13.

Corresponding Author: Robert A. Casero, Jr., CRB 1 Room 551, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Bunting Blaustein Building, Baltimore, MD 21287.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808125PMC
October 2013

Potential modification of the UKPDS risk engine and evaluation of macrovascular event rates in controlled clinical trials.

Diabetes Metab Syndr Obes 2013 12;6:247-56. Epub 2013 Jul 12.

Alternative Development Program, GlaxoSmithKline, King of Prussia, PA.

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http://dx.doi.org/10.2147/DMSO.S43724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716447PMC
July 2013

Choreography of importin-α/CAS complex assembly and disassembly at nuclear pores.

Proc Natl Acad Sci U S A 2013 Apr 8;110(17):E1584-93. Epub 2013 Apr 8.

Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M Health Science Center, Texas A&M University, College Station, TX 77843, USA.

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http://dx.doi.org/10.1073/pnas.1220610110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637723PMC
April 2013

Role of major sperm protein (MSP) in the protrusion and retraction of Ascaris sperm.

Int Rev Cell Mol Biol 2012 ;297:265-93

Department of Biological Science, Florida State University, Tallahassee, Florida, USA.

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http://dx.doi.org/10.1016/B978-0-12-394308-8.00007-8DOI Listing
December 2012

GANP enhances the efficiency of mRNA nuclear export in mammalian cells.

Nucleus 2010 Sep-Oct;1(5):393-6

MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, UK.

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http://dx.doi.org/10.4161/nucl.1.5.12351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037533PMC
July 2012

Structural basis for the assembly and disassembly of mRNA nuclear export complexes.

Biochim Biophys Acta 2012 Jun 2;1819(6):578-92. Epub 2012 Mar 2.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.bbagrm.2012.02.017DOI Listing
June 2012

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.

Biochem J 2012 Mar;442(3):693-701

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1042/BJ20111271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286856PMC
March 2012

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex.

Nat Struct Mol Biol 2012 Feb 19;19(3):328-36. Epub 2012 Feb 19.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/nsmb.2235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303126PMC
February 2012

Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction.

Curr Biol 2011 Oct 13;21(20):1727-31. Epub 2011 Oct 13.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1016/j.cub.2011.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210573PMC
October 2011

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15354-9. Epub 2011 Aug 29.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.1010203108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174648PMC
September 2011

Electrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo.

J Biol Chem 2011 Aug 27;286(33):29325-35. Epub 2011 Jun 27.

Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.245092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190738PMC
August 2011

A simple assay for mammalian spermine oxidase: a polyamine catabolic enzyme implicated in drug response and disease.

Methods Mol Biol 2011 ;720:173-81

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-61779-034-8_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652264PMC
May 2011

Nuclear export of mRNA.

Authors:
Murray Stewart

Trends Biochem Sci 2010 Nov 16;35(11):609-17. Epub 2010 Aug 16.

MRC Laboratory of Molecular Biology, Hills Rd., Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.tibs.2010.07.001DOI Listing
November 2010

Quantitative structural analysis of importin-β flexibility: paradigm for solenoid protein structures.

Structure 2010 Sep;18(9):1171-83

School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales 2650, Australia.

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September 2010

Structural basis for the function of the Saccharomyces cerevisiae Gfd1 protein in mRNA nuclear export.

J Biol Chem 2010 Jul 12;285(27):20704-15. Epub 2010 May 12.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.107276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898303PMC
July 2010

Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha.

J Biol Chem 2010 Jun 23;285(23):17628-35. Epub 2010 Mar 23.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.102343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878527PMC
June 2010

Simulation of cell motility that reproduces the force-velocity relationship.

Proc Natl Acad Sci U S A 2010 May 3;107(20):9141-6. Epub 2010 May 3.

Cavendish Laboratory, University of Cambridge, 19 J J Thomson Avenue, Cambridge CB3 0HE, England.

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http://dx.doi.org/10.1073/pnas.1002538107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889078PMC
May 2010

Polyamine catabolism is enhanced after traumatic brain injury.

J Neurotrauma 2010 Mar;27(3):515-25

Department of Internal Medicine, Division of Nephrology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1089/neu.2009.1097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867553PMC
March 2010

Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.

J Biol Chem 2010 Feb 9;285(6):3850-6. Epub 2009 Dec 9.

From the Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom and.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.070839
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http://dx.doi.org/10.1074/jbc.M109.070839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823527PMC
February 2010

mRNA export from mammalian cell nuclei is dependent on GANP.

Curr Biol 2010 Jan 10;20(1):25-31. Epub 2009 Dec 10.

MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1016/j.cub.2009.10.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869303PMC
January 2010

Cell biology. Nuclear export of small RNAs.

Authors:
Murray Stewart

Science 2009 Nov;326(5957):1195-6

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.1183273DOI Listing
November 2009

Mutational uncoupling of the role of Sus1 in nuclear pore complex targeting of an mRNA export complex and histone H2B deubiquitination.

J Biol Chem 2009 May 5;284(18):12049-56. Epub 2009 Mar 5.

Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M900502200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673274PMC
May 2009

Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export.

J Biol Chem 2008 Oct 5;283(40):27130-43. Epub 2008 Aug 5.

Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M803649200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555995PMC
October 2008

Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.

FEBS J 2008 Jun 17;275(11):2795-806. Epub 2008 Apr 17.

Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06419.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631774PMC
June 2008

Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T.

Proc Natl Acad Sci U S A 2008 May 15;105(20):7200-5. Epub 2008 May 15.

Department of Biosciences, School of Science and Engineering, Teikyo University, Toyosatodai 1-1, Utsunomiya 320-8551, Japan.

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http://dx.doi.org/10.1073/pnas.0801950105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438227PMC
May 2008

Structural basis for the nuclear import of the human androgen receptor.

J Cell Sci 2008 Apr 4;121(Pt 7):957-68. Epub 2008 Mar 4.

Uro-Oncology Research Group, Cancer Research UK Cambridge Research Institute, Robinson Way, Cambridge, CB2 0RE, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.022103
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April 2008

Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.

J Med Chem 2008 Apr 19;51(8):2447-56. Epub 2008 Mar 19.

Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Avenue, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1021/jm701384xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556737PMC
April 2008

The role of filament-packing dynamics in powering amoeboid cell motility.

Proc Natl Acad Sci U S A 2008 Apr 2;105(14):5390-5. Epub 2008 Apr 2.

Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1073/pnas.0708416105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291107PMC
April 2008

Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA export factor Mex67.

Mol Biol Cell 2007 Jul 2;18(7):2561-8. Epub 2007 May 2.

Institut Jacques Monod, Universités Paris VI and VII, Centre National de la Recherche Scientifique, 75251 Paris Cedex 05, France.

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http://dx.doi.org/10.1091/mbc.e07-02-0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924821PMC
July 2007

A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris.

Mol Biol Cell 2007 May 7;18(5):1816-25. Epub 2007 Mar 7.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.1091/mbc.e06-08-0741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855020PMC
May 2007

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.

Proc Natl Acad Sci U S A 2007 May 26;104(19):8023-8. Epub 2007 Apr 26.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1073/pnas.0700720104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857229PMC
May 2007

Inflammation and polyamine catabolism: the good, the bad and the ugly.

Biochem Soc Trans 2007 Apr;35(Pt 2):300-4

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1042/BST0350300DOI Listing
April 2007

Ratcheting mRNA out of the nucleus.

Authors:
Murray Stewart

Mol Cell 2007 Feb;25(3):327-30

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.molcel.2007.01.016DOI Listing
February 2007