Murray Raskind

Murray Raskind

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Murray Raskind

Murray Raskind

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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Prazosin for Alcohol Use Disorder: Response to Kleinman and Ostacher.

Am J Psychiatry 2019 Feb;176(2):165-166

Center of Excellence in Substance Abuse Treatment and Education (Simpson, Saxon) and the Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle (Simpson, Raskind); Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle (Simpson, Saxon, Raskind).

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http://dx.doi.org/10.1176/appi.ajp.2018.18101143rDOI Listing
February 2019

Double-Blind Randomized Clinical Trial of Prazosin for Alcohol Use Disorder.

Am J Psychiatry 2018 Dec 29;175(12):1216-1224. Epub 2018 Aug 29.

From the Center of Excellence in Substance Abuse Treatment and Education and the Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle; the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle; and the Seattle Institute for Biomedical and Clinical Research, Seattle.

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http://dx.doi.org/10.1176/appi.ajp.2018.17080913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395537PMC
December 2018

Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?

Biol Psychiatry 2018 07 12;84(2):e19-e20. Epub 2017 Oct 12.

VA Cooperative Studies Program Central Office, VA Office of Research and Development, Washington, DC.

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http://dx.doi.org/10.1016/j.biopsych.2017.09.031DOI Listing
July 2018

Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes.

Sci Rep 2018 Jul 27;8(1):11344. Epub 2018 Jul 27.

Geriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.

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http://dx.doi.org/10.1038/s41598-018-29341-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063850PMC
July 2018

Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia.

Int J Geriatr Psychiatry 2018 05 15;33(5):763-768. Epub 2018 Feb 15.

Mental Illness Research, Education, and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA, USA.

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http://dx.doi.org/10.1002/gps.4856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882504PMC
May 2018

Retrospective and Prospective Memory Among OEF/OIF/OND Veterans With a Self-Reported History of Blast-Related mTBI.

J Int Neuropsychol Soc 2018 Apr 29;24(4):324-334. Epub 2017 Dec 29.

1Veterans Affairs (VA) Northwest Network (VISN 20) Mental Illness,Research,Education,and Clinical Center (MIRECC),Veterans Affairs Puget Sound Health Care System,Seattle,Washington.

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http://dx.doi.org/10.1017/S1355617717001217DOI Listing
April 2018

Prazosin for Post-Traumatic Stress Disorder.

N Engl J Med 2018 04;378(17):1649-1650

VA Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA

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http://dx.doi.org/10.1056/NEJMc1803171DOI Listing
April 2018

Effect of dietary palmitic and stearic acids on sucrose motivation and hypothalamic and striatal cell signals in the rat.

Am J Physiol Regul Integr Comp Physiol 2018 02 1;314(2):R191-R200. Epub 2017 Nov 1.

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine , Seattle, Washington.

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http://dx.doi.org/10.1152/ajpregu.00340.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867676PMC
February 2018

Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans.

N Engl J Med 2018 02;378(6):507-517

From the Veterans Affairs (VA) Northwest Network Mental Illness Research, Education, and Clinical Center (M.A.R., E.R.P., H.A.H., K.L.H., M.M.) and the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine (M.A.R., E.R.P., M.M.), Seattle; VA Cooperative Studies Program Coordinating Center, Palo Alto (B.C., M.-C.S., Y.L.), VA Long Beach Healthcare System, Department of Human Behavior, University of California, Irvine (C.R.), the Department of Health Research and Policy, Stanford University School of Medicine, Stanford (M.-C.S., Y.L.), and the VA San Diego Healthcare System (M.B.S.) and the Departments of Psychiatry and Family Medicine and Public Health, University of California at San Diego (M.B.S.), San Diego - all in California; VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (C.H., A.D.-K.); the Department of Psychiatry, Howard University (T.A.M.), and the Cooperative Studies Program Central Office (G.D.H.), Department of Veterans Affairs, Office of Research and Development (T.G.), Washington, DC; VA Salt Lake City, Salt Lake City (J.R.); VA Northeast Program Evaluation Center, West Haven, and the Departments of Psychiatry and Public Health, Yale School of Medicine, New Haven - both in Connecticut (R.R.); and Providence VA Medical Center and the Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Providence, RI (R.S.).

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http://dx.doi.org/10.1056/NEJMoa1507598DOI Listing
February 2018

Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress.

Neurobiol Stress 2018 Feb 15;8:103-111. Epub 2018 Mar 15.

VISN 20 Northwest Network Mental Illness Research, Education, and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1016/j.ynstr.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991318PMC
February 2018

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults.

Neurology 2017 Sep 18;89(12):1251-1255. Epub 2017 Aug 18.

From the Geriatric Research, Education, and Clinical Center (G.L., W.H.R.) and Northwest Network (VISN-20) Mental Illness, Research, Education, and Clinical Center (G.L., C.L.M., D.M., S.P.M., E.C.P., M.A.R., E.R.P.), Veterans Affairs Puget Sound Health Care System; Departments of Psychiatry and Behavioral Sciences (G.L., E.C.P., M.C., M.A.R., E.R.P.) and Medicine (W.H.R.), University of Washington, Seattle; and Department of Neurology (A.M.F.), Washington University in St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000004392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606918PMC
September 2017

Higher Pretreatment Blood Pressure Is Associated With Greater Posttraumatic Stress Disorder Symptom Reduction in Soldiers Treated With Prazosin.

Biol Psychiatry 2016 11 11;80(10):736-742. Epub 2016 Apr 11.

Northwest Network Veterans Integrated Service Network 20 Mental Illness Research, Education and Clinical Center; Seattle; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle.

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http://dx.doi.org/10.1016/j.biopsych.2016.03.2108DOI Listing
November 2016

Noradrenergic dysregulation in the pathophysiology of PTSD.

Exp Neurol 2016 Oct 21;284(Pt B):181-195. Epub 2016 May 21.

VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), United States; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S00144886163012
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http://dx.doi.org/10.1016/j.expneurol.2016.05.014DOI Listing
October 2016

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.

Acta Neuropathol 2016 10 29;132(4):545-61. Epub 2016 Jul 29.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.

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http://dx.doi.org/10.1007/s00401-016-1600-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026939PMC
October 2016

Posttraumatic Stress Disorder and Aging.

Am J Geriatr Psychiatry 2016 Mar 15;24(3):177-80. Epub 2016 Jan 15.

VA Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), Seattle, WA, USA; VA Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), Portland, OR, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jagp.2016.01.133DOI Listing
March 2016

Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine.

Neuropharmacology 2016 Feb 8;101:76-86. Epub 2015 Sep 8.

Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782767PMC
February 2016

Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction.

Sci Transl Med 2016 Jan;8(321):321ra6

Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA. Department of Medicine, University of Washington, Seattle, WA 98195, USA. Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa9585DOI Listing
January 2016

A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder.

Alcohol Clin Exp Res 2015 May 1;39(5):808-17. Epub 2015 Apr 1.

Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, Seattle, Washington; Mental Illness Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1111/acer.12703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400241PMC
May 2015

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Authors:
Li-San Wang Adam C Naj Robert R Graham Paul K Crane Brian W Kunkle Carlos Cruchaga Josue D Gonzalez Murcia Lisa Cannon-Albright Clinton T Baldwin Henrik Zetterberg Kaj Blennow Walter A Kukull Kelley M Faber Nicole Schupf Maria C Norton JoAnn T Tschanz Ronald G Munger Christopher D Corcoran Ekaterina Rogaeva Chiao-Feng Lin Beth A Dombroski Laura B Cantwell Amanda Partch Otto Valladares Hakon Hakonarson Peter St George-Hyslop Robert C Green Alison M Goate Tatiana M Foroud Regina M Carney Eric B Larson Timothy W Behrens John S K Kauwe Jonathan L Haines Lindsay A Farrer Margaret A Pericak-Vance Richard Mayeux Gerard D Schellenberg Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Michael Barmada Lisa L Barnes Thomas G Beach James T Becker Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Steven L Carroll Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky F Yesim Demirci Malcolm Dick Dennis W Dickson Ranjan Duara Nilufer Ertekin-Taner Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass Neill R Graff-Radford John H Growdon Ronald L Hamilton Kara L Hamilton-Nelson Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun Gyungah Jun M Ilyas Kamboh Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Gei Li Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Constantine G Lyketsos Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee W Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Jill R Murrell John M Olichney Joseph E Parisi William Perry Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2015 Feb;72(2):209-16

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2014.2157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324097PMC
February 2015

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.

PLoS Genet 2014 Dec 4;10(12):e1004803. Epub 2014 Dec 4.

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256087PMC
December 2014

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Authors:
Adam C Naj Gyungah Jun Christiane Reitz Brian W Kunkle William Perry Yo Son Park Gary W Beecham Ruchita A Rajbhandary Kara L Hamilton-Nelson Li-San Wang John S K Kauwe Matthew J Huentelman Amanda J Myers Thomas D Bird Bradley F Boeve Clinton T Baldwin Gail P Jarvik Paul K Crane Ekaterina Rogaeva M Michael Barmada F Yesim Demirci Carlos Cruchaga Patricia L Kramer Nilufer Ertekin-Taner John Hardy Neill R Graff-Radford Robert C Green Eric B Larson Peter H St George-Hyslop Joseph D Buxbaum Denis A Evans Julie A Schneider Kathryn L Lunetta M Ilyas Kamboh Andrew J Saykin Eric M Reiman Philip L De Jager David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Eden R Martin Jonathan L Haines Richard P Mayeux Lindsay A Farrer Gerard D Schellenberg Margaret A Pericak-Vance Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Lisa L Barnes Thomas G Beach James T Becker Duane Beekly Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Minerva M Carrasquillo Steven L Carroll Helena C Chui David G Clark Jason Corneveaux David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky Malcolm Dick Dennis W Dickson Ranjan Duara Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Chiao-Feng Lin Oscar L Lopez Constantine G Lyketsos Wendy J Mack Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Jill R Murrell John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Otto Valladares Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2014 Nov;71(11):1394-404

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaneurol.2014.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314944PMC
November 2014

Violence in war and violence back home.

Am J Psychiatry 2014 Jul;171(7):701-4

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http://dx.doi.org/10.1176/appi.ajp.2014.14040528DOI Listing
July 2014

Antipsychotic drugs for psychosis and agitation in dementia: efficacy, safety, and a possible noradrenergic mechanism of action.

Int Psychogeriatr 2014 Jun 4;26(6):879-83. Epub 2014 Apr 4.

Veterans Affairs Northwest Network (VISN 20) Mental Illness Research, Education and Clinical Center, Mental Health Service, VA Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA Email:

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http://dx.doi.org/10.1017/S1041610214000477DOI Listing
June 2014

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

N Engl J Med 2014 Jan;370(4):322-33

From Butler Hospital, Providence, RI (S.S.); Brigham and Women's Hospital, Boston (R.S.); University College London, Institute of Neurology, London (N.C.F.); University of Göteborg, Sahlgrenska University Hospital, Mölndal, Sweden (K.B.); University of Pittsburgh, Pittsburgh (W.K.); Veterans Affairs Medical Center, Seattle (M.R.); Cleo Roberts Center for Clinical Research/Sun Health Research Institute, Sun City, AZ (M.S.); Columbia University (L.S.H.) and New York University Langone Medical Center (S.F.), New York; University of Rochester School of Medicine and Dentistry, Rochester, NY (A.P.P.); Janssen Alzheimer Immunotherapy Research and Development, South San Francisco, CA (M.R., N.K., B.N., V.G., M.M., D.W., Y.L., I.C.T., E.L., E.Y., H.R.B.); Janssen Research and Development, Titusville, NJ (J.L.); Global R&D Partners and the University of California, San Diego - both in San Diego (M.G.); and Pfizer, Collegeville, PA (R.B.).

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http://dx.doi.org/10.1056/NEJMoa1304839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159618PMC
January 2014

Cerebrospinal fluid norepinephrine and cognition in subjects across the adult age span.

Neurobiol Aging 2013 Oct 30;34(10):2287-92. Epub 2013 Apr 30.

Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706572PMC
October 2013

Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration.

Front Pharmacol 2012 22;3:184. Epub 2012 Oct 22.

Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System Seattle, WA, USA ; Department of Psychiatry and Behavioral Sciences, University of Washington Seattle, WA, USA.

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http://dx.doi.org/10.3389/fphar.2012.00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487487PMC
November 2012

Differential Clinical Characteristics of Older Black and White Nursing Home Residents: A Pilot Study.

Am J Geriatr Psychiatry 1995 Summer;3(3):229-238. Epub 2012 Aug 15.

University of Washington Department of Psychiatry and Behavioral Sciences and the Seattle VA Medical Center, Seattle, WA.

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http://dx.doi.org/10.1097/00019442-199522330-00006DOI Listing
August 2012

Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Authors:
Mariet Allen Fanggeng Zou High Seng Chai Curtis S Younkin Julia Crook V Shane Pankratz Minerva M Carrasquillo Christopher N Rowley Asha A Nair Sumit Middha Sooraj Maharjan Thuy Nguyen Li Ma Kimberly G Malphrus Ryan Palusak Sarah Lincoln Gina Bisceglio Constantin Georgescu Debra Schultz Fariborz Rakhshan Christopher P Kolbert Jin Jen Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg Ronald C Petersen Neill R Graff-Radford Dennis W Dickson Steven G Younkin Nilüfer Ertekin-Taner Liana G Apostolova Steven E Arnold Clinton T Baldwin Robert Barber Michael M Barmada Thomas Beach Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Jacqueline Buros Joseph D Buxbaum Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Paul K Crane Carlos Cruchaga Jeffrey L Cummings Philip L De Jager Charles DeCarli Steven T DeKosky F Yesim Demirci Ramon Diaz-Arrastia Malcolm Dick Beth A Dombroski Ranjan Duara William D Ellis Denis Evans Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Tatiana M Foroud Matthew Frosch Douglas R Galasko Paul J Gallins Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass Alison M Goate Robert C Green John H Growdon Hakon Hakonarson Ronald L Hamilton John Hardy Lindy E Harrell Elizabeth Head Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun M Ilyas Kamboh Jason Karlawish Anna Karydas John S K Kauwe Jeffrey A Kaye Nancy Kennedy Ronald Kim Edward H Koo Neil W Kowall Patricia Kramer Walter A Kukull James J Lah Eric B Larson Allan I Levey Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Amanda J Myers Adam C Naj Petra Nowotny Joseph E Parisi Daniel P Perl Elaine Peskind Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Ruchita A Rajbhandary Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Peter St George-Hyslop Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Badri Narayan Vardarajan Harry V Vinters Jean Paul Vonsattel Li-San Wang Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer

Neurology 2012 Jul 20;79(3):221-8. Epub 2012 Jun 20.

Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA.

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http://dx.doi.org/10.1212/WNL.0b013e3182605801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398432PMC
July 2012

Truncation of tau at E391 promotes early pathologic changes in transgenic mice.

J Neuropathol Exp Neurol 2011 Nov;70(11):1006-19

Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31823557fbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237612PMC
November 2011

The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder.

Biol Psychiatry 2011 Sep 20;70(5):441-8. Epub 2011 Jan 20.

Mental Illness Research, Education, and Clinical Center, Department of Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1016/j.biopsych.2010.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740168PMC
September 2011

The neurobiology of the stress-resistant brain.

Stress 2011 Sep 26;14(5):498-502. Epub 2011 Jul 26.

Department of Integrative Physiology, University of Colorado, Boulder, CO 80309-0354, USA.

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http://dx.doi.org/10.3109/10253890.2011.596865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287388PMC
September 2011

The role of intimate relationships, appraisals of military service, and gender on the development of posttraumatic stress symptoms following Iraq deployment.

J Trauma Stress 2011 Jun 5;24(3):277-86. Epub 2011 May 5.

National Center for Telehealth and Technology, Tacoma, Washington 98431-1100, USA.

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http://dx.doi.org/10.1002/jts.20632DOI Listing
June 2011

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:
Adam C Naj Gyungah Jun Gary W Beecham Li-San Wang Badri Narayan Vardarajan Jacqueline Buros Paul J Gallins Joseph D Buxbaum Gail P Jarvik Paul K Crane Eric B Larson Thomas D Bird Bradley F Boeve Neill R Graff-Radford Philip L De Jager Denis Evans Julie A Schneider Minerva M Carrasquillo Nilufer Ertekin-Taner Steven G Younkin Carlos Cruchaga John S K Kauwe Petra Nowotny Patricia Kramer John Hardy Matthew J Huentelman Amanda J Myers Michael M Barmada F Yesim Demirci Clinton T Baldwin Robert C Green Ekaterina Rogaeva Peter St George-Hyslop Steven E Arnold Robert Barber Thomas Beach Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Jeffrey L Cummings Charles DeCarli Steven T DeKosky Ramon Diaz-Arrastia Malcolm Dick Dennis W Dickson William G Ellis Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Nancy Johnson Jason Karlawish Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall James J Lah Allan I Levey Andrew P Lieberman Oscar L Lopez Wendy J Mack Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Joseph E Parisi Daniel P Perl Elaine Peskind Ronald C Petersen Wayne W Poon Joseph F Quinn Ruchita A Rajbhandary Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Roger N Rosenberg Mary Sano Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer Laura B Cantwell Beth A Dombroski Duane Beekly Kathryn L Lunetta Eden R Martin M Ilyas Kamboh Andrew J Saykin Eric M Reiman David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg

Nat Genet 2011 May 3;43(5):436-41. Epub 2011 Apr 3.

The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.

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http://dx.doi.org/10.1038/ng.801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745PMC
May 2011

Prevention of posttraumatic stress disorder.

Psychiatr Clin North Am 2011 Mar;34(1):79-94

San Diego State University/University of California-San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, San Diego, CA 92120-4913, USA.

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http://dx.doi.org/10.1016/j.psc.2010.11.001DOI Listing
March 2011

Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.

Brain Res 2011 Feb 11;1373:240-52. Epub 2010 Dec 11.

Northwest Network for Mental Illness, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038670PMC
February 2011

Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms.

Neuroimage 2011 Jan 10;54 Suppl 1:S76-82. Epub 2010 Apr 10.

Northwest Network Mental Illness, Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2010.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264671PMC
January 2011

Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq.

J Trauma Stress 2010 Oct;23(5):645-8

Madigan Army Medical Center and VA Northwest Network Mental Illness, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1002/jts.20570DOI Listing
October 2010

Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder.

Front Behav Neurosci 2009 30;3:40. Epub 2009 Oct 30.

Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System Seattle, WA, USA.

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http://journal.frontiersin.org/article/10.3389/neuro.08.040.
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http://dx.doi.org/10.3389/neuro.08.040.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773172PMC
December 2009

Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression.

Am J Geriatr Psychiatry 2009 Sep;17(9):744-51

VA Northwest Network Mental Illness Research, Education, and Clinical Center (MIRECC), Seattle, WA 98115, USA.

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http://dx.doi.org/10.1097/JGP.0b013e3181ab8c61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842091PMC
September 2009

A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence.

Alcohol Clin Exp Res 2009 Feb 21;33(2):255-63. Epub 2008 Oct 21.

Center of Excellence in Substance Abuse Treatment and Education, University of Washington, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2008.00807.xDOI Listing
February 2009

The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats.

Alcohol Clin Exp Res 2009 Feb 19;33(2):264-72. Epub 2008 Nov 19.

VISN 20 Mental Illness Research Education and Clinical Center, Mental Health Service, Department of Veterans Affairs Medical Center and University of Washington, Seattle, Washington, USA.

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http://doi.wiley.com/10.1111/j.1530-0277.2008.00829.x
Publisher Site
http://dx.doi.org/10.1111/j.1530-0277.2008.00829.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692839PMC
February 2009

Diagnosis and treatment of depression comorbid with neurologic disorders.

Authors:
Murray A Raskind

Am J Med 2008 Nov;121(11 Suppl 2):S28-37

Mental Health Service, VA Puget Sound Health Care System Mental Illness Research, University of Washington, Seattle, Washington 98108, USA.

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http://dx.doi.org/10.1016/j.amjmed.2008.09.011DOI Listing
November 2008

Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

J Trauma Stress 2008 Aug;21(4):417-20

VA Northwest Network, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1002/jts.20351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542062PMC
August 2008

Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study.

Biol Psychiatry 2008 Mar 14;63(6):629-32. Epub 2007 Sep 14.

Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA.

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http://dx.doi.org/10.1016/j.biopsych.2007.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350188PMC
March 2008

alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol.

Alcohol 2008 Mar;42(2):91-7

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.alcohol.2007.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587143PMC
March 2008

A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder.

Biol Psychiatry 2007 Apr 25;61(8):928-34. Epub 2006 Oct 25.

Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), University of Washington, Seattle, Washington, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000632230600862
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http://dx.doi.org/10.1016/j.biopsych.2006.06.032DOI Listing
April 2007

Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats.

Neuropsychopharmacology 2007 Feb 10;32(2):284-8. Epub 2006 May 10.

VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1038/sj.npp.1301093DOI Listing
February 2007

Salivary cortisol and memory function in human aging.

Neurobiol Aging 2006 Nov 4;27(11):1705-14. Epub 2005 Nov 4.

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2005.09.031DOI Listing
November 2006

Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during "abstinence".

Alcohol 2006 Apr;38(3):173-7

VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center, University of Washington, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1016/j.alcohol.2006.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839872PMC
April 2006

Safety and acceptability of the research lumbar puncture.

Alzheimer Dis Assoc Disord 2005 Oct-Dec;19(4):220-5

VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center (MIRECC), University of Washington School of Medicine, Seattle, WA 98108, USA.

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March 2006

Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.

Arch Neurol 2006 Mar;63(3):370-6

Parkinson's Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA.

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http://dx.doi.org/10.1001/archneur.63.3.370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892620PMC
March 2006

Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.

J Neurosci 2006 Jan;26(2):467-78

Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4265-05.2006DOI Listing
January 2006

Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression.

Brain Res Mol Brain Res 2005 Oct;139(2):367-71

Northwest Network Mental Illness Research, Education and Clinical Center (S-116), VA Puget Sound Health Care System, S-116 MIRECC, 1660 S. Columbian Way, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1016/j.molbrainres.2005.06.013DOI Listing
October 2005

Antipsychotic polypharmacy: do benefits justify the risks?

Ann Pharmacother 2005 Oct 6;39(10):1759-60. Epub 2005 Sep 6.

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http://dx.doi.org/10.1345/aph.1E429DOI Listing
October 2005

Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study.

Alzheimer Dis Assoc Disord 2005 Jan-Mar;19(1):23-8

Department of Veterans Affairs Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, Seattle, WA, USA.

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September 2005

Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report.

Int Psychogeriatr 2005 Jun;17(2):313-8

Department of Veterans Affairs, Puget Sound Health Care System Mental Illness Research, Education, and Clinical Center (MIRECC), Seattle, WA 98108, USA.

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June 2005

The challenge of a PTSD brain bank.

Authors:
Murray A Raskind

Psychiatry 2004 ;67(4):404-6

Department of Psychiatry and Behavioral Sciences, VA Puget Sound Health Care System, Seattle, Washington 98108, USA.

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May 2005

Increased galanin receptor occupancy in Alzheimer's disease.

Neurobiol Aging 2004 Nov-Dec;25(10):1309-14

Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.01.004DOI Listing
December 2004

Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus.

J Neurochem 2004 Nov;91(4):843-51

Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2004.02760.x
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http://dx.doi.org/10.1111/j.1471-4159.2004.02760.xDOI Listing
November 2004

The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial.

Arch Neurol 2004 Feb;61(2):252-6

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA.

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http://dx.doi.org/10.1001/archneur.61.2.252DOI Listing
February 2004

Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder.

J Geriatr Psychiatry Neurol 2003 Sep;16(3):165-71

Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1177/0891988703256050DOI Listing
September 2003

Update on Alzheimer drugs (galantamine).

Authors:
Murray A Raskind

Neurologist 2003 Sep;9(5):235-40

Northwest Network VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Alzheimer Disease Research Center, University of Washington, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1097/01.nrl.0000087722.46430.c4DOI Listing
September 2003

17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study.

Am J Geriatr Psychiatry 2003 Mar-Apr;11(2):239-44

Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle/Tacoma, WA, USA.

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July 2003

Depression in Kraepelinian schizophrenia.

Compr Psychiatry 2003 Jan-Feb;44(1):1-6

Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1053/comp.2003.50002DOI Listing
April 2003

Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.

Am J Psychiatry 2003 Feb;160(2):371-3

Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA.

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http://dx.doi.org/10.1176/appi.ajp.160.2.371DOI Listing
February 2003

Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study.

Arch Neurol 2002 Jul;59(7):1099-106

Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1001/archneur.59.7.1099DOI Listing
July 2002

Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder.

J Clin Psychiatry 2002 Jul;63(7):565-8

Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA.

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July 2002

The alpha1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorder.

J Clin Psychopharmacol 2002 Feb;22(1):82-5

Rainier Associates, Tacoma, WA 98467, USA.

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February 2002

Rivastigmine for Alzheimer's Disease: Improvement Versus Reduced Worsening.

Prim Care Companion J Clin Psychiatry 2000 Aug;2(4):134-138

University of Washington School of Medicine and Veterans Affairs Puget Sound Health Care System, Seattle; the Department of Psychiatry, University of Illinois, Chicago; the Rutgers University College of Pharmacy, Piscataway; and Novartis Pharmaceuticals, East Hanover, N.J.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC181126PMC
http://dx.doi.org/10.4088/pcc.v02n0406DOI Listing
August 2000