Murray Brilliant

AJOB Empir Bioeth 2018 Jul-Sep;9(3):128-142. Epub 2018 Sep 21.

x Division of Genetics and Genomics and the Manton Center for Orphan Diseases Research , Boston Children's Hospital.

BMC Cardiovasc Disord 2019 Oct 29;19(1):240. Epub 2019 Oct 29.

Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.

Clin Transl Sci 2019 Aug 6. Epub 2019 Aug 6.

Center for Devices and Radiological Health, US Food and Drug Administration (CDRH/FDA), Silver Spring, Maryland, USA.

JAMA Ophthalmol 2019 Aug 22. Epub 2019 Aug 22.

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear, Boston.

Sci Adv 2019 Aug 21;5(8):eaaw7195. Epub 2019 Aug 21.

Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.

Nat Genet 2019 Jul;51(7):1191-1192

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Sci Rep 2019 Apr 15;9(1):6077. Epub 2019 Apr 15.

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

J Allergy Clin Immunol 2019 Mar 9;143(3):1229-1231. Epub 2018 Nov 9.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.

Am J Health Syst Pharm 2019 02;76(6):387-397

Clinical Pharmacy Services, Marshfield Clinic Health Systems, Marshfield, WI.

Invest Ophthalmol Vis Sci 2018 11;59(13):5336-5348

Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.

Circulation 2018 11;138(22):2469-2481

Department of Medicine (J.D.M., C.M.S., J.F.F., J.C.D., T.J.W.), Vanderbilt University Medical Center, Nashville, TN.

Autism Res 2018 08 7;11(8):1120-1128. Epub 2018 May 7.

Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI, 53705.

Nat Commun 2018 08 30;9(1):3522. Epub 2018 Aug 30.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

Nat Genet 2018 05;50(5):765-766

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Nat Genet 2018 05;50(5):766-767

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Front Genet 2018 16;9:173. Epub 2018 May 16.

Department of Pediatrics, Rush University Medical Center, Chicago, IL, United States.

J Med Virol 2018 03 11;90(3):436-446. Epub 2017 Nov 11.

Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin.

Science 2018 03;359(6381):1233-1239

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Bioinformatics 2018 02;34(4):635-642

Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.

Invest Ophthalmol Vis Sci 2018 02;59(2):629-636

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Nat Genet 2018 01 22;50(1):26-41. Epub 2017 Dec 22.

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

J Genet Couns 2017 Dec 30;26(6):1401-1410. Epub 2017 Jun 30.

Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.

Eur J Hum Genet 2017 11 30;25(11):1261-1267. Epub 2017 Aug 30.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Nat Commun 2017 10 27;8(1):1167. Epub 2017 Oct 27.

Biomedical and Translational Informatics Institute, Geisinger Health System, Danville, PA, 17821, USA.

JMIR Med Inform 2017 Sep 13;5(3):e27. Epub 2017 Sep 13.

Marshfield Clinic Research Foundation, Human Genetics, Marshfield, WI, United States.

Sci Transl Med 2017 05;9(389)

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Circ Cardiovasc Genet 2017 Apr;10(2)

From the Department of Medicine (J.D.M., M.B.S., Q.S.W., C.M.S., J.C.D., D.M.R.), Vanderbilt Epidemiology Center (T.L.E.), Department of Biomedical Informatics (L.B., J.C.D., D.M.R.), Department of Pharmacology (D.M.R.), Vanderbilt University, Nashville, TN; Division of Cardiology, University of Illinois at Chicago (D.D.); Essentia Institute of Rural Health, Duluth, MN (C.A.M.); Center for Biomedical Research Informatics, NorthShore University Health System, Evanston, IL (W.T.); School of Medicine (C.G.C.), School of Public Health (C.G.C.), and School of Nursing (C.G.C.), Johns Hopkins University, Baltimore, MD; Division of Medical Genetics, Department of Medicine (G.P.J.), Department of Genome Sciences (G.P.J.), Department of Biomedical Informatics (D.R.C.), Department of Medical Education (D.R.C.), University of Washington; Group Health Research Institute, Seattle, WA (E.B.L.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (I.J.K.); Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (J.A.P.); Biomedical Informatics Research Center (P.L.P.), Center for Human Genetics (M.H.B., J.G.L.), Marshfield Clinic Research Foundation, WI; and Department of Epidemiology and Biostatistics, University of California, San Francisco (J.S.W.).

Am J Hum Genet 2017 Mar 9;100(3):414-427. Epub 2017 Feb 9.

Division of Genetics and Genomics and the Manton Center for Orphan Diseases Research, Boston Children's Hospital, Boston, MA 02115, USA.

Am J Respir Crit Care Med 2017 Feb;195(4):456-463

1 Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Menopause 2017 02;24(2):150-156

1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary 2Channing Division of Network Medicine, Brigham and Women's Hospital 3Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, MA 4Department of Epidemiology and Biostatistics 5Institute of Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH 6Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 7Department of Ophthalmology 8Department of Medicine, Duke University, Duke University Medical Center, Durham, NC 9Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 10Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 11Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 12Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA 13Departments of Ophthalmology and Anatomy/Cell Biology, University of Iowa, College of Medicine, Iowa City, IO 14Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 15Department of Ophthalmology, WVU Eye Institute, Morgantown, WV 16Scripps Genome Center, University of California at San Diego, San Diego, CA 17Emmes Corporation, Chevy Chase, MD 18Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 19Department of Ophthalmology, Stanford University, Palo Alto, CA 20Department of Ophthalmology, Mayo Clinic, Rochester, MN 21Wills Eye Institute, Philadelphia, PA 22Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 23Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, OH 24Department of Ophthalmology & Visual Sciences, University of Nebraska Medical Center, Omaha, NE 25Department of Genetics; Stanford University, Palo Alto, CA 26Wilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, MD 27Department of Ophthalmology, Hamilton Eye Center; University of California at San Diego, San Diego, CA 28Department of Cellular Biology & Anatomy, Augusta University, Augusta, GA.

Lancet Diabetes Endocrinol 2017 02 29;5(2):97-105. Epub 2016 Nov 29.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address:

Nature 2017 02 1;542(7640):186-190. Epub 2017 Feb 1.

Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.

Circ Cardiovasc Genet 2016 Dec 25;9(6):521-530. Epub 2016 Oct 25.

From the Department of Medicine (J.D.M., S.L.v.D., Q.S.W., C.M.S., J.C.D., D.M.R.), Department of Pediatrics (S.L.v.D.), Vanderbilt Epidemiology Center (T.L.E.), Biomedical Informatics (L.B., J.C.D., D.M.R.), and Department of Pharmacology (D.M.R.), Vanderbilt University, Nashville, TN; Essentia Institute of Rural Health, Duluth, MN (C.A.M.); Center for Biomedical Research Informatics, North Shore University Health System, Evanston, IL (W.T.); Department of Health Policy and Management Schools of Medicine, Public Health, and Nursing, Johns Hopkins University, Baltimore, MD (C.G.C.); Departments of Medicine (Medical Genetics) and Genome Sciences (G.P.J.) and Departments of Biomedical Informatics and Medical Education (D.R.C.), University of Washington, Seattle; Group Health Research Institute, Seattle, WA (E.B.L.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (I.J.K.); Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (J.A.P.); and Biomedical Informatics Research Center (P.L.P., J.G.L.) and Center for Human Genetics (M.H.B.), Marshfield Clinic Research Foundation, WI.

BMC Med Res Methodol 2016 11 24;16(1):162. Epub 2016 Nov 24.

Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Pac Symp Biocomput 2016 ;21:249-60

Department of Biochemistry, Microbiology and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.

Pac Symp Biocomput 2016 ;21:357-68

Center for Systems Genomics, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.

J Med Genet 2016 10 10;53(10):681-9. Epub 2016 Jun 10.

Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA.

PLoS Genet 2016 09 13;12(9):e1006186. Epub 2016 Sep 13.

Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, Pennsylvania, United States of America.

Invest Ophthalmol Vis Sci 2016 Sep;57(11):5046-5052

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States.

Invest Ophthalmol Vis Sci 2016 08;57(10):4528-4535

Department of Ophthalmology, Mass Eye & Ear, Boston, Massachusetts, United States.

PLoS One 2015 28;10(9):e0138677. Epub 2015 Sep 28.

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, United States of America; University of Cincinnati, College of Medicine, Cincinnati, OH, United States of America; U.S. Department of Veterans Affairs Medical Center, Cincinnati, OH, United States of America.

J Neurosurg 2016 Jun 20;124(6):1746-51. Epub 2015 Nov 20.

Division of Cardiovascular Medicine, College of Medicine, and.

BioData Min 2016 10;9:18. Epub 2016 May 10.

Center for Systems Genomics, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA ; Biomedical & Translational Informatics, Geisinger Health System, Danville, Pennsylvania USA.

Nat Commun 2016 04 25;7:11433. Epub 2016 Apr 25.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

PLoS One 2015 1;10(6):e0127791. Epub 2015 Jun 1.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America.

Am J Med 2016 Mar 30;129(3):292-8. Epub 2015 Oct 30.

Department of Ophthalmology and Vision Science, University of Arizona, Tucson; Department of Cellular and Molecular Medicine, University of Arizona, Tucson. Electronic address:

Nat Genet 2016 Feb 21;48(2):134-43. Epub 2015 Dec 21.

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.

Nat Genet 2016 Feb 11;48(2):189-94. Epub 2016 Jan 11.

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

J Pediatr Ophthalmol Strabismus 2015 May-Jun;52(3):167-72

JAMA 2016 Jan;315(1):47-57

Vanderbilt University Medical Center, Nashville, Tennessee.

J AAPOS 2015 Dec;19(6):562-4

Department of Pediatrics, University of Minnesota, Minneapolis; Department of Ophthalmology & Visual Neurosciences, University of Minnesota, Minneapolis. Electronic address:

Immun Inflamm Dis 2015 Dec 14;3(4):350-9. Epub 2015 Jul 14.

Channing Division of Network Medicine, Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMassachusetts02115; Center for Child Health Care Studies, Department of Population MedicineHarvard Pilgrim Health Care Institute and Harvard Medical SchoolBostonMassachusetts02115.

J Pathol Inform 2015 28;6:50. Epub 2015 Sep 28.

Department of Preventive Medicine, Division of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Am J Hum Genet 2015 Oct 10;97(4):512-20. Epub 2015 Sep 10.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address:

J Pathol Inform 2015 31;6:46. Epub 2015 Aug 31.

Department of Preventive Medicine, Division of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

J Oral Microbiol 2015 4;7:28223. Epub 2015 Sep 4.

Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.

J Cardiovasc Pharmacol 2015 Aug;66(2):183-8

*Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI; †Health Services Research and Development, Michael E. DeBakey Veterans Affairs Medical Center and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX; and ‡Division of Genetics and Endocrinology, Cook Children's Medical Center, Fort Worth, TX.

Trends Mol Med 2015 Aug 27;21(8):461-2. Epub 2015 Jun 27.

Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.

Int Health 2015 Jul 10;7(4):223-5. Epub 2015 Jun 10.

Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA

Hum Genet 2015 Jun 19;134(6):659-69. Epub 2015 Apr 19.

Center for Human Genetics, Marshfield Clinic Research Foundation, 1000 N Oak Ave-MLR, Marshfield, WI, 54449, USA,

Genome Biol 2015 Jun 25;16:133. Epub 2015 Jun 25.

Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Kerpener Strasse 62, D-50924, Cologne, Germany.

Eur J Hum Genet 2015 Apr 30;23(4):523-9. Epub 2014 Jul 30.

1] Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA [2] Computation and Informatics in Biology and Medicine, University of Wisconsin Madison, Madison, WI, USA.

J Med Genet 2015 Apr 13;52(4):282-8. Epub 2015 Jan 13.

Utah Foundation for Biomedical Research, Provo, Utah, USA Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA Department of Psychiatry, University of Southern California, Los Angeles, California, USA.

Circ Res 2014 Dec 17;115(12):1017-25. Epub 2014 Oct 17.

From the Center for Pharmacogenomics, College of Medicine, The Ohio State University, Columbus (E.S.B., J.K.P., W.S.); Department of Human Genetics, Emory University School of Medicine, Atlanta, GA (D.W., J.F.C.); Center for Systems Genomics, Pennsylvania State University, University Park (A.V., S.A.P., M.D.R.); Department of Genetics, University of North Carolina School of Medicine, Chapel Hill (L.A.L.); Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (J.G.W.); The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, PA (H.K., G.T., D.J.C.); Institute for Personalized Medicine, The Pennsylvania State University College of Medicine, Hershey (G.S.G.); Center for Human Genetics, Marshfield Clinic Research Foundation, WI (M.H.B., S.J.H.); and Department of Psychology, The University of Chicago, IL (G.J.N.).

Clin Exp Ophthalmol 2014 Nov 5;42(8):713-21. Epub 2014 May 5.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.

Invest Ophthalmol Vis Sci 2014 Nov 20;55(12):8251-8. Epub 2014 Nov 20.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States.

Hum Genet 2014 Oct 19;133(10):1319-30. Epub 2014 Jul 19.

Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.

Front Genet 2014 5;5:250. Epub 2014 Aug 5.

Department of Medicine, Vanderbilt University Nashville, TN, USA ; Department of Biomedical Informatics, Vanderbilt University Nashville, TN, USA.

Invest Ophthalmol Vis Sci 2014 Sep 18;55(9):5923. Epub 2014 Sep 18.

Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States;

Pac Symp Biocomput 2014 :200-11

Center for Systems Genomics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 512 Wartik Lab, University Park, PA 16802, USA.

Optom Vis Sci 2014 Aug;91(8):939-49

*MD †BS ‡PhD §MS Department of Ophthalmology (MEL, JY, KES, JC, TC), Division of Biostatistics, Institute for Health and Society (QX, AS, CDP), Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin (RFC); Department of Computer Sciences, University of Wisconsin-Madison, Madison, Wisconsin (EB); and Center for Human Genetics (TK, MB), Core Laboratory (LCI), Marshfield Clinic Research Foundation, Marshfield, Wisconsin.

Front Genet 2014 2;5:162. Epub 2014 Jun 2.

Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh PA, USA.

Invest Ophthalmol Vis Sci 2014 May 20;55(7):4186-98. Epub 2014 May 20.

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin, United States Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.

Front Genet 2014 9;5:125. Epub 2014 May 9.

Center for Human Genetics, Marshfield Clinic Research Foundation Marshfield, WI, USA.

BMJ Case Rep 2014 Feb 11;2014. Epub 2014 Feb 11.

Department of Internal Medicine and Clinical Research, Marshfield Clinic, Marshfield, Wisconsin, USA.

Ophthalmology 2014 Feb 25;121(2):508-16. Epub 2013 Oct 25.

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. Electronic address:

BMC Med Genomics 2014 Jan 14;7. Epub 2014 Jan 14.

Division of Research, Essentia Institute of Rural Health, 502 East Second Street, Duluth, MN 55805, USA.

Nat Biotechnol 2013 Dec;31(12):1102-10

Genet Med 2013 Oct 6;15(10):761-71. Epub 2013 Jun 6.

Mount Sinai School of Medicine, New York, New York, USA.

Genet Med 2013 Oct 12;15(10):792-801. Epub 2013 Sep 12.

The Information School, University of Washington, Seattle, Washington, USA.

Mol Vis 2013 12;19:1471-81. Epub 2013 Jul 12.

Department of Ophthalmology, Mass Eye & Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

Am J Med Genet B Neuropsychiatr Genet 2013 Jul 5;162B(5):466-73. Epub 2013 Jun 5.

Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.

Genet Med 2013 Apr 10;15(4):258-67. Epub 2013 Jan 10.

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Blood 2013 Jan;121(1):237-8

Med Hypotheses 2012 Dec 12;79(6):875-8. Epub 2012 Oct 12.

Department of Pediatrics, University of Arizona, Tucson, AZ 85724, USA.

Virtual Mentor 2012 Aug 1;14(8):653-6. Epub 2012 Aug 1.

Center for Human Genetics at Marshfield Clinic Research Foundation in Marshfield, Wisconsin, USA.

J Clin Invest 2011 Oct;121(10):3914-23

Unit on Pediatric, Developmental, and Genetic Eye Disease, National Eye Institute, NIH, Bethesda, Maryland 20892, USA.

Pigment Cell Melanoma Res 2011 Aug 17;24(4):605-13. Epub 2011 May 17.

Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.

PLoS One 2010 Aug 20;5(8):e12278. Epub 2010 Aug 20.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

J Forensic Sci 2010 Mar 11;55(2):315-22. Epub 2010 Feb 11.

Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.

Am J Hum Genet 2010 Feb 4;86(2):148-60. Epub 2010 Feb 4.

Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Pigment Cell Melanoma Res 2009 Oct 24;22(5):645-7. Epub 2009 Apr 24.

Mini Rev Med Chem 2008 Jun;8(7):669-76

University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721, USA.

Exp Hematol 2007 Mar;35(3):358-67

Department of Pediatrics, University of Arizona, College of Medicine, Tucson, AZ 85724, USA.