Publications by authors named "Muriel Laffargue"

37Publications

Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cells.

Circ Res 2020 Dec 5;127(12):1473-1487. Epub 2020 Oct 5.

I2MC, Institut National de la Santé et de la Recherche Médicale (INSERM) U 1048, University of Toulouse 3, France (R.Z., M.D., N.S., M.B., E.L., A.L., R.S., A.V., F.L., M.L., J.-F.A., C.F.).

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December 2020

A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage.

J Cell Sci 2020 Jul 9;133(13). Epub 2020 Jul 9.

Department of Vascular Biology of the Institute of Metabolic and Cardiovascular Diseases (I2MC), Université de Toulouse 3, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1048, Toulouse, France

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July 2020

PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress.

Nat Commun 2020 01 15;11(1):294. Epub 2020 Jan 15.

Institut Necker-Enfants Malades (INEM), INSERM U1151 CNRS UMR 8253, Université Paris Descartes-Sorbonne Paris Cité, Paris, France.

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January 2020

Immune and Smooth Muscle Cells Interactions in Atherosclerosis: How to Target a Breaking Bad Dialogue?

Front Pharmacol 2019 22;10:1276. Epub 2019 Nov 22.

Department of Vascular Biology of the Institute of Metabolic and Cardiovascular Diseases (I2MC), Université de Toulouse 3, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1048, Toulouse, France.

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November 2019

Role of reactive oxygen species in atherosclerosis: Lessons from murine genetic models.

Free Radic Biol Med 2020 03 25;149:8-22. Epub 2019 Nov 25.

Inserm U-1048, Université de Toulouse, France.

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March 2020

Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage.

Matrix Biol 2019 11 18;84:57-67. Epub 2019 Jun 18.

UMR CNRS 7369 MEDyC, SFR CAP-Santé, Université de Reims Champagne-Ardenne, Reims, France. Electronic address:

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November 2019

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response.

Cardiovasc Res 2020 02;116(2):438-449

Institute of Metabolic and Cardiovascular Diseases (I2MC), Université de Toulouse, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1048, Toulouse F-31432, France.

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February 2020

Small GTPases orchestrate cell-cell communication during collective cell movement.

Small GTPases 2020 03 17;11(2):103-112. Epub 2017 Dec 17.

INSERM, U1048, I2MC and Université Toulouse III, Toulouse, France.

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March 2020

PI3K and Calcium Signaling in Cardiovascular Disease.

Circ Res 2017 Jul;121(3):282-292

From the Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Italy (A.G., M. Li, E.H.); and INSERM U1048, I2MC and Université Toulouse III, France (M. Laffargue).

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July 2017

PI3Kβ Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.

Cell Physiol Biochem 2017 5;42(2):579-593. Epub 2017 Jun 5.

Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.

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August 2017

Matrix ageing and vascular impacts: focus on elastin fragmentation.

Cardiovasc Res 2016 06 22;110(3):298-308. Epub 2016 Mar 22.

Team 2: Matrix aging and Vascular remodelling, UMR CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), Université de Reims Champagne Ardenne (URCA), UFR Sciences Exactes et Naturelles, Reims, France

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June 2016

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.

Circ Res 2015 Oct 27;117(9):770-8. Epub 2015 Aug 27.

From the Department of Vascular Biology of the Institute of Metabolic and Cardiovascular Diseases (I2MC), Université de Toulouse 3, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France (N.F.S., C.F., M.B., A.L., A.V., M.-C.V., M.G., N.M., F.L., P.G., M.L., J.-F.A.); Laboratory of Tumor and Developmental Biology, GIGA-Cancer, Université de Liège, Groupe Interdisciplinaire de Génoprotéomique Appliquée, Liège, Belgique (J.-M.F.); UMR INRA/DGER 1225, Université de Toulouse, INP, ENVT, Toulouse, France (I.R.-L.); Departments of Molecular and Integrative Biology (B.S.K.) and Chemistry, University of Illinois at Urbana-Champaign (J.A.K.).

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October 2015

PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms.

Adv Biol Regul 2015 Sep 26;59:4-18. Epub 2015 Jul 26.

INSERM, U1048, I2MC and Université Toulouse III, Toulouse, F-31300, France. Electronic address:

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September 2015

Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.

Cardiovasc Res 2015 May 13;106(2):314-23. Epub 2015 Mar 13.

INSERM, UMR 1048, Institut de Maladies Métaboliques et Cardiovasculaires, Toulouse, France Université de Toulouse III, UMR 1048, Toulouse, France CHU de Toulouse, Hôpital Purpan, Toulouse, France INSERM U1048, Bât. L3, Hôpital Rangueil, BP 84225, 31432 Toulouse cedex 04, France

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May 2015

Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.

Circulation 2015 Mar 22;131(12):1061-70. Epub 2015 Jan 22.

From Sorbonne Universités, UPMC Université Paris 06, Biological Adaptation and Ageing-IBPS, Paris, France (A.A., D.C., D.F.D.M., R.E.H., B.F., K.E.H., M.R.); CNRS-UMR 8256, Paris, France (A.A., D.C., D.F.D.M., R.E.H., F.B., K.E.H., M.R.); Inserm U1164, Paris, France (A.A., D.C., D.F.D.M., R.E.H., B.F., K.E.H., M.R.); INSERM-UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France (C.V., M.L.); Centre de Recherche d'Immunologie et Maladies Infectieuses, CIMI-Paris UPMC UMRS CR7, INSERM U-1135, CNRS ERL 8255, Hôpital Pitié-Salpêtrière, Paris, France (V.M.); Ulm University, Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm, Germany (B.B., M.R.A., M.E.G., T.S., T.S.); Biochemistry Laboratory, Faculty of Medicine, TN-Monastir, Tunisia (M.-N.S.); and Centre de Recherche sur le Vieillissement, Service Gériatrique, Département de Médecine, Université de Sherbrooke, Sherbrooke, QC, Canada (T.F.).

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March 2015

Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.

Cell Mol Life Sci 2014 May 13;71(9):1775-88. Epub 2013 Sep 13.

INSERM, UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, 31432, France,

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May 2014

Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study.

J Lipid Res 2013 Sep 21;54(9):2550-8. Epub 2013 Jun 21.

Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, 31000, France.

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September 2013

Elastin fragmentation and atherosclerosis progression: the elastokine concept.

Trends Cardiovasc Med 2013 Aug 2;23(6):211-21. Epub 2013 Apr 2.

Laboratoire Signalisation et Récepteurs Matriciels (SiRMa), FRE CNRS 3481 MEDyC, Université de Reims Champagne Ardenne, Faculté des Sciences Exactes et Naturelles, Reims, France.

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August 2013

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

J Immunol 2010 Jul 16;185(2):1169-76. Epub 2010 Jun 16.

Institut National de la Santé et de la Recherche Médicale Unité 858, Institut de Médecine Moléculaire de Rangueil, Université de Toulouse, France.

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July 2010

Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis?

Clin Sci (Lond) 2009 May 1;116(11):791-804. Epub 2009 May 1.

Département Lipoprotéines et Médiateurs lipidiques, INSERM U563, site Toulouse-Purpan, BP 3028, 31024 Toulouse Cedex 3, France.

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May 2009

Selective activation of nuclear phospholipase D-1 by g protein-coupled receptor agonists in vascular smooth muscle cells.

Circ Res 2006 Jul 15;99(2):132-9. Epub 2006 Jun 15.

Département Lipoprotéines and Médiateurs Lipidiques, CPTP, INSERM Unité 563, Bâtiment C, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France.

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July 2006

Phosphoinositide 3-kinase signalling--which way to target?

Trends Pharmacol Sci 2003 Jul;24(7):366-76

Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland.

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July 2003

The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.

Development 2002 Sep;129(17):4103-9

Universität Zürich, Zoologisches Institut, Winterthurerstrasse 190, CH - 8057, Switzerland.

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September 2002

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function.

Immunity 2002 Mar;16(3):441-51

Institute of Biochemistry, Department of Medicine, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland.

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March 2002

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

Science 2002 Mar 28;295(5562):2088-91. Epub 2002 Feb 28.

Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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March 2002