Publications by authors named "Muredach Reilly"

100Publications

Novel mechanistic links between high-protein diets and atherosclerosis.

Nat Metab 2020 Jan;2(1):7-8

Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s42255-019-0163-3DOI Listing
January 2020

Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy.

J Cardiovasc Transl Res 2020 Jun 27. Epub 2020 Jun 27.

Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12265-020-10051-2DOI Listing
June 2020

Inflammation and Circulating Natriuretic Peptide Levels.

Circ Heart Fail 2020 Jul 8;13(7):e006570. Epub 2020 Jun 8.

Vanderbilt Translational and Clinical Cardiovascular Research Center, University Medical Center, Nashville, TN (H.F.-T., J.F.F., K.N.B., D.K.G).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.006570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375923PMC
July 2020

Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis.

Nat Commun 2020 05 11;11(1):2338. Epub 2020 May 11.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41467-020-15851-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214470PMC
May 2020

ASEP: Gene-based detection of allele-specific expression across individuals in a population by RNA sequencing.

PLoS Genet 2020 05 11;16(5):e1008786. Epub 2020 May 11.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241832PMC
May 2020

Promoting interdisciplinary research to respond to public health crises: The response of the Columbia University CTSA to the opioid crisis.

J Clin Transl Sci 2020 Feb 30;4(1):22-27. Epub 2019 Oct 30.

Irving Institute for Clinical and Translational Research, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1017/cts.2019.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103466PMC
February 2020

Sex Differences in Genomic Drivers of Adipose Distribution and Related Cardiometabolic Disorders: Opportunities for Precision Medicine.

Arterioscler Thromb Vasc Biol 2020 01 21;40(1):45-60. Epub 2019 Nov 21.

From the Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY (H.S.L., M.O., M.P.R.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313154DOI Listing
January 2020

Functional Characterization of LIPA (Lysosomal Acid Lipase) Variants Associated With Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2019 12 24;39(12):2480-2491. Epub 2019 Oct 24.

From the Cardiovascular Division, Department of Medicine (T.D.E., X.Z., R.E.C., A.A., E.S., N.O.S., B.R.), Washington University in St. Louis School of Medicine, MO.

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http://dx.doi.org/10.1161/ATVBAHA.119.313443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050600PMC
December 2019

Comparison of Effectiveness of Alcohol Septal Ablation Versus Ventricular Septal Myectomy on Acute Care Use for Cardiovascular Disease in Patients With Hypertrophic Cardiomyopathy.

Am J Cardiol 2019 10 29;124(8):1272-1278. Epub 2019 Jul 29.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.amjcard.2019.07.031DOI Listing
October 2019

A protective smooth muscle cell transition in atherosclerosis.

Nat Med 2019 08;25(8):1194-1195

Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-019-0541-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307968PMC
August 2019

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation.

Circ Res 2019 08 18;125(6):590-605. Epub 2019 Jul 18.

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314402DOI Listing
August 2019

Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy.

J Cardiovasc Transl Res 2019 12 5;12(6):569-579. Epub 2019 Jul 5.

Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12265-019-09896-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102897PMC
December 2019

Endothelial Forkhead Box Transcription Factor P1 Regulates Pathological Cardiac Remodeling Through Transforming Growth Factor-β1-Endothelin-1 Signal Pathway.

Circulation 2019 08 10;140(8):665-680. Epub 2019 Jun 10.

Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (J.L., T.Z., X.C., Z.Y., L.Z., Z.L., Y.Z.), Tongji University School of Medicine, China.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039767DOI Listing
August 2019

Stochastic imputation for integrated transcriptome association analysis of a longitudinally measured trait.

Stat Methods Med Res 2020 04 7;29(4):1167-1180. Epub 2019 Jun 7.

Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA, USA.

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http://dx.doi.org/10.1177/0962280219852720DOI Listing
April 2020

Cell-Specific Effects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in Vascular Smooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation.

Arterioscler Thromb Vasc Biol 2019 05;39(5):888-901

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., Y.K., Y.W., Z.Y., L.Z., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

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http://dx.doi.org/10.1161/ATVBAHA.118.312263DOI Listing
May 2019

Tissue-Specific Differential Expression of Novel Genes and Long Intergenic Noncoding RNAs in Humans With Extreme Response to Evoked Endotoxemia.

Circ Genom Precis Med 2018 11;11(11):e001907

Cardiology Division, Department of Medicine, Columbia University Medical Center, New York, NY (C.X., Y.G., J.S., X.Z., Y.W., Y.D.L., H.Z., M.P.R.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309423PMC
November 2018

A likelihood-based approach to transcriptome association analysis.

Stat Med 2019 04 4;38(8):1357-1373. Epub 2018 Dec 4.

Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, Massachusetts.

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http://doi.wiley.com/10.1002/sim.8040
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http://dx.doi.org/10.1002/sim.8040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907891PMC
April 2019

Who Done It? Macrophage Mayhem in Atherosclerosis

Circ Res 2018 10;123(10):1106-1108

From the Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York (H.Z., M.P.R.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488510PMC
October 2018

Long intergenic noncoding RNAs in cardiovascular diseases: Challenges and strategies for physiological studies and translation.

Atherosclerosis 2019 02 29;281:180-188. Epub 2018 Sep 29.

Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA; Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183141
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307970PMC
February 2019

First Giant Steps Toward a Cell Atlas of Atherosclerosis.

Circ Res 2018 06;122(12):1632-1634

From the Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York (H.Z., M.P.R.)

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31307
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018056PMC
June 2018

Human Induced Pluripotent Stem Cell-Derived Macrophages for Unraveling Human Macrophage Biology.

Arterioscler Thromb Vasc Biol 2017 11 5;37(11):2000-2006. Epub 2017 Oct 5.

From the Division of Cardiology, Department of Medicine (H.Z., M.P.R.) and Irving Institute for Clinical and Translational Research (M.P.R.), Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1161/ATVBAHA.117.309195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687272PMC
November 2017

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.

Arterioscler Thromb Vasc Biol 2017 11 7;37(11):2156-2160. Epub 2017 Sep 7.

From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York (H.Z., J.S., M.A.H., C.X., R.C.B., M.P.R.); Irving Institute for Clinical and Translational Research, Columbia University, New York (H.J., M.P.R.); Cardiovascular Institute, Perelman School of Medicine (W.L.), Division of Translational Medicine and Human Genetics, Departments of Genetics and Medicine, Perelman School of Medicine (J.T., J.B., M.C.P., D.J.R.), and Metabolic Tracer Resource, Institute for Diabetes, Obesity and Metabolism, Department of Medicine (J.M.), University of Pennsylvania, Philadelphia; and Department of Pathology and Immunology, Washington University in St. Louis, MO (B.R.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659288PMC
November 2017

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

Nat Genet 2017 Oct 4;49(10):1450-1457. Epub 2017 Sep 4.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844224PMC
October 2017

Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).

Arterioscler Thromb Vasc Biol 2017 10 24;37(10):1971-1978. Epub 2017 Aug 24.

From the Division of General Internal Medicine, Department of Medicine (A.B.), Division of Vascular Surgery (S.M.D.), Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics (A.H.A., D.X., D.S., J.C.), Department of Genetics (D.S., D.J.R.), Department of Medicine (D.J.R.), Department of Pediatrics (D.J.R.), The Penn Cardiovascular Institute (D.J.R.), and Institute for Translational Medicine and Therapeutics (D.J.R.), University of Pennsylvania, Philadelphia; Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA (S.M.D.); Department of Medicine, Los Angeles Biomedical Research Institute at Harbor, University of California-Los Angles (M.J.B.); Division of Research, Kaiser Permanente Northern California, Oakland, CA (A.S.G.); Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (J.H.); Division of Nephrology, Department of Medicine, University of Illinois at Chicago (J.P.L.); Department of Medicine, University of Michigan, Ann Arbor (A.O.); Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (W.S.P.); Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD (W.S.P.); Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH (M.R.); Division of Cardiology, Department of Medicine, (M.P.R.) and Irving Institute for Clinical and Translational Research (M.P.R.), Columbia University, New York, NY; and Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (R.R.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620129PMC
October 2017

Synergistic Modulation of Inflammatory but not Metabolic Effects of High-Fat Feeding by CCR2 and CX3CR1.

Obesity (Silver Spring) 2017 Aug 26;25(8):1410-1420. Epub 2017 Jun 26.

Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1002/oby.21900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610963PMC
August 2017

A score test for genetic class-level association with nonlinear biomarker trajectories.

Stat Med 2017 Aug 23;36(19):3075-3091. Epub 2017 May 23.

Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA, U.S.A.

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http://dx.doi.org/10.1002/sim.7314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002775PMC
August 2017

Variants in Genome-Wide Association Studies of Coronary Artery Diseases: Loss-of-Function or Gain-of-Function?

Arterioscler Thromb Vasc Biol 2017 06;37(6):1015-1017

From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York (H.Z., M.P.R.); and Irving Institute for Clinical and Translational Research, Columbia University, New York (M.P.R.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526101PMC
June 2017

Loss of Cardioprotective Effects at the Locus as a Result of Gene-Smoking Interactions.

Circulation 2017 Jun 1;135(24):2336-2353. Epub 2017 May 1.

From Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (D.S., W.Z.); Center for Non-Communicable Diseases, Karachi, Pakistan (D.S., A.R., P.M.F., PROMIS); Department of Public Health and Primary Care, University of Cambridge, United Kingdom (R.Y., W.K.H., EPIC-CVD); Department of Cardiovascular Sciences, University of Leicester, United Kingdom (C.P.N., N.J.S.); Cardiology Division, Department of Medicine, Vanderbilt University, Nashville, TN (J.F.F., K.O.); Division of Cardiovascular Medicine, Radcliffe Department of Medicine & Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom (A.G., M.F.); The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Canada (A.F.R.S., R.M.); Institute for Genetic Medicine and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (J.H., H.A.); Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom (W.Z., J.C.C., J.K.); Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, United Kingdom (W.Z., J.C.C.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S.); Helsinki University Central Hospital HUCH Heart and Lung Center, Helsinki, Uusimaa, Finland (J.S.); Cardiology Division, Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY (R.C.B., M.P.R.); William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.K., E.M., P.D.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (S.S., A.D.); Department of Dietetics-Nutrition, Harokopio University, Athens, Greece (E.M., G.D.); National Institute for Health and Welfare, Helsinki, Finland (K.K., A.J., V.S., K.K., M.P.); MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, United Kingdom (J.H.Z., R.S.); INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France (D.G., N.W.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.H.S.); Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V.G.); Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.v.Z., C.N.A.P.); Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC (A.J.C., D.W.B.); Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Germany (C.W., J.E.); DZHK (German Research Center for Cardiovascular Research) partner site Hamburg-Lübeck-Kiel, Germany (C.W., J.E.); Deutsches Herzzentrum München, Technische Universität München, Germany (T.K., L.Z., H.S.); Klinikum rechts der Isar, München, Germany (T.K.); DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Germany (L.Z., H.S.); Department of Genetics, Washington University School of Medicine, St. Louis, MO (M.A.P., M.F.F.); Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (A.G.); Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (A.G.); Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Sweden (L.L.); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (N.L.P.); Department of Biostatistics Boston University School of Public Health Framingham Heart Study, MA (C.C.W.); Faculty of Medicine, University of Iceland, Reykjavik (A.V.S., V.G.); University of Helsinki, Institute for Molecular Medicine, Finland (FIMM) (A.J., M.P.); Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Germany (M.E.K.); Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom (A.S.H.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany and Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria (W.M.); National Heart, Lung, and Blood Institute and the Framingham Heart Study, National Institutes of Health, Bethesda, MD (C.O'D.); Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden (E.I.); Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (E.I.); Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (U.D.F.); Lebanese American University, School of Medicine, Beirut (P.Z.); Department of Health Sciences, University of Leicester, United Kingdom (J.R.T.); Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.K.); Cardiovascular Science, National Heart and Lung Institute, Imperial College London, United Kingdom (J.K.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia (P.D.); deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland (G.T., K.S.); University of Iceland, School of Medicine, Reykjavik, Iceland (G.T., K.S.); Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge (S.K.); Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.K.); Center for Human Genetic Research, Massachusetts General Hospital, Boston (S.K.); Department of Medicine, Harvard Medical School, Boston, MA (S.K.); Department of Genetics, University of Pennsylvania, Philadelphia (D.J.R.); and Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.T.N., D.J.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612779PMC
June 2017

Coronary Artery Calcification and Risk of Cardiovascular Disease and Death Among Patients With Chronic Kidney Disease.

JAMA Cardiol 2017 06;2(6):635-643

Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana2Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.

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http://dx.doi.org/10.1001/jamacardio.2017.0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798875PMC
June 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Authors:
Thomas R Webb Jeanette Erdmann Kathleen E Stirrups Nathan O Stitziel Nicholas G D Masca Henning Jansen Stavroula Kanoni Christopher P Nelson Paola G Ferrario Inke R König John D Eicher Andrew D Johnson Stephen E Hamby Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Peter E Weeke Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenborg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Pier A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian Shaffer Nour Eddine El-Mokhtari Andre Franke Stefanie Heilmann Christian Hengstenberg Per Hoffmann Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Jarma Virtamo Majid Nikpay Oliviero Olivieri Sylvie Provost Alaa AlQarawi Neil R Robertson Karen O Akinsansya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Martina Müller-Nurasyid Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Rajiv Chowdhury Veikko Salomaa Ian Ford J Wouter Jukema Philippe Amouyel Jukka Kontto Børge G Nordestgaard Jean Ferrières Danish Saleheen Naveed Sattar Praveen Surendran Aline Wagner Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel J Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Nilesh J Samani Heribert Schunkert Panos Deloukas Sekar Kathiresan

J Am Coll Cardiol 2017 Feb;69(7):823-836

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2016.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314135PMC
February 2017

Expression of Calgranulin Genes S100A8, S100A9 and S100A12 Is Modulated by n-3 PUFA during Inflammation in Adipose Tissue and Mononuclear Cells.

PLoS One 2017 26;12(1):e0169614. Epub 2017 Jan 26.

Division of Cardiovascular Medicine, and Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC), Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169614PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268473PMC
August 2017

Bayesian variable selection for post-analytic interrogation of susceptibility loci.

Biometrics 2017 06 17;73(2):603-614. Epub 2016 Nov 17.

Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, Massachusetts, U.S.A.

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http://dx.doi.org/10.1111/biom.12620DOI Listing
June 2017

Distinct functions of PPARγ isoforms in regulating adipocyte plasticity.

Biochem Biophys Res Commun 2016 Dec 3;481(1-2):132-138. Epub 2016 Nov 3.

Department of Pathology and Cell Biology, Naomi Berrie Diabetes Center, Columbia University College of Physicians & Surgeons, New York, NY, 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.10.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147489PMC
December 2016

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

Sci Rep 2016 10 12;6:35278. Epub 2016 Oct 12.

Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1038/srep35278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059659PMC
October 2016

Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study.

Diabetes 2017 02 4;66(2):543-550. Epub 2016 Oct 4.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db16
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http://dx.doi.org/10.2337/db16-0868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248987PMC
February 2017

GlycA Is a Novel Biomarker of Inflammation and Subclinical Cardiovascular Disease in Psoriasis.

Circ Res 2016 Nov 21;119(11):1242-1253. Epub 2016 Sep 21.

From the Cardiovascular and Pulmonary Branch (A.A.J., J.B.L., T.M.A., H.L.T., J.A.R., Q.N., T.Z.A., T.S., B.N., M.Y.C., A.T.R., D.A.B., M.P.P., N.N.M.), Section of Inflammation and Cardiometabolic Diseases (A.A.J., J.B.L., T.M.A., H.L.T., J.A.R., Q.N., T.Z.A., T.S., B.N., A.T.R., M.P.P., N.N.M.), National Heart, Lung, and Blood Institute, Bethesda, MD; Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA (A.A.J.); Department of Medicine, McGill University, Montreal, QC, Canada (M.A.); Department of Cardiology, Einstein Institute for Heart and Vascular Health, Albert Einstein Medical Center, Philadelphia, PA (P.K.); Department of Internal Medicine, University of Colorado, Denver (T.S.); Department of Internal Medicine, University of Arizona College of Medicine at South Campus, Tucson (B.N.); Derm Associates, Silver Spring, MD (B.N.L.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Research Center, Bethesda, MD (M.A.A.); Perelman School of Medicine (D.J.R.), Department of Dermatology (J.M.G.), and The Center for Clinical Epidemiology and Biostatistics (J.M.G.), University of Pennsylvania, Philadelphia; and Division of Cardiology, Department of Medicine, Irving Institute for Clinical and Translational Research, Columbia University, New York (M.P.R.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215065PMC
November 2016

Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits.

Hum Mol Genet 2016 07 10;25(14):3125-3141. Epub 2016 Jun 10.

Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA

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http://dx.doi.org/10.1093/hmg/ddw154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181595PMC
July 2016

Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing.

Arterioscler Thromb Vasc Biol 2016 07 26;36(7):1434-47. Epub 2016 May 26.

From the Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine (J.L.), Department of Biostatistics and Epidemiology (Y.H., M.L.), Department of Genetics, Perelman School of Medicine (B.C., K.M., D.J.R.), and Cardiovascular Institute, Department of Medicine, Perelman School of Medicine (M.G., W.L., K.M.), University of Pennsylvania, Philadelphia; Irving Institute for Clinical and Translational Research (M.P.R.) and Division of Cardiology, Department of Medicine (C.X., H.Z., M.P.R.), Columbia University Medical Center, New York, NY; and Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA (S.N., A.S.F.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919157PMC
July 2016

Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.

N Engl J Med 2016 Jun 18;374(22):2131-41. Epub 2016 May 18.

From deCODE Genetics-Amgen (P.N., A.S., G. Thorleifsson, H. Helgason, A.B.A., G.L.N., A.H., A.M., A.J., S.G., I.J., V.S., T.R., G.M., H. Holm, D.G., P.S., U.T., K.S.), Faculty of Medicine (A.H., I.J., G. Thorgeirsson, U.T., K.S.) and School of Engineering and Natural Sciences (H. Helgason, D.G.), University of Iceland, the Laboratory in Mjodd (G.I.E.), and the Department of Clinical Biochemistry (I.O.) and Division of Cardiology, Department of Internal Medicine (G. Thorgeirsson, H. Holm), Landspitali, National University Hospital of Iceland, Reykjavik, and the Department of Clinical Biochemistry, Akureyri Hospital, Akureyri (O.S.) - all in Iceland; Radboud Institute for Molecular Life Sciences, Department of Laboratory Medicine (D.W.S.), Radboud Institute for Health Sciences (T.E.G., L.A.K.), and the Department of Health Evidence (L.A.K.), Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics (N.G., H.V., T.H., N.T.K., O.P.), and Institute of Public Health, Faculty of Health and Medical Science (T.J., A.L.), University of Copenhagen, and Research Center for Prevention and Health, Capital Region of Denmark (T.J., A.L.), Copenhagen, Faculty of Medicine, University of Aalborg, Aalborg (T.J.), Faculty of Health Sciences, University of Southern Denmark, Odense (T.H.), Department of Public Health, Section of General Practice, University of Aarhus, Aarhus (T.L.), Department of Clinical Experimental Research, Rigshospitalet, Glostrup (A.L.), Department of Clinical Biochemistry, University Hospital of Copenhagen at Hvidovre, Hvidovre (M.F.), Department of Cardiology, Gentofte University Hospital, Hellerup (U.A., P.R.H., A.M.G.), and Department of Cardiology, Roskilde Hospital, Roskilde (A.M.G.) - all in Denmark; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany (N.F.); Department of Cardiovascular Sciences, Uni

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http://dx.doi.org/10.1056/NEJMoa1508419DOI Listing
June 2016

High-Density Lipoprotein Proteomic Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets.

Circulation 2016 May 14;133(19):1838-50. Epub 2016 Apr 14.

From Nutrigenomics Research Group (M.O., E.D., W.G., O.F., A. McMorrow, A. Murphy, C.L., D.J., H.M.R., F.C.M.), UCD Institute of Food and Health (M.R., M.G., E.G., L.B., H.M.R., F.C.M.), Diabetes Complications Research Centre (F.C.M.), UCD Conway Institute and School of Medicine, University College Dublin, Ireland; Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, PA (M.d.l.L.M.); and Cardiovascular Institute (M.P.R.) and Institute for Translational Medicine and Therapeutics (M.P.R.), University of Pennsylvania School of Medicine, Philadelphia.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122580PMC
May 2016

Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits.

Circ Cardiovasc Genet 2016 Jun 24;9(3):250-8. Epub 2016 Mar 24.

From the Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia (J.R.G.); Cardiovascular Division, Department of Medicine (N.O.S.), Department of Genetics and McDonnell Genome Institute (N.O.S.), Washington University School of Medicine, St. Louis, MO; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia (W.Z., C.X., D.S.); Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom (M.F., H.W.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (R.M.); Medizinische Klinik II, University of Lübeck, Lübeck, Germany (J.E.); William Harvey Research Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom (P.D.); Deutsches Herzzentrum München, Technische Universität München, DZHK, Munich Heart Alliance, München, Germany (H.S.); Department of Cardiovascular Sciences, University of Leicester & NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom (N.J.S.); Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.K.); Department of Medicine, Harvard Medical School, Boston, MA (S.K.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S.K.); and Department of Medicine, Columbia University, New York, NY (M.P.R.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015681PMC
June 2016

Adipose tissue RNASeq reveals novel gene-nutrient interactions following n-3 PUFA supplementation and evoked inflammation in humans.

J Nutr Biochem 2016 Apr 11;30:126-32. Epub 2016 Jan 11.

Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jnutbio.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808243PMC
April 2016

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

Authors:
Nathan O Stitziel Kathleen E Stirrups Nicholas G D Masca Jeanette Erdmann Paola G Ferrario Inke R König Peter E Weeke Thomas R Webb Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Stavroula Kanoni Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenberg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Piera A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian M Shaffer Nour Eddine El-Mokhtari Andre Franke Omri Gottesman Stefanie Heilmann Christian Hengstenberg Per Hoffman Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Martina Müller-Nurasyid Majid Nikpay Oliviero Olivieri Louis-Philippe Lemieux Perreault Alaa AlQarawi Neil R Robertson Karen O Akinsanya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Aldi T Kraja Chunyu Liu George B Ehret Christopher Newton-Cheh Daniel I Chasman Rajiv Chowdhury Marco Ferrario Ian Ford J Wouter Jukema Frank Kee Kari Kuulasmaa Børge G Nordestgaard Markus Perola Danish Saleheen Naveed Sattar Praveen Surendran David Tregouet Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Sekkar Kathiresan Panos Deloukas Nilesh J Samani Heribert Schunkert

N Engl J Med 2016 03 2;374(12):1134-44. Epub 2016 Mar 2.

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http://dx.doi.org/10.1056/NEJMoa1507652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850838PMC
March 2016

Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography.

Biomaterials 2016 May 9;87:93-103. Epub 2016 Feb 9.

Department of Radiology, University of Pennsylvania, 3400 Spruce St, 1 Silverstein, Philadelphia, PA 19104, USA; Department of Bioengineering, University of Pennsylvania, 3400 Spruce St, 1 Silverstein, Philadelphia, PA 19104, USA; Department of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania, 3400 Spruce St, 1 Silverstein, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783300PMC
May 2016

From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease.

Circ Res 2016 Feb;118(4):586-606

From the Division of Translational Medicine and Human Genetics, Department of Medicine (S.T.N., R.C.B., D.J.R.), Penn Cardiovascular Institute, Department of Medicine (H.Z., M.P.R., D.J.R.), Department of Genetics (N.J.H., D.J.R.), and Department of Biostatistics and Epidemiology (D.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863243PMC
February 2016

A Simple Test of Class-Level Genetic Association Can Reveal Novel Cardiometabolic Trait Loci.

PLoS One 2016 9;11(2):e0148218. Epub 2016 Feb 9.

Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747495PMC
July 2016

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.

J Am Coll Cardiol 2016 Feb;67(4):407-416

Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Non-Communicable Diseases, Karachi, Pakistan; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://content.onlinejacc.org/data/Journals/JAC/934865/10086
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http://linkinghub.elsevier.com/retrieve/pii/S073510971507523
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http://dx.doi.org/10.1016/j.jacc.2015.10.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503188PMC
February 2016

MultiGeMS: detection of SNVs from multiple samples using model selection on high-throughput sequencing data.

Bioinformatics 2016 05 18;32(10):1486-92. Epub 2016 Jan 18.

Department of Statistics, University of California, Riverside, CA 92521, USA, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.

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http://dx.doi.org/10.1093/bioinformatics/btv753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280882PMC
May 2016

IRF2BP2: A New Player at the Crossroads of Inflammation and Lipid Metabolism.

Circ Res 2015 Sep;117(8):656-8

From the Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862198PMC
September 2015

The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury.

Am J Physiol Renal Physiol 2015 Dec 23;309(11):F901-13. Epub 2015 Sep 23.

Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajprenal.00290.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669357PMC
December 2015

Metabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese Mice.

PLoS One 2015 22;10(9):e0138317. Epub 2015 Sep 22.

Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579121PMC
June 2016

A guide to genome-wide association analysis and post-analytic interrogation.

Stat Med 2015 Dec 6;34(28):3769-92. Epub 2015 Sep 6.

Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA, U.S.A.

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http://dx.doi.org/10.1002/sim.6605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019244PMC
December 2015

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Authors:
Majid Nikpay Anuj Goel Hong-Hee Won Leanne M Hall Christina Willenborg Stavroula Kanoni Danish Saleheen Theodosios Kyriakou Christopher P Nelson Jemma C Hopewell Thomas R Webb Lingyao Zeng Abbas Dehghan Maris Alver Sebastian M Armasu Kirsi Auro Andrew Bjonnes Daniel I Chasman Shufeng Chen Ian Ford Nora Franceschini Christian Gieger Christopher Grace Stefan Gustafsson Jie Huang Shih-Jen Hwang Yun Kyoung Kim Marcus E Kleber King Wai Lau Xiangfeng Lu Yingchang Lu Leo-Pekka Lyytikäinen Evelin Mihailov Alanna C Morrison Natalia Pervjakova Liming Qu Lynda M Rose Elias Salfati Richa Saxena Markus Scholz Albert V Smith Emmi Tikkanen Andre Uitterlinden Xueli Yang Weihua Zhang Wei Zhao Mariza de Andrade Paul S de Vries Natalie R van Zuydam Sonia S Anand Lars Bertram Frank Beutner George Dedoussis Philippe Frossard Dominique Gauguier Alison H Goodall Omri Gottesman Marc Haber Bok-Ghee Han Jianfeng Huang Shapour Jalilzadeh Thorsten Kessler Inke R König Lars Lannfelt Wolfgang Lieb Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Patrik K Magnusson Nadeem H Mallick Narinder Mehra Thomas Meitinger Fazal-Ur-Rehman Memon Andrew P Morris Markku S Nieminen Nancy L Pedersen Annette Peters Loukianos S Rallidis Asif Rasheed Maria Samuel Svati H Shah Juha Sinisalo Kathleen E Stirrups Stella Trompet Laiyuan Wang Khan S Zaman Diego Ardissino Eric Boerwinkle Ingrid B Borecki Erwin P Bottinger Julie E Buring John C Chambers Rory Collins L Adrienne Cupples John Danesh Ilja Demuth Roberto Elosua Stephen E Epstein Tõnu Esko Mary F Feitosa Oscar H Franco Maria Grazia Franzosi Christopher B Granger Dongfeng Gu Vilmundur Gudnason Alistair S Hall Anders Hamsten Tamara B Harris Stanley L Hazen Christian Hengstenberg Albert Hofman Erik Ingelsson Carlos Iribarren J Wouter Jukema Pekka J Karhunen Bong-Jo Kim Jaspal S Kooner Iftikhar J Kullo Terho Lehtimäki Ruth J F Loos Olle Melander Andres Metspalu Winfried März Colin N Palmer Markus Perola Thomas Quertermous Daniel J Rader Paul M Ridker Samuli Ripatti Robert Roberts Veikko Salomaa Dharambir K Sanghera Stephen M Schwartz Udo Seedorf Alexandre F Stewart David J Stott Joachim Thiery Pierre A Zalloua Christopher J O'Donnell Muredach P Reilly Themistocles L Assimes John R Thompson Jeanette Erdmann Robert Clarke Hugh Watkins Sekar Kathiresan Ruth McPherson Panos Deloukas Heribert Schunkert Nilesh J Samani Martin Farrall

Nat Genet 2015 Oct 7;47(10):1121-1130. Epub 2015 Sep 7.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589895PMC
October 2015

The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis.

Clin J Am Soc Nephrol 2015 Nov 4;10(11):1911-20. Epub 2015 Sep 4.

Divisions of Pulmonary, Allergy, and Critical Care and Center for Clinical Epidemiology and Biostatistics, and.

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http://dx.doi.org/10.2215/CJN.12201214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633800PMC
November 2015

Relation of atherogenic lipoproteins with estimated glomerular filtration rate decline: a longitudinal study.

BMC Nephrol 2015 Aug 4;16:130. Epub 2015 Aug 4.

Section of Nephrology, Department of Medicine, Yale School of Medicine, Program of Applied Translational Research, Yale University, New Haven, USA.

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http://dx.doi.org/10.1186/s12882-015-0122-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545861PMC
August 2015

Bioactive products formed in humans from fish oils.

J Lipid Res 2015 Sep 15;56(9):1808-20. Epub 2015 Jul 15.

Institute for Translational Medicine and Therapeutics (ITMAT), Smilow Center for Translational Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.

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http://dx.doi.org/10.1194/jlr.M060392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548785PMC
September 2015

Ascending and descending thoracic aorta calcification in type 2 diabetes mellitus.

J Cardiovasc Comput Tomogr 2015 Sep-Oct;9(5):373-81. Epub 2015 May 16.

Division of Cardiology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jcct.2015.04.008DOI Listing
June 2016

Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics.

Arterioscler Thromb Vasc Biol 2015 Aug 11;35(8):1880-8. Epub 2015 Jun 11.

From the Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.Q., S.A.K., D.J.R., M.P.R.); Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (A.V.K.); and Division of Cardiology, Department of Medicine, University of California at San Francisco (A.Q.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556282PMC
August 2015

ABO Blood Group as a Model for Platelet Glycan Modification in Arterial Thrombosis.

Arterioscler Thromb Vasc Biol 2015 Jul 4;35(7):1570-8. Epub 2015 Jun 4.

From the Cardiology Division, Department of Medicine, Cardiovascular Institute (M.Z., H.Z., M.P.R.) and Pulmonology, Allergy, and Critical Care Division, Department of Medicine (J.P.R., J.D.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Complex Carbohydrate Research Center, University of Georgia, Athens (M.I., T.K., P.A.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521621PMC
July 2015

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.

Circ Res 2015 Jun 22;117(1):17-28. Epub 2015 Apr 22.

From the Cardiovascular Institute (H.Z., C.X., R.S., K.B., C.C.H., W.L., A.R., J.T.-M., E.E.P., E.E.M., D.J.R., M.P.R.), and Department of Biostatistics and Epidemiology (M.L.), Perelman School of Medicine, Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism (A.R., M.C., E.E.P., D.J.R.), Department of Medicine, Metabolic Tracer Resource, Institute for Diabetes, Obesity, and Metabolism (J.S.M.), Institute for Regenerative Medicine (Y.L., R.Y., W.Y., E.E.M.), Department of Biology, Perelman School of Medicine and School of Arts and Science (S.J.G., B.D.G.), PENN Genome Frontiers Institute (S.J.G., B.D.G.), Department of Pediatrics, Perelman School of Medicine (S.T.C.), Department of Cell and Developmental Biology, Perelman School of Medicine (E.E.M.), and Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Division of Hematology, The Children's Hospital of Philadelphia, PA (D.V., S.T.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.305860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565503PMC
June 2015

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.

J Am Heart Assoc 2015 Mar 11;4(3):e001544. Epub 2015 Mar 11.

National Heart, Blood, and Lung Institute's Framingham Heart Study, Framingham, MA (B.M.K., S.R.P., A.S.B., Q.Y., S.S., R.S.V.) Sections of Preventive Medicine and Epidemiology and Cardiology, Boston University School of Medicine, Boston, MA (R.S.V.).

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http://dx.doi.org/10.1161/JAHA.114.001544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392437PMC
March 2015

Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases.

Arterioscler Thromb Vasc Biol 2015 Mar 30;35(3):525-34. Epub 2014 Dec 30.

From the Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (P.N.P., R.Y.S., M.P.R.); and Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN (J.F.F.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.304455
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http://dx.doi.org/10.1161/ATVBAHA.114.304455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344396PMC
March 2015

Plasma lipoprotein(a) levels are associated with mild renal impairment in type 2 diabetics independent of albuminuria.

PLoS One 2014 9;9(12):e114397. Epub 2014 Dec 9.

Section of Nephrology, Program of Applied Translational Research Department of Medicine, Yale School of Medicine, Yale University, New Haven, CT, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260843PMC
September 2015

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Nature 2015 Feb 10;518(7537):102-6. Epub 2014 Dec 10.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [2] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA. [4] Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://kooperberg.fhcrc.org/papers/2015do.pdf
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http://dx.doi.org/10.1038/nature13917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319990PMC
February 2015

Effects of niacin, statin, and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 levels in patients with dyslipidemia.

Am J Cardiol 2015 Jan 31;115(2):178-82. Epub 2014 Oct 31.

Department of Medicine, Smilow Center for Translational Research, Perelman School of Medicine, Philadelphia, Pennsylvania; Cardiovascular Institute, Smilow Center for Translational Research, Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.amjcard.2014.10.018DOI Listing
January 2015

Inactivating mutations in NPC1L1 and protection from coronary heart disease.

N Engl J Med 2014 Nov 12;371(22):2072-82. Epub 2014 Nov 12.

Cardiovascular Division, Department of Medicine, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1056/NEJMoa1405386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335708PMC
November 2014

Distribution and medical impact of loss-of-function variants in the Finnish founder population.

PLoS Genet 2014 Jul 31;10(7):e1004494. Epub 2014 Jul 31.

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117444PMC
July 2014