Publications by authors named "Murat Ozturk"

93 Publications

Ocular surface characteristics in acne vulgaris.

Clin Exp Optom 2021 Mar 15:1-5. Epub 2021 Mar 15.

Pathology Department, Van Yüzüncüyıl University, Van, Turkey.

: Since acne vulgaris is a disease of the sebaceous glands, it may have potential effects on the ocular surface and tear homoeostasis, which are essential for good vision. Optometrists should be aware of ocular surface pathologies when prescribing glasses or contact lenses for the visual rehabilitation of these young patients.: To evaluate the ocular surface features, meibomian glands, and tear parameters of patients with acne vulgaris.: The right eyes of 70 individuals (34 patients with acne vulgaris, 36 healthy volunteers) were evaluated. The tear break-up time of participants was measured, and the Schirmer test was performed. Then, to determine ocular surface characteristics, samples were taken from the conjunctiva for impression cytology. Finally, the loss rates of the upper and lower eyelid meibomian glands were determined by taking meibography (Sirius, CSO, Florence, Italy).: Tear break-up time was significantly lower in the study group compared to the control group (p < 0.001). No statistically significant difference was determined between the groups in respect of Nelson grade in the conjunctival impression cytology (p = 0.141). Grade 3 cytological changes were not observed in either group. The median value of the loss rate in the meibomian glands in the upper eyelid of patients with acne vulgaris was 19.10% (IQR: 18%), while it was 8.75% (IQR: 9.53%) in the control group (p = 0.001). The median value of the loss rate in the meibomian glands in the lower eyelid was 15.70% (IQR: 15.13%) and 7.70% (IQR: 6.53%) in the acne vulgaris and control groups, respectively (p < 0.001).: Our study shows that patients with acne vulgaris may have a predisposition to meibomian gland damage and tear instability. Therefore, we consider that a more detailed ophthalmologic examination should be performed in patients with acne vulgaris.
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http://dx.doi.org/10.1080/08164622.2021.1896336DOI Listing
March 2021

The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study.

Int J Clin Pract 2021 Feb 24:e14114. Epub 2021 Feb 24.

Department of Dermatology, Van Training and Research Hospital, Van, Turkey.

Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients receiving secukinumab treatment for psoriasis vulgaris (PV).

Materials And Methods: In this retrospective study, we evaluated the laboratory results of 40 patients who were followed up with a diagnosis of PV and received secukinumab treatment in three different dermatology clinics between July 2018 and September 2019.

Results: Neutrophil count and leukocyte count were significantly decreased after secukinumab treatment. (P < .001) There was no statistically significant difference between lymphocyte count, platelet count, MPV, NLR and PLR values before treatment and at the 4th month of treatment (P values .230, .065, .110, .915 and .365, respectively).

Conclusion: In conclusion, it can be concluded that parameters such as NLR, PLR and MPV are not suitable parameters for monitoring the effects of secukinumab treatment on inflammation.
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http://dx.doi.org/10.1111/ijcp.14114DOI Listing
February 2021

Comparative efficacy and safety profile of 4 vs 8 mg of silodosin once daily usage in patients with benign prostatic hyperplasia-related lower urinary tract symptoms divided into subgroups according to International Prostate Symptom Score severity.

Prostate Int 2020 Dec 19;8(4):152-157. Epub 2020 May 19.

University of Health Sciences, Van Education and Research Hospital, Department of Urology, Van, Turkey.

Background: The purpose of this study was to compare once daily (QD) usage of 4 and 8 mg of silodosin in patients divided as those with moderate and with severe lower urinary tract symptoms (LUTSs) according to International Prostate Symptom Score (IPSS) categories in terms of effectiveness and adverse events.

Methods: A total of 234 patients aged ≥ 40 years were evaluated prospectively. All participants were divided firstly into two groups according to their IPSS severity as moderate and severe. They were further allocated to receive 4 mg of silodosin and 8 mg of silodosin QD. Demographic features and laboratory tests were recorded. The patients were questioned with International Index of Erectile Function-5 and IPSS along with quality of life index. Uroflowmetric measurements were applied to the patients. All tests and measurements were repeated at the 3rd month, and changes from pretreatment to posttreatment were analyzed by SPSS 21.0 Program. The statistical significance level was set at p < 0.05.

Results: Both treatments provided benefit in patients with both moderate and severe LUTSs. While results did not differ among 4 mg and 8 mg of silodosin in patients with moderate LUTSs, 8 mg of silodosin was significantly better than 4mg in those with severe LUTSs in terms of improvement of the total IPSS, IPSS voiding subtotal score, and quality of life score (p = 0.015, 0.030, <0.001, respectively). Both treatments did not affect erectile functions. Adverse events were seen more frequently in patients receiving 8 mg of silodosin than those treated with 4 mg of silodosin (p = 0.024).

Conclusion: Our study revealed that 4 mg of silodosin QD was as effective as 8 mg of silodosin QD in patients with moderate LUTSs but not with severe LUTSs. It can be inferred from this study that prescription of 4 and 8 mg of silodosin may be chosen to treat the patients with moderate and severe LUTSs due to benign prostatic heperplasia, respectively.
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http://dx.doi.org/10.1016/j.prnil.2020.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767940PMC
December 2020

Premature or nevoid sebaceous hyperplasia? Two case reports of a rare disease.

J Cosmet Dermatol 2021 Mar 23;20(3):835-837. Epub 2020 Dec 23.

Department of Pathology, University of Health Sciences Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Early or familial cases of sebaceous hyperplasia (SH) with multiple lesions, thought to be associated with genetic predisposition, have been reported in young individuals. Rarely reported variants include the giant, diffuse, zosteriform, and/or linear (nevoid) form. However, premature SH, defined as benign proliferation of sebaceous glands that occurs during or after puberty, is histologically similar to SH. Whether the definitions of nevoid SH or premature SH are the same remains unclear. We report two sporadic cases of premature SH.
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http://dx.doi.org/10.1111/jocd.13906DOI Listing
March 2021

COVID-19 infection under omalizumab therapy for chronic spontaneous urticaria: three cases.

Int J Dermatol 2021 Feb 17;60(2):253-254. Epub 2020 Dec 17.

Department of Infectious Diseases and Clinical Microbiology, Bismil State Hospital, Diyarbakır, Turkey.

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http://dx.doi.org/10.1111/ijd.15379DOI Listing
February 2021

Evaluation of inflammatory parameters in patients with cutaneous leishmaniasis.

Dermatol Ther 2021 Jan 7;34(1):e14603. Epub 2020 Dec 7.

Department of Microbiology, Harran University Medical Faculty, Sanlıurfa, Turkey.

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease characterized by various skin lesions that can cause deformities when healed. Our aim in this study is to show the utility of parameters such as neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio (TLR), and mean thrombocyte volume (MTV) as auxiliary laboratory methods in CL patients. About 107 patients who were admitted to our dermatological and venereal diseases outpatient clinic between January 2018 and January 2019 and were diagnosed with CL by microscopic examination and 74 healthy individuals were included in the study. There were no significant differences between the patient and control group in terms of neutrophil counts, leukocyte counts, platelet counts, and NLR values (P values: .271, .053, .263, and .459, respectively). When the TLR and MTV values of patients with CL and those of the healthy controls were compared, it was found that TLR and MTV values were statistically higher in patients with CL (P values of .010 and .044, respectively). Based on these data, NLR was not considered to be a suitable parameter for demonstrating inflammation in CL patients, but TLR and MTV were held to be an appropriate parameter for demonstrating inflammation in CL patients. In addition, we think that the increase in MTV and TLR, can be used as an auxiliary laboratory test in the diagnosis of CL disease.
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http://dx.doi.org/10.1111/dth.14603DOI Listing
January 2021

Atypical and unusual morphological variants of cutaneous leishmaniasis.

Int J Clin Pract 2020 Oct 26:e13730. Epub 2020 Oct 26.

Department of Pathology, Harran University Medical Faculty, Sanliurfa, Turkey.

Objective: Cutaneous leishmaniasis (CL) is a skin disease characterised by prolonged nodulo-ulcerative lesions of the skin that heals with atrophic scar. Clinical features of CL vary depending on the type of parasite and host immune resistance. The aim of this study was to investigate the clinical features of atypical and unusual morphological variants of CL patients diagnosed in our clinic.

Materials And Methods: In this prospective study, 27 CL patients with atypical clinical features among 486 patients admitted to our clinic between July 2018 and September 2019 and diagnosed as CL by slit-skin smear examination or histopathological examination were included.

Results: Of 27 patients, 15 (55.5%) were male and 12 (44.5%) were female. The mean age of the patients was 25.8 ± 7.62 years. Seven (25.9%) patients had lupoid lesions, five (18.6%) patients had eczematoid lesions, four (14.8%) patients had lip lesions, three (11.1%) patients had erysipelas-like lesions, two (7.4%) patients had eyelid lesions, two (7.4%) patients had sporotrichoid lesions, two (7.4%) patients had verrucous lesions, one (3.7%) patient had psoriasiform lesion and one (3.7%) patient had paronychial lesion.

Conclusion: In conclusion, rare clinical forms of CL are presented in this study. It should be kept in mind that CL may have very different clinical features and should be considered in the differential diagnosis of eczema, psoriasis, erysipelas, sporotrichosis, paronychia and verrucous lesions.
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http://dx.doi.org/10.1111/ijcp.13730DOI Listing
October 2020

Evaluation of hirsutism and hormonal parameters in acne vulgaris patients treated with isotretinoin.

Int J Clin Pract 2020 Oct 25:e13791. Epub 2020 Oct 25.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.

Background: Although the effect of isotretinoin use on hormonal changes in acne pathogenesis is not fully known, there are limited studies on its effects on the development of hirsutism. In this study, it was aimed to evaluate the effect of isotretinoin use on hirsutism and hormonal parameters in patients with acne vulgaris.

Methods: In this study, 30 female acne patients and 30 healthy females were evaluated prospectively. Menstrual irregularity, LH, FSH, prolactin, progesterone, 17-OH progesterone, oestradiol, total testosterone, DHEA-S, insulin, glucose, TSH levels, Ferriman-Gallwey (FG) score and ultrasonography (USG) findings of control group and patient group were recorded.

Results: Pre-treatment progesterone (P = .007) and oestradiol (P = .001) levels of the patients were statistically lower than the control group. In the patient group, menstrual irregularity (P < 001) and FG hirsutism score at the third month of treatment were significantly higher than before treatment. In 10% of the patients, there were abnormal findings on pelvic USG in the third month of treatment.

Conclusion: In our study, it could not be revealed that isotretinoin has a significant effect on pituitary, adrenal hormones and insulin resistance. We found that 3 months of isotretinoin treatment caused an increase in menstrual irregularity and FG hirsutism score.
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http://dx.doi.org/10.1111/ijcp.13791DOI Listing
October 2020

Can continuous positive airway pressure improve lower urinary tract symptoms and erectile dysfunction in male patients with severe obstructive sleep apnea syndrome?

Investig Clin Urol 2020 11 24;61(6):607-612. Epub 2020 Sep 24.

Department of Urology, University of Health Sciences, Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.

Purpose: We aimed to investigate the effect of continuous positive airway pressure (CPAP) administered for the treatment of obstructive upper airway on lower urinary tract symptoms and erectile dysfunction in male patients.

Materials And Methods: A total of 626 male with suspected obstructive sleep apnea syndrome (OSAS) were evaluated prospectively. Nocturnal polysomnography tests were administered to the male. After application of the exclusion criteria, 54 patients with severe OSAS (Apnea-Hypopnea Index ≥30) were included in the study. International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF-15), and nocturia were assessed in all patients before and after CPAP therapy, and prostate volume, total prostate-specific antigen (tPSA), and uroflowmetric measurements were assessed in patients aged >40 years.

Results: The mean age of the 54 patients was 47.06±11.15 years. Post-treatment IIEF scores were better than pre-treatment scores (24.27±7.58 vs. 22.68±8.65, p=0.014). IPSS values, nocturia, and uroflowmetric outcomes significantly improved after CPAP therapy (p<0.05). On the other hand, mean values of body mass index, tPSA, prostate volume, and postvoid residual urine volume did not differ significantly after treatment.

Conclusions: CPAP therapy improves lower urinary tract symptoms, nocturia, and erectile dysfunction in male with severe OSAS.
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http://dx.doi.org/10.4111/icu.20200105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606120PMC
November 2020

H syndrome: A rare genodermatosis.

J Cosmet Dermatol 2020 Sep 12;19(9):2449-2450. Epub 2020 Jul 12.

Department of Pathology, Dicle University Medical Faculty, Diyarbakır, Turkey.

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http://dx.doi.org/10.1111/jocd.13572DOI Listing
September 2020

Acne in pregnancy: A prospective multicenter, cross-sectional study of 295 patients in Turkey.

Int J Dermatol 2020 Sep 20;59(9):1098-1105. Epub 2020 Jun 20.

Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.

Background: There are only a few studies on acne in pregnancy. This study was aimed to investigate the demographic, clinical, and familial characteristics of acne in pregnancy, triggering factors including endocrine diseases, and association of these findings with acne in different trimesters of pregnancy.

Methods: Pregnant women aged 18 years and older with acne at any stage of pregnancy were consecutively interviewed at the participating centers during the study period from 2016 to 2019. Acne severity was evaluated using the Comprehensive Acne Severity Scale.

Results: A total of 295 pregnant women with acne were included, with 167 (56.6%) patients showing mild, 87 (29.5%) moderate, six (12.2%) severe, and five (1.7%) very severe acne. Truncal acne was significantly higher in the third trimester than in the other stages (P < 0.001). Onset of acne before pregnancy, prepubertal, pubertal or adult onset, or acne history in previous pregnancies did not influence acne severity in pregnancy. Women with irregular menstruation before pregnancy, polycystic ovary syndrome, hirsutism, and higher body weight index tended to show severe acne in pregnancy.

Conclusions: Severe acne during pregnancy is generally uncommon, while severity of facial acne, truncal acne, and hirsutism is higher in the third trimester than in other trimesters. Acne in pregnancy shares many characteristics with female adult acne. Substantial changes in different kinds of hormones play a more complex role in acne during pregnancy, but the pathogenesis remains to be determined.
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http://dx.doi.org/10.1111/ijd.14999DOI Listing
September 2020

Vitamin D and thiol-disulfide homeostasis levels in postmenopausal women with overactive bladder syndrome.

J Med Biochem 2020 Jan;39(1):1-6

Ankara Yildirim Beyazit University, Clinical Biochemistry, Ankara, Turkey.

Background: This study aimed to find a relationship between vitamin D concentration and thiol-disulfide homeostasis in the pathophysiology of overactive bladder (OAB) syndrome in postmenopausal women.

Methods: A total of 76 postmenopausal women, referred for routine controls, were recruited between January and March 2018 to participate in this study. Participants with an overactive bladder questionnaire (OAB-q) score of >11 (n = 34) were included in the OAB syndrome group, while those with a score of <5 (n = 42) were included in the control group. Serum total antioxidant capacity, ischemia-modified albumin, C-reactive protein, 25-hydroxy vitamin D levels, and thiol-disulfide homeostasis were measured.

Results: Patients with OAB syndrome had waist circumferences of 106 ± 11 cm, and their body mass indexes (BMIs) were 30.8 ± 4.8 kg/m2. The control groups' waist circumferences were 102 ± 11 cm and their BMIs were 28.9 ± 4.3 kg/m2 (p = 0.069 and p = 0.098, respectively). The level of vitamin D in the control group was 33.7 (IQR: 30.7) nmol/L and 27.0 (IQR: 27.5) nmol/L (p = 0.081) in the OAB syndrome group.

Conclusions: We were not able to demonstrate with certainty any significant relationships between serum 25-hydroxy vitamin D levels and thiol-disulfide homeostasis parameters and OAB syndrome.
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http://dx.doi.org/10.2478/jomb-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282226PMC
January 2020

The effect of biological agent treatment on neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume, and C-reactive protein in psoriasis patients.

Postepy Dermatol Alergol 2020 Apr 5;37(2):202-206. Epub 2020 May 5.

Department of Dermatology, Van Training and Research Hospital, Van, Turkey.

Introduction: In recent years, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV) and C reactive protein (CRP) have been shown to be important indicators of systemic inflammation. Studies have shown that NLR, PLR, MPV and CRP are higher in psoriasis patients than in the control group.

Aim: To investigate the NLR, PLR, MPV and serum CRP levels in patients who were treated with biological agents for psoriasis.

Material And Methods: In our study, 75 patients who were followed up and had a diagnosis of psoriasis vulgaris and took a biological agent therapy between January 2014 and December 2017 in the Dermatology Clinic of the Dicle University Medical Faculty Hospital were evaluated before treatment, and 3 and 6 months after treatment.

Results: Neutrophil count, lymphocyte count, thrombocyte count, NLR, PLR, MPV and CRP values before the biological agent treatment were statistically higher than the values at 3 and 6 months of treatment. There was no statistically significant difference between pre-treatment neutrophil, lymphocyte, leukocyte, platelet, NLR, PLR, MPV, CRP values and values at 3 and 6 months after treatment when we compared four different biological agents.

Conclusions: It was seen that NLR, PLR, MPV and CRP values decreased independently of the type of the biological agent used in our study. Therefore, we think that these parameters can be used to evaluate the effects of biological agent treatment on systemic inflammation in psoriasis patients and to monitor the course of the disease.
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http://dx.doi.org/10.5114/ada.2020.94838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262800PMC
April 2020

Potential role of anti-interleukin-17 in COVID-19 treatment.

Dermatol Ther 2020 Jul 20;33(4):e13715. Epub 2020 Jun 20.

Department of Internal Medicine, University of Health Sciences Gazi Yaşargil Trainning and Research Hospital, Diyarbakır, Turkey.

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http://dx.doi.org/10.1111/dth.13715DOI Listing
July 2020

Spontaneous resolution of human papillomavirus infection in a patient with psoriasis given secukinumab.

Int J Dermatol 2020 Jul 2;59(7):e256-e257. Epub 2020 May 2.

Department of Dermatology, Şanlıurfa Education and Research Hospital, Şanlıurfa, Turkey.

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http://dx.doi.org/10.1111/ijd.14910DOI Listing
July 2020

Systemic isotretinoin therapy in the era of COVID-19.

Dermatol Ther 2020 Jul 20;33(4):e13482. Epub 2020 May 20.

Department of Dermatology, University of Rome G. Marconi, Rome, Italy.

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http://dx.doi.org/10.1111/dth.13482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261989PMC
July 2020

First clinical picture of a very rare disease: Primary cutaneous adenomyoepithelioma.

J Cosmet Dermatol 2020 Sep 12;19(9):2444-2446. Epub 2020 Apr 12.

Department of Dermatology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey.

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http://dx.doi.org/10.1111/jocd.13408DOI Listing
September 2020

Temporal decline in diarrhea episodes and mortality in Kiribati children two years following rotavirus vaccine introduction, despite high malnutrition rates: a retrospective review.

BMC Infect Dis 2020 Mar 12;20(1):207. Epub 2020 Mar 12.

Murdoch Children's Research Institute, Melbourne, Australia.

Background: Kiribati introduced rotavirus vaccine in 2015. To estimate the impact of rotavirus vaccine on acute gastroenteritis (AGE) and severe acute malnutrition (SAM) among children under 5 in Kiribati, a retrospective review of inpatient and outpatient AGE and hospitalized SAM was undertaken.

Methods: Inpatient data for admissions and hospital deaths due to AGE, SAM and all-causes were collected for children under 5 from all hospitals on the main island, Tarawa, from January 2010-December 2013 (pre-rotavirus vaccine) and January 2016-September 2017 (post-rotavirus vaccine). National outpatient diarrhea data were collected from January 2010 to August 2017 for under 5. An interrupted time-series analysis was undertaken to estimate the effect of rotavirus vaccine on the rates of inpatient and outpatient AGE, inpatient SAM; and inpatient case fatality rates for AGE and SAM, were calculated pre- and post-rotavirus vaccine introduction.

Results: The incidence rate of AGE admissions from Tarawa and national AGE outpatient presentations significantly declined by 37 and 44%, respectively, 2 years following rotavirus vaccine introduction. There was a significant decline in the percentage of AGE contributing to all-cause under 5 admissions (12·8% vs. 7·2%, p < 0·001) and all-cause under-five mortality (15·9% vs. 5·7%, p = 0·006) pre- and post-rotavirus vaccine introduction. The estimated incidence rate of inpatient SAM decreased by 24% in under 5 s, 2 years following rotavirus vaccine introduction.

Conclusions: AGE morbidity and mortality and hospitalized SAM rates have declined following rotavirus vaccine introduction in Kiribati children.
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http://dx.doi.org/10.1186/s12879-020-4874-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069014PMC
March 2020

Can monocyte/HDL show inflammatory activity of isotretinoin treatment in acne patients?

Cutan Ocul Toxicol 2020 Jun 9;39(2):111-114. Epub 2020 Mar 9.

Department of Dermatology, Health Sciences University, Van Training and Research Hospital, Van, Turkey.

There are reports that isotretinoin causes some important diseases such as teratogenicity, inflammatory bowel disease and sacroiliitis by triggering inflammation. (Monocyte/HDL (high density lipoprotein) ratio) MHR is closely related to inflammation and is thought to be an indicator of atherosclerotic development. We aimed to investigate how isotretinoin (ISO) affects the immunoinflammatory response in acne patients. In this study, 116 nodulocystic acne patients who received ISO treatment for at least three months were evaluated retrospectively. ISO treatment was given to patients at a dose of 0.5-1 mg/kg. Pre-treatment and post-treatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, mean platelet volume (MPV), platelet, plateletcrit, platelet distribution width (PDW), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), total cholesterol, LDL cholesterol, triglyceride, HDL cholesterol and MHR were evaluated. MPV and MHR values were significantly increased after 3 month treatment ( < 0.05). There was no significant change in NLR and PLR values ( > 0.05). There was a significant decrease in neutrophil count ( < 0.05). There were no significant changes in WBC, lymphocyte, monocyte, platelet, plateletcrit values (p > 0.05). Total cholesterol, LDL cholesterol and triglyceride levels were significantly increased after three months of treatment ( < 0.05). HDL cholesterol levels decreased significantly after three months of treatment ( < 0.05). We concluded that ISO treatment may trigger inflammation due to the increase in MPV and MHR value. MHR can show inflammation after ISO treatment.
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http://dx.doi.org/10.1080/15569527.2020.1734815DOI Listing
June 2020

Assessment of HLA-A, HLA-DR, and HLA-DQ alleles in patients with pemphigus vulgaris from eastern of Turkey.

J Cosmet Dermatol 2020 Sep 16;19(9):2432-2437. Epub 2020 Jan 16.

Department of Dermatology, Van Training and Research Hospital, Health Sciences Universty, Van, Turkey.

Background: Pemphigus vulgaris (PV) is a chronic progressive autoimmune bullous disease caused by the interaction of pathogenic factors, genetic, and environmental factors. HLA alleles, which are considered as protective factors against disease or predisposing factors, may be different in various populations and ethnic groups.

Aims: The purpose of this study is to examine the HLA-A, HLA-DR, and HLA-DQ alleles in patients that are diagnosed with PV in and around eastern of Turkey and to determine the alleles that create predisposition to disease or protect against the disease.

Patients/methods: Thirty patients diagnosed as PV with clinical, histopathological, and immunofluorescence findings and 30 healthy subjects were included in this study. The HLA-A, HLA-DR, and HLA-DQ typology in the DNA samples that were obtained from the blood samples of the groups was performed by using the PCR-SSP low-resolution gene panels.

Results: The HLA-A*03 allele was found to be significantly higher in patient group than the control group (P-value: .020). HLA-DRB1*04 and HLA-DRB1*14 alleles in PV patients were found to be significantly higher than the control group (P-value = .000).

Conclusion: It was concluded that the HLA-DRB1*03, HLADQB1*02, and HLA-DQB1*06 alleles in and around eastern of Turkey showed protective effects against pemphigus vulgaris. It was also concluded that the HLA-A*03, HLA-DRB1*04, HLA-DRB1*14, HLA-DRB4, HLA-DQB1*03, and HLA-DQB1*05 alleles could cause predisposition to the disease.
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http://dx.doi.org/10.1111/jocd.13298DOI Listing
September 2020

Comment on ''how does omalizumab affect the immunoinflammatory response in patients with chronic spontaneous urticaria?'': reply from author.

Cutan Ocul Toxicol 2020 03 12;39(1):73. Epub 2020 Jan 12.

Department of Dermatology, Van Training and Research Hospital, Health Sciences University, Van, Turkey.

We read Cosansu's commentary entitled ''Hematological parameters in patients with chronic spontaneous urticaria'' to our study with a great interest. The author noted that monocytes increased in inflammatory diseases such as urticaria but decreased after treatment. She argued that NMR was not used as an inflammatory marker in previous studies, so that NMR should not be used to evaluate the response to omalizumab treatment in urticaria and decreased by chance. We thank the author for her interest in our article.
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http://dx.doi.org/10.1080/15569527.2019.1710181DOI Listing
March 2020

Molluscum Contagiosum in Interdigital Area of Foot in a Pregnant Patient.

Indian Dermatol Online J 2019 Nov-Dec;10(6):755-756. Epub 2019 Nov 1.

Department of Pathology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.

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http://dx.doi.org/10.4103/idoj.IDOJ_408_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859778PMC
November 2019

Clinical features and etiology of patients with erythema ab igne: A retrospective multicenter study.

Authors:
Murat Ozturk Isa An

J Cosmet Dermatol 2020 Jul 7;19(7):1774-1779. Epub 2019 Nov 7.

Department of Dermatology, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey.

Objective: The aim of this study was to investigate the demographic and clinical features, etiology of patients with erythema ab igne (EAI) who presented to our clinics.

Materials And Methods: The present study was conducted on 71 patients who were admitted to our dermatology clinics between April 2018 and June 2019 and were diagnosed with EAI by clinical or histopathological examination. Age, gender, localization of lesions, and etiologic causes of lesions were recorded.

Results: Of the 71 patients, 48 (67.6%) were women and 23 (32.4%) were men. The mean age of the patients was 28.6 ± 10.4 years. Most of the lesions were localized (60.6%, n = 43) on the anterior aspect of both legs. Among the etiological reasons, 53 (74.6%) patients had exposure to heater, 14 (19.7%) patients had exposure to stove, 2 (2.8%) patients had laptop use, 1 (1.4%) patient had tandoor contact, and 1 (1.4%) patient had exposure to hot water bag. One patient was diagnosed with bullous EAI.

Conclusion: In conclusion, EAI was also more common in females and lower extremities, which is in accordance with the literature. However, the mean age of occurrence in our study is younger when compared with that in the literature. One case of EAI due to the use of tandoor in our study has not been reported previously. It should be kept in mind that bullous EAI may develop in patients with diabetes mellitus.
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http://dx.doi.org/10.1111/jocd.13210DOI Listing
July 2020

How does omalizumab affect the immunoinflammatory response in patients with chronic spontaneous urticaria?

Cutan Ocul Toxicol 2020 Mar 6;39(1):31-35. Epub 2019 Nov 6.

Department of Dermatology, Van Training and Research Hospital, Health Sciences University, Van, Turkey.

The aim of this study was to evaluate the effect of omalizumab on immunoinflammatory cells in patients with chronic spontaneous urticaria (CSU). The study was designed retrospectively. Seventy-four patients diagnosed with CSU and taking omalizumab between 2016 and 2019 were included in this study. Hematological parameters of the patients before treatment and after 12 weeks of treatment were recorded. Lymphocyte/monocyte ratio (LMR), neutrophil/monocyte ratio (NMR), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were examined and the effects of omalizumab treatment on inflammatory parameters were evaluated. Angioedema status of patients, total IgE levels and the relationship between these variables were investigated. The results were evaluated statistically. The neutrophil count, the neutrophil/lymphocyte ratio and neutrophil/monocyte ratio showed a statistically significant reduction after 12 weeks of omalizumab treatment. There was no significant change in other data. In our study, omalizumab treatment significantly reduced neutrophil/lymphocyte ratio and neutrophil/monocyte ratio. Further studies are needed to assess the correlation between treatment response and these parameters to determine the likelihood of a decrease in these values by the antiinflammatory effect of omalizumab.
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http://dx.doi.org/10.1080/15569527.2019.1684316DOI Listing
March 2020

Do blood groups play a role in etiology of rosacea?

Authors:
Murat Ozturk Isa An

J Cosmet Dermatol 2020 Feb 5;19(2):400-403. Epub 2019 Sep 5.

Department of Dermatology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.

Background: The pathogenesis of rosacea is not fully understood. The innate immune system is impaired in patients with rosacea. This leads to abnormal inflammatory cytokine release. It has been proposed that the molecular mechanism for the role of the ABO antigenic system in human diseases may arise from its relationship with the von Willebrand factor and several pro-inflammatory and adhesion molecules. To our knowledge, the relationship between ABO-Rh groups and rosacea has not been investigated previously.

Materials And Methods: One hundred and fourteen patients with rosacea and 258 healthy individuals who had blood group record were included in this study. The results were analyzed statistically.

Results: In terms of ABO blood groups, 54 (47.4%) patients had A, 14 (12.3%) patients had B, 7 (6.1%) patients had AB, and 39 (34.2%) patients had O blood groups in the patient group. In the control group, 109 (42.2%) individuals had A, 45 (17.5%) individuals had B, 29 (11.2%) individuals had AB, and 75 (29.1%) individuals had O blood group. There was no significant difference between the groups (P > .05). In terms of Rh groups, 103 (90.4%) patients were Rh (+) and 11 (9.6%) patients were Rh (-). In the control group, 220 (85.3%) individuals were Rh (+) and 38 (14.7%) were Rh (-). There was no significant difference between the groups (P > .05).

Conclusion: We did not find a relationship between blood groups and rosacea. But, we think this is an interesting hypothesis. To clarify this possible relationship, comprehensive and further studies are needed in different races and geographic regions.
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http://dx.doi.org/10.1111/jocd.13143DOI Listing
February 2020

Eosinophilic Cellulitis Successfully Treated with Colchicine.

Indian Dermatol Online J 2019 Jul-Aug;10(4):467-468

Department of Pathology, Dicle Universty, Diyarbakir, Turkey.

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http://dx.doi.org/10.4103/idoj.IDOJ_387_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615380PMC
July 2019

Effects of omalizumab therapy on peripheral nerve functions: short observational study.

Postepy Dermatol Alergol 2019 Apr 3;36(2):211-216. Epub 2018 Apr 3.

Department of Dermatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.

Introduction: Peripheral neuropathy (PN) is a common neurological condition causing symmetrical and diffuse damage in nerves. The etiology of PN includes systemic diseases, toxic exposure, medications, infections, and hereditary diseases. Omalizumab is a humanized monoclonal anti-IgE antibody that exerts its activity by binding to free IgE in circulation.

Aim: To investigate the relationship between omalizumab and peripheral neuropathy.

Material And Methods: The study included 30 patients who underwent omalizumab therapy (Xolair) due to the diagnosis of chronic urticaria. A detailed neurological and physical examination was performed in each patient both before and 3 months after the therapy. Electrophysiological examination was also performed using a Medelec Synergy instrument.

Results: The 30 patients included 8 (26.7%) men and 22 (73.3%) women with a mean age of 37.5 ±14.14 years. No serious side effect of the medication was detected in any patient although local wound irritation occurred in 3 (10%) patients. Moreover, no change occurred in the pre-treatment Neuropathy Symptom Score (NSS) or Neurological Disability Score (NDS) of the patients and no pathological values that could result in neuropathy were observed during motor/sensory nerve conduction. However, significant changes were detected in the sensory and motor components of the nerves with regards to pre- and post-treatment values.

Conclusions: Omalizumab therapy caused no peripheral neuropathy in any of our patients but altered the latency, amplitude, and velocity values of the peripheral nerves.
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http://dx.doi.org/10.5114/ada.2018.74834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627259PMC
April 2019

Comparative Analysis of the Healing Effects of the Transplanted Cell Sheets to the Experimentally Injured Maxillary Sinuses.

J Craniofac Surg 2019 Oct;30(7):2285-2292

Department of Otorhinolaryngology, Kocaeli Medical Park Hospital, Kocaeli, Turkey.

Background: In our study, the authors aimed to obtain a live and functional sinus epithelium with mesenchymal stem cells and nasal mucosa epithelial cells from rabbits which are cultured in temperature-responsive culture plates to get a single-layer.

Methodology/principal: Twenty-two female New Zealand rabbits were included in the study. Two of them were used to obtain mesenchymal stem cells. A total of 40 maxillary sinuses were randomly divided into 5 groups: 1) control group which is used to investigate normal rabbit maxillary mucosa, 2) secondary healing group, 3) mesenchymal stem cell graft group, 4) differentiated mesenchymal stem cell group, and 5) nasal mucosal graft group. The animals were sacrificed at the 28th day after the surgery.Scanning electron microscopy, transmission electron microscopy, and immunohistochemical investigations were performed.

Results: With these investigations, it was shown that; all graft groups were histologically better than secondary healing group and when the authors compared the graft groups, differentiated mesenchymal stem cell group were the best.

Conclusion: Our study results showed that endoscopic sinus surgery and treatment with cell sheets, which were generated in temperature-responsive culture dishes, had more functional respiratory epithelium.
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http://dx.doi.org/10.1097/SCS.0000000000005638DOI Listing
October 2019

Immunohistochemical evaluation of the effect of acitretin and systemic steroid treatments on Ki-67, Bcl-2, and COX-2 levels in cutaneous lichen planus patients.

Int J Dermatol 2019 Dec 19;58(12):1444-1450. Epub 2019 Jun 19.

Department of Dermatology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.

Background: Lichen planus (LP) is an inflammatory disease that affects skin, hair follicles, mucous membranes, and nails. Ki-67 is an antigen associated with the proliferation of cells in all stages of cell cycle except G0. Bcl-2 is a protooncogene that protects cells from apoptosis. COX-2 is an antiapoptotic protein that increases in inflammation. The infiltration of T cells in LP seems to be responsible in the apoptosis of the basal keratinocytes.

Objective: The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki-67, Bcl-2, and COX-2 expression and apoptosis in patients with LP and the role of Ki-67, Bcl-2, and COX-2 proteins in LP.

Methods: Fifty-eight patients with clinically and histopathologically diagnosed LP who had not been treated with systemic treatment before and 15 healthy volunteers were evaluated prospectively. Pretreatment and posttreatment biopsies were immunohistochemically stained with Ki-67, Bcl-2, and COX-2. The percentage of the stained cells were calculated and recorded.

Results: Although the percentage of staining with Ki-67 and Bcl-2 after treatment with prednisolone and acitretin decreased significantly (P < 0.05) in both groups, there was no significant difference between groups (P > 0.05). COX-2 decreased but was not statistically significant.

Conclusions: With this study in cutaneous lichen planus, prednisolone and acitretin treatments reduced Bcl-2 and Ki-67 levels and did not effect COX-2 levels. It should be clarified whether these results can be obtained with any treatment effective in cutaneous lichen planus.
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http://dx.doi.org/10.1111/ijd.14543DOI Listing
December 2019

Clarifying the dermoscopic features of irritation fibroma by mobile photograph editor application.

Skin Res Technol 2019 Sep 17;25(5):768-769. Epub 2019 May 17.

Department of Otorhinolaryngology, University of Health Sciences Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey.

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http://dx.doi.org/10.1111/srt.12715DOI Listing
September 2019