Publications by authors named "Munir Pirmohamed"

99Publications

Examining the uptake of predictive BRCA testing in the UK; findings and implications.

Eur J Hum Genet 2020 Dec 16. Epub 2020 Dec 16.

National Institute for Health Research, Collaborations for Leadership in Applied Health Research and Care, North West Coast (NIHR CLAHRC NWC), North West Coast, UK.

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December 2020

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda.

Clin Pharmacol Ther 2020 Dec 6. Epub 2020 Dec 6.

The Wolfson Centre for Personalized Medicine and MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, UK.

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December 2020

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.

Br J Clin Pharmacol 2020 Nov 20. Epub 2020 Nov 20.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, The University of Liverpool, Liverpool, UK.

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November 2020

Pharmacogenomics for Primary Care: An Overview.

Genes (Basel) 2020 Nov 12;11(11). Epub 2020 Nov 12.

Wolfson Centre for Personalised Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GL, UK.

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November 2020

A Review of the Important Role of in Pharmacogenomics.

Genes (Basel) 2020 Oct 30;11(11). Epub 2020 Oct 30.

Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool L69 3BX, UK.

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October 2020

Pharmacogenomics in the UK National Health Service: opportunities and challenges.

Pharmacogenomics 2020 11 29;21(17):1237-1246. Epub 2020 Oct 29.

Department of Pharmacology & Therapeutics, University of Liverpool, Liverpool, L69 3GL, UK.

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November 2020

Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature.

Pharmacol Ther 2020 Oct 20:107710. Epub 2020 Oct 20.

MRC Centre for Drug Safety Science and Wolfson Centre for Personalised Medicine, Institute of Systems, Molecular and Integrative Biology (ISMIB), University of Liverpool, Liverpool, UK. Electronic address:

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October 2020

Warfarin dosing algorithms: A systematic review.

Br J Clin Pharmacol 2020 Oct 20. Epub 2020 Oct 20.

The Wolfson Centre for Personalized Medicine, MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, United Kingdom.

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October 2020

Characterization of Clozapine-Responsive Human T Cells.

J Immunol 2020 Nov 28;205(9):2375-2390. Epub 2020 Sep 28.

Medical Research Council Centre for Drug Safety Science, Department Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom;

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November 2020

HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts.

Toxicol Sci 2020 11;178(1):115-126

Department of Molecular & Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool L693GE, UK.

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November 2020

Safety perspectives on presently considered drugs for the treatment of COVID-19.

Br J Pharmacol 2020 10 13;177(19):4353-4374. Epub 2020 Aug 13.

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.

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October 2020

Alcohol-related brain injury: An unrecognized problem in acute medicine.

Alcohol 2020 11 2;88:49-53. Epub 2020 Jun 2.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, United Kingdom; Liverpool Centre for Alcohol Research, University of Liverpool, United Kingdom; Gastroenterology and Hepatology, Royal Liverpool University Hospital Trust, Ward 5z Link, United Kingdom.

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November 2020

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response.

Br J Clin Pharmacol 2020 Jun 5. Epub 2020 Jun 5.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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June 2020

Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients.

Sci Rep 2020 05 21;10(1):8394. Epub 2020 May 21.

The Wolfson Centre for Personalised Medicine, The MRC Centre for Drug Safety Science, Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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May 2020

Two distinct clinical patterns of checkpoint inhibitor-induced thyroid dysfunction.

Endocr Connect 2020 Mar 1. Epub 2020 Mar 1.

M Pirmohamed, Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom of Great Britain and Northern Ireland.

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March 2020

Author Correction: A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

Sci Rep 2020 Mar 10;10(1):4730. Epub 2020 Mar 10.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, United Kingdom.

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March 2020

A Genome-wide Association Study of Circulating Levels of Atorvastatin and Its Major Metabolites.

Clin Pharmacol Ther 2020 Aug 8;108(2):287-297. Epub 2020 Apr 8.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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August 2020

Genetic associations with clozapine-induced myocarditis in patients with schizophrenia.

Transl Psychiatry 2020 01 27;10(1):37. Epub 2020 Jan 27.

MRC Centre for Drug Safety Science, Wolfson Centre for Personalised Medicine, University of Liverpool, The Royal Liverpool and Broadgreen University Hospitals NHS Trust, and Liverpool Health Partners, Liverpool, UK.

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January 2020

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

Sci Rep 2020 02 4;10(1):1796. Epub 2020 Feb 4.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, United Kingdom.

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February 2020

Functional validity, role, and implications of heavy alcohol consumption genetic loci.

Sci Adv 2020 01 15;6(3):eaay5034. Epub 2020 Jan 15.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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January 2020

Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components.

J Clin Med 2019 Dec 20;9(1). Epub 2019 Dec 20.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GL, UK.

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December 2019

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

Clin Pharmacol Ther 2020 01 6;107(1):57-61. Epub 2019 Nov 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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January 2020

Genetic Predisposition to Anticonvulsant Hypersensitivity.

Authors:
Munir Pirmohamed

Clin Pharmacol Ther 2019 11 13;106(5):919-922. Epub 2019 Sep 13.

Department of Molecular and Clinical Pharmacology, The Royal Liverpool, Broadgreen University Hospitals NHS Trust, MRC Centre for Drug Safety Science, Liverpool Health Partners, University of Liverpool, Liverpool, UK.

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November 2019

Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials.

J Pers Med 2019 09 1;9(3). Epub 2019 Sep 1.

Institute of Translational Medicine, Department of Biostatistics, University of Liverpool, Waterhouse Building, 1-5 Brownlow Street, Liverpool L69 3GL, UK.

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September 2019

Genetic testing for prevention of severe drug-induced skin rash.

Cochrane Database Syst Rev 2019 07 17;7:CD010891. Epub 2019 Jul 17.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Centre for Personalised Medicine, Block A: Waterhouse Building, 1-5 Brownlow Street, Liverpool, UK, L69 3GE.

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July 2019

Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink.

Clin Pharmacol Ther 2019 12 31;106(6):1353-1361. Epub 2019 Jul 31.

Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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December 2019

Trends in BRCA testing and socioeconomic deprivation.

Eur J Hum Genet 2019 09 3;27(9):1351-1360. Epub 2019 May 3.

Liverpool Women's Hospital NHS Foundation Trust, Liverpool, UK.

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September 2019

Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics.

Pharmacogenomics 2019 06 3;20(8):599-608. Epub 2019 May 3.

David Weatherall Chair of Medicine, University of Liverpool & Royal Liverpool & Broadgreen University Hospitals NHS Trust, Liverpool, UK.

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June 2019

HLA- and immune-mediated adverse drug reactions: Another hit with vancomycin.

Authors:
Munir Pirmohamed

J Allergy Clin Immunol 2019 07 25;144(1):44-45. Epub 2019 Apr 25.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Royal Liverpool and Broadgreen University Hospitals NHS Trust, and Liverpool Health Partners, Liverpool, United Kingdom. Electronic address:

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July 2019

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study.

BMC Med 2019 04 8;17(1):76. Epub 2019 Apr 8.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool and The Royal Liverpool and Broadgreen University Hospitals NHS Trust, members of Liverpool Health Partners, Liverpool, UK.

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April 2019

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Gastroenterology 2019 05 18;156(6):1707-1716.e2. Epub 2019 Jan 18.

UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina; University of North Carolina Institute for Drug Safety Sciences, Research Triangle Park, North Carolina.

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May 2019

Controversies in drug allergy: Testing for delayed reactions.

J Allergy Clin Immunol 2019 01 17;143(1):66-73. Epub 2018 Dec 17.

Dermatology and Allergy Department, Tenon Hospital, Medecine Sorbonne University, Paris, France; Assistance publique-hopitaux de Paris, Paris, France.

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January 2019

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.

Clin Pharmacol Ther 2019 06 17;105(6):1477-1491. Epub 2019 Feb 17.

General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.

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June 2019

Cost-Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework.

Clin Pharmacol Ther 2019 06 28;105(6):1429-1438. Epub 2019 Jan 28.

Centre for Health Economics and Medicines Evaluation, Bangor University, Wales, UK.

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June 2019

Drug repurposing: progress, challenges and recommendations.

Nat Rev Drug Discov 2019 01 12;18(1):41-58. Epub 2018 Oct 12.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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January 2019

Nonmedical prescriber experiences of training and competence to report adverse drug reactions in the UK.

J Clin Pharm Ther 2019 Feb 11;44(1):78-83. Epub 2018 Sep 11.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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February 2019

Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies.

Crit Rev Oncol Hematol 2018 Oct 3;130:92-107. Epub 2018 Aug 3.

National Institute for Health Research, Collaborations for Leadership in Applied Health Research and Care, North West Coast (NIHR CLAHRC NWC), United Kingdom; Wolfson Centre for Personalised Medicine, University of Liverpool, United Kingdom.

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October 2018

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.

J Invest Dermatol 2019 01 17;139(1):100-107. Epub 2018 Jul 17.

Centre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.

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January 2019

Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort.

J Pharm Biomed Anal 2018 Sep 3;159:272-281. Epub 2018 Jul 3.

The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GL, UK; Centre for Drug Safety Science, University of Liverpool, Liverpool, L69 3GE, UK. Electronic address:

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September 2018

Warfarin: The End or the End of One Size Fits All Therapy?

Authors:
Munir Pirmohamed

J Pers Med 2018 Jun 28;8(3). Epub 2018 Jun 28.

Department of Molecular and Clinical Pharmacology, Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool L69 3GL, UK.

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June 2018

New uses for old drugs.

BMJ 2018 Jun 26;361:k2701. Epub 2018 Jun 26.

University of Liverpool, Liverpool, UK.

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June 2018

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions.

Curr Opin Allergy Clin Immunol 2018 08;18(4):325-332

Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool.

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August 2018

Adrenal suppression with inhaled corticosteroids: the seed and the soil - Authors' reply.

Lancet Respir Med 2018 06;6(6):e20

Wolfson Centre for Personalised Medicine, Medical Research Council (MRC) Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L12 2AP, UK.

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June 2018

Pharmacogenetics of Adverse Drug Reactions.

Adv Pharmacol 2018 ;83:155-190

Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, United Kingdom. Electronic address:

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July 2019

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach.

JMIR Public Health Surveill 2018 May 9;4(2):e51. Epub 2018 May 9.

Department of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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May 2018

TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.

J Hepatol 2018 May 3. Epub 2018 May 3.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Electronic address:

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May 2018

Letter to the Editor: Response to Costa et al.

Eur Neuropsychopharmacol 2018 05 12;28(5):658. Epub 2018 Apr 12.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, United Kingdom.

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May 2018

Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin.

Sci Rep 2018 03 23;8(1):5094. Epub 2018 Mar 23.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, United Kingdom.

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March 2018

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

Lancet Respir Med 2018 06 15;6(6):442-450. Epub 2018 Mar 15.

Wolfson Centre for Personalised Medicine, Medical Research Council (MRC) Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK. Electronic address:

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June 2018

Direct oral anticoagulants versus warfarin: is new always better than the old?

Open Heart 2018;5(1):e000712. Epub 2018 Feb 7.

Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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February 2018

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.

Diab Vasc Dis Res 2018 05 21;15(3):233-242. Epub 2018 Feb 21.

1 Department of Molecular and Clinical Pharmacology, The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.

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May 2018

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

Chem Res Toxicol 2018 03 14;31(3):165-167. Epub 2018 Feb 14.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , Liverpool L69 3GE , England.

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March 2018

Nucleic acid based therapies: developing frontier for precision medicine.

Authors:
Munir Pirmohamed

BMJ 2018 01 23;360:k223. Epub 2018 Jan 23.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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January 2018

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.

Lancet Gastroenterol Hepatol 2018 02 14;3(2):104-113. Epub 2017 Nov 14.

MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK. Electronic address:

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February 2018

Repurposing Statins for Renal Protection: Is It a Class Effect?

Clin Transl Sci 2018 03 15;11(2):100-102. Epub 2017 Nov 15.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, UK.

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March 2018