Munir Pirmohamed

Munir Pirmohamed

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Munir Pirmohamed

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Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink.

Clin Pharmacol Ther 2019 Dec 31;106(6):1353-1361. Epub 2019 Jul 31.

Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1002/cpt.1557DOI Listing
December 2019

Genetic Predisposition to Anticonvulsant Hypersensitivity.

Authors:
Munir Pirmohamed

Clin Pharmacol Ther 2019 Nov 13;106(5):919-922. Epub 2019 Sep 13.

Department of Molecular and Clinical Pharmacology, The Royal Liverpool, Broadgreen University Hospitals NHS Trust, MRC Centre for Drug Safety Science, Liverpool Health Partners, University of Liverpool, Liverpool, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1610
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http://dx.doi.org/10.1002/cpt.1610DOI Listing
November 2019

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

Clin Pharmacol Ther 2019 Nov 6. Epub 2019 Nov 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpt.1664DOI Listing
November 2019

Trends in BRCA testing and socioeconomic deprivation.

Eur J Hum Genet 2019 Sep 3;27(9):1351-1360. Epub 2019 May 3.

Liverpool Women's Hospital NHS Foundation Trust, Liverpool, UK.

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http://dx.doi.org/10.1038/s41431-019-0424-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777468PMC
September 2019

Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials.

J Pers Med 2019 09 1;9(3). Epub 2019 Sep 1.

Institute of Translational Medicine, Department of Biostatistics, University of Liverpool, Waterhouse Building, 1-5 Brownlow Street, Liverpool L69 3GL, UK.

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http://dx.doi.org/10.3390/jpm9030042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789450PMC
September 2019

Pharmacogenetics of Adverse Drug Reactions.

Adv Pharmacol 2018 ;83:155-190

Institute of Cellular Medicine, Newcastle University, Medical School, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.apha.2018.03.002DOI Listing
July 2019

HLA- and immune-mediated adverse drug reactions: Another hit with vancomycin.

Authors:
Munir Pirmohamed

J Allergy Clin Immunol 2019 Jul 25;144(1):44-45. Epub 2019 Apr 25.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Royal Liverpool and Broadgreen University Hospitals NHS Trust, and Liverpool Health Partners, Liverpool, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.04.009DOI Listing
July 2019

Genetic testing for prevention of severe drug-induced skin rash.

Cochrane Database Syst Rev 2019 07 17;7:CD010891. Epub 2019 Jul 17.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Centre for Personalised Medicine, Block A: Waterhouse Building, 1-5 Brownlow Street, Liverpool, UK, L69 3GE.

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http://dx.doi.org/10.1002/14651858.CD010891.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636675PMC
July 2019

Cost-Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework.

Clin Pharmacol Ther 2019 Jun 28;105(6):1429-1438. Epub 2019 Jan 28.

Centre for Health Economics and Medicines Evaluation, Bangor University, Wales, UK.

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http://dx.doi.org/10.1002/cpt.1312DOI Listing
June 2019

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.

Clin Pharmacol Ther 2019 Jun 17;105(6):1477-1491. Epub 2019 Feb 17.

General Medicine and Hypertension Unit, Department of Medicine, University of Verona, Verona, Italy.

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http://doi.wiley.com/10.1002/cpt.1323
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http://dx.doi.org/10.1002/cpt.1323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542461PMC
June 2019

Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics.

Pharmacogenomics 2019 06 3;20(8):599-608. Epub 2019 May 3.

David Weatherall Chair of Medicine, University of Liverpool & Royal Liverpool & Broadgreen University Hospitals NHS Trust, Liverpool, UK.

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http://dx.doi.org/10.2217/pgs-2019-0021DOI Listing
June 2019

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study.

BMC Med 2019 04 8;17(1):76. Epub 2019 Apr 8.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool and The Royal Liverpool and Broadgreen University Hospitals NHS Trust, members of Liverpool Health Partners, Liverpool, UK.

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http://dx.doi.org/10.1186/s12916-019-1308-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454722PMC
April 2019

Nonmedical prescriber experiences of training and competence to report adverse drug reactions in the UK.

J Clin Pharm Ther 2019 Feb 11;44(1):78-83. Epub 2018 Sep 11.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/jcpt.12756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378616PMC
February 2019

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.

J Invest Dermatol 2019 01 17;139(1):100-107. Epub 2018 Jul 17.

Centre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1016/j.jid.2018.04.041DOI Listing
January 2019

Drug repurposing: progress, challenges and recommendations.

Nat Rev Drug Discov 2019 01 12;18(1):41-58. Epub 2018 Oct 12.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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http://www.nature.com/doifinder/10.1038/nrd.2018.168
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http://dx.doi.org/10.1038/nrd.2018.168DOI Listing
January 2019

Controversies in drug allergy: Testing for delayed reactions.

J Allergy Clin Immunol 2019 01 17;143(1):66-73. Epub 2018 Dec 17.

Dermatology and Allergy Department, Tenon Hospital, Medecine Sorbonne University, Paris, France; Assistance publique-hopitaux de Paris, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2018.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429556PMC
January 2019

Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies.

Crit Rev Oncol Hematol 2018 Oct 3;130:92-107. Epub 2018 Aug 3.

National Institute for Health Research, Collaborations for Leadership in Applied Health Research and Care, North West Coast (NIHR CLAHRC NWC), United Kingdom; Wolfson Centre for Personalised Medicine, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.critrevonc.2018.07.012DOI Listing
October 2018

Identifying cisplatin-induced kidney damage in paediatric oncology patients.

Pediatr Nephrol 2018 09 18;33(9):1467-1474. Epub 2017 Aug 18.

Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/s00467-017-3765-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061670PMC
September 2018

Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort.

J Pharm Biomed Anal 2018 Sep 3;159:272-281. Epub 2018 Jul 3.

The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GL, UK; Centre for Drug Safety Science, University of Liverpool, Liverpool, L69 3GE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.06.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109775PMC
September 2018

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions.

Curr Opin Allergy Clin Immunol 2018 08;18(4):325-332

Department of Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool.

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http://dx.doi.org/10.1097/ACI.0000000000000459DOI Listing
August 2018

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

Lancet Respir Med 2018 06 15;6(6):442-450. Epub 2018 Mar 15.

Wolfson Centre for Personalised Medicine, Medical Research Council (MRC) Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30058-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971210PMC
June 2018

Adrenal suppression with inhaled corticosteroids: the seed and the soil - Authors' reply.

Lancet Respir Med 2018 06;6(6):e20

Wolfson Centre for Personalised Medicine, Medical Research Council (MRC) Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L12 2AP, UK.

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http://dx.doi.org/10.1016/S2213-2600(18)30149-8DOI Listing
June 2018

New uses for old drugs.

BMJ 2018 Jun 26;361:k2701. Epub 2018 Jun 26.

University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1136/bmj.k2701DOI Listing
June 2018

Warfarin: The End or the End of One Size Fits All Therapy?

Authors:
Munir Pirmohamed

J Pers Med 2018 Jun 28;8(3). Epub 2018 Jun 28.

Department of Molecular and Clinical Pharmacology, Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool L69 3GL, UK.

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http://dx.doi.org/10.3390/jpm8030022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163581PMC
June 2018

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.

Diab Vasc Dis Res 2018 05 21;15(3):233-242. Epub 2018 Feb 21.

1 Department of Molecular and Clinical Pharmacology, The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1177/1479164118757924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949706PMC
May 2018

Letter to the Editor: Response to Costa et al.

Eur Neuropsychopharmacol 2018 05 12;28(5):658. Epub 2018 Apr 12.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.euroneuro.2018.03.002DOI Listing
May 2018

TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.

J Hepatol 2018 May 3. Epub 2018 May 3.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183204
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http://dx.doi.org/10.1016/j.jhep.2018.04.024DOI Listing
May 2018

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach.

JMIR Public Health Surveill 2018 May 9;4(2):e51. Epub 2018 May 9.

Department of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.2196/publichealth.8214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966656PMC
May 2018

Repurposing Statins for Renal Protection: Is It a Class Effect?

Clin Transl Sci 2018 03 15;11(2):100-102. Epub 2017 Nov 15.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, UK.

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http://dx.doi.org/10.1111/cts.12521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867006PMC
March 2018

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

Chem Res Toxicol 2018 03 14;31(3):165-167. Epub 2018 Feb 14.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , Liverpool L69 3GE , England.

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http://dx.doi.org/10.1021/acs.chemrestox.8b00030DOI Listing
March 2018

Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin.

Sci Rep 2018 03 23;8(1):5094. Epub 2018 Mar 23.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-23466-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865203PMC
March 2018

Biomarkers of adverse drug reactions.

Exp Biol Med (Maywood) 2018 02 26;243(3):291-299. Epub 2017 Sep 26.

1 Department of Molecular and Clinical Pharmacology, Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, 4591 University of Liverpool , Liverpool L69 3GL, UK.

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http://dx.doi.org/10.1177/1535370217733425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813863PMC
February 2018

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.

Lancet Gastroenterol Hepatol 2018 02 14;3(2):104-113. Epub 2017 Nov 14.

MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(17)30266-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777094PMC
February 2018

Direct oral anticoagulants versus warfarin: is new always better than the old?

Open Heart 2018 7;5(1):e000712. Epub 2018 Feb 7.

Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1136/openhrt-2017-000712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845414PMC
February 2018

Renal function monitoring in heart failure - what is the optimal frequency? A narrative review.

Br J Clin Pharmacol 2018 Jan 22;84(1):5-17. Epub 2017 Oct 22.

The Wolfson Centre for Personalised Medicine, The University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/bcp.13434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736847PMC
January 2018

Nucleic acid based therapies: developing frontier for precision medicine.

Authors:
Munir Pirmohamed

BMJ 2018 01 23;360:k223. Epub 2018 Jan 23.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1136/bmj.k223DOI Listing
January 2018

HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study.

Ann Rheum Dis 2017 12 12;76(12):e51. Epub 2017 May 12.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211512DOI Listing
December 2017

How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?

Eur J Obstet Gynecol Reprod Biol 2017 Dec 3;219:1-9. Epub 2017 Oct 3.

The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Brownlow Street, Liverpool, L69 3GL, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S03012115173046
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http://dx.doi.org/10.1016/j.ejogrb.2017.10.004DOI Listing
December 2017

Aminoglycoside-induced nephrotoxicity in children.

Pediatr Nephrol 2017 Nov 15;32(11):2015-2025. Epub 2016 Nov 15.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/s00467-016-3533-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624973PMC
November 2017

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

Biomarkers 2017 Nov 8;22(7):635-642. Epub 2016 Dec 8.

a Department of Molecular and Clinical Pharmacology , Institute of Translational Medicine University of Liverpool , Liverpool , United Kingdom.

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http://dx.doi.org/10.1080/1354750X.2016.1265003DOI Listing
November 2017

Systematic review: Baclofen dosing protocols for alcohol use disorders used in observational studies.

Eur Neuropsychopharmacol 2017 11 20;27(11):1077-1089. Epub 2017 Sep 20.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.euroneuro.2017.08.434DOI Listing
November 2017

An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review.

Pharmacogenomics 2017 Nov 2;18(16):1541-1550. Epub 2017 Nov 2.

NIHR CLAHRC NWC Wolfson Centre for Personalised Medicine, University of Liverpool, Block A: Waterhouse Buildings, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.

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http://dx.doi.org/10.2217/pgs-2017-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694021PMC
November 2017

Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome.

J Clin Lipidol 2017 Jan - Feb;11(1):204-214. Epub 2016 Dec 28.

Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, Merseyside, UK.

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http://dx.doi.org/10.1016/j.jacl.2016.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399750PMC
October 2017

Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout.

Rheumatology (Oxford) 2017 10;56(10):1729-1739

Centre for Health Economics and Medicines Evaluation, Bangor University, Wales.

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http://dx.doi.org/10.1093/rheumatology/kex253DOI Listing
October 2017

Development of the Liverpool Adverse Drug Reaction Avoidability Assessment Tool.

PLoS One 2017 3;12(1):e0169393. Epub 2017 Jan 3.

Paediatric Medicines Research Unit, Institute in the Park, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169393PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207751PMC
August 2017

Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study.

PLoS One 2017 20;12(3):e0173272. Epub 2017 Mar 20.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173272PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358741PMC
August 2017

Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink.

PLoS One 2017 31;12(3):e0174818. Epub 2017 Mar 31.

Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376077PMC
August 2017

The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.

J Immunol 2017 08 7;199(4):1223-1237. Epub 2017 Jul 7.

Department of Molecular and Clinical Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1602029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551967PMC
August 2017

Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia.

Circ Cardiovasc Genet 2017 Aug;10(4)

From the Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (M.K.S., A.V., C.M., R.T., F.C., E.P., J.G., A.D., C.N.A.P.); Centre for Genomic and Experimental Medicine (H.C.) and Usher Institute of Population Health Sciences and Informatics (A.D.M.), University of Edinburgh, United Kingdom; Institute of Translational Medicine, University of Liverpool, United Kingdom (M.P., A.A.); Department of Medical Sciences, Clinical Pharmacology and Science of Life Laboratory, Uppsala University, Sweden (M.W.); Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, The Netherlands (A.H.M.v.d.Z.); Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands (A.H.M.v.d.Z.); Brigham and Women's Hospital and Harvard Medical School, Boston, MA (P.M.R., D.I.C.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001737DOI Listing
August 2017

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients.

Chem Res Toxicol 2017 07 12;30(7):1419-1435. Epub 2017 Jun 12.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, The University of Liverpool , Liverpool L69 3GE, United Kingdom.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00063DOI Listing
July 2017

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.

Pharmacogenet Genomics 2017 06;27(6):213-222

The Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical, Pharmacology, Institute of Translational Medicine, University of Liverpool. 1-5 Brownlow Street, Liverpool L69 3GL, UK.

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http://dx.doi.org/10.1097/FPC.0000000000000281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432027PMC
June 2017

Effect of Genetic Variability in the , , and Genes on Liver mRNA Levels and Warfarin Response.

Front Pharmacol 2017 31;8:323. Epub 2017 May 31.

Wolfson Centre for Personalized Medicine, Department of Molecular and Clinical Pharmacology, The University of LiverpoolLiverpool, United Kingdom.

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http://dx.doi.org/10.3389/fphar.2017.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449482PMC
May 2017

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.

Pharmacol Ther 2017 Apr 27;172:181-194. Epub 2017 Jan 27.

MRC Centre for Drug Safety Science, Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1016/j.pharmthera.2017.01.002DOI Listing
April 2017

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.

Sci Rep 2017 03 8;7:43580. Epub 2017 Mar 8.

Molecular Biophysics Group, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, UK.

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http://dx.doi.org/10.1038/srep43580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341093PMC
March 2017

Identifying new antiepileptic drugs through genomics-based drug repurposing.

Hum Mol Genet 2017 02;26(3):527-537

Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool L69 3GL, UK.

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http://dx.doi.org/10.1093/hmg/ddw410DOI Listing
February 2017

New Approaches to Investigate Drug-Induced Hypersensitivity.

Chem Res Toxicol 2017 01 15;30(1):239-259. Epub 2016 Nov 15.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00333DOI Listing
January 2017

Defining drug response for stratified medicine.

Drug Discov Today 2017 01 3;22(1):173-179. Epub 2016 Nov 3.

Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool L69 3GL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.10.016DOI Listing
January 2017

Open letter on access to the BIA 10-2474 clinical trial data.

Lancet 2017 01 10;389(10065):156. Epub 2016 Dec 10.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany.

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http://dx.doi.org/10.1016/S0140-6736(16)32515-6DOI Listing
January 2017

Genomics of Adverse Drug Reactions.

Trends Pharmacol Sci 2017 01 10;38(1):100-109. Epub 2016 Dec 10.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Block A Waterhouse Buildings, 1-5 Brownlow Street, Liverpool, L69 3GL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2016.11.003DOI Listing
January 2017

The allele: influence on carbamazepine treatment.

Pharmgenomics Pers Med 2017 31;10:29-38. Epub 2017 Jan 31.

MRC Centre for Drug Safety Science, Institute of Translational Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool; Department of Clinical Pharmacology, The Royal Liverpool and Broadgreen University Hospital NHS Trust, Liverpool, UK.

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http://dx.doi.org/10.2147/PGPM.S108598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293506PMC
January 2017

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.

Toxicol Sci 2016 12 16;154(2):416-429. Epub 2016 Sep 16.

Department of Molecular and Clinical Pharmacology, Centre for Drug Safety Science;

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http://dx.doi.org/10.1093/toxsci/kfw177DOI Listing
December 2016

A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting.

Alcohol Alcohol 2016 Sep 5;51(5):584-92. Epub 2016 May 5.

The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool , 1-5 Brownlow Street, Liverpool L69 3GL, UK.

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http://dx.doi.org/10.1093/alcalc/agw023DOI Listing
September 2016

Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis.

Antimicrob Agents Chemother 2016 08 22;60(8):4511-8. Epub 2016 Jul 22.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00280-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958147PMC
August 2016