Muireann Coen

Muireann Coen

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Muireann Coen

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A comparison of collision cross section values obtained via travelling wave ion mobility-mass spectrometry and ultra high performance liquid chromatography-ion mobility-mass spectrometry: Application to the characterisation of metabolites in rat urine.

Authors:
Leanne C Nye Jonathan P Williams Nyasha C Munjoma Marine P M Letertre Muireann Coen Robbin Bouwmeester Lennart Martens Jonathan R Swann Jeremy K Nicholson Robert S Plumb Michael McCullagh Lee A Gethings Steven Lai James I Langridge Johannes P C Vissers Ian D Wilson

J Chromatogr A 2019 Sep 27;1602:386-396. Epub 2019 Jun 27.

Section of Computational and Systems Medicine, Imperial College, London, SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2019.06.056DOI Listing
September 2019

Development of a rapid profiling method for the analysis of polar analytes in urine using HILIC-MS and ion mobility enabled HILIC-MS.

Authors:
Adam M King Lauren G Mullin Ian D Wilson Muireann Coen Paul D Rainville Robert S Plumb Lee A Gethings Garth Maker Robert Trengove

Metabolomics 2019 Jan 22;15(2):17. Epub 2019 Jan 22.

Separations Science and Metabolomics laboratory, Murdoch University, South Street, 6150, Murdoch, WA, Australia.

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http://dx.doi.org/10.1007/s11306-019-1474-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342856PMC
January 2019

In-utero and childhood chemical exposome in six European mother-child cohorts.

Authors:
Line Småstuen Haug Amrit Kaur Sakhi Enrique Cequier Maribel Casas Léa Maitre Xavier Basagana Sandra Andrusaityte Georgia Chalkiadaki Leda Chatzi Muireann Coen Jeroen de Bont Audrius Dedele Joane Ferrand Regina Grazuleviciene Juan Ramon Gonzalez Kristine Bjerve Gutzkow Hector Keun Rosie McEachan Helle Margrete Meltzer Inga Petraviciene Oliver Robinson Pierre-Jean Saulnier Rémy Slama Jordi Sunyer José Urquiza Marina Vafeiadi John Wright Martine Vrijheid Cathrine Thomsen

Environ Int 2018 12 14;121(Pt 1):751-763. Epub 2018 Oct 14.

Norwegian Institute of Public Health, Oslo, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183122
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http://dx.doi.org/10.1016/j.envint.2018.09.056DOI Listing
December 2018

Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.

Authors:
Léa Maitre Oliver Robinson David Martinez Mireille B Toledano Jesús Ibarluzea Loreto Santa Marina Jordi Sunyer Cristina M Villanueva Hector C Keun Martine Vrijheid Muireann Coen

Environ Sci Technol 2018 11 30;52(22):13469-13480. Epub 2018 Oct 30.

Integrative Systems Medicine & Digestive Disease, Department of Surgery & Cancer, Faculty of Medicine , Imperial College London , U.K.

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http://pubs.acs.org/doi/10.1021/acs.est.8b02215
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http://dx.doi.org/10.1021/acs.est.8b02215DOI Listing
November 2018

Determinants of the urinary and serum metabolome in children from six European populations.

Authors:
Chung-Ho E Lau Alexandros P Siskos Léa Maitre Oliver Robinson Toby J Athersuch Elizabeth J Want Jose Urquiza Maribel Casas Marina Vafeiadi Theano Roumeliotaki Rosemary R C McEachan Rafaq Azad Line S Haug Helle M Meltzer Sandra Andrusaityte Inga Petraviciene Regina Grazuleviciene Cathrine Thomsen John Wright Remy Slama Leda Chatzi Martine Vrijheid Hector C Keun Muireann Coen

BMC Med 2018 11 8;16(1):202. Epub 2018 Nov 8.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.

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https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291
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http://dx.doi.org/10.1186/s12916-018-1190-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223046PMC
November 2018

Human Early Life Exposome (HELIX) study: a European population-based exposome cohort.

Authors:
Léa Maitre Jeroen de Bont Maribel Casas Oliver Robinson Gunn Marit Aasvang Lydiane Agier Sandra Andrušaitytė Ferran Ballester Xavier Basagaña Eva Borràs Céline Brochot Mariona Bustamante Angel Carracedo Montserrat de Castro Audrius Dedele David Donaire-Gonzalez Xavier Estivill Jorunn Evandt Serena Fossati Lise Giorgis-Allemand Juan R Gonzalez Berit Granum Regina Grazuleviciene Kristine Bjerve Gützkow Line Småstuen Haug Carles Hernandez-Ferrer Barbara Heude Jesus Ibarluzea Jordi Julvez Marianna Karachaliou Hector C Keun Norun Hjertager Krog Chung-Ho E Lau Vasiliki Leventakou Sarah Lyon-Caen Cyntia Manzano Dan Mason Rosemary McEachan Helle Margrete Meltzer Inga Petraviciene Joane Quentin Theano Roumeliotaki Eduard Sabido Pierre-Jean Saulnier Alexandros P Siskos Valérie Siroux Jordi Sunyer Ibon Tamayo Jose Urquiza Marina Vafeiadi Diana van Gent Marta Vives-Usano Dagmar Waiblinger Charline Warembourg Leda Chatzi Muireann Coen Peter van den Hazel Mark J Nieuwenhuijsen Rémy Slama Cathrine Thomsen John Wright Martine Vrijheid

BMJ Open 2018 09 10;8(9):e021311. Epub 2018 Sep 10.

ISGlobal, Institute for Global Health, Barcelona, Spain.

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http://dx.doi.org/10.1136/bmjopen-2017-021311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144482PMC
September 2018

Capillary ultra performance liquid chromatography-tandem mass spectrometry analysis of tienilic acid metabolites in urine following intravenous administration to the rat.

Authors:
Adam M King Isobelle Grant Paul D Rainville Giorgis Isaac Muireann Coen Ian D Wilson Robert S Plumb

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Jun 26;1087-1088:142-148. Epub 2018 Apr 26.

Waters Corporation, Milford, MA, 01757, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.04.034DOI Listing
June 2018

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective.

Authors:
Toby J Athersuch Daniel J Antoine Alan R Boobis Muireann Coen Ann K Daly Lucia Possamai Jeremy K Nicholson Ian D Wilson

Toxicol Res (Camb) 2018 May 6;7(3):347-357. Epub 2018 Mar 6.

Division of Computational and Systems Medicine , Department of Surgery and Cancer , Faculty of Medicine , Imperial College London , South Kensington , London SW7 2AZ , UK . Email:

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http://dx.doi.org/10.1039/c7tx00340dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062253PMC
May 2018

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.

Authors:
Evangelos Triantafyllou Oltin T Pop Lucia A Possamai Annika Wilhelm Evaggelia Liaskou Arjuna Singanayagam Christine Bernsmeier Wafa Khamri Gemma Petts Rebecca Dargue Scott P Davies Joseph Tickle Muhammed Yuksel Vishal C Patel Robin D Abeles Zania Stamataki Stuart M Curbishley Yun Ma Ian D Wilson Muireann Coen Kevin J Woollard Alberto Quaglia Julia Wendon Mark R Thursz David H Adams Chris J Weston Charalambos G Antoniades

Gut 2018 02 27;67(2):333-347. Epub 2017 Apr 27.

Institute of Liver Studies, King's College Hospital, King's College London, London, UK.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2016-313615
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http://dx.doi.org/10.1136/gutjnl-2016-313615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868289PMC
February 2018

Assessment of metabolic phenotypic variability in children's urine using H NMR spectroscopy.

Authors:
Léa Maitre Chung-Ho E Lau Esther Vizcaino Oliver Robinson Maribel Casas Alexandros P Siskos Elizabeth J Want Toby Athersuch Remy Slama Martine Vrijheid Hector C Keun Muireann Coen

Sci Rep 2017 04 19;7:46082. Epub 2017 Apr 19.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1038/srep46082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395814PMC
April 2017

High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.

Authors:
Nicola Gray Rabiya Zia Adam King Vishal C Patel Julia Wendon Mark J W McPhail Muireann Coen Robert S Plumb Ian D Wilson Jeremy K Nicholson

Anal Chem 2017 02 7;89(4):2478-2487. Epub 2017 Feb 7.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.6b04623DOI Listing
February 2017

Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.

Authors:
Michael Kyriakides Lea Maitre Brendan D Stamper Isaac Mohar Terrance J Kavanagh John Foster Ian D Wilson Elaine Holmes Sidney D Nelson Muireann Coen

Arch Toxicol 2016 Dec 9;90(12):3073-3085. Epub 2016 Jan 9.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1007/s00204-015-1655-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104807PMC
December 2016

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model.

Authors:
Oliver Robinson Mireille B Toledano Caroline Sands Olaf Beckonert Elizabeth J Want Rob Goldin Michael L Hauser Alan Fenwick Mark R Thursz Muireann Coen

Toxicol Res (Camb) 2016 Nov 12;5(6):1594-1603. Epub 2016 Aug 12.

Computational and Systems Medicine , Department of Surgery & Cancer , Faculty of Medicine , Imperial College London , UK . Email:

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http://dx.doi.org/10.1039/c6tx00221hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060677PMC
November 2016

Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study.

Authors:
Léa Maitre Cristina M Villanueva Matthew R Lewis Jesús Ibarluzea Loreto Santa-Marina Martine Vrijheid Jordi Sunyer Muireann Coen Mireille B Toledano

BMC Med 2016 Nov 4;14(1):177. Epub 2016 Nov 4.

Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England (MRC-PHE) Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG, London, UK.

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http://dx.doi.org/10.1186/s12916-016-0706-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097405PMC
November 2016

Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis.

Authors:
Mark J W McPhail Debbie L Shawcross Matthew R Lewis Iona Coltart Elizabeth J Want Charalambos G Antoniades Kiril Veselkov Evangelos Triantafyllou Vishal Patel Oltin Pop Maria Gomez-Romero Michael Kyriakides Rabiya Zia Robin D Abeles Mary M E Crossey Wayel Jassem John O'Grady Nigel Heaton Georg Auzinger William Bernal Alberto Quaglia Muireann Coen Jeremy K Nicholson Julia A Wendon Elaine Holmes Simon D Taylor-Robinson

J Hepatol 2016 May 18;64(5):1058-1067. Epub 2016 Jan 18.

Division of Digestive Health, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital Campus, South Wharf Street, London NW1 2NY, United Kingdom.

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http://dx.doi.org/10.1016/j.jhep.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876170PMC
May 2016

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

Authors:
Simone H Stahl James W Yates Andrew W Nicholls J Gerry Kenna Muireann Coen Fernando Ortega Jeremy K Nicholson Ian D Wilson

Drug Discov Today Technol 2015 Aug 16;15:9-14. Epub 2015 Jul 16.

Department of Surgery and Cancer, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ddtec.2015.06.003DOI Listing
August 2015

Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.

Authors:
Muireann Coen

Drug Metab Rev 2015 Feb 23;47(1):29-44. Epub 2014 Dec 23.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , London , UK.

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http://dx.doi.org/10.3109/03602532.2014.982865DOI Listing
February 2015

Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis.

Authors:
Caroline J Sands Indra N Guha Michael Kyriakides Mark Wright Olaf Beckonert Elaine Holmes William M Rosenberg Muireann Coen

Am J Gastroenterol 2015 Jan 23;110(1):159-69. Epub 2014 Dec 23.

Section of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ajg.2014.370DOI Listing
January 2015

Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat.

Authors:
Michael Kyriakides Rhiannon N Hardwick Zhaosheng Jin Michael J Goedken Elaine Holmes Nathan J Cherrington Muireann Coen

Toxicol Sci 2014 Nov 21;142(1):105-16. Epub 2014 Aug 21.

Biomolecular Medicine, Division of Computational Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK

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http://dx.doi.org/10.1093/toxsci/kfu160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226764PMC
November 2014

Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study.

Authors:
Léa Maitre Eleni Fthenou Toby Athersuch Muireann Coen Mireille B Toledano Elaine Holmes Manolis Kogevinas Leda Chatzi Hector C Keun

BMC Med 2014 Jul 11;12:110. Epub 2014 Jul 11.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1186/1741-7015-12-110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094172PMC
July 2014

The human early-life exposome (HELIX): project rationale and design.

Authors:
Martine Vrijheid Rémy Slama Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J Athersuch Narcis Avellana Xavier Basagaña Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R Gonzalez Berit Granum Regina Gražulevičienė Kristine B Gutzkow Jordi Julvez Hector C Keun Manolis Kogevinas Rosemary R C McEachan Helle Margrete Meltzer Eduard Sabidó Per E Schwarze Valérie Siroux Jordi Sunyer Elizabeth J Want Florence Zeman Mark J Nieuwenhuijsen

Environ Health Perspect 2014 Jun 7;122(6):535-44. Epub 2014 Mar 7.

Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.

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http://dx.doi.org/10.1289/ehp.1307204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048258PMC
June 2014

Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method.

Authors:
Alison V M Rodrigues James L Maggs Stephen J McWilliam Munir Pirmohamed Muireann Coen Ian D Wilson B Kevin Park Daniel J Antoine

Bioanalysis 2014 Apr;6(7):919-33

>MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.

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http://www.future-science.com/doi/10.4155/bio.13.350
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http://dx.doi.org/10.4155/bio.13.350DOI Listing
April 2014

Hirmi Valley liver disease: a disease associated with exposure to pyrrolizidine alkaloids and DDT.

Authors:
Oliver Robinson Elizabeth Want Muireann Coen Ruth Kennedy Catharina van den Bosch Yohannes Gebrehawaria Hiromi Kudo Fouzia Sadiq Robert D Goldin Michael L Hauser Alan Fenwick Mireille B Toledano Mark R Thursz

J Hepatol 2014 Jan 20;60(1):96-102. Epub 2013 Aug 20.

Department of Medicine, Imperial College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.07.039DOI Listing
January 2014

Metabolomics in toxicology and preclinical research.

Authors:
Tzutzuy Ramirez Mardas Daneshian Hennicke Kamp Frederic Y Bois Malcolm R Clench Muireann Coen Beth Donley Steven M Fischer Drew R Ekman Eric Fabian Claude Guillou Joachim Heuer Helena T Hogberg Harald Jungnickel Hector C Keun Gerhard Krennrich Eckart Krupp Andreas Luch Fozia Noor Erik Peter Bjoern Riefke Mark Seymour Nigel Skinner Lena Smirnova Elwin Verheij Silvia Wagner Thomas Hartung Bennard van Ravenzwaay Marcel Leist

ALTEX 2013 ;30(2):209-25

BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821217PMC
http://dx.doi.org/10.14573/altex.2013.2.209DOI Listing
October 2013

Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer.

Authors:
Muireann Coen Peter M Rademacher Wei Zou Michael Scott Patricia E Ganey Robert Roth Sidney D Nelson

Chem Res Toxicol 2012 Nov 5;25(11):2412-22. Epub 2012 Nov 5.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/tx3002803DOI Listing
November 2012

Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response.

Authors:
Katharine Cunningham Sandrine P Claus John C Lindon Elaine Holmes Jeremy R Everett Jeremy K Nicholson Muireann Coen

J Proteome Res 2012 Sep 9;11(9):4630-42. Epub 2012 Aug 9.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1021/pr300430uDOI Listing
September 2012

Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity.

Authors:
Muireann Coen Françoise Goldfain-Blanc Gaëlle Rolland-Valognes Bernard Walther Donald G Robertson Elaine Holmes John C Lindon Jeremy K Nicholson

J Proteome Res 2012 Apr 2;11(4):2427-40. Epub 2012 Mar 2.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom.

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http://pubs.acs.org/doi/10.1021/pr201161f
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http://dx.doi.org/10.1021/pr201161fDOI Listing
April 2012

Statistical total correlation spectroscopy scaling for enhancement of metabolic information recovery in biological NMR spectra.

Authors:
Anthony D Maher Judith M Fonville Muireann Coen John C Lindon Caroline D Rae Jeremy K Nicholson

Anal Chem 2012 Jan 27;84(2):1083-91. Epub 2011 Dec 27.

Neuroscience Research Australia, Barker Street, Randwick 2031, Australia.

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http://pubs.acs.org/doi/10.1021/ac202720f
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http://dx.doi.org/10.1021/ac202720fDOI Listing
January 2012

Non-linear modeling of 1H NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing.

Authors:
Judith M Fonville Max Bylesjö Muireann Coen Jeremy K Nicholson Elaine Holmes John C Lindon Mattias Rantalainen

Anal Chim Acta 2011 Oct 20;705(1-2):72-80. Epub 2011 Apr 20.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.aca.2011.04.016DOI Listing
October 2011

Processing and modeling of nuclear magnetic resonance (NMR) metabolic profiles.

Authors:
Timothy M D Ebbels John C Lindon Muireann Coen

Methods Mol Biol 2011 ;708:365-88

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1007/978-1-61737-985-7_21DOI Listing
April 2011

Data-driven approach for metabolite relationship recovery in biological 1H NMR data sets using iterative statistical total correlation spectroscopy.

Authors:
Caroline J Sands Muireann Coen Timothy M D Ebbels Elaine Holmes John C Lindon Jeremy K Nicholson

Anal Chem 2011 Mar 16;83(6):2075-82. Epub 2011 Feb 16.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac102870uDOI Listing
March 2011

Urinary metabolites of 2-bromoethanamine identified by stable isotope labelling: evidence for carbamoylation and glutathione conjugation.

Authors:
Petia Shipkova Jeffrey D Vassallo Nelly Aranibar Serhiy Hnatyshyn Haiying Zhang T Andrew Clayton Glenn H Cantor Mark Sanders Muireann Coen John C Lindon Elaine Holmes Jeremy K Nicholson Lois Lehman-McKeeman

Xenobiotica 2011 Feb 2;41(2):144-54. Epub 2010 Nov 2.

Bristol-Myers Squibb, Princeton, NJ 08543, USA.

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http://www.tandfonline.com/doi/full/10.3109/00498254.2010.52
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http://dx.doi.org/10.3109/00498254.2010.529179DOI Listing
February 2011

HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies.

Authors:
Konstantina Spagou Ian D Wilson Perrine Masson Georgios Theodoridis Nikolaos Raikos Muireann Coen Elaine Holmes John C Lindon Robert S Plumb Jeremy K Nicholson Elizabeth J Want

Anal Chem 2011 Jan 13;83(1):382-90. Epub 2010 Dec 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1021/ac102523qDOI Listing
January 2011

A metabonomic approach for mechanistic exploration of pre-clinical toxicology.

Authors:
Muireann Coen

Toxicology 2010 Dec 10;278(3):326-40. Epub 2010 Aug 10.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW72AZ, UK.

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http://dx.doi.org/10.1016/j.tox.2010.07.022DOI Listing
December 2010

Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies.

Authors:
Elizabeth J Want Muireann Coen Perrine Masson Hector C Keun Jake T M Pearce Michael D Reily Donald G Robertson Cynthia M Rohde Elaine Holmes John C Lindon Robert S Plumb Jeremy K Nicholson

Anal Chem 2010 Jun;82(12):5282-9

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK.

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http://dx.doi.org/10.1021/ac1007078DOI Listing
June 2010

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues.

Authors:
Olaf Beckonert Muireann Coen Hector C Keun Yulan Wang Timothy M D Ebbels Elaine Holmes John C Lindon Jeremy K Nicholson

Nat Protoc 2010 Jun 13;5(6):1019-32. Epub 2010 May 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London, UK.

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http://dx.doi.org/10.1038/nprot.2010.45DOI Listing
June 2010

Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification.

Authors:
Judith M Fonville Anthony D Maher Muireann Coen Elaine Holmes John C Lindon Jeremy K Nicholson

Anal Chem 2010 Mar;82(5):1811-21

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac902443kDOI Listing
March 2010

Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat.

Authors:
Eszter Bohus Akos Rácz Béla Noszál Muireann Coen Olaf Beckonert Hector C Keun Timothy M D Ebbels Glenn H Cantor John A Wijsman Elaine Holmes John C Lindon Jeremy K Nicholson

Magn Reson Chem 2009 Dec;47 Suppl 1:S26-35

Department of Pharmaceutical Chemistry, Semmelweis University, Högyes Endre u. 9. Budapest 1092, Hungary.

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http://dx.doi.org/10.1002/mrc.2485DOI Listing
December 2009

Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity.

Authors:
Young-Shick Hong Muireann Coen Cynthia M Rhode Michael D Reily Donald G Robertson Elaine Holmes John C Lindon Jeremy K Nicholson

Magn Reson Chem 2009 Dec;47 Suppl 1:S47-53

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1002/mrc.2521DOI Listing
December 2009

High-resolution 1H NMR spectroscopic investigation of a chick embryo model of neural tube development.

Authors:
Muireann Coen Ron A Wevers John C Lindon Henk J Blom

Magn Reson Chem 2009 Dec;47 Suppl 1:S62-7

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1002/mrc.2534DOI Listing
December 2009

Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.

Authors:
Muireann Coen Elizabeth J Want T Andrew Clayton Cynthia M Rhode Young Shick Hong Hector C Keun Glenn H Cantor Alan L Metz Donald G Robertson Michael D Reily Elaine Holmes John C Lindon Jeremy K Nicholson

J Proteome Res 2009 Nov;8(11):5175-87

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1021/pr9005266DOI Listing
November 2009

Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery.

Authors:
Caroline J Sands Muireann Coen Anthony D Maher Timothy M D Ebbels Elaine Holmes John C Lindon Jeremy K Nicholson

Anal Chem 2009 Aug;81(15):6458-66

Department of Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac900828pDOI Listing
August 2009

Cluster analysis statistical spectroscopy using nuclear magnetic resonance generated metabolic data sets from perturbed biological systems.

Authors:
Steven L Robinette Kirill A Veselkov Eszter Bohus Muireann Coen Hector C Keun Timothy M D Ebbels Olaf Beckonert Elaine C Holmes John C Lindon Jeremy K Nicholson

Anal Chem 2009 Aug;81(16):6581-9

Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology, and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac901240jDOI Listing
August 2009

Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.

Authors:
Ruey Leng Loo Muireann Coen Timothy Ebbels Olivier Cloarec Elaine Maibaum Magda Bictash Ivan Yap Paul Elliott Jeremiah Stamler Jeremy K Nicholson Elaine Holmes

Anal Chem 2009 Jul;81(13):5119-29

Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK.

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http://dx.doi.org/10.1021/ac900567eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726443PMC
July 2009

Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis.

Authors:
Eszter Bohus Muireann Coen Hector C Keun Timothy M D Ebbels Olaf Beckonert John C Lindon Elaine Holmes Béla Noszál Jeremy K Nicholson

J Proteome Res 2008 Oct 19;7(10):4435-45. Epub 2008 Aug 19.

Department of Pharmaceutical Chemistry, Semmelweis University, Hogyes Endre u. 9, Budapest 1092, Hungary.

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http://dx.doi.org/10.1021/pr800407jDOI Listing
October 2008

Species variation in the fecal metabolome gives insight into differential gastrointestinal function.

Authors:
Jasmina Saric Yulan Wang Jia Li Muireann Coen Jürg Utzinger Julian R Marchesi Jennifer Keiser Kirill Veselkov John C Lindon Jeremy K Nicholson Elaine Holmes

J Proteome Res 2008 Jan 1;7(1):352-60. Epub 2007 Dec 1.

Department of Public Health and Epidemiology, Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/pr070340kDOI Listing
January 2008

NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology.

Authors:
Muireann Coen Elaine Holmes John C Lindon Jeremy K Nicholson

Chem Res Toxicol 2008 Jan 3;21(1):9-27. Epub 2008 Jan 3.

Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK.

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http://www.researchgate.net/profile/Jeremy_Nicholson2/public
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http://pubs.acs.org/doi/abs/10.1021/tx700335d
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http://dx.doi.org/10.1021/tx700335dDOI Listing
January 2008

Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.

Authors:
Muireann Coen Young-Shick Hong Olivier Cloarec Cindy M Rhode Michael D Reily Donald G Robertson Elaine Holmes John C Lindon Jeremy K Nicholson

Anal Chem 2007 Dec 1;79(23):8956-66. Epub 2007 Nov 1.

Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, U.K.

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http://dx.doi.org/10.1021/ac0713961DOI Listing
December 2007

Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.

Authors:
Elaine Holmes Ruey Leng Loo Olivier Cloarec Muireann Coen Huiru Tang Elaine Maibaum Stephen Bruce Queenie Chan Paul Elliott Jeremiah Stamler Ian D Wilson John C Lindon Jeremy K Nicholson

Anal Chem 2007 Apr 27;79(7):2629-40. Epub 2007 Feb 27.

Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, SW7 2AZ, UK.

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http://pubs.acs.org/doi/abs/10.1021/ac062305n
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http://dx.doi.org/10.1021/ac062305nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688492PMC
April 2007

Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy.

Authors:
Muireann Coen Jennifer Bodkin Damla Power William A Bubb Uwe Himmelreich Philip W Kuchel Tania C Sorrell

Antimicrob Agents Chemother 2006 Dec 18;50(12):4018-26. Epub 2006 Sep 18.

School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00439-06
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http://dx.doi.org/10.1128/AAC.00439-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693988PMC
December 2006

Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis.

Authors:
Muireann Coen Matthew O'Sullivan William A Bubb Philip W Kuchel Tania Sorrell

Clin Infect Dis 2005 Dec 25;41(11):1582-90. Epub 2005 Oct 25.

School of Molecular and Microbial Biosciences, Westmead Millennium Institute, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1086/497836DOI Listing
December 2005

Probing molecular dynamics in chromatographic systems using high-resolution 1H magic-angle-spinning NMR spectroscopy: interaction between p-Xylene and C18-bonded silica.

Authors:
Muireann Coen Ian D Wilson Jeremy K Nicholson Huiru Tang John C Lindon

Anal Chem 2004 Jun;76(11):3023-8

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ UK.

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http://dx.doi.org/10.1021/ac049789cDOI Listing
June 2004

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse.

Authors:
Muireann Coen Stefan U Ruepp John C Lindon Jeremy K Nicholson François Pognan Eva M Lenz Ian D Wilson

J Pharm Biomed Anal 2004 Apr;35(1):93-105

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.jpba.2003.12.019DOI Listing
April 2004

An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy.

Authors:
Muireann Coen Eva M Lenz Jeremy K Nicholson Ian D Wilson Francois Pognan John C Lindon

Chem Res Toxicol 2003 Mar;16(3):295-303

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/tx0256127DOI Listing
March 2003

Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids.

Authors:
Bridgette M Beckwith-Hall Joanne T Brindle Richard H Barton Muireann Coen Elaine Holmes Jeremy K Nicholson Henrik Antti

Analyst 2002 Oct;127(10):1283-8

Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, London, UK.

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http://dx.doi.org/10.1039/b205128cDOI Listing
October 2002