Publications by authors named "Muireann Coen"

61Publications

Metabolomics to discriminate between acute decompensation and acute-on-chronic liver failure in cirrhosis.

J Hepatol 2020 Sep 14;73(3):730-732. Epub 2020 Jul 14.

Department of Metabolism, Digestion and Reproduction, Imperial College, London, United Kingdom; Oncology Safety, Clinical Pharmacology & Safety Sciences, R&D, Astra Zeneca, Cambridge, United Kingdom.

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September 2020

The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC-MS.

Bioanalysis 2020 Apr 28;12(7):485-500. Epub 2020 Apr 28.

Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.

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April 2020

Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.

Toxicol Sci 2020 05;175(1):87-97

Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, UK.

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May 2020

Proteolysis-targeting chimeras in drug development: A safety perspective.

Br J Pharmacol 2020 04 25;177(8):1709-1718. Epub 2020 Feb 25.

Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge, UK.

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April 2020

Development of a rapid profiling method for the analysis of polar analytes in urine using HILIC-MS and ion mobility enabled HILIC-MS.

Metabolomics 2019 01 22;15(2):17. Epub 2019 Jan 22.

Separations Science and Metabolomics laboratory, Murdoch University, South Street, 6150, Murdoch, WA, Australia.

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January 2019

Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.

Environ Sci Technol 2018 11 30;52(22):13469-13480. Epub 2018 Oct 30.

Integrative Systems Medicine & Digestive Disease, Department of Surgery & Cancer, Faculty of Medicine , Imperial College London , U.K.

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November 2018

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective.

Toxicol Res (Camb) 2018 May 6;7(3):347-357. Epub 2018 Mar 6.

Division of Computational and Systems Medicine , Department of Surgery and Cancer , Faculty of Medicine , Imperial College London , South Kensington , London SW7 2AZ , UK . Email:

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May 2018

Assessment of metabolic phenotypic variability in children's urine using H NMR spectroscopy.

Sci Rep 2017 04 19;7:46082. Epub 2017 Apr 19.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.

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April 2017

High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.

Anal Chem 2017 02 7;89(4):2478-2487. Epub 2017 Feb 7.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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February 2017

Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study.

BMC Med 2016 Nov 4;14(1):177. Epub 2016 Nov 4.

Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England (MRC-PHE) Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG, London, UK.

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November 2016

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model.

Toxicol Res (Camb) 2016 Nov 12;5(6):1594-1603. Epub 2016 Aug 12.

Computational and Systems Medicine , Department of Surgery & Cancer , Faculty of Medicine , Imperial College London , UK . Email:

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November 2016

Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.

Arch Toxicol 2016 Dec 9;90(12):3073-3085. Epub 2016 Jan 9.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK.

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December 2016

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

Drug Discov Today Technol 2015 Aug 16;15:9-14. Epub 2015 Jul 16.

Department of Surgery and Cancer, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address:

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August 2015

Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.

Authors:
Muireann Coen

Drug Metab Rev 2015 Feb 23;47(1):29-44. Epub 2014 Dec 23.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , London , UK.

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February 2015

Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis.

Am J Gastroenterol 2015 Jan 23;110(1):159-69. Epub 2014 Dec 23.

Section of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

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January 2015

Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat.

Toxicol Sci 2014 Nov 21;142(1):105-16. Epub 2014 Aug 21.

Biomolecular Medicine, Division of Computational Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK

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November 2014

Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study.

BMC Med 2014 Jul 11;12:110. Epub 2014 Jul 11.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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July 2014

Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method.

Bioanalysis 2014 Apr;6(7):919-33

>MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.

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April 2014

Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer.

Chem Res Toxicol 2012 Nov 5;25(11):2412-22. Epub 2012 Nov 5.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.

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November 2012

Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response.

J Proteome Res 2012 Sep 9;11(9):4630-42. Epub 2012 Aug 9.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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September 2012

Non-linear modeling of 1H NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing.

Anal Chim Acta 2011 Oct 20;705(1-2):72-80. Epub 2011 Apr 20.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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October 2011

Data-driven approach for metabolite relationship recovery in biological 1H NMR data sets using iterative statistical total correlation spectroscopy.

Anal Chem 2011 Mar 16;83(6):2075-82. Epub 2011 Feb 16.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, United Kingdom.

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March 2011

Processing and modeling of nuclear magnetic resonance (NMR) metabolic profiles.

Methods Mol Biol 2011 ;708:365-88

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK.

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April 2011

HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies.

Anal Chem 2011 Jan 13;83(1):382-90. Epub 2010 Dec 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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January 2011

A metabonomic approach for mechanistic exploration of pre-clinical toxicology.

Authors:
Muireann Coen

Toxicology 2010 Dec 10;278(3):326-40. Epub 2010 Aug 10.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW72AZ, UK.

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December 2010

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues.

Nat Protoc 2010 Jun 13;5(6):1019-32. Epub 2010 May 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London, UK.

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June 2010

Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification.

Anal Chem 2010 Mar;82(5):1811-21

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom.

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March 2010

High-resolution 1H NMR spectroscopic investigation of a chick embryo model of neural tube development.

Magn Reson Chem 2009 Dec;47 Suppl 1:S62-7

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK.

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December 2009

Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity.

Magn Reson Chem 2009 Dec;47 Suppl 1:S47-53

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK.

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December 2009

Cluster analysis statistical spectroscopy using nuclear magnetic resonance generated metabolic data sets from perturbed biological systems.

Anal Chem 2009 Aug;81(16):6581-9

Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology, and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.

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August 2009

Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery.

Anal Chem 2009 Aug;81(15):6458-66

Department of Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.

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August 2009

Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis.

J Proteome Res 2008 Oct 19;7(10):4435-45. Epub 2008 Aug 19.

Department of Pharmaceutical Chemistry, Semmelweis University, Hogyes Endre u. 9, Budapest 1092, Hungary.

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October 2008

NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology.

Chem Res Toxicol 2008 Jan 3;21(1):9-27. Epub 2008 Jan 3.

Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK.

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January 2008

Species variation in the fecal metabolome gives insight into differential gastrointestinal function.

J Proteome Res 2008 Jan 1;7(1):352-60. Epub 2007 Dec 1.

Department of Public Health and Epidemiology, Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland.

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January 2008

Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.

Anal Chem 2007 Dec 1;79(23):8956-66. Epub 2007 Nov 1.

Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, U.K.

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December 2007

Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.

Anal Chem 2007 Apr 27;79(7):2629-40. Epub 2007 Feb 27.

Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, SW7 2AZ, UK.

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April 2007

Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy.

Antimicrob Agents Chemother 2006 Dec 18;50(12):4018-26. Epub 2006 Sep 18.

School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia.

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December 2006

Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis.

Clin Infect Dis 2005 Dec 25;41(11):1582-90. Epub 2005 Oct 25.

School of Molecular and Microbial Biosciences, Westmead Millennium Institute, University of Sydney, Sydney, Australia.

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December 2005

Probing molecular dynamics in chromatographic systems using high-resolution 1H magic-angle-spinning NMR spectroscopy: interaction between p-Xylene and C18-bonded silica.

Anal Chem 2004 Jun;76(11):3023-8

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ UK.

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June 2004

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse.

J Pharm Biomed Anal 2004 Apr;35(1):93-105

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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April 2004

An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy.

Chem Res Toxicol 2003 Mar;16(3):295-303

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom.

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March 2003