Muireann Coen

Muireann Coen

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Muireann Coen

Muireann Coen

Publications by authors named "Muireann Coen"

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Development of a rapid profiling method for the analysis of polar analytes in urine using HILIC-MS and ion mobility enabled HILIC-MS.

Metabolomics 2019 Jan 22;15(2):17. Epub 2019 Jan 22.

Separations Science and Metabolomics laboratory, Murdoch University, South Street, 6150, Murdoch, WA, Australia.

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http://dx.doi.org/10.1007/s11306-019-1474-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342856PMC
January 2019

Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.

Environ Sci Technol 2018 11 30;52(22):13469-13480. Epub 2018 Oct 30.

Integrative Systems Medicine & Digestive Disease, Department of Surgery & Cancer, Faculty of Medicine , Imperial College London , U.K.

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http://pubs.acs.org/doi/10.1021/acs.est.8b02215
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http://dx.doi.org/10.1021/acs.est.8b02215DOI Listing
November 2018

Capillary ultra performance liquid chromatography-tandem mass spectrometry analysis of tienilic acid metabolites in urine following intravenous administration to the rat.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Jun 26;1087-1088:142-148. Epub 2018 Apr 26.

Waters Corporation, Milford, MA, 01757, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.04.034DOI Listing
June 2018

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective.

Toxicol Res (Camb) 2018 May 6;7(3):347-357. Epub 2018 Mar 6.

Division of Computational and Systems Medicine , Department of Surgery and Cancer , Faculty of Medicine , Imperial College London , South Kensington , London SW7 2AZ , UK . Email:

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http://dx.doi.org/10.1039/c7tx00340dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062253PMC
May 2018

Assessment of metabolic phenotypic variability in children's urine using H NMR spectroscopy.

Sci Rep 2017 04 19;7:46082. Epub 2017 Apr 19.

Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1038/srep46082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395814PMC
April 2017

High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.

Anal Chem 2017 02 7;89(4):2478-2487. Epub 2017 Feb 7.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London , South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/acs.analchem.6b04623DOI Listing
February 2017

Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.

Arch Toxicol 2016 Dec 9;90(12):3073-3085. Epub 2016 Jan 9.

Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1007/s00204-015-1655-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104807PMC
December 2016

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model.

Toxicol Res (Camb) 2016 Nov 12;5(6):1594-1603. Epub 2016 Aug 12.

Computational and Systems Medicine , Department of Surgery & Cancer , Faculty of Medicine , Imperial College London , UK . Email:

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http://dx.doi.org/10.1039/c6tx00221hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060677PMC
November 2016

Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study.

BMC Med 2016 Nov 4;14(1):177. Epub 2016 Nov 4.

Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England (MRC-PHE) Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG, London, UK.

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http://dx.doi.org/10.1186/s12916-016-0706-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097405PMC
November 2016

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

Drug Discov Today Technol 2015 Aug 16;15:9-14. Epub 2015 Jul 16.

Department of Surgery and Cancer, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ddtec.2015.06.003DOI Listing
August 2015

Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.

Authors:
Muireann Coen

Drug Metab Rev 2015 Feb 23;47(1):29-44. Epub 2014 Dec 23.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , London , UK.

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http://dx.doi.org/10.3109/03602532.2014.982865DOI Listing
February 2015

Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis.

Am J Gastroenterol 2015 Jan 23;110(1):159-69. Epub 2014 Dec 23.

Section of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ajg.2014.370DOI Listing
January 2015

Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat.

Toxicol Sci 2014 Nov 21;142(1):105-16. Epub 2014 Aug 21.

Biomolecular Medicine, Division of Computational Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK

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http://dx.doi.org/10.1093/toxsci/kfu160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226764PMC
November 2014

Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study.

BMC Med 2014 Jul 11;12:110. Epub 2014 Jul 11.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1186/1741-7015-12-110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094172PMC
July 2014

Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method.

Bioanalysis 2014 Apr;6(7):919-33

>MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK.

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http://www.future-science.com/doi/10.4155/bio.13.350
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http://dx.doi.org/10.4155/bio.13.350DOI Listing
April 2014

Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer.

Chem Res Toxicol 2012 Nov 5;25(11):2412-22. Epub 2012 Nov 5.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/tx3002803DOI Listing
November 2012

Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response.

J Proteome Res 2012 Sep 9;11(9):4630-42. Epub 2012 Aug 9.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1021/pr300430uDOI Listing
September 2012

Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity.

J Proteome Res 2012 Apr 2;11(4):2427-40. Epub 2012 Mar 2.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom.

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http://pubs.acs.org/doi/10.1021/pr201161f
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http://dx.doi.org/10.1021/pr201161fDOI Listing
April 2012

Statistical total correlation spectroscopy scaling for enhancement of metabolic information recovery in biological NMR spectra.

Anal Chem 2012 Jan 27;84(2):1083-91. Epub 2011 Dec 27.

Neuroscience Research Australia, Barker Street, Randwick 2031, Australia.

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http://pubs.acs.org/doi/10.1021/ac202720f
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http://dx.doi.org/10.1021/ac202720fDOI Listing
January 2012

Non-linear modeling of 1H NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing.

Anal Chim Acta 2011 Oct 20;705(1-2):72-80. Epub 2011 Apr 20.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.aca.2011.04.016DOI Listing
October 2011

Processing and modeling of nuclear magnetic resonance (NMR) metabolic profiles.

Methods Mol Biol 2011 ;708:365-88

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1007/978-1-61737-985-7_21DOI Listing
April 2011

Data-driven approach for metabolite relationship recovery in biological 1H NMR data sets using iterative statistical total correlation spectroscopy.

Anal Chem 2011 Mar 16;83(6):2075-82. Epub 2011 Feb 16.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac102870uDOI Listing
March 2011

HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies.

Anal Chem 2011 Jan 13;83(1):382-90. Epub 2010 Dec 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1021/ac102523qDOI Listing
January 2011

A metabonomic approach for mechanistic exploration of pre-clinical toxicology.

Authors:
Muireann Coen

Toxicology 2010 Dec 10;278(3):326-40. Epub 2010 Aug 10.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW72AZ, UK.

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http://dx.doi.org/10.1016/j.tox.2010.07.022DOI Listing
December 2010

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues.

Nat Protoc 2010 Jun 13;5(6):1019-32. Epub 2010 May 13.

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London, UK.

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http://dx.doi.org/10.1038/nprot.2010.45DOI Listing
June 2010

Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification.

Anal Chem 2010 Mar;82(5):1811-21

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac902443kDOI Listing
March 2010

Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity.

Magn Reson Chem 2009 Dec;47 Suppl 1:S47-53

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1002/mrc.2521DOI Listing
December 2009

High-resolution 1H NMR spectroscopic investigation of a chick embryo model of neural tube development.

Magn Reson Chem 2009 Dec;47 Suppl 1:S62-7

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1002/mrc.2534DOI Listing
December 2009

Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery.

Anal Chem 2009 Aug;81(15):6458-66

Department of Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac900828pDOI Listing
August 2009

Cluster analysis statistical spectroscopy using nuclear magnetic resonance generated metabolic data sets from perturbed biological systems.

Anal Chem 2009 Aug;81(16):6581-9

Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology, and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/ac901240jDOI Listing
August 2009

Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis.

J Proteome Res 2008 Oct 19;7(10):4435-45. Epub 2008 Aug 19.

Department of Pharmaceutical Chemistry, Semmelweis University, Hogyes Endre u. 9, Budapest 1092, Hungary.

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http://dx.doi.org/10.1021/pr800407jDOI Listing
October 2008

Species variation in the fecal metabolome gives insight into differential gastrointestinal function.

J Proteome Res 2008 Jan 1;7(1):352-60. Epub 2007 Dec 1.

Department of Public Health and Epidemiology, Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/pr070340kDOI Listing
January 2008

NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology.

Chem Res Toxicol 2008 Jan 3;21(1):9-27. Epub 2008 Jan 3.

Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK.

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http://www.researchgate.net/profile/Jeremy_Nicholson2/public
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http://pubs.acs.org/doi/abs/10.1021/tx700335d
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http://dx.doi.org/10.1021/tx700335dDOI Listing
January 2008

Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.

Anal Chem 2007 Dec 1;79(23):8956-66. Epub 2007 Nov 1.

Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, U.K.

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http://dx.doi.org/10.1021/ac0713961DOI Listing
December 2007

Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy.

Antimicrob Agents Chemother 2006 Dec 18;50(12):4018-26. Epub 2006 Sep 18.

School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00439-06
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http://dx.doi.org/10.1128/AAC.00439-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693988PMC
December 2006

Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis.

Clin Infect Dis 2005 Dec 25;41(11):1582-90. Epub 2005 Oct 25.

School of Molecular and Microbial Biosciences, Westmead Millennium Institute, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1086/497836DOI Listing
December 2005

Probing molecular dynamics in chromatographic systems using high-resolution 1H magic-angle-spinning NMR spectroscopy: interaction between p-Xylene and C18-bonded silica.

Anal Chem 2004 Jun;76(11):3023-8

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ UK.

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http://dx.doi.org/10.1021/ac049789cDOI Listing
June 2004

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse.

J Pharm Biomed Anal 2004 Apr;35(1):93-105

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.jpba.2003.12.019DOI Listing
April 2004

An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy.

Chem Res Toxicol 2003 Mar;16(3):295-303

Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1021/tx0256127DOI Listing
March 2003

Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids.

Analyst 2002 Oct;127(10):1283-8

Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, London, UK.

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http://dx.doi.org/10.1039/b205128cDOI Listing
October 2002