Publications by authors named "Muhammad Salim"

53 Publications

Phytotoxicity of petroleum hydrocarbons: Sources, impacts and remediation strategies.

Environ Res 2021 Mar 18;197:111031. Epub 2021 Mar 18.

National Engineering Laboratory for Improving Quality of Arable Land, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, PR China. Electronic address:

Extraction and exploration of petroleum hydrocarbons (PHs) to satisfy the rising world population's fossil fuel demand is playing havoc with human beings and other life forms by contaminating the ecosystem, particularly the soil. In the current review, we highlighted the sources of PHs contamination, factors affecting the PHs accumulation in soil, mechanisms of uptake, translocation and potential toxic effects of PHs on plants. In plants, PHs reduce the seed germination andnutrients translocation, and induce oxidative stress, disturb the plant metabolic activity and inhibit the plant physiology and morphology that ultimately reduce plant yield. Moreover, the defense strategy in plants to mitigate the PHs toxicity and other potential remediation techniques, including the use of organic manure, compost, plant hormones, and biochar, and application of microbe-assisted remediation, and phytoremediation are also discussed in the current review. These remediation strategies not only help to remediate PHs pollutionin the soil rhizosphere but also enhance the morphological and physiological attributes of plant and results to improve crop yield under PHs contaminated soils. This review aims to provide significant information on ecological importance of PHs stress in various interdisciplinary investigations and critical remediation techniques to mitigate the contamination of PHs in agricultural soils.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2021.111031DOI Listing
March 2021

Bidirectional Self-Folding with Atomic Layer Deposition Nanofilms for Microscale Origami.

Nano Lett 2020 07 17;20(7):4850-4856. Epub 2020 Jun 17.

Laboratory of Atomic and Solid State Physics, Cornell University, 511 Clark Hall, Ithaca, New York 14853, United States.

Origami design principles are scale invariant and enable direct miniaturization of origami structures provided the sheets used for folding have equal thickness to length ratios. Recently, seminal steps have been taken to fabricate microscale origami using unidirectionally actuated sheets with nanoscale thickness. Here, we extend the full power of origami-inspired fabrication to nanoscale sheets by engineering bidirectional folding with 4 nm thick atomic layer deposition (ALD) SiN-SiO bilayer films. Strain differentials within these bilayers result in bending, producing microscopic radii of curvature. We lithographically pattern these bilayers and localize the bending using rigid panels to fabricate a variety of complex micro-origami devices. Upon release, these devices self-fold according to prescribed patterns. Our approach combines planar semiconductor microfabrication methods with computerized origami design, making it easy to fabricate and deploy such microstructures en masse. These devices represent an important step forward in the fabrication and assembly of deployable micromechanical systems that can interact with and manipulate micro- and nanoscale environments.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.nanolett.0c00824DOI Listing
July 2020

Physical Activity Before, During, and After Chemotherapy for High-Risk Breast Cancer: Relationships With Survival.

J Natl Cancer Inst 2021 Jan;113(1):54-63

Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: Although physical activity has been consistently associated with reduced breast cancer mortality, evidence is largely based on data collected at one occasion. We examined how pre- and postdiagnosis physical activity was associated with survival outcomes in high-risk breast cancer patients.

Methods: Included were 1340 patients enrolled in the Diet, Exercise, Lifestyle and Cancer Prognosis (DELCaP) Study, a prospective study of lifestyle and prognosis ancillary to a SWOG clinical trial (S0221). Activity before diagnosis, during treatment, and at 1- and 2-year intervals after enrollment was collected. Patients were categorized according to the Physical Activity Guidelines for Americans as meeting the minimum guidelines (yes/no) and incrementally as inactive, low active, moderately active (meeting the guidelines), or high active.

Results: In joint-exposure analyses, patients meeting the guidelines before and 1 year after diagnosis experienced statistically significant reductions in hazards of recurrence (hazard ratio [HR] = 0.59, 95% confidence interval [CI] = 0.42 to 0.82) and mortality (HR = 0.51, 95% CI = 0.34-0.77); associations were stronger at 2-year follow-up for recurrence (HR = 0.45, 95% CI = 0.31 to 0.65) and mortality (HR = 0.32, 95% CI = 0.19 to 0.52). In time-dependent analyses, factoring in activity from all time points, we observed striking associations with mortality for low- (HR = 0.41, 95% CI = 0.24 to 0.68), moderate- (HR = 0.42, 95% CI = 0.23 to 0.76), and high-active patients (HR = 0.31, 95% CI = 0.18 to 0.53).

Conclusions: Meeting the minimum guidelines for physical activity both before diagnosis and after treatment appears to be associated with statistically significantly reduced hazards of recurrence and mortality among breast cancer patients. When considering activity from all time points, including during treatment, lower volumes of regular activity were associated with similar overall survival advantages as meeting and exceeding the guidelines.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djaa046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781460PMC
January 2021

Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221).

J Clin Oncol 2020 03 19;38(8):804-814. Epub 2019 Dec 19.

Loyola University Chicago Stritch School of Medicine, Chicago, IL.

Purpose: Despite reported widespread use of dietary supplements during cancer treatment, few empirical data with regard to their safety or efficacy exist. Because of concerns that some supplements, particularly antioxidants, could reduce the cytotoxicity of chemotherapy, we conducted a prospective study ancillary to a therapeutic trial to evaluate associations between supplement use and breast cancer outcomes.

Methods: Patients with breast cancer randomly assigned to an intergroup metronomic trial of cyclophosphamide, doxorubicin, and paclitaxel were queried on their use of supplements at registration and during treatment (n =1,134). Cox proportional hazards regression adjusting for clinical and lifestyle variables was used. Recurrence and survival were indexed at 6 months after enrollment using a landmark approach.

Results: There were indications that use of any antioxidant supplement (vitamins A, C, and E; carotenoids; coenzyme Q10) both before and during treatment was associated with an increased hazard of recurrence (adjusted hazard ratio [adjHR], 1.41; 95% CI, 0.98 to 2.04; = .06) and, to a lesser extent, death (adjHR, 1.40; 95% CI, 0.90 to 2.18; = .14). Relationships with individual antioxidants were weaker perhaps because of small numbers. For nonantioxidants, vitamin B12 use both before and during chemotherapy was significantly associated with poorer disease-free survival (adjHR, 1.83; 95% CI, 1.15 to 2.92; < .01) and overall survival (adjHR, 2.04; 95% CI, 1.22 to 3.40; < .01). Use of iron during chemotherapy was significantly associated with recurrence (adjHR, 1.79; 95% CI, 1.20 to 2.67; < .01) as was use both before and during treatment (adjHR, 1.91; 95% CI, 0.98 to 3.70; = .06). Results were similar for overall survival. Multivitamin use was not associated with survival outcomes.

Conclusion: Associations between survival outcomes and use of antioxidant and other dietary supplements both before and during chemotherapy are consistent with recommendations for caution among patients when considering the use of supplements, other than a multivitamin, during chemotherapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.19.01203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062457PMC
March 2020

Genetic study of Khyber-Pukhtunkhwa resident Pakistani families presenting primary microcephaly with intellectual disability.

J Pak Med Assoc 2019 Dec;69(12):1812-1816

Gomal Centre of Biochemistry and Biotechnology, Gomal University, D.I. Khan, Khyber Pakhtunkhwa, Pakistan.

Objective: To investigate the genetic factor responsible for causing microcephaly and determine allelic heterogeneity of Abnormal spindle microtubule gene.

Methods: The genetic study was conducted at the Kohat University of Science and Technology, Kohat, and Gomal University, D.I.Khan, Pakistan, during 2017-18, and comprised 5 consanguineous families from South Waziristan, Kurram Agency, Karak, Bannu and Dera Ismail Khan regions of the country's Khyber Pakhtukhwa province. Blood samples from all available and cooperative family members (including normal and affected) were obtained, and molecular analysis was carried out through whole genome single nucleotide polymorphisms genotyping, exome sequencing and Sanger sequencing.

Results: Of the 15 patients, 9(60%) were males and 6(40%) were females. Genetic mapping revealed linkage to the MCPH5 locus which harbours the microcephaly-associated abnormal spindle-like microcephaly gene. Mutation analysis of the gene identified missense mutation c.3978G>A (p.Trp1326*) in families A, B and C, a deletion mutation c.7782_7783delGA (p.(Lys2595Serfs*6)) in family D, and a splice site defect c.2936+5G>A in family E.

Conclusions: There was suggestion of strong founder effect of mutation c.3978G>A (p.Trp1326*).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5455/JPMA.300681DOI Listing
December 2019

A Phase II Study of PX-866 in Patients With Recurrent or Metastatic Castration-resistant Prostate Cancer: Canadian Cancer Trials Group Study IND205.

Clin Genitourin Cancer 2019 06 15;17(3):201-208.e1. Epub 2019 Mar 15.

Canadian Cancer Trials Group, Kingston, ON, Canada.

Background: In PTEN-loss models, the phosphatidylinositol 3-kinase (PI3K)/AKT and androgen receptor signaling pathways cross-regulate by reciprocal feedback whereby inhibition of one activates the other, creating a rationale for co-targeting. We studied the irreversible, pan-isoform inhibitor of Class I PI-3K PX-866 singly (part A) and with abiraterone acetate (AA) in patients on AA with rising prostate-specific antigen (PSA) (part B).

Patients And Methods: The primary endpoint was lack of progression at 12 weeks. Exploratory endpoints included changes in circulating tumor cells (CTC), pharmacodynamic studies on platelets (part A), and archival tumor exploration of PTEN as predictor of response (part B).

Results: A total of 43 and 25 patients accrued to parts A and B, respectively. In part A, 14 (33%) patients were progression-free at 12 weeks, with 2 partial objective responses and 1 confirmed PSA response. Favorable CTC conversion (< 5 CTC/7.5 mL) occurred in 6 (24%) of 25 evaluable patients. In part B, 11 of 25 patients had measurable disease. Six (24%) patients were progression-free at 12 weeks. No objective or PSA responses were observed. For all 68 patients, the most common toxicities were diarrhea (53 patients), nausea (36), anorexia (24), fatigue (22), and vomiting (20). Among 17 patients for whom PTEN testing was possible, 3 had PTEN homozygous deletion and 14 had no change. No correlation between PTEN status and response was seen.

Conclusions: PX-866 had modest single agent activity. Adding AA to PX-866 showed no evidence of resistance reversal. Strategies to combine PI3K inhibition with androgen receptor-targeted therapies could consider initiation earlier, combination with other agents, and/or recruiting a selected population.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clgc.2019.03.005DOI Listing
June 2019

Regional trade of medicinal plants has facilitated the retention of traditional knowledge: case study in Gilgit-Baltistan Pakistan.

J Ethnobiol Ethnomed 2019 Jan 28;15(1). Epub 2019 Jan 28.

Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.

Background: The ethnic groups in Gilgit-Baltistan have been utilizing local resources in their centuries-old traditional healing system. Most tribes within these ethnic groups still rely on traditional healing systems. We aim to understand the current status, uses, and abundance of medicinal plants, associated traditional knowledge, and trade.

Materials And Methods: The study incorporated over 300 local community members (70% men and 30% women) in focused group discussions, semi-structured interviews, and homework assignments for 8th to 12th grade students to document traditional knowledge (TK) in six districts in Northeast Pakistan. We calculated various indices such as informant consensus factor, use value, relative frequency of citation, and CoKriging. These indices, along with repetitively used medicinal plants, were used to analyze differences in studied locations.

Results: Most of the community members still rely on traditional medication in the study areas. However, we found the highest number of medicinal plants used in Skardu and Gilgit compared to other districts and these two districts also represent trade centers and a highly populated area regarding medicinal plants. Results indicate connection amongst the surveyed villages signifying mixing of knowledge from different sources, with certain areas more influenced by traditional Chinese medicine and others more by Ayurveda and Unani.

Conclusion: TK is mostly retained with elder community members; however, those directly linked with market value chain retain rich knowledge on traditional use of the medicinal plants from the region. Major trade centers in the region also coincide with a high density of medicinal plant occurrence, knowledge, and higher utilization. Therefore, with the increasing trade in medicinal plant in the region, there is potential for rejuvenation of this knowledge and of plant use in the region.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13002-018-0281-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348662PMC
January 2019

Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221).

Breast Cancer Res 2018 11 28;20(1):146. Epub 2018 Nov 28.

Roswell Park Cancer Institute, Buffalo, NY, USA.

Background: The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment.

Methods: Women with stage II or III invasive breast cancer were enrolled into an ancillary study to the North American Breast Cancer Intergroup phase III trial (S0221) led by the Southwest Oncology Group (SWOG). Questionnaires including a food frequency questionnaire and the Functional Assessment of Cancer Treatment Gynecologic Oncology Group-Neurotoxicity were administered to assess diet and neuropathic conditions at baseline and during chemotherapy. Ordinal regression was used to estimate odds ratios (ORs) for associations between various food groups and change in neuropathy score (< 10%, 10-30%, > 30%) (n = 900).

Results: The odds of worse neuropathy decreased by 21% for each increase in tertile of grain consumption (OR = 0.79, 95% CI 0.66-0.94, p = 0.009). We also observed a nominal 19% increase with higher consumption of citrus fruits (OR = 1.19, 95% CI 1.01-1.40, p = 0.05).

Conclusions: Distinguishing between those who experienced a moderate and a severe change in neuropathy, we found that citrus fruit and grain consumption may play a role in the severity of symptoms. Since there are no existing dietary recommendations for the management of CIPN, further research is needed to investigate whether there may be certain foods that could worsen or alleviate neuropathy symptoms associated with treatment for breast cancer.

Trial Registration: ClinicalTrials.gov, NCT03413761 . Registered retrospectively on 29 January 2018.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13058-018-1077-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264595PMC
November 2018

Investigating the relationship between proteomic, compositional, and histologic biomarkers and cartilage biomechanics using artificial neural networks.

J Biomech 2018 10 4;80:136-143. Epub 2018 Sep 4.

Bioengineering, Orthopaedic Surgery, University of Missouri, Columbia, MO, USA. Electronic address:

A thorough understanding of the relationship between the biological and mechanical functions of articular cartilage is necessary to develop diagnostics and treatments for arthritic diseases. A key step in developing this understanding is the establishment of models which utilize large numbers of biomarkers to create comprehensive models of the interplay between cartilage biology and biomechanics, which will more accurately demonstrate the complex etiology and progression of tissue adaptation and degradation. It is the goal of this study to demonstrate the ability of artificial neural networks (ANNs) to utilize biomarkers to create predictive models of articular cartilage biomechanics, which will provide a basis for more sophisticated research in the future. Osteochondral plugs were collected from patients undergoing total knee arthroplasty, cultured, then analyzed to collect proteomic, compositional, and histologic biomarker data. Samples were subjected to stress relaxation testing as well as computational simulations using finite element analysis (FEA) modeling and optimization to determine key mechanical properties. The acquired data was fed into an ANN to generate a model which predicts the biomechanical properties of cartilage from given biomarkers. Using all significant inputs, the developed neural network predicted the ground substance modulus with a moderate degree of accuracy, but had difficulty predicting the collagen fiber modulus and cartilage permeability. Using only clinically attainable biomarkers, the best-performing model produced comparably accurate and more consistent predictions of all three mechanical properties. These models demonstrate the potential for ANNs to be included in clinical studies of articular cartilage.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiomech.2018.08.032DOI Listing
October 2018

Angiogenesis activity of L. latex in cream formulation on wound healing in mice.

Vet World 2018 Jul 15;11(7):939-943. Epub 2018 Jul 15.

Laboratory of Pathology, Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh 23111, Indonesia.

Aim: The aim of this research was to determine the angiogenesis activity of latex in cream formulation on CD34 immune expression during wound healing phase in mice skin.

Materials And Methods: Amount of 36 2-month-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. All mice were divided into four groups, namely the base cream as control group (A), sulfadiazine 0.1% cream (B), latex cream 10% (C), and latex cream 15% (D). All groups were treated entire surface of wound. All experiments were performed twice a day for 10 days. Experiments were terminated on days 3, 7, and 10, respectively. The wound healing was assayed in stained histological section in immunohistochemical of the wounds. The CD34 expression was investigated under a microscope.

Results: The results showed that the cream from 10% and 15% latex revealed moderate immune reaction to CD34 on days 3 and 7 in wound healing of mice skin.

Conclusion: We concluded that the cream from 10% and 15% latex has potential as angiogenesis activity in wound healing of mice skin.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.14202/vetworld.2018.939-943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097565PMC
July 2018

Anti-inflammatory activity of Linn. latex in cream formulation on CD68 expression in mice skin wound.

Vet World 2018 Feb 2;11(2):99-103. Epub 2018 Feb 2.

Laboratory of Microbiology, Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh 23111, Indonesia.

Aim: The purpose of the present study was to determine the potential of latex in the cream formulation on CD68 immune expression (macrophages) during inflammatory phase wound healing process in mice skin.

Materials And Methods: Amount of 12 two-months-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. The mice were allotted into four groups of each, entire surface of each group wound covered by base cream control, sulfadiazine 0.1% cream, latex cream 10% and, 15%, respectively. All experiments were performed twice a day for 3 days. The wound healing was assayed in stained histological sections in immunohistochemical of the wounds. CD68 expression was investigated under a microscope.

Results: The results showed that the cream from the 10% and 15% latex of revealed moderate immune reaction to CD68 on wound healing.

Conclusion: We concluded that the latex cream of possesses anti-inflammatory activity in wound healing process of mice skin.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.14202/vetworld.2018.99-103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891885PMC
February 2018

Supplement Use and Chemotherapy-Induced Peripheral Neuropathy in a Cooperative Group Trial (S0221): The DELCaP Study.

J Natl Cancer Inst 2017 12;109(12)

Roswell Park Cancer Institute, Buffalo, NY.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) can interfere with daily function and quality of life, and there are no known preventive approaches. In a cohort of breast cancer patients receiving paclitaxel as part of a clinical trial (SWOG 0221), we examined the use of dietary supplements both before diagnosis and during treatment in relation to CIPN.

Methods: At registration to S0221, 1225 breast cancer patients completed questionnaires regarding the use of multivitamins and supplements before and at diagnosis. A second questionnaire at six months queried use during treatment. Supplement use was evaluated in relation to CIPN, assessed via the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE v. 3.0) and the self-reported Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity (FACT/GOG-Ntx) subscale. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed with logistic regression for the CTCAE analyses and ordinal regression for the FACT/GOG-Ntx analyses.

Results: Multivitamin use before diagnosis was associated with reduced symptoms of CIPN (CTCAE-adjusted OR = 0.60, 95% CI = 0.42 to 0.87; FACT/GOG-Ntx-adjusted OR = 0.78, 95% CI = 0.61 to 1.00). Use during treatment was marginally inversely associated with CIPN (CTCAE-adjusted OR = 0.73, 95% CI = 0.49 to 1.08; FACT/GOG-Ntx-adjusted OR = 0.77, 95% CI = 0.60 to 0.99). Other supplement use, either before diagnosis or during treatment, was not statistically significantly associated with CIPN.

Conclusions: Multivitamin use may be associated with reduced risk of CIPN, although individual dietary supplement use did not appreciably affect risk. Multivitamin use could be a surrogate for other related behaviors that are the actual drivers of the association with reduced CIPN. Without prospective randomized trials of vitamin supplementation, recommendations for use or changes to clinical practice are clearly not warranted.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djx098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075365PMC
December 2017

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

Pharmacogenet Genomics 2018 02;28(2):49-55

Roswell Park Cancer Institute, Buffalo.

Objective: Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN.

Patients And Methods: Women with high-risk breast cancer enrolled in SWOG 0221 were genotyped using the Illumina 1M chip. Genome-wide analyses were performed in relation to ≥grade 3 Common Terminology Criteria for Adverse Events (CTCAE) neuropathy in European and African Americans. Data were meta-analyzed with GW associations of CTCAE ≥grade 3 versus
Results: The percentage of ≥grade 3 TIPN in 1269 European Americans and 139 African Americans in S0221, was 11.6 and 22.3%, respectively. CALGB 40101 ≥grade 3 TOPN was 7.2%. The most significant association with ≥grade 3 TIPN was the G allele of rs1858826 in GNGT1 (Pmeta=1.1×10), which showed a decrease in risk of ≥grade 3 TIPN (odds ratio=0.29, 95% confidence interval: 0.18-0.46).

Conclusion: The genetic variants associated with ≥grade 3 TIPN are hypothesized to have biochemical functions and reside in and near genes involved in diabetes and diabetic neuropathy. This finding is consistent with results from CALGB 40101 pathway analyses. Larger homogeneous trials with similar dosing and criteria for defining neuropathy are needed to properly assess the relationship of genomics with the neuropathy spectrum.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824720PMC
February 2018

Abruptio Placentae with Type II Respiratory Failure Secondary to Acute Interstitial Pneumonia Responsive to Steroids.

J Coll Physicians Surg Pak 2017 Sep;27(9):S106-S107

Department of Critical Care, Patel Hospital, Karachi.

Acute Interstitial Pneumonia (AIP) is categorized as Idiopathic Interstitial Pneumonia (IIP), in which the cause is unknown. Ayoung female of 22 years presented in 34 weeks gestation with abruptio placentae (AP) and underwent Lower Segment Caesarian Section (LSCS) for AP. It progressed to type II respiratory failure secondary to AIPon 4th day post-surgery. It remained unresponsive when treated with noninvasive ventilation (NIV-BiPAP) along with antibiotics. Later, a trial treatment of pulse therapy of Methylprednisolone was executed on 7th day post-surgery which resulted in dramatic improvement in symptoms. It is uncommon to have type II respiratory failure secondary to AIP, and it is rarely steroid responsive.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/275DOI Listing
September 2017

Deposition of DNA Nanostructures on Highly Oriented Pyrolytic Graphite.

Langmuir 2017 04 13;33(16):3991-3997. Epub 2017 Apr 13.

Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.

We report the deposition of DNA origami nanostructures on highly oriented pyrolytic graphite (HOPG). The DNA origami goes through a structural rearrangement and the DNA base is exposed to interact with the graphite surface. Exposure to ambient air, which is known to result in a hydrophilic-to-hydrophobic wetting transition of HOPG, does not significantly impact the deposition yield or the shape deformation of DNA nanostructures. The deposited DNA nanostructures maintain their morphology for at least a week and promote site-selective chemical vapor deposition of SiO. This process is potentially useful for a range of applications that include but are not limited to nanostructure fabrication, sensing, and electronic and surface engineering.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.6b03836DOI Listing
April 2017

The CDK inhibitor AT7519M in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. A Phase II study of the Canadian Cancer Trials Group.

Leuk Lymphoma 2017 06 17;58(6):1358-1365. Epub 2016 Oct 17.

i Canadian Cancer Trials Group , Queen's University , Kingston , ON , Canada.

AT7519M is a small molecule inhibitor of cyclin-dependent kinases 1, 2, 4, 5, and 9 with in vitro activity against lymphoid malignancies. In two concurrent Phase II trials, we evaluated AT7519M in relapsed or refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) using the recommended Phase II dosing of 27 mg/m twice weekly for 2 of every 3 weeks. Primary objective was objective response rate (ORR). Nineteen patients were accrued (7 CLL, 12 MCL). Four CLL patients achieved stable disease (SD). Two MCL patients achieved partial response (PR), and 6 had SD. One additional MCL patient with SD subsequently achieved PR 9 months after completion of AT7519M. Tumor lysis syndrome was not reported. In conclusion, AT7519M was safely administered to patients with relapsed/refractory CLL and MCL. In CLL, some patients had tumor reductions, but the ORR was low. In MCL, activity was noted with ORR of 27%.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2016.1239259DOI Listing
June 2017

Asymptomatic inhaled foreign body. A bullet in the lung for 2 years.

Saudi Med J 2016 Oct;37(10):1136-9

Department of Respiratory Medicine, Jinnah Postgraduate Medical Centre, Karachi, Pakistan. E-mail.

It is very rare to have a big foreign body in the lungs without any complications or symptoms for 2 years. A 14-year-old male with episodes of minor hemoptysis for 4 weeks had a history of inhalation of a bullet 2 years earlier. He had asymptomatic for lung complications for 2 years. The bullet was removed by right thoracotomy and  non-anatomical wedge stapled resection, and he followed an uneventful recovery. An aspirated foreign body although big can remain asymptomatic for a long time, especially if it has migrated to the periphery.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.15537/smj.2016.10.16046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075379PMC
October 2016

Canadian Cancer Trials Group IND197: a phase II study of foretinib in patients with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2-negative recurrent or metastatic breast cancer.

Breast Cancer Res Treat 2016 05 26;157(1):109-16. Epub 2016 Apr 26.

University Health Network-OCI/Princess Margaret Hospital, Toronto, ON, Canada.

In murine models, overexpression of the MET receptor transgene induces tumors with human basal gene expression characteristics supporting MET inhibition as a treatment strategy for triple-negative breast cancer (TNBC). Foretinib is an oral multi-kinase inhibitor of MET, RON, AXL, TIE-2, and VEGF receptors with anti-tumor activity in advanced HCC and papillary renal cell cancer. Patients with centrally reviewed primary TNBC and 0-1 prior regimens for metastatic disease received daily foretinib 60 mg po in a 2-stage single-arm trial. Primary endpoints were objective response and early progression rates per RECIST 1.1. In stage 2, correlative studies of MET, PTEN, EGFR, and p53 on archival and fresh tumor specimens were performed along with enumeration of CTCs. 45 patients were enrolled with 37 patients having response evaluable and centrally confirmed primary TNBC (cTNBC). There were 2 partial responses (ITT 4.7 % response evaluable cTNBC 5.4 %) with a median duration of 4.4 months (range 3.7-5 m) and 15 patients had stable disease (ITT 33 %, response evaluable cTNBC 40.5 %) with a median duration of 5.4 months (range 2.3-9.7 m). The most common toxicities (all grades/grade 3) were nausea (64/4 %), fatigue (60/4 %), hypertension (58/49 %), and diarrhea (40/7 %). Six serious adverse events were considered possibly related to foretinib and 4 patients went off study due to adverse events. There was no correlation between MET positivity and response nor between response and PTEN, EGFR, p53, or MET expression in CTCs. Although CCTG IND 197 did not meet its primary endpoint, the observation of a clinical benefit rate of 46 % in this cTNBC population suggests that foretinib may have clinical activity as a single, non-cytotoxic agent in TNBC (ClinicalTrials.gov number, NCT01147484).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-016-3812-1DOI Listing
May 2016

A Simplified Supine Technique Expedites the Delivery of Effective Craniospinal Radiation to Medulloblastoma - Comparison with Other Techniques in the Literature.

Cureus 2015 Dec 15;7(12):e404. Epub 2015 Dec 15.

Department of Medical Oncology, Allan Blair Cancer Center, University of Saskatchewan.

A 28-year-old man presented to the emergency room with a severe headache of one day's duration. A computerized tomography scan showed a hemorrhagic tumor measuring 3.9 x 4.4 cm in the left cerebellar hemisphere. The resection specimen revealed medulloblastoma. He had two episodes of rebleeding and multiple postoperative issues preventing the use of prone craniospinal radiotherapy. We designed a supine technique for this tall man, which was not complicated to set up. The rapid safe implementation of this technique allowed us to avoid further rebleeding and successfully treat the residual tumor. This technique is the described technique in this case report and is compared to other techniques. At 7.5 years after surgery, he is alive without cancer and with only a mild residual deficit. This case is unusual since the majority of patients with the diagnosis of hemorrhagic medulloblastoma died.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723302PMC
December 2015

Insecticide resistance and its molecular basis in urban insect pests.

Parasitol Res 2016 Apr 13;115(4):1363-73. Epub 2016 Jan 13.

Department of Plant Production & Technologies, Ayhan Şahenk Faculty of Agricultural Sciences and Technologies, Niğde University, Niğde, Turkey.

Insecticide resistance is one of the most important evolutionary phenomena for researchers. Overuse of chemicals has induced resistance in insect pests that ultimately has led to the collapse of disease control programs in many countries. The erroneous and inappropriate management of insect vectors has resulted in dissemination of many vector-borne diseases like dengue, malaria, diarrhea, leishmaniasis, and many others. In most cases, the emergence of new diseases and the revival of old ones can be related with ecological changes that have favored rapid growth of vector densities. Understanding molecular mechanisms in resistant strains can assist in the development of management programs to control the development and spread of resistant insect populations. The dominant, recessive, and co-dominant forms of genes encoding resistance can be investigated, and furthermore, resistance development can be addressed either by the release of susceptible strains or timely insecticide rotation. The present review discusses the resistance level in all important insect vectors of human diseases; the molecular basis of evolvement of resistance has also been discussed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00436-015-4898-9DOI Listing
April 2016

Water Protects Graphitic Surface from Airborne Hydrocarbon Contamination.

ACS Nano 2016 Jan 17;10(1):349-59. Epub 2015 Dec 17.

Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.

The intrinsic wettability of graphitic materials, such as graphene and graphite, can be readily obscured by airborne hydrocarbon within 5-20 min of ambient air exposure. We report a convenient method to effectively preserve a freshly prepared graphitic surface simply through a water treatment technique. This approach significantly inhibits the hydrocarbon adsorption rate by a factor of ca. 20×, thus maintaining the intrinsic wetting behavior for many hours upon air exposure. Follow-up characterization shows that a nanometer-thick ice-like water forms on the graphitic surface, which remains stabilized at room temperature for at least 2-3 h and thus significantly decreases the adsorption of airborne hydrocarbon on the graphitic surface. This method has potential implications in minimizing hydrocarbon contamination during manufacturing, characterization, processing, and storage of graphene/graphite-based devices. As an example, we show that a water-treated graphite electrode maintains a high level of electrochemical activity in air for up to 1 day.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.5b04843DOI Listing
January 2016

Diagnosis and Management of Spinal Metastasis of Glioblastoma.

Can J Neurol Sci 2015 Nov 27;42(6):410-3. Epub 2015 Aug 27.

2CancerCare Manitoba,Winnipeg,Manitoba.

Background: When patients with cranial glioblastoma develop weakness, a rare differential diagnosis is spinal metastases.

Methods: Chart and literature reviews were performed.

Results: The reported patient had delayed onset spinal drop metastasis that was only detected by magnetic resonance imaging (MRI). A 48-year-old patient had supratentorial glioblastoma, treated with radiotherapy (RT) and concurrent temozolomide followed by six cycles of adjuvant temozolomide. Four years after completion of all treatments (62 months from initial presentation), he developed low backache and weakness in both legs. Positron emission tomography/computed tomography scans demonstrated intracranial recurrence only. Spinal drop metastases were detected only by MRI scan. Local spinal RT 40 Gy in 20 fractions with concurrent and maintenance temozolomide were given. Because of disease progression after nine cycles of temozolomide, systemic therapy was changed to bevacizumab, which greatly improved his symptoms for 4 months before deterioration of mental status. He is still alive with disease at 22 months after diagnosis of spinal metastases (84 months from initial glioblastoma diagnosis).

Conclusions: MRI is the diagnostic imaging of choice for spinal metastases. This illustrative case of delayed-onset spinal metastases shows unusual slow progression. Local RT, temozolomide, and targeted therapy may improve survival. This illustrative case is the first report of bevacizumab as a second-line therapy in drop metastasis of glioblastoma.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1017/cjn.2015.285DOI Listing
November 2015

Crystal structure of 3,4-di-chloro-anilinium hydrogen phthalate.

Acta Crystallogr E Crystallogr Commun 2015 Jul 3;71(Pt 7):o446. Epub 2015 Jun 3.

Department of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan.

In the title salt, C6H6Cl2N(+)·C8H5O4 (-), the carb-oxy-lic acid and carboxyl-ate groups of the anion form dihedral angles of 20.79 (19) and 74.76 (14)°, respectively, with the plane of the benzene ring. In the crystal, mol-ecules are assembled into a two-dimensional polymeric network parallel to (100) via N-H⋯O and O-H⋯O hydrogen bonds. In addition, within the layer, there are π-π stacking inter-actions between the benzene rings of the cation and the anion [centroid-centroid distance = 3.6794 (17) Å]. A weak C-H⋯O interaction is also observed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2056989015010300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518937PMC
July 2015

1-{[(E)-(4-{[(2Z)-2,3-Di-hydro-1,3-thia-zol-2-yl-idene]sulfamo-yl}phen-yl)iminium-yl]meth-yl}naphthalen-2-olate.

Acta Crystallogr E Crystallogr Commun 2015 Jun 23;71(Pt 6):o421-2. Epub 2015 May 23.

Department of Chemistry, University of Sargodha, Sargodha, Punjab, Pakistan.

In the title zwitterionic compound, C20H15N3O3S2, the 2-hy-droxy-naphthalene-1-carbaldehyde group A, the anilinic unit B and the 1,3-thia-zol-2(3H)-imine group C are each approximately planar with r.m.s. deviation of 0.0721, 0.0412 and 0.0125 Å, respectively. The dihedral angles between A/B, A/C and B/C are 24.70 (10), 79.97 (7) and 83.14 (6)°, respectively. There is an intra-molecular S(6) motif involving the imine N-H and the naphtho-late O atom. In the crystal, inversion-related mol-ecules form dimers as a result of N-H⋯N and N-H⋯O hydrogen bonds with R 2 (2)(8) and R 1 (2)(4) motifs, respectively. Weak π-π inter-actions between the benzene and naphthyl rings of inversion-related mol-ecules have ring centroid-centroid distances of 3.638 (2) and 4.041 (2) Å. A C-H⋯π inter-action occurs between the thia-zol ring and the benzene ring of an adjacent mol-ecule.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2056989015009640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459363PMC
June 2015

Crystal structure of 4-chloro-2-{(E)-[(3,4-di-methyl-phen-yl)imino]-meth-yl}phenol.

Acta Crystallogr E Crystallogr Commun 2015 Jun 23;71(Pt 6):o416. Epub 2015 May 23.

Department of Chemistry, University of Sargodha, Sargodha, Punjab, Pakistan.

In the title compound, C15H14ClNO, which is isostructural with its bromo analogue [Tahir et al. (2012 ▶). Acta Cryst., E68, o2730], the dihedral angle between the planes of the aromatic rings is 2.71 (7)° and an intra-molecular O-H⋯N hydrogen bond closes an S(6) ring. In the crystal, extremely weak C-H⋯π inter-actions link the mol-ecules into a three-dimensional network.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2056989015009354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459303PMC
June 2015

Crystal structure of (4E)-4-(8-meth-oxy-2H-chromen-2-yl-idene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

Acta Crystallogr E Crystallogr Commun 2015 Jun 23;71(Pt 6):o414-5. Epub 2015 May 23.

Department of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan.

In the title compound, C20H16N2O3, the phenyl substituent attached to the pyrazole ring makes a dihedral angle of 4.87 (7)° with the rest of the mol-ecule. In the crystal, mol-ecules are connected into inversion dimers of the R 2 (2)(14) type by pairs of C-H⋯O inter-actions. π-π inter-actions exist between the benzene and pyrazole rings at a distance of 3.701 (1) Å. Similarly, π-π inter-actions are present at a centroid-centroid distance of 3.601 (1) Å between the oxygen-containing heterocyclic ring and meth-oxy substituted aromatic ring of a neighbouring mol-ecule. Additional C-H⋯π and C=O⋯π inter-actions are also observed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2056989015009445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459315PMC
June 2015

Crystal structure of 3-(3,4-di-methyl-anilino)-2-benzo-furan-1(3H)-one.

Acta Crystallogr E Crystallogr Commun 2015 Jun 20;71(Pt 6):o413. Epub 2015 May 20.

Department of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan.

In the title compound, C16H15NO2, the 2-benzo-furan-1(3H)-one and 3,4-di-methyl-aniline fragments are oriented with a dihedral angle of 89.12 (5)°. N-H⋯O hydrogen-bond inter-actions join mol-ecules into C(6) chains propagating along the a axis. In addition, there are π-π stacking inter-actions between the 2-benzo-furan-one benzene rings [centroid-centroid dis-tance = 3.7870 (13) Å] and C-H⋯π inter-actions between one of the methyl groups and the 3,4-di-methyl-aniline benzene ring.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2056989015009299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459309PMC
June 2015

Crystal structure of 4-benzamido-2-hy-droxy-benzoic acid.

Acta Crystallogr E Crystallogr Commun 2015 Jun 20;71(Pt 6):o409. Epub 2015 May 20.

Department of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan.

In the title compound, C14H11NO4, the dihedral angle between the mean planes of the aromatic rings is 3.96 (12)° and an intra-molecular O-H⋯O hydrogen bond closes an S(6) ring. A short intra-molecular C-H⋯O contact is also seen. In the crystal, carb-oxy-lic acid inversion dimers linked by pairs of O-H⋯O hydrogen bonds generate R 2 (2)(8) loops. Conversely, the N-H group does not form a hydrogen bond. Aromatic π-π inter-actions exist at a centroid-centroid distance of 3.8423 (15) Å between the benzene rings. An extremely weak C-H⋯π inter-action also is present.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2056989015009032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459298PMC
June 2015

Crystal structure of (4Z)-4-[(2E)-3-(2-chloro-phen-yl)-1-hy-droxy-prop-2-en-1-yl-idene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

Acta Crystallogr E Crystallogr Commun 2015 Jun 20;71(Pt 6):o407-8. Epub 2015 May 20.

Department of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan.

In the title compound, C19H15ClN2O2, the pyrazole ring is almost planar (r.m.s. deviation = 0.002 Å) and subtends dihedral angles of 5.31 (16) and 1.86 (16)° with the phenyl and chloro-benzene rings, respectively. An intra-molecular O-H⋯O hydrogen bond closes an S(6) ring and a short C-H⋯O contact is also observed. In the crystal, mol-ecules are linked by weak C-H⋯O inter-actions to generate (001) sheets. Weak aromatic π-π inter-actions between the chloro-benzene and pyrazole rings, with a centroid-centroid distance of 3.7956 (17) Å are also observed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2056989015009020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459312PMC
June 2015

Crystal structure of (4Z)-4-[(2E)-3-(4-chloro-phen-yl)-1-hy-droxy-prop-2-en-1-yl-idene]-5-methyl-2-phenyl-1H-pyrazol-5(4H)-one.

Acta Crystallogr E Crystallogr Commun 2015 Jun 13;71(Pt 6):o393-4. Epub 2015 May 13.

Department of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan.

In the the asymmetric unit of the title compound, C19H15ClN2O2, there are two symmetry-independent mol-ecules, which adopt similar conformations. The largest difference is observed in the dihedral angles between the phenyl and the pyrazole fragments [17.00 (12) and 23.42 (10)°]. A strong intra-molecular O-H⋯O hydrogen bond with the S (6) motif is observed in both mol-ecules. Pairs of π-π stacking inter-actions between the phenyl groups [centroid-centroid distances = 3.6627 (13) and 3.7156 (14) Å] assemble the mol-ecules into two types of centrosymmetric dimers. Weak C-H⋯O inter-actions connect mol-ecules into chains along the b axis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S205698901500883XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459345PMC
June 2015