Publications by authors named "Mubashir Sharif"

2 Publications

  • Page 1 of 1

COVID-19 Era: Challenges and Solutions in Dental Education.

J Coll Physicians Surg Pak 2020 10;30(10):129-131

Armed Forces Institute of Dentistry (AFID), Rawalpindi, Pakistan.

Coronavirus infecious disease 2019 (COVID-19) pandemic has brought a myriad of challenges to the dental education. Amidst the quarantine and lockdown measures, face-to-face education is disrupted around the globe. Dental educators have come up with innovative solutions to resume dental education remotely. Different online platforms are being utilised for didactic teaching and learning as well as for students 2019; assessment and examination. Clinical learning has also shifted to virtual learning. Manikins and virtual reality/augmented reality (VR/AR)-based simulation devices along with haptic technology can be very helpful for skills training. However, some sorts of blended learning and virtual curriculum may be incorporated in dental education in the future. For this narrative review, a thorough in-depth review of the available literature, relevant to our field, was carried out. In this article, impact of COVID-19 on dental education has been discussed along with some solutions to these challenges. Key Words: COVID-19, Dental education, E-learning, Virtual/augmented reality.
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October 2020

Protective effects of beclomethasone against insulin induced airway hyper-reactivity in guinea pig and exploration of its mechanism of action.

J Ayub Med Coll Abbottabad 2014 Jan-Mar;26(1):3-6

Background: Inhalational insulin was withdrawn from market in 2007 due to its potential to produce airway hyper-reactivity and bronchoconstriction. So we explored the possible mechanism underlying the acute contractile effects of insulin and protective effects of beclomethasone against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig in vitro.

Methods: This was a laboratory based experimental study. Effects of increasing concentrations of histamine (10(-8)-10(-3) M), insulin (10(-8)-10(-3) M), insulin pretreated with fixed concentration of indomethacin (10(-6) M), and beclomethasone (10(-6) M), were studied on isolated tracheal tissue of guinea pig in vitro by constructing cumulative concentration response curves. The tracheal smooth muscle contractions were recorded with Transducer on Four Channel Oscillograph.

Results: Histamine and insulin produced a concentration dependent reversible contraction of isolated tracheal muscle of guinea pig. The mean ± SEM of maximum amplitudes of contraction with histamine, insulin and insulin pretreated with indomethacin and beclomethasone were 92.5 ± 1.20 mm, 35 ± 1.13 mm, 14.55 ± 0.62 mm and 22 ± 1.154 mm respectively. Beclomethasone shifted the concentration response curve of insulin to the right and downwards.

Conclusion: Beclomethasone significantly inhibited the contractile response of insulin which was presumably prostaglandin mediated. So pretreatment of inhaled insulin with beclomethasone may have clinical implication in amelioration of its notential resniratorv adverse effects such as bronchoconstriction.
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December 2014