Publications by authors named "Moutasem S Aboonq"

4 Publications

  • Page 1 of 1

Al-hijamah (wet cupping therapy of prophetic medicine) as a novel alternative to surgery for carpal tunnel syndrome.

Neurosciences (Riyadh) 2019 Apr;24(2):137-142

Taibah College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia. E-mail:

Carpal tunnel syndrome (CTS) is the most common neuropathy of median nerve causing decreased physical and work performance. Herein, a 37-year-old male manual worker diagnosed with severe CTS exhibited severe pain with frequent awakening from night sleep to put hands in ice. Patients consent and ethical guidelines were carried out. As a novel approach, Al-hijamah was performed to both hands at the anterior and posterior carpal regions (using scarification safety technique) and at the back region. Immediately after Al-hijamah, a dramatic decrease in pain, numbness and parathesia occurred. Nerve conduction velocity and electromyography carried out few days after Al-hijamah confirmed improved voluntary motor unit morphologies in both hands. The severe degree of bilateral CTS improved electrophysiologically to be moderate. Scheduled surgical intervention was cancelled. This did better than a German report treating CTS using traditional Chinese wet cupping therapy at the trapezius muscle without applying sucking cups at the carpal region.
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http://dx.doi.org/10.17712/nsj.2019.2.20180036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015467PMC
April 2019

Pathophysiology of carpal tunnel syndrome.

Neurosciences (Riyadh) 2015 Jan;20(1):4-9

Department of Physiology, College of Medicine, Taibah University, Al-Madinah Al-Munawwarah 30001, Kingdom of Saudi Arabia. E-mail:

Carpal tunnel syndrome (CTS) is the most common median nerve neuropathy, accounting for 90% of all neuropathies. Carpal tunnel syndrome presents in 3.8% of the general population, with a higher prevalence among women. There are several risk factors associated with CTS, including both medical and non medical factors. The pathophysiologic mechanisms involved in the median nerve compression and traction are thought to be complex, and as yet are not fully understood. The present review aimed to provide an overview of the pathophysiology of median nerve neuropathy in the carpal tunnel, and subsequent development of CTS.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727604PMC
January 2015

Anti-parkinsonism, hypoglycemic and anti-microbial activities of new poly fused ring heterocyclic candidates.

Int J Biol Macromol 2013 Jun 15;57:165-73. Epub 2013 Mar 15.

Pharmacology and Toxicology Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

A new series of poly fused pyrazolothienopyrimidine derivatives (2-14) were synthesized and their anti-parkinsonism, hypoglycemic and anti-microbial activities were evaluated. Some of the newly synthesized compounds exhibited better pharmacological and biological activities than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences. The detailed synthesis, spectroscopic data, and pharmacological activities were reported.
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http://dx.doi.org/10.1016/j.ijbiomac.2013.03.019DOI Listing
June 2013

Activity-dependent neuroprotective protein modulates its own gene expression.

J Mol Neurosci 2012 Jan 7;46(1):33-9. Epub 2011 Jun 7.

Institute of Translational Medicine, Sherrington Building, Ashton Street, University of Liverpool, Liverpool, L69 3GE, UK.

We investigated whether activity-dependent neuroprotective protein (ADNP) could autoregulate its own expression. Both the endogenous ADNP gene and reporter gene constructs were analysed in response to overexpression of ADNP, supplied either as wild-type ADNP or a mutant form lacking the NAP motif, a motif which has neuroprotective properties. Overexpression of these two forms of ADNP resulted in both decreased endogenous ADNP expression and repressed ADNP promoter-directed reporter gene activity. Chromatin immunoprecipitation demonstrated the ability of ADNP to bind to its own promoter which is consistent with its action as a repressor of both promoter-supported and endogenous ADNP expression.
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http://dx.doi.org/10.1007/s12031-011-9562-yDOI Listing
January 2012
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