Publications by authors named "Mou Yang"

11 Publications

  • Page 1 of 1

Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer's disease and their potential links in the pathogenesis.

Gut Microbes 2021 Jan-Dec;13(1):1957407

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.

ABSTRATCIn recent years, emerging studies have observed gut microbiota (GM) alterations in Alzheimer's disease (AD), even in individuals with mild cognitive impairment (MCI). Further, impaired sleep and circadian patterns are common symptoms of AD, while sleep and circadian rhythm disruption (SCRD) is associated with greater β-amyloid (Aβ) burden and AD risk, sometimes years before the clinical onset of AD. Moreover, reports have demonstrated that GM and its metabolites exhibit diurnal rhythmicity and the role of SCRD in dampening the GM rhythmicity and eubiosis. This review will provide an evaluation of clinical and animal studies describing GM alterations in distinct conditions, including AD, sleep and circadian disruption. It aims to identify the overlapping and distinctive GM alterations in these conditions and their contributions to pathophysiology. Although most studies are observational and use different methodologies, data indicate partial commonalities in GM alterations and unanimity at functional level. Finally, we discuss the possible interactions between SCRD and GM in AD pathogenesis, as well as several methodological improvements that are necessary for future research.
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http://dx.doi.org/10.1080/19490976.2021.1957407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463034PMC
September 2021

Neurexin and Neuroligins Maintain the Balance of Ghost and Satellite Boutons at the Neuromuscular Junction.

Front Neuroanat 2020 9;14:19. Epub 2020 Jun 9.

The Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, China.

Neurexins and neuroligins are common synaptic adhesion molecules that are associated with autism and interact with each other in the synaptic cleft. The neuromuscular junction (NMJ) bouton is a well-known model system in neuroscience, and ghost and satellite boutons, respectively, indicate the poor development and overgrowth of the NMJ boutons. However, the neurexin (DNrx) and neuroligins (DNlgs) are mainly observed in type Ib boutons, indicating the ultrastructural and developmental phenotypes of the NMJ. Here, we identified the ultrastructural and developmental features of ghost and satellite boutons by utilizing () and () fly mutants and other associated fly strains. Ghost boutons contain synaptic vesicles with multiple diameters but very rarely contain T-bar structures and swollen or thin subsynaptic reticulum (SSR) membranes. The muscle cell membrane is invaginated at different sites, stretches to the ghost bouton from different directions, forms several layers that enwrap the ghost bouton, and then branches into the complex SSR. Satellite boutons share a common SSR membrane and present either a typical profile in which a main bouton is encircled by small boutons or two atypical profiles in which the small boutons are grouped together or distributed in beads without a main bouton. Electron and confocal microscopy data showed that , , , , and mutations led to ghost boutons; the overexpression of , , , , and led to satellite boutons; and the double mutation also led to satellite boutons. These results suggested that DNrx and DNlgs jointly maintain the development and function of NMJ boutons by regulating the balance of ghost and satellite boutons in .
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http://dx.doi.org/10.3389/fnana.2020.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296126PMC
June 2020

Photogalvanic Effect in Nitrogen-Doped Monolayer MoS from First Principles.

Nanoscale Res Lett 2019 Dec 16;14(1):380. Epub 2019 Dec 16.

Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, GPETR Center for Quantum Precision Measurement, Guangdong Engineering Technology Research Center of Efficient Green Energy and Environment Protection Materials, SPTE, South China Normal University, Guangzhou, 510006, China.

We investigate the photogalvanic effect in nitrogen-doped monolayer molybdenum disulfide (MoS) under the perpendicular irradiation, using first-principles calculations combined with non-equilibrium Green function formalism. We provide a detailed analysis on the behavior of photoresponse based on the band structure and in particular the joint density of states. We thereby identify different mechanisms leading to the existence of zero points, where the photocurrent vanishes. In particular, while the zero point in the linear photovoltaic effect is due to forbidden transition, their appearance in the circular photovoltaic effect results from the identical intensity splitting of the valance band and the conduction band in the presence of Rashba and Dresslhaus spin-orbit coupling. Furthermore, our results reveal a strong circular photogalvanic effect of nitrogen-doped monolayer MoS, which is two orders of magnitude larger than that induced by the linearly polarized light.
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http://dx.doi.org/10.1186/s11671-019-3222-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914753PMC
December 2019

Transport theory for electrical detection of the spin-momentum locking of topological surface states.

J Phys Condens Matter 2018 Aug 9;30(33):335404. Epub 2018 Jul 9.

Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Material, ICMP and SPTE, South China Normal University, Guangzhou 510006, People's Republic of China.

We provide a general transport theory for spin-polarized scanning tunneling microscopy (STM) through a doped topological insulator (TI) surface. It is found that different from the conventional magnetic substrate, the tunneling conductance through the tip-TI surface acquires an extra component determined by the in-plane spin texture, exclusively associated with the spin momentum locking. Importantly, this extra conductance unconventionally depends on the spatial azimuthal angle of the magnetized STM tip. By introducing a magnetic impurity to break the symmetry of rotation and local time reversal of the TI surface, we find that the measurement of the spatial resolved conductance can reconstruct the helical structure of spin texture, from which the spin-momentum locking angle can be extracted if the in-plane magnetization is induced purely by the spin-orbit coupling of surface Dirac electrons. Our theory offers an alternative way, differing from existing in-plane-current polarization probed in a multi-terminal setup or angle resolved photoemission spectroscopy, to electrically identify the helical spin texture on TI surfaces.
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http://dx.doi.org/10.1088/1361-648X/aad218DOI Listing
August 2018

Bulk RKKY signatures of topological phase transition in silicene.

Sci Rep 2018 Apr 18;8(1):6185. Epub 2018 Apr 18.

Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou, 510006, China.

Silicene offers an ideal platform for exploring the phase transition due to strong spin-orbit interaction and its unique structure with strong tunability. With applied electric field and circularly polarized light, silicone is predicted to exhibit rich phases. We propose that these intricate phase transitions can be detected by measuring the bulk Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction. We have in detail analyzed the dependence of RKKY interaction on phase parameters for different impurity configurations along zigzag direction. Importantly, we present an interesting comparison between different terms of RKKY interaction with phase diagram. It is found that the in-plane and out-of-plane terms can exhibit the local extreme value or change of sign at the phase critical point and remarkable difference in magnitude for different phase regions. Consequently, the magnetic measurement provides unambiguous signatures to identify various types of phase transition simultaneously, which can be carried out with present technique.
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http://dx.doi.org/10.1038/s41598-018-24567-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906674PMC
April 2018

Effect of impurity resonant states on optical and thermoelectric properties on the surface of a topological insulator.

Sci Rep 2017 06 21;7(1):3971. Epub 2017 Jun 21.

Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou, 510006, China.

We investigate the thermoelectric effect on a topological insulator surface with particular interest in impurity-induced resonant states. To clarify the role of the resonant states, we calculate the dc and ac conductivities and the thermoelectric coefficients along the longitudinal direction within the full Born approximation. It is found that at low temperatures, the impurity resonant state with strong energy de-pendence can lead to a zero-energy peak in the dc conductivity, whose height is sensitively dependent on the strength of scattering potential, and even can reverse the sign of the thermopower, implying the switching from n- to p-type carriers. Also, we exhibit the thermoelectric signatures for the filling process of a magnetic band gap by the resonant state. We further study the impurity effect on the dynamic optical conductivity, and find that the resonant state also generates an optical conductivity peak at the absorption edge for the interband transition. These results provide new perspectives for understanding the doping effect on topological insulator materials.
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http://dx.doi.org/10.1038/s41598-017-04360-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479872PMC
June 2017

[Karyotype and evolutionary trend analysis of Scutellaria species in Jinyun mountain, Chongqing].

Zhongguo Zhong Yao Za Zhi 2016 Jun;41(12):2201-2207

School of Life Sciences, Southwest University, Key Laboratory of Eco-envrionments of Three Gores Reservoir Region of Ministry of Education, Chongqing Key Laboratory of Plant Ecology and Resources Research for Three Gorges Reservoir Region, Chongqing 400715, China.

Traditional squash method was used to analyze chromosome number and karyotypes of four Scutellaria species in Chongqing Jinyun Mountain Natural Reserve: Scutellaria tsinyunensis, S.yunnanensis, S.franchetiana and S.indica.The result showed that the chromosome numbers were 26 except for S.franchetiana, which had 24 chromosomes.These species were all diploid with metacentric and submetacentric chromosomes.Their karyotypes were symmetrical and primitive.The karyotype formula of S.tsinyunensis is 2n=2x=26=24m+2sm, 1B type, As.k=55.28%; the karyotype formula of S.yunnanensis var.salicifolia is 2n=2x=26=26m, 1B type, As.k=56.11%; the karyotype formula of S.franchetiana is 2n=2x=24=20m+4sm, 2B type, As.k=58.50%; the karyotype formula of S.indica is 2n=2x=24=20m+4sm, 2B type, As.k=58.41%.The results were compared with the reported data of S.baicalensis and S.alaschanica.S.alaschanica is expected to be the most advanced one whereas S.tsinyunensis, and S.yunnanensis var. salicifolia primitive.These results are expected to provide some references to the origin and differentiation of genus Scutellaria.
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http://dx.doi.org/10.4268/cjcmm20161205DOI Listing
June 2016

[Study on relieving effects of exogenous SNP, Spd on Belamcanda chinensis under salt-alkalline stress].

Zhongguo Zhong Yao Za Zhi 2014 Dec;39(23):4553-8

The study is aimed to provide the theoretical basis for exploiting and utilization of salt-alkaline soil and cultivating Belamcanda chinensis. In this study, we exerted exogenous substances SNP, Spd to relieve the damage of the mixing salt-alkaline stress on B. chinensis seedling which is NaCl, Na2SO4, NaHCO3 and Na2CO3 four kinds of salt molar ratio of 9: 1: 9: 1, salt concentration of 100 mmol x L(-1). The result illustrated that high pH stress is a major factor caused the salt-alkaline stress, the interaction between time and the concentration of each, treatment was observed, what is more, there are synergies between the salt and alkali stress. The content of B. chinensis seedling leaves' membrane peroxidation index (MDA, O2-*) and metabolites (soluble protein, soluble sugars, organic acids) are showing an upward trend in varying degrees under 100 mmol x L(-1) salt-alkaline stress. It is effective to reduce the content of MDA and O2-*. and improve the levels of metabolites, in which the SNP (0.05 mmol x L(-1)) and Spd (0.5 mmol x L(-1)) to alleviate damage effects is the best. Therefore we can hold the conclusion that SNP and Spd can effectively mitigate the damage of B. chinensis seedling on salt-alkaline stress, improve the resistance ability of B. chinensis seedling which can provide the scientific basis for the utilization of salt-alkaline soil, and the cultivation of B. chinensis.
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December 2014

[Application of bionic technology to speciation analysis and bioavailability assessment of nickel in transgenic soybean].

Guang Pu Xue Yu Guang Pu Fen Xi 2013 Nov;33(11):3075-8

Department of Chemistry, Minnan Normal University, Zhangzhou 363000, China

The safety of transgenic food has been paid the most attention to by the public and scientists. Trace metal bioavailability could provide information for safety assessment of transgenic food. The critical functional digestion and absorption in the gastrointestinal tract were simulated by bionic gastrointestinal digestion, metabolism of gut microbiota, and bionic biomembrane adsorption with liposome and then used for the pretreatment of transgenic and general soybeans. Ni speciation in the chyme was defined as affinity-liposome and water soluble Ni. Nickel bioavailability was assessed by the content of affinity-liposome Ni. Water soluble Ni was the main species of nickel complex in the chyme. Nickel bioavailability was 4.1% for transgenic soybean and 3.3% for general soybean, which could be enhanced by gastrointestinal digestion and metabolism of gut microbiota. After transgene, nickel bioavailability was increased 24% but the content of affinity-liposome Ni was 122.3 ng x g(-1) for transgenic soybean, just as 36% as that of general soybean.
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November 2013

Polyurethanes containing zwitterionic sulfobetaines and their molecular chain rearrangement in water.

J Biomed Mater Res A 2013 Mar 18;101(3):909-18. Epub 2012 Dec 18.

College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China.

Novel polyurethanes with zwitterionic sulfobetaines, termed PUR-APS, were designed and synthesized by chain-extension of biodegradable poly(ε-caprolactone) containing N,N'-bis (2-hydroxyethyl) methylamine ammonium propane sulfonate (PCL-APS) with hexamethylene diisocyanate (HDI). The bulk properties of polymers were characterized by nuclear magnetic resonance spectrum (NMR), Fourier transform infrared spectroscopy (FTIR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). Results showed that the polymers were successfully synthesized. Water contact angles (WCAs) and X-ray photoelectron spectroscopy (XPS) revealed that molecular chains of the polymers rearranged after soaking in water. The amount of protein adsorption, determined by bicinchoninic acid (BCA) assay, was less than 300 ng/cm(2) and decreased after hydration. The blood compatibility of the polymers was evaluated by the degree of hemolytic and activated partial thromboplastic time (APTT) and prothrombin time (PT). Results indicated that PUR-APS polymers had good blood compatibility. Therefore, polyurethanes containing sulfobetaines have a great potential for biomedical application.
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http://dx.doi.org/10.1002/jbm.a.34384DOI Listing
March 2013

[Diameter and length measurement of infrarenal inferior vena cava in Shandong Peninsula adult and its significance].

Zhonghua Wai Ke Za Zhi 2011 Jun;49(6):514-6

Vascular Surgery, Yantai Yuhuangding Hospital Affiliated with Qingdao University, Yantai 264000, China.

Objective: To measure the diameter and length of infrarenal inferior vena cava (IVC) in Shandong Peninsula adult through digital subtraction angiography (DSA) for better vena cava filter (VCF) choice and placement.

Methods: From April 2008 to June 2010, 83 discontinuous patients (49 males and 34 females, mean age 56.4 years) with deep venous thrombosis (DVT) of lower extremity were placed VCF through DSA according to ACCP-8. During operation, diameter and length of infrarenal IVC were measured. At the same time, the renal vein location and the type of the IVC were identified to help the VCF choice.

Results: All the VCFs were placed successfully, no complications occurred. The diameter of infrarenal IVC was 10 to 26 mm with a mean of (19 ± 5) mm. The average length from beginning of IVC to the lower renal vein was (10.6 ± 2.8) cm. The renal vein was located between the first and second lumbar vertebra, the IVC beginning was located between the fourth and fifth lumbar vertebra.

Conclusions: Diameter and length measurement of infrarenal IVC is helpful to the VCF selection and the domestic VCF research. Vena cava angiography is very important to the accurate placement of VCF.
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June 2011
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