Motomu Kanai

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Motomu Kanai

Publications by authors named "Motomu Kanai"

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100Publications

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C(sp )-H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis.

Chemistry 2018 Jun 4;24(32):8051-8055. Epub 2018 May 4.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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June 2018

Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α- C-Allyl Carboxylic Acids.

J Am Chem Soc 2018 05 26;140(18):5899-5903. Epub 2018 Apr 26.

Graduate School of Pharmaceutical Sciences , The University of Tokyo , Hongo, Bunkyo-ku , Tokyo 113-0033 , Japan.

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May 2018

Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.

Sci Rep 2018 May 16;8(1):7671. Epub 2018 May 16.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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May 2018

Acceptorless Dehydrogenation of Hydrocarbons by Noble-Metal-Free Hybrid Catalyst System.

Org Lett 2018 Apr 20;20(7):2042-2045. Epub 2018 Mar 20.

Graduate School of Pharmaceutical Sciences , The University of Tokyo , Tokyo 113-0033 , Japan.

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April 2018

Leading approaches in synthetic epigenetics for novel therapeutic strategies.

Curr Opin Chem Biol 2018 Apr 6;46:10-17. Epub 2018 Apr 6.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; JST-ERATO, Japan. Electronic address:

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April 2018

Copper(I)-Catalyzed Enantio- and Diastereodivergent Borylative Coupling of Styrenes and Imines.

Angew Chem Int Ed Engl 2018 Apr 30. Epub 2018 Apr 30.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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April 2018

Boron-Catalyzed Carboxylic Acid-Selective Aldol Reaction with Trifluoromethyl Ketones.

Chem Pharm Bull (Tokyo) 2018 Mar 19;66(3):231-234. Epub 2017 Aug 19.

Graduate School of Pharmaceutical Sciences, The University of Tokyo.

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March 2018

Sulfonamides as new hydrogen atom transfer (HAT) catalysts for photoredox allylic and benzylic C-H arylations.

Chem Commun (Camb) 2018 Mar;54(26):3215-3218

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2018

2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives.

Org Lett 2018 Mar 8;20(6):1593-1596. Epub 2018 Mar 8.

Institute for Materials Chemistry and Engineering , Kyushu University , 6-1 Kasugakoen , Kasuga-shi, Fukuoka 816-8580 , Japan.

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March 2018

Total synthesis of (+)-lysergic acid.

J Antibiot (Tokyo) 2018 Feb 19;71(2):240-247. Epub 2017 Jul 19.

Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.

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February 2018

LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes.

Sci Rep 2018 Feb 8;8(1):2656. Epub 2018 Feb 8.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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February 2018

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1 mutation.

Biochem Biophys Res Commun 2018 02 9;497(1):298-304. Epub 2018 Feb 9.

Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan; Research Center for Advanced Immunology, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address:

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February 2018

Iridium/Bipyridine-Catalyzed ortho-Selective C-H Borylation of Phenol and Aniline Derivatives.

Org Lett 2017 11;19(21):5944-5947

ERATO, Japan Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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November 2017

Stereoselective Synthesis of Tetrasubstituted Alkenes via a Cp*Co -Catalyzed C-H Alkenylation/Directing Group Migration Sequence.

Angew Chem Int Ed Engl 2017 Jun 16;56(25):7156-7160. Epub 2017 May 16.

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, 060-0812, Japan.

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June 2017

Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin.

J Am Chem Soc 2017 06 23;139(22):7568-7576. Epub 2017 May 23.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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June 2017

Iron-Catalyzed Acyloxyalkylation of Styrenes Using Hypervalent Iodine Reagents.

Org Lett 2017 05 25;19(9):2398-2401. Epub 2017 Apr 25.

Institute for Materials Chemistry and Engineering, Kyushu University , 6-1 Kasugakoen, Kasuga-shi, Fukuoka 816-8580, Japan.

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May 2017

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.

Cell Rep 2017 05;19(5):969-980

Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan; Research Center for Advanced Immunology, Kyushu University, Fukuoka 812-8582, Japan. Electronic address:

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May 2017

Copper(I)-Catalyzed Enantioselective Addition of Enynes to Ketones.

J Am Chem Soc 2017 04 21;139(13):4647-4650. Epub 2017 Mar 21.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2017

Scandium(iii) triflate-promoted serine/threonine-selective peptide bond cleavage.

Chem Commun (Camb) 2017 Mar;53(23):3311-3314

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan. and Japan Science Technology Agency (JST), ERATO Kanai Life Science Catalysis Project, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2017

Silver-Catalyzed C(sp)-H Chlorination.

Org Lett 2017 03 3;19(6):1430-1433. Epub 2017 Mar 3.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2017

Lewis Acid-Base Interaction-Controlled ortho-Selective C-H Borylation of Aryl Sulfides.

Angew Chem Int Ed Engl 2017 Feb 30;56(6):1495-1499. Epub 2016 Dec 30.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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February 2017

Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes.

J Am Chem Soc 2017 02 6;139(6):2204-2207. Epub 2017 Feb 6.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , Tokyo 113-0033, Japan.

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February 2017

Enhanced Structural Variety of Nonplanar N-Oxyl Radical Catalysts and Their Application to the Aerobic Oxidation of Benzylic C-H Bonds.

Chem Pharm Bull (Tokyo) 2016 ;64(7):737-53

Graduate School of Pharmaceutical Sciences, The University of Tokyo.

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January 2017

Site- and Regioselective Monoalkenylation of Pyrroles with Alkynes via Cp*Co Catalysis.

Org Lett 2016 11 24;18(21):5732-5735. Epub 2016 Oct 24.

Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.

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November 2016

Switchable photooxygenation catalysts that sense higher-order amyloid structures.

Nat Chem 2016 Oct 27;8(10):974-82. Epub 2016 Jun 27.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2016

5-Position-selective C-H trifluoromethylation of 8-aminoquinoline derivatives.

Org Biomol Chem 2016 Sep 10;14(34):8092-100. Epub 2016 Aug 10.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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September 2016

Tris(pentafluorophenyl)borane-Catalyzed Acceptorless Dehydrogenation of N-Heterocycles.

Angew Chem Int Ed Engl 2016 Sep 19;55(40):12224-7. Epub 2016 Aug 19.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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September 2016

Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins.

J Am Chem Soc 2016 08 17;138(34):10798-801. Epub 2016 Aug 17.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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August 2016

Site-Selective Peptide/Protein Cleavage.

Top Curr Chem 2016 ;372:103-23

Graduate School of Pharmaceutical Sciences, The University of Tokyo, and JST-ERATO, Kanai Life Science Catalysis Project, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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June 2016

Ligand-Enabled, Copper-Catalyzed Regio- and Stereoselective Synthesis of Trialkylsubstituted Alkenylboronates from Unactivated Internal Alkynes.

J Am Chem Soc 2016 06 9;138(24):7528-31. Epub 2016 Jun 9.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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June 2016

Ligand-Promoted, Boron-Mediated Chemoselective Carboxylic Acid Aldol Reaction.

Org Lett 2016 05 22;18(9):2276-9. Epub 2016 Apr 22.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2016

Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondary C(sp(3))-H bonds in aliphatic alcohols.

Org Biomol Chem 2016 May;14(19):4378-81

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan. and Japan Science Technology Agency (JST), ERATO Kanai Life Science Catalysis Project, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2016

Cp*Co(III)-Catalyzed Dehydrative C-H Allylation of 6-Arylpurines and Aromatic Amides Using Allyl Alcohols in Fluorinated Alcohols.

Org Lett 2016 05 27;18(9):2216-9. Epub 2016 Apr 27.

Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.

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May 2016

4-Position-Selective C-H Perfluoroalkylation and Perfluoroarylation of Six-Membered Heteroaromatic Compounds.

J Am Chem Soc 2016 05 6;138(19):6103-6. Epub 2016 May 6.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2016

Rhenium-Catalyzed Synthesis of 1,3-Diiminoisoindolines via Insertion of Carbodiimides into a C-H Bond of Aromatic and Heteroaromatic Imidates.

Org Lett 2016 05 6;18(10):2459-62. Epub 2016 May 6.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2016

Chemo- and regioselective oxygenation of C(sp)-H bonds in aliphatic alcohols using a covalently bound directing activator and atmospheric oxygen.

Chem Sci 2016 Mar 27;7(3):1904-1909. Epub 2015 Nov 27.

Graduate School of Pharmaceutical Sciences , The University of Tokyo , 7-3-1 Bunkyo-ku , Tokyo 113-0033 , Japan . Email: ; Email:

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March 2016

An Expeditious Synthesis of Sialic Acid Derivatives by Copper(I)-Catalyzed Stereodivergent Propargylation of Unprotected Aldoses.

ACS Cent Sci 2016 Jan 4;2(1):21-6. Epub 2016 Jan 4.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; JST, ERATO, Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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January 2016

Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes.

Chembiochem 2015 Dec 18;16(18):2599-604. Epub 2015 Nov 18.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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December 2015

Catalytic Asymmetric Iterative/Domino Aldehyde Cross-Aldol Reactions for the Rapid and Flexible Synthesis of 1,3-Polyols.

J Am Chem Soc 2015 Dec 3;137(49):15418-21. Epub 2015 Dec 3.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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December 2015

Copper-Catalyzed Oxyboration of Unactivated Alkenes.

Chemistry 2015 Nov 17;21(45):15955-9. Epub 2015 Sep 17.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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November 2015

Cp*Co(III) Catalyzed Site-Selective C-H Activation of Unsymmetrical O-Acyl Oximes: Synthesis of Multisubstituted Isoquinolines from Terminal and Internal Alkynes.

Angew Chem Int Ed Engl 2015 Oct 28;54(44):12968-72. Epub 2015 Sep 28.

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812 (Japan).

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October 2015

A meta-selective C-H borylation directed by a secondary interaction between ligand and substrate.

Nat Chem 2015 Sep 17;7(9):712-7. Epub 2015 Aug 17.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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September 2015

Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif.

Bioorg Med Chem Lett 2015 Aug 19;25(15):2972-5. Epub 2015 May 19.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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August 2015

Synthesis of chemically-tethered amyloid-β segment trimer possessing amyloidogenic properties.

Bioorg Med Chem Lett 2015 Aug 19;25(15):2976-9. Epub 2015 May 19.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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August 2015

Dehydrative Direct C-H Allylation with Allylic Alcohols under [Cp*Co(III)] Catalysis.

Angew Chem Int Ed Engl 2015 Aug 1;54(34):9944-7. Epub 2015 Jul 1.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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August 2015

Benzylic C(sp(3) )H Perfluoroalkylation of Six-Membered Heteroaromatic Compounds.

Angew Chem Int Ed Engl 2015 Aug 29;54(35):10263-6. Epub 2015 Jul 29.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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August 2015

Structure-based design of a streptavidin mutant specific for an artificial biotin analogue.

J Biochem 2015 Jun 2;157(6):467-75. Epub 2015 Feb 2.

Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan; and Radioisotope Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

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June 2015

Palladium-Catalyzed Construction of Heteroatom-Containing π-Conjugated Systems by Intramolecular Oxidative C-H/C-H Coupling Reaction.

Chemistry 2015 Jun 23;21(23):8365-8. Epub 2015 Apr 23.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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June 2015

Metal-free C(3)-H arylation of coumarins promoted by catalytic amounts of 5,10,15,20-tetrakis(4-diethylaminophenyl)porphyrin.

Chem Commun (Camb) 2015 Jun;51(47):9718-21

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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June 2015

Chemoselective Boron-Catalyzed Nucleophilic Activation of Carboxylic Acids for Mannich-Type Reactions.

J Am Chem Soc 2015 Jun 29;137(22):7075-8. Epub 2015 May 29.

†Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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June 2015

Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond Activation.

J Am Chem Soc 2015 May 6;137(19):6140-3. Epub 2015 May 6.

†Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2015

Copper-catalyzed intermolecular C(sp)-H bond functionalization towards the synthesis of tertiary carbamates.

Chem Sci 2015 May 23;6(5):3195-3200. Epub 2015 Mar 23.

Graduate School of Pharmaceutical Sciences , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku , Tokyo 113-0033 , Japan . Email: ; Email:

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May 2015

Design and synthesis of biotin analogues reversibly binding with streptavidin.

Chem Asian J 2015 Apr 5;10(4):1071-8. Epub 2015 Mar 5.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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April 2015

Iridium-catalyzed ortho-selective C-H silylation of aromatic compounds directed toward the synthesis of π-conjugated molecules with Lewis acid-base interaction.

Org Lett 2015 Apr 24;17(7):1758-61. Epub 2015 Mar 24.

†Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2015

A Cp*CoI2-dimer as a precursor for cationic Co(III)-catalysis: application to C-H phosphoramidation of indoles.

Chem Commun (Camb) 2015 Mar;51(22):4659-61

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2015

A cyclic KLVFF-derived peptide aggregation inhibitor induces the formation of less-toxic off-pathway amyloid-β oligomers.

Chembiochem 2014 Nov 26;15(17):2577-83. Epub 2014 Sep 26.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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November 2014

Copper-mediated direct C(sp3)-H and C(sp2)-H acetoxylation.

Org Lett 2014 Sep 2;16(18):4790-3. Epub 2014 Sep 2.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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September 2014

Reaction mediated artificial cell termination: control of vesicle viability using Rh(I)-catalyzed hydrogenation.

Phys Chem Chem Phys 2014 Aug;16(31):16454-7

MANA, National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan.

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August 2014

Rational design and identification of a non-peptidic aggregation inhibitor of amyloid-β based on a pharmacophore motif obtained from cyclo[-Lys-Leu-Val-Phe-Phe-].

Angew Chem Int Ed Engl 2014 Jul 16;53(31):8236-9. Epub 2014 Jun 16.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, Tokyo 113-0033 (Japan).

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July 2014

Serine-selective aerobic cleavage of peptides and a protein using a water-soluble copper-organoradical conjugate.

Angew Chem Int Ed Engl 2014 Jun 14;53(25):6501-5. Epub 2014 May 14.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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June 2014

Regiodivergent kinetic resolution of terminal and internal rac-aziridines with malonates under dinuclear Schiff base catalysis.

J Am Chem Soc 2014 Jun 16;136(25):9190-4. Epub 2014 Jun 16.

Graduate School of Pharmaceutical Sciences, the University of Tokyo , 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan.

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June 2014

Copper-catalyzed regio- and stereoselective intermolecular three-component oxyarylation of allenes.

Org Lett 2014 May 25;16(10):2736-9. Epub 2014 Apr 25.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2014

Synthesis of pyridine N-oxide-BF₂CF₃ complexes and their fluorescence properties.

Chem Asian J 2014 Apr 12;9(4):1026-30. Epub 2014 Feb 12.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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April 2014

Copper-catalyzed benzylic C(sp(3))-H alkoxylation of heterocyclic compounds.

Org Biomol Chem 2014 Apr;12(16):2528-32

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2014

Palladium-catalyzed direct C-H silylation and germanylation of benzamides and carboxamides.

Org Lett 2014 Apr 19;16(7):1968-71. Epub 2014 Mar 19.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2014

Pyrroloindolone synthesis via a Cp*Co(III)-catalyzed redox-neutral directed C-H alkenylation/annulation sequence.

J Am Chem Soc 2014 Apr 31;136(14):5424-31. Epub 2014 Mar 31.

Graduate School of Pharmaceutical Sciences, The University of Tokyo , Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2014

Copper-catalyzed intramolecular C(sp³)-H and C(sp²)-H amidation by oxidative cyclization.

Angew Chem Int Ed Engl 2014 Mar 24;53(13):3496-9. Epub 2014 Feb 24.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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March 2014

Regioselective trifluoromethylation of N-heteroaromatic compounds using trifluoromethyldifluoroborane activator.

Nat Commun 2014 Mar 13;5:3387. Epub 2014 Mar 13.

1] Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [2] Japan Science and Technology Agency (JST), ERATO, Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2014

Palladium-catalyzed C-H fluorosilylation of 2-phenylpyridines: synthesis of silafluorene equivalents.

Angew Chem Int Ed Engl 2014 Mar;53(12):3168-72

Graduate School of Pharmaceutical Sciences, The University of Tokyo, ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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March 2014

Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation.

Angew Chem Int Ed Engl 2014 Jan 11;53(5):1382-5. Epub 2013 Dec 11.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Japan Science and Technology Agency (JST), ERATO, Kanai Life Science Catalysis Project, Bunkyo-ku, Tokyo 113-0033 (Japan).

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January 2014

Rh-catalyzed aldehyde-aldehyde cross-aldol reaction under base-free conditions: in situ aldehyde-derived enolate formation through orthogonal activation.

Chem Asian J 2013 Dec 23;8(12):2974-83. Epub 2013 Sep 23.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5684-5206; Kanai Life Science Catalysis Project, ERATO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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December 2013

Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents.

J Antibiot (Tokyo) 2013 Nov 3;66(11):663-7. Epub 2013 Jul 3.

Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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November 2013

Rhenium-catalyzed synthesis of 3-imino-1-isoindolinones by C-H bond activation: application to the synthesis of polyimide derivatives.

Angew Chem Int Ed Engl 2013 Nov 13;52(45):11879-83. Epub 2013 Sep 13.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); CREST (Japan) Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

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November 2013

Catalytic asymmetric synthesis of spirooxindoles via addition of isothiocyanato oxindoles to aldehydes under dinuclear nickel Schiff base catalysis.

Chem Asian J 2013 Aug 15;8(8):1768-71. Epub 2013 Apr 15.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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August 2013

Catalytic anomeric aminoalkynylation of unprotected aldoses.

Org Lett 2013 Aug 31;15(16):4130-3. Epub 2013 Jul 31.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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August 2013

Cp*Co(III)-catalyzed C2-selective addition of indoles to imines.

Chemistry 2013 Jul 31;19(28):9142-6. Epub 2013 May 31.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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July 2013

In situ catalytic generation of allylcopper species for asymmetric allylation: toward 1H-isochromene skeletons.

Angew Chem Int Ed Engl 2013 Jul 3;52(28):7177-80. Epub 2013 Jun 3.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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July 2013

Manganese-catalyzed aerobic dehydrogenative cyclization toward ring-fused indole skeletons.

Org Biomol Chem 2013 Jul 6;11(28):4569-72. Epub 2013 Jun 6.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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July 2013

Copper-catalyzed intramolecular N-S bond formation by oxidative dehydrogenative cyclization.

J Org Chem 2013 Jul 1;78(14):7337-42. Epub 2013 Jul 1.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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July 2013

Sultam synthesis via Cu-catalyzed intermolecular carboamination of alkenes with N-fluorobenzenesulfonimide.

Org Lett 2013 May 29;15(10):2502-5. Epub 2013 Apr 29.

Graduate School of Pharmaceutical Sciences, the University of Tokyo , Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan, and ACT-C, Japan Science and Technology Agency (JST) , Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2013

Intracellular activation of acetyl-CoA by an artificial reaction promoter and its fluorescent detection.

Chem Commun (Camb) 2013 Apr;49(28):2876-8

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2013

Iron-catalyzed oxidative C(3)-H functionalization of amines.

Org Lett 2013 Apr 11;15(8):1918-21. Epub 2013 Apr 11.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2013

Cobalt-catalyzed C4-selective direct alkylation of pyridines.

Angew Chem Int Ed Engl 2013 Mar 1;52(11):3213-6. Epub 2013 Feb 1.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2013

A cationic high-valent Cp*Co(III) complex for the catalytic generation of nucleophilic organometallic species: directed C-H bond activation.

Angew Chem Int Ed Engl 2013 Feb 16;52(8):2207-11. Epub 2013 Jan 16.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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February 2013

Copper-catalyzed C-H alkoxylation of azoles.

Org Lett 2013 Feb 31;15(4):844-7. Epub 2013 Jan 31.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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February 2013

Functional-group-tolerant catalytic migratory oxidative coupling of nitrones.

Chem Asian J 2012 Nov 4;7(11):2600-6. Epub 2012 Jul 4.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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November 2012

Rhodium-catalyzed cross-aldol reaction: in situ aldehyde-enolate formation from allyloxyboranes and primary allylic alcohols.

Angew Chem Int Ed Engl 2012 Oct 13;51(41):10275-9. Epub 2012 Sep 13.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2012

Copper(I)-catalyzed enantioselective incorporation of ketones to cyclic hemiaminals for the synthesis of versatile alkaloid precursors.

J Am Chem Soc 2012 Oct 8;134(41):17019-22. Epub 2012 Oct 8.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2012

Catalytic asymmetric synthesis of spirooxindoles by a mannich-type reaction of isothiocyanato oxindoles.

Angew Chem Int Ed Engl 2012 Jul 4;51(28):7007-10. Epub 2012 Jun 4.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Japan.

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July 2012

Mg-catalyzed enantioselective benzylic C-H bond functionalization of isoindolinones: addition to imines.

Chemistry 2012 Jun 21;18(25):7654-7. Epub 2012 May 21.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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June 2012

Catalytic asymmetric total synthesis of chimonanthine, folicanthine, and calycanthine through double Michael reaction of bisoxindole.

Angew Chem Int Ed Engl 2012 May 12;51(21):5217-21. Epub 2012 Apr 12.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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May 2012

Asymmetric synthesis of dihydropyranones from ynones by sequential copper(I)-catalyzed direct aldol and silver(I)-catalyzed oxy-Michael reactions.

Angew Chem Int Ed Engl 2012 Apr 2;51(16):3932-5. Epub 2012 Mar 2.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Japan.

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April 2012

Catalytic migratory oxidative coupling of nitrones through an outer-sphere C(sp3)-H activation process.

Chem Rec 2011 Sep 6;11(5):236-41. Epub 2011 Sep 6.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Tokyo 113-0033, Japan.

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September 2011

A facile pathway to enantiomerically enriched 3-hydroxy-2-oxindoles: asymmetric intramolecular arylation of α-keto amides catalyzed by a palladium-DifluorPhos complex.

Angew Chem Int Ed Engl 2011 Aug 1;50(33):7620-3. Epub 2011 Jun 1.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Tokyo113-0033, Japan.

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August 2011

Catalytic migratory oxidative coupling of nitrones.

Org Lett 2011 Aug 18;13(16):4288-91. Epub 2011 Jul 18.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Tokyo 113-0033, Japan.

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August 2011