Publications

Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin.
J Am Chem Soc 2017 Jun 23;139(22):7568-7576. Epub 2017 May 23.
Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.
Cell Rep 2017 May;19(5):969-980
Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan; Research Center for Advanced Immunology, Kyushu University, Fukuoka 812-8582, Japan. Electronic address:

Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondary C(sp(3))-H bonds in aliphatic alcohols.
Org Biomol Chem 2016 May;14(19):4378-81
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan. and Japan Science Technology Agency (JST), ERATO Kanai Life Science Catalysis Project, 7-3-1 Bunkyo-ku, Tokyo 113-0033, Japan.

Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif.
Bioorg Med Chem Lett 2015 Aug 19;25(15):2972-5. Epub 2015 May 19.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Synthesis of chemically-tethered amyloid-β segment trimer possessing amyloidogenic properties.
Bioorg Med Chem Lett 2015 Aug 19;25(15):2976-9. Epub 2015 May 19.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Structure-based design of a streptavidin mutant specific for an artificial biotin analogue.
J Biochem 2015 Jun 2;157(6):467-75. Epub 2015 Feb 2.
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan; and Radioisotope Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan


A cyclic KLVFF-derived peptide aggregation inhibitor induces the formation of less-toxic off-pathway amyloid-β oligomers.
Chembiochem 2014 Nov 26;15(17):2577-83. Epub 2014 Sep 26.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

Rational design and identification of a non-peptidic aggregation inhibitor of amyloid-β based on a pharmacophore motif obtained from cyclo[-Lys-Leu-Val-Phe-Phe-].
Angew Chem Int Ed Engl 2014 Jul 16;53(31):8236-9. Epub 2014 Jun 16.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); ERATO (Japan) Science and Technology Agency (JST), Kanai Life Science Catalysis Project, Tokyo 113-0033 (Japan).

Regioselective trifluoromethylation of N-heteroaromatic compounds using trifluoromethyldifluoroborane activator.
Nat Commun 2014 Mar 13;5:3387. Epub 2014 Mar 13.
1] Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [2] Japan Science and Technology Agency (JST), ERATO, Kanai Life Science Catalysis Project, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation.
Angew Chem Int Ed Engl 2014 Jan 11;53(5):1382-5. Epub 2013 Dec 11.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Japan Science and Technology Agency (JST), ERATO, Kanai Life Science Catalysis Project, Bunkyo-ku, Tokyo 113-0033 (Japan).

Rh-catalyzed aldehyde-aldehyde cross-aldol reaction under base-free conditions: in situ aldehyde-derived enolate formation through orthogonal activation.
Chem Asian J 2013 Dec 23;8(12):2974-83. Epub 2013 Sep 23.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5684-5206; Kanai Life Science Catalysis Project, ERATO, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

Rhenium-catalyzed synthesis of 3-imino-1-isoindolinones by C-H bond activation: application to the synthesis of polyimide derivatives.
Angew Chem Int Ed Engl 2013 Nov 13;52(45):11879-83. Epub 2013 Sep 13.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); CREST (Japan) Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).



Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.
Science 2009 Apr 26;324(5925):384-7. Epub 2009 Mar 26.
Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.


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