Dr Motomi Osato, MD, PhD - National University of Singapore - Associate Professor

Dr Motomi Osato

MD, PhD

National University of Singapore

Associate Professor

Singapore | Singapore

Main Specialties: Hematology & Oncology

Additional Specialties: Hematology Oncology

Dr Motomi Osato, MD, PhD - National University of Singapore - Associate Professor

Dr Motomi Osato

MD, PhD

Introduction

Primary Affiliation: National University of Singapore - Singapore , Singapore

Specialties:

Additional Specialties:

Publications

74Publications

1196Reads

3Profile Views

1102PubMed Central Citations

Systematic Review of Normal Subjects Harbouring BCR-ABL1 Fusion Gene.

Acta Haematol 2020 9;143(2):96-111. Epub 2019 Aug 9.

International Research Centre for Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1159/000501146DOI Listing
April 2020
0.994 Impact Factor

Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.

Int J Hematol 2020 Feb 9;111(2):217-224. Epub 2019 Nov 9.

Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Kumamoto, 860-0811, Japan.

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http://dx.doi.org/10.1007/s12185-019-02768-xDOI Listing
February 2020
1.679 Impact Factor

A two-pronged anti-leukemic agent based on a hyaluronic acid-green tea catechin conjugate for inducing targeted cell death and terminal differentiation.

Biomater Sci 2019 Dec;8(1):497-505

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669.

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http://dx.doi.org/10.1039/c9bm01146cDOI Listing
December 2019

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia.

Haematologica 2019 Nov 7. Epub 2019 Nov 7.

Cancer Science Institute of Singapore, National University of Singapore, Republic of Singapore;

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http://dx.doi.org/10.3324/haematol.2019.230482DOI Listing
November 2019
5.868 Impact Factor

Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.

Nat Commun 2019 Aug 28;10(1):3943. Epub 2019 Aug 28.

Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo Ward, Kumamoto, 860-0811, Japan.

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http://dx.doi.org/10.1038/s41467-019-11919-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713738PMC
August 2019
10.742 Impact Factor

TUBB1 dysfunction in inherited thrombocytopenia causes genome instability.

Br J Haematol 2019 06 10;185(5):888-902. Epub 2019 Mar 10.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://doi.wiley.com/10.1111/bjh.15835
Publisher Site
http://dx.doi.org/10.1111/bjh.15835DOI Listing
June 2019
26 Reads
4.711 Impact Factor

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.

Nat Commun 2019 04 10;10(1):1653. Epub 2019 Apr 10.

Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University, 2-2-1 Honjo, Chuo Ward, Kumamoto, 860-0811, Japan.

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http://dx.doi.org/10.1038/s41467-019-09710-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458132PMC
April 2019
2 Reads
10.742 Impact Factor

Correction to: Systematic review of pre-clinical chronic myeloid leukaemia.

Int J Hematol 2019 Jan;109(1):130

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1007/s12185-018-2556-6DOI Listing
January 2019
2 Reads
1.680 Impact Factor

Systematic review of pre-clinical chronic myeloid leukaemia.

Int J Hematol 2018 Nov 14;108(5):465-484. Epub 2018 Sep 14.

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1007/s12185-018-2528-xDOI Listing
November 2018
2 Reads
1.680 Impact Factor

Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline mutation.

Biomark Res 2018 11;6:16. Epub 2018 May 11.

2Department of Haematology-Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore, 119228 Singapore.

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http://dx.doi.org/10.1186/s40364-018-0130-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948813PMC
May 2018
13 Reads

LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML.

Mol Cancer Res 2017 03 23;15(3):294-303. Epub 2016 Dec 23.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore, Republic of Singapore.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0275-TDOI Listing
March 2017
46 Reads
7 Citations
4.380 Impact Factor

Activation of EVI1 transcription by the LEF1/β-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia.

Biochem Biophys Res Commun 2017 Jan 28;482(4):994-1000. Epub 2016 Nov 28.

Division of Tumor and Cellular Biochemistry, Department of Medical Science, Faculty of Medicine, University of Miyazaki, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.11.146DOI Listing
January 2017
20 Reads
1 Citation
2.300 Impact Factor

Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.

Gastroenterology 2017 01 23;152(1):218-231.e14. Epub 2016 Sep 23.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.018DOI Listing
January 2017
71 Reads
23 Citations
16.720 Impact Factor

Cyclin A2 regulates erythrocyte morphology and numbers.

Cell Cycle 2016 Nov 22;15(22):3070-3081. Epub 2016 Sep 22.

a Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research) , Singapore , Republic of Singapore.

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http://dx.doi.org/10.1080/15384101.2016.1234546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134699PMC
November 2016
41 Reads
2 Citations

RNA helicase DP103 and TAK1: a new connection in cancer.

Mol Cell Oncol 2015 Jul-Sep;2(3):e985911. Epub 2015 Jan 26.

Institute of Molecular and Cellular Biology; ASTAR, Singapore; Department of Biochemistry; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.

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http://dx.doi.org/10.4161/23723556.2014.985911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905301PMC
June 2016
34 Reads

Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum).

PLoS One 2014 18;9(11):e113445. Epub 2014 Nov 18.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113445PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236176PMC
January 2016
26 Reads
6 Citations
3.234 Impact Factor

The artificial loss of Runx1 reduces the expression of quiescence-associated transcription factors in CD4(+) T lymphocytes.

Mol Immunol 2015 Dec 5;68(2 Pt A):223-33. Epub 2015 Sep 5.

Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

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http://dx.doi.org/10.1016/j.molimm.2015.08.012DOI Listing
December 2015
57 Reads
2.973 Impact Factor

Isolation of Undifferentiated Female Germline Cells from Adult Drosophila Ovaries.

Curr Protoc Stem Cell Biol 2015 Aug 3;34:2E.3.1-2E.3.15. Epub 2015 Aug 3.

Temasek Life Sciences Laboratory, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/9780470151808.sc02e03s34DOI Listing
August 2015
38 Reads
1 Citation

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.

Nature 2015 Jul 11;523(7558):96-100. Epub 2015 May 11.

1] Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore [2] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore [3] Cancer Science Institute of Singapore (CSI), National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.

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http://dx.doi.org/10.1038/nature14351DOI Listing
July 2015
15 Reads
53 Citations
42.351 Impact Factor

Hematopoietic stem cell enhancer: a powerful tool in stem cell biology.

Histol Histopathol 2015 Jun 9;30(6):661-72. Epub 2015 Jan 9.

Cancer Science Institute of Singapore, National University of Singapore, Institute of Bioengineering and Nanotechnology, A*STAR, Department of Paediatrics, National University of Singapore, Singapore and International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.14670/HH-30.661DOI Listing
June 2015
10 Reads
1 Citation
2.100 Impact Factor

Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress.

Haematologica 2015 Apr 23;100(4):431-8. Epub 2015 Jan 23.

Institute of Molecular and Cell Biology, A*STAR Agency for Science, Technology and Research, Republic of Singapore National University of Singapore, Department of Biochemistry, Republic of Singapore

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http://dx.doi.org/10.3324/haematol.2014.106468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380715PMC
April 2015
15 Reads
4 Citations
5.870 Impact Factor

Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii).

PLoS One 2014 3;9(4):e93816. Epub 2014 Apr 3.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093816PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974841PMC
January 2015
9 Reads
2 Citations
3.234 Impact Factor

Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

Cell Rep 2014 Aug 24;8(3):767-82. Epub 2014 Jul 24.

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Institute of Molecular and Cell Biology, A(∗)STAR, Singapore 138673, Singapore; Institute of Bioengineering and Nanotechnology, A(∗)STAR, Singapore 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.046DOI Listing
August 2014
65 Reads
12 Citations
7.210 Impact Factor

RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells.

Gene 2014 Jul 2;545(1):111-6. Epub 2014 May 2.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Institute of Bioengineering and Nanotechnology, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2014.04.074DOI Listing
July 2014
30 Reads
2 Citations
2.140 Impact Factor

An unsung runt 6e isoform for HSC expansion.

Authors:
Motomi Osato

Blood 2014 Jun;123(24):3684-6

NATIONAL UNIVERSITY OF SINGAPORE.

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http://dx.doi.org/10.1182/blood-2014-05-572891DOI Listing
June 2014
7 Reads
10.452 Impact Factor

[RUNX family genes and hematopoiesis].

Rinsho Ketsueki 2013 Oct;54(10):1547-53

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October 2013
1 Read

RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes.

Leukemia 2013 Sep 2;27(9):1793-802. Epub 2013 Jul 2.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/leu.2013.200DOI Listing
September 2013
19 Reads
10 Citations
10.431 Impact Factor

Runx3 deficiency results in myeloproliferative disorder in aged mice.

Blood 2013 Jul 5;122(4):562-6. Epub 2013 Jun 5.

Institute of Molecular and Cell Biology, Singapore.

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http://dx.doi.org/10.1182/blood-2012-10-460618DOI Listing
July 2013
4 Reads
5 Citations
10.452 Impact Factor

Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia.

J Clin Invest 2013 Mar 22;123(3):1123-37. Epub 2013 Feb 22.

Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

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http://dx.doi.org/10.1172/JCI63711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582118PMC
March 2013
33 Reads
12 Citations
13.215 Impact Factor

In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues.

Sci Rep 2012 7;2:642. Epub 2012 Sep 7.

Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, 54 Shogoin-Kawahara-cho,Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1038/srep00642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435563PMC
February 2013
24 Reads
3 Citations
5.080 Impact Factor

Runx1: no longer just for leukemia.

EMBO J 2012 Nov 12;31(21):4098-9. Epub 2012 Oct 12.

Laboratory for Transcriptional Regulation, Research Center for Allergy and Immunology, RIKEN, Yokohama, Japan.

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http://dx.doi.org/10.1038/emboj.2012.282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492739PMC
November 2012
5 Reads
9 Citations
10.434 Impact Factor

Isolation of undifferentiated female germline cells from adult Drosophila ovaries.

Curr Protoc Stem Cell Biol 2012 Aug;Chapter 2:Unit2E.3

Temasek Life Sciences Laboratory, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/9780470151808.sc02e03s22DOI Listing
August 2012
36 Reads
2 Citations

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Blood 2011 Dec 19;118(25):6544-52. Epub 2011 Oct 19.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1182/blood-2010-11-317909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242717PMC
December 2011
7 Reads
22 Citations
10.452 Impact Factor

Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation.

J Immunol 2011 Jun 22;186(11):6515-20. Epub 2011 Apr 22.

Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.4049/jimmunol.1001671DOI Listing
June 2011
6 Reads
10 Citations
4.922 Impact Factor

Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters.

Blood 2011 Jun 19;117(23):6132-4. Epub 2011 Apr 19.

Department of Cell Biology, Erasmus MC Stem Cell Institute, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-02-334037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122938PMC
June 2011
5 Reads
15 Citations
10.452 Impact Factor

Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis.

Development 2011 Feb 12;138(4):619-29. Epub 2011 Jan 12.

State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China.

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http://dx.doi.org/10.1242/dev.054536DOI Listing
February 2011
24 Reads
8 Citations
6.462 Impact Factor

A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells.

Stem Cells 2010 Oct;28(10):1869-81

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/stem.507DOI Listing
October 2010
25 Reads
24 Citations
6.523 Impact Factor

Runx family genes, niche, and stem cell quiescence.

Blood Cells Mol Dis 2010 Apr 9;44(4):275-86. Epub 2010 Feb 9.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.bcmd.2010.01.006DOI Listing
April 2010
4 Reads
15 Citations
2.650 Impact Factor

Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling.

J Immunol 2010 Mar 8;184(6):2785-92. Epub 2010 Feb 8.

Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.4049/jimmunol.0901823DOI Listing
March 2010
13 Reads
26 Citations
4.922 Impact Factor

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.

Blood 2010 Feb 14;115(8):1610-20. Epub 2009 Dec 14.

Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore.

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http://dx.doi.org/10.1182/blood-2009-07-232249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830765PMC
February 2010
18 Reads
32 Citations
10.452 Impact Factor

Retroviral integration sites (RIS) mark cis-regulatory elements.

Crit Rev Oncol Hematol 2009 Jul 28;71(1):1-11. Epub 2008 Nov 28.

Institute of Molecular and Cell Biology, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.critrevonc.2008.10.008DOI Listing
July 2009
1 Read
4.030 Impact Factor

Stem cell exhaustion and leukemogenesis.

J Cell Biochem 2009 Jun;107(3):393-9

Institute of Molecular and Cell Biology, Singapore 138673, Singapore.

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http://dx.doi.org/10.1002/jcb.22150DOI Listing
June 2009
5 Reads
7 Citations
3.263 Impact Factor

RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.

Cancer Cell 2008 Sep;14(3):226-37

Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673.

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http://dx.doi.org/10.1016/j.ccr.2008.08.004DOI Listing
September 2008
6 Reads
61 Citations
23.523 Impact Factor

Genetic evidence of PEBP2beta-independent activation of Runx1 in the murine embryo.

Int J Hematol 2008 Sep 2;88(2):134-138. Epub 2008 Jul 2.

Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore.

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http://dx.doi.org/10.1007/s12185-008-0121-4DOI Listing
September 2008
1 Read
3 Citations
1.680 Impact Factor

Runx1 is involved in primitive erythropoiesis in the mouse.

Blood 2008 Apr 4;111(8):4075-80. Epub 2008 Feb 4.

Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1182/blood-2007-05-091637DOI Listing
April 2008
3 Reads
24 Citations
10.452 Impact Factor

Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult.

Stem Cells 2007 Dec 6;25(12):2976-86. Epub 2007 Sep 6.

Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore.

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http://dx.doi.org/10.1634/stemcells.2007-0061DOI Listing
December 2007
78 Reads
22 Citations
6.523 Impact Factor

cDNA cloning of Runx family genes from the pufferfish (Fugu rubripes).

Gene 2007 Sep 5;399(2):162-73. Epub 2007 Jun 5.

Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore.

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http://dx.doi.org/10.1016/j.gene.2007.05.014DOI Listing
September 2007
5 Reads
6 Citations
2.140 Impact Factor

The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons.

J Biol Chem 2007 Aug 20;282(33):24175-84. Epub 2007 Jun 20.

Institute of Molecular and Cell Biology, Singapore 13 8673.

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http://dx.doi.org/10.1074/jbc.M703746200DOI Listing
August 2007
2 Reads
16 Citations
4.573 Impact Factor

The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development.

Blood 2007 Jul 16;110(1):99-106. Epub 2007 Mar 16.

Laboratory of Molecular & Developmental Immunology, Institute of Molecular and Cell Biology, Proteos, Singapore.

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http://dx.doi.org/10.1182/blood-2006-11-059204DOI Listing
July 2007
28 Reads
12 Citations
10.452 Impact Factor

Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia.

Blood 2007 May 23;109(9):4023-7. Epub 2007 Jan 23.

Department of Hematology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1182/blood-2006-01-031781DOI Listing
May 2007
2 Reads
3 Citations
10.452 Impact Factor

Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo.

EMBO J 2007 Jan 7;26(1):184-96. Epub 2006 Dec 7.

Institute of Basic Medical Sciences and Center for TARA, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1038/sj.emboj.7601480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782368PMC
January 2007
9 Reads
19 Citations
10.434 Impact Factor

PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo.

Cancer Res 2006 Oct;66(19):9625-35

Institute of Molecular and Cell Biology, Singapore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0726DOI Listing
October 2006
5 Reads
26 Citations
9.330 Impact Factor

Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?

Crit Rev Eukaryot Gene Expr 2005 ;15(3):217-28

Institute of Molecular and Cell Biology, Oncology Research Institute, National University of Singapore.

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http://dx.doi.org/10.1615/critreveukargeneexpr.v15.i3.40DOI Listing
March 2006
44 Reads
5 Citations
1.571 Impact Factor

Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice.

Br J Haematol 2005 Nov;131(4):495-507

Institute of Molecular and Cell Biology, Singapore.

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http://dx.doi.org/10.1111/j.1365-2141.2005.05793.xDOI Listing
November 2005
8 Reads
8 Citations
4.711 Impact Factor

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.

Blood 2005 Jan 28;105(2):784-93. Epub 2004 Sep 28.

Department of Carcinogenesis, Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://www.bloodjournal.org/content/105/2/784.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2004-04-15
Publisher Site
http://dx.doi.org/10.1182/blood-2004-04-1508DOI Listing
January 2005
6 Reads
19 Citations
10.452 Impact Factor

Functional analysis of RUNX2 mutations in cleidocranial dysplasia: novel insights into genotype-phenotype correlations.

Blood Cells Mol Dis 2003 Mar-Apr;30(2):184-93

Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/s1079-9796(03)00020-2DOI Listing
August 2004
11 Citations
2.650 Impact Factor

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.

Authors:
Motomi Osato

Oncogene 2004 May;23(24):4284-96

Institute of Molecular and Cell Biology, Oncology Research Institute, National University of Singapore, Singapore, 30 Medical Drive, Singapore 117609.

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http://dx.doi.org/10.1038/sj.onc.1207779DOI Listing
May 2004
61 Citations
8.460 Impact Factor

Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera.

Blood 2004 Apr 24;103(8):3200-7. Epub 2003 Dec 24.

Institute for Virus Research, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1182/blood-2003-07-2188DOI Listing
April 2004
2 Reads
6 Citations
10.452 Impact Factor

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

Cell 2002 Nov;111(5):621-33

Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)01111-xDOI Listing
November 2002
17 Reads
226 Citations
32.242 Impact Factor

Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations.

Am J Hum Genet 2002 Oct 26;71(4):724-38. Epub 2002 Aug 26.

Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.

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http://dx.doi.org/10.1086/342717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC378531PMC
October 2002
3 Reads
34 Citations
10.931 Impact Factor

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

Blood 2002 Aug;100(3):998-1007

Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood.v100.3.998DOI Listing
August 2002
5 Reads
50 Citations
10.452 Impact Factor

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Yoshiaki Ito
Yoshiaki Ito

Saiseikai Yokohama City Eastern Hospital

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Tomomasa Yokomizo
Tomomasa Yokomizo

Juntendo University School of Medicine

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Norio Asou
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Kumamoto University School of Medicine

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Masatoshi Yanagida
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Global Research Center for Environment and Energy based on Nanomaterials Science (GREEN)

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Nara Medical University

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Cancer Science Institute of Singapore

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Graduate School of Medicine

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