Moshe Szyf

Moshe Szyf

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Moshe Szyf

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A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

J Psychiatry Neurosci 2019 05;44(3):205-213

From the Eating Disorders Program, Douglas University Institute (Steiger, Kahan, Thaler, Fletcher, Israël, St-Hilaire, Rossi); the Research Centre, Douglas University Institute (Steiger, Kahan, Thaler, Fletcher, Joober, Israël, St-Hilaire, Rossi); the Department of Psychiatry, McGill University (Steiger, Booij, Thaler, Joober, Israël, St-Hilaire); the Department of Psychology, Concordia University (Booij); the Sainte-Justine Hospital Research Centre, University of Montreal (Booij); the Department of Epidemiology, Biostatistics, and Occupational Health, McGill University (McGregor); the Department of Decision Sciences, HEC Montreal (Labbe); the Department of Pharmacology and Therapeutics, McGill University (Szyf); the School of Human Nutrition, McGill University (Agellon); and the Centre de recherche du Centre Hospitalier, de l’Université de Montréal (CRCHUM) (Gauvin), Montreal, Que., Canada.

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http://dx.doi.org/10.1503/jpn.170242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488489PMC
May 2019

The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics.

Authors:
Elad Lax Moshe Szyf

Prog Mol Biol Transl Sci 2018 11;157:93-104. Epub 2018 Apr 11.

Department of Pharmacology and Therapeutics, McGill University Medical School, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2018.01.003DOI Listing
March 2019

Differential genome-wide DNA methylation patterns in childhood obesity.

BMC Res Notes 2019 Mar 25;12(1):174. Epub 2019 Mar 25.

Department of Psychiatry, McGill University and Douglas Hospital Research Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1186/s13104-019-4189-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434834PMC
March 2019

The signature of liver cancer in immune cells DNA methylation.

Clin Epigenetics 2018 18;10. Epub 2018 Jan 18.

2Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G 1Y6 Canada.

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http://dx.doi.org/10.1186/s13148-017-0436-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774119PMC
February 2019

DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation.

Am J Med Genet B Neuropsychiatr Genet 2018 12 9;177(8):746-764. Epub 2018 Nov 9.

Division of Psychology and Language Sciences, University College London, London, United Kingdom.

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http://doi.wiley.com/10.1002/ajmg.b.32689
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http://dx.doi.org/10.1002/ajmg.b.32689DOI Listing
December 2018

Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women.

J Bone Miner Res 2018 11 20;33(11):1980-1989. Epub 2018 Jul 20.

Department of Medicine, McGill University Health Center, Montreal, QC, Canada.

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http://doi.wiley.com/10.1002/jbmr.3527
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http://dx.doi.org/10.1002/jbmr.3527DOI Listing
November 2018

Peripheral DNA methylation of HPA axis-related genes in humans: Cross-tissue convergence, two-year stability and behavioural and neural correlates.

Psychoneuroendocrinology 2018 11 27;97:196-205. Epub 2018 Jul 27.

CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064530173164
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http://dx.doi.org/10.1016/j.psyneuen.2018.07.019DOI Listing
November 2018

DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse.

Psychiatry Res 2018 07 8;265:341-348. Epub 2018 May 8.

Department of Psychiatry, School of Medicine, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland; Trinity Centre for Health Sciences, AMNCH (Tallaght Hospital), Tallaght, Dublin 24, Ireland.

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https://linkinghub.elsevier.com/retrieve/pii/S01651781173206
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http://dx.doi.org/10.1016/j.psychres.2018.04.064DOI Listing
July 2018

DNA methylation signatures of breast cancer in peripheral T-cells.

BMC Cancer 2018 May 18;18(1):574. Epub 2018 May 18.

Department of Medicine, McGill University Health Center, 1001 Décarie Blvd., Room EM1.3232, Montréal, QC, H4A3J1, Canada.

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http://dx.doi.org/10.1186/s12885-018-4482-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960123PMC
May 2018

Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.

Neuropsychopharmacology 2018 04 28;43(5):1138-1145. Epub 2017 Nov 28.

Department of Psychiatry, Trinity College School of Medicine and Trinity College Institute of Neuroscience, Dublin, Ireland.

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http://dx.doi.org/10.1038/npp.2017.290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854813PMC
April 2018

The DNA methylation landscape of enhancers in the guinea pig hippocampus.

Epigenomics 2018 04 4;10(4):349-365. Epub 2018 Apr 4.

Department of Pharmacology & Therapeutics, Sackler Program for Epigenetics & Psychobiology, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.2217/epi-2017-0064DOI Listing
April 2018

Anxiety-Related Behaviours Associated with microRNA-206-3p and BDNF Expression in Pregnant Female Mice Following Psychological Social Stress.

Mol Neurobiol 2018 02 14;55(2):1097-1111. Epub 2017 Jan 14.

Beijing Institutes of Life Science, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s12035-016-0378-1DOI Listing
February 2018

S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice.

Neurotoxicol Teratol 2019 Jan - Feb;71:64-74. Epub 2018 Jan 16.

Department of Molecular Biology and Pre-Medical Studies, Ariel University, Ariel, Israel.

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http://dx.doi.org/10.1016/j.ntt.2018.01.005DOI Listing
January 2018

S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells.

Oncotarget 2017 Dec 5;8(67):111866-111881. Epub 2017 Dec 5.

Department of Pharmacology and Therapeutics, McGill University Montreal, Quebec, Canada.

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http://www.oncotarget.com/fulltext/22942
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http://dx.doi.org/10.18632/oncotarget.22942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762365PMC
December 2017

Serotonin transporter gene promoter methylation in peripheral cells in healthy adults: Neural correlates and tissue specificity.

Eur Neuropsychopharmacol 2017 10 31;27(10):1032-1041. Epub 2017 Jul 31.

CHU Sainte-Justine Research Centre, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychology, Concordia University, Montreal, Canada; Department of Psychiatry, McGill University, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2017.07.005DOI Listing
October 2017

Epigenetic Alterations and Prenatal Maternal Depression.

Birth Defects Res 2017 Jul;109(12):888-897

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/bdr2.1081DOI Listing
July 2017

DNA methylation and transcription onset in the brain.

Epigenomics 2017 06 18;9(6):797-809. Epub 2017 May 18.

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.2217/epi-2016-0184DOI Listing
June 2017

Therapeutic benefits of the methyl donor S-adenosylmethionine on nerve injury-induced mechanical hypersensitivity and cognitive impairment in mice.

Pain 2017 05;158(5):802-810

aAlan Edwards Centre for Research on Pain, Montreal, QC, Canada bFaculty of Dentistry, McGill University, Montreal, QC, Canada cFaculty of Medicine, Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.

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http://Insights.ovid.com/crossref?an=00006396-201705000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000000811DOI Listing
May 2017

DNA methylation controls unmethylated transcription start sites in the genome in trans.

Epigenomics 2017 05 4;9(5):611-633. Epub 2017 May 4.

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.2217/epi-2016-0141DOI Listing
May 2017

Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders.

Biol Psychiatry 2017 02 12;81(3):265-276. Epub 2016 Aug 12.

Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.08.010DOI Listing
February 2017

Prospects for Medications to Reverse Causative Epigenetic Processes in Neuropsychiatry Disorders.

Authors:
Moshe Szyf

Neuropsychopharmacology 2017 01;42(1):367-368

Department of Pharmacology and Therapeutics McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1038/npp.2016.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143508PMC
January 2017

DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½  years: Project Ice Storm.

Clin Epigenetics 2016 12;8:54. Epub 2016 May 12.

Department of Psychiatry, McGill University and Douglas Hospital Research Centre, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3 Canada.

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http://dx.doi.org/10.1186/s13148-016-0219-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866030PMC
December 2016

Pregnant women's cognitive appraisal of a natural disaster affects their children's BMI and central adiposity via DNA methylation: Project Ice Storm.

Early Hum Dev 2016 12 5;103:189-192. Epub 2016 Oct 5.

Department of Psychiatry, McGill University and Psychosocial Research Division, Douglas Hospital Research Centre, Montreal, Quebec, Canada.. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2016.09.013DOI Listing
December 2016

The elusive role of 5'-hydroxymethylcytosine.

Authors:
Moshe Szyf

Epigenomics 2016 11 13;8(11):1539-1551. Epub 2016 Oct 13.

Department of Pharmacology & Therapeutics, McGill University Medical School, 3655 Sir William Osler Promenade #1309, Montreal, QC, H3G 1Y6, Canada.

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http://dx.doi.org/10.2217/epi-2016-0076DOI Listing
November 2016

DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy controls.

PLoS One 2015 17;10(3):e0119061. Epub 2015 Mar 17.

Department of Psychiatry, University of Dublin, Trinity College Dublin, Dublin, Ireland; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany; Centre of Advanced Medical Imaging, St. James's Hospital & Trinity College Dublin, Dublin, Ireland; Institute of Neuroscience, University of Dublin, Trinity College Dublin, Dublin, Ireland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119061PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363605PMC
February 2016

Diabetes in the Cohen Rat Intensifies the Fetal Pancreatic Damage Induced by the Diabetogenic High Sucrose Low Copper Diet.

Birth Defects Res B Dev Reprod Toxicol 2016 Feb 7;107(1):21-31. Epub 2016 Jan 7.

Laboratory of Teratology, Department of Medical Neurobiology, Hadassah Medical School, Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1002/bdrb.21169DOI Listing
February 2016

Demethylation of c-MYB binding site mediates upregulation of Bdnf IV in cocaine-conditioned place preference.

Sci Rep 2016 Feb 25;6:22087. Epub 2016 Feb 25.

Key Lab of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Rd., Beijing 100101, China.

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http://dx.doi.org/10.1038/srep22087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766519PMC
February 2016

Association of childhood chronic physical aggression with a DNA methylation signature in adult human T cells.

PLoS One 2014 1;9(4):e89839. Epub 2014 Apr 1.

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada; Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089839PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972178PMC
December 2015

Impact of Early Environment on Children's Mental Health: Lessons From DNA Methylation Studies With Monozygotic Twins.

Twin Res Hum Genet 2015 Dec 26;18(6):623-34. Epub 2015 Nov 26.

Department of Psychology,Queen's University,Kingston,Ontario,Canada.

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http://dx.doi.org/10.1017/thg.2015.84DOI Listing
December 2015

DNA methylation in individuals with anorexia nervosa and in matched normal-eater controls: A genome-wide study.

Int J Eat Disord 2015 Nov 23;48(7):874-82. Epub 2015 Mar 23.

Department of Psychiatry, McGill University, Montreal, QC, Canada, H3A1 A1.

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http://dx.doi.org/10.1002/eat.22374DOI Listing
November 2015

DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli.

J Psychiatry Neurosci 2015 Sep;40(5):296-305

Department of Psychiatry, University of Dublin, Trinity College Dublin, Ireland (Frodl, Carballedo, Morris, Gill); Institute of Neuroscience, University of Dublin, Trinity College Dublin, Ireland (Frodl, Gill); Department of Psychiatry and Psychotherapy, University of Regensburg, Germany (Frodl); Centre of Advanced Medical Imaging, St. James's Hospital & Trinity College Dublin, Ireland (Frodl, Meaney); Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada (Szyf, Ly, Dymov, Vaisheva); Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, University of Dublin, Trinity College Dublin, Ireland ( Fahey, Gill); Department of Psychology and Psychiatry, Queen's University, Kingston, Canada (Booij); Sainte-Justine Hospital Research Center and Université de Montréal, Montréal, Canada (Booij); Department of Psychiatry, McGill University, Montréal, Canada (Booij).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543092PMC
September 2015

New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males.

Borderline Personal Disord Emot Dysregul 2015 15;2. Epub 2015 Apr 15.

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1186/s40479-015-0029-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579500PMC
September 2015

Prospects for the development of epigenetic drugs for CNS conditions.

Authors:
Moshe Szyf

Nat Rev Drug Discov 2015 Jul 22;14(7):461-74. Epub 2015 May 22.

Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Canada H3G 1Y6.

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http://dx.doi.org/10.1038/nrd4580DOI Listing
July 2015

DNA demethylation and invasive cancer: implications for therapeutics.

Br J Pharmacol 2015 Jun 27;172(11):2705-15. Epub 2015 Apr 27.

Department of Pharmacology and Therapeutics, McGill University Medical School, Montreal, QC, Canada.

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http://dx.doi.org/10.1111/bph.12885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439869PMC
June 2015

DNA methylation signatures triggered by prenatal maternal stress exposure to a natural disaster: Project Ice Storm.

PLoS One 2014 19;9(9):e107653. Epub 2014 Sep 19.

Department of Psychiatry, McGill University and Psychosocial Research Division, Douglas Hospital Research Centre, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107653PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169571PMC
June 2015

Gestational Diabetes Alters Offspring DNA Methylation Profiles in Human and Rat: Identification of Key Pathways Involved in Endocrine System Disorders, Insulin Signaling, Diabetes Signaling, and ILK Signaling.

Endocrinology 2015 Jun 16;156(6):2222-38. Epub 2014 Dec 16.

Department of Pharmacology and Therapeutics (S.P., C.G., S.D., M.Su., M.Sz.) and Sackler Program for Epigenetics and Psychobiology (M.Sz.), McGill University, Montréal, Canada H3G 1Y6; and Laboratory of Teratology (Z.E., L.W.-F., A.O.), Department of Medical Neurobiology, Hebrew University-Haddassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1210/en.2014-1643DOI Listing
June 2015

Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo.

Br J Pharmacol 2015 Jun 27;172(11):2769-81. Epub 2015 Mar 27.

Department of Medicine, McGill University Health Center, Montreal, QC, Canada.

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http://dx.doi.org/10.1111/bph.13102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439874PMC
June 2015

Dynamic changes in global and gene-specific DNA methylation during hibernation in adult thirteen-lined ground squirrels, Ictidomys tridecemlineatus.

J Exp Biol 2015 Jun 23;218(Pt 11):1787-95. Epub 2015 Apr 23.

Department of Pharmacology, McGill University, 3655 Sir William Osler Suite 1309, Montreal, QC, Canada H3G 1Y6; Sackler program in Epigenetics and Psychobiology at McGill University

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http://dx.doi.org/10.1242/jeb.116046DOI Listing
June 2015

Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform.

Sci Rep 2015 Jun 19;5:11464. Epub 2015 Jun 19.

1] Cancer Epigenetics Program, Anhui Cancer Hospital, Hefei, Anhui 230031, China [2] Cancer Epigenetics Program, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University, Shanghai 200032, China.

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http://dx.doi.org/10.1038/srep11464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155572PMC
June 2015

Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications.

Authors:
Moshe Szyf

Eur Neuropsychopharmacol 2015 May 18;25(5):682-702. Epub 2014 Jan 18.

Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada H3G1Y5. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2014.01.009DOI Listing
May 2015

Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving.

J Neurosci 2015 May;35(21):8042-58

Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel,

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http://dx.doi.org/10.1523/JNEUROSCI.3053-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605346PMC
May 2015

An epigenetic hypothesis for the genomic memory of pain.

Front Cell Neurosci 2015 24;9:88. Epub 2015 Mar 24.

Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University Montréal, QC, Canada ; Sackler Program for Epigenetics and Developmental Psychobiology, McGill University Montréal, QC, Canada ; Integrated Program in Neuroscience, McGill University Montréal, QC, Canada.

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http://dx.doi.org/10.3389/fncel.2015.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371710PMC
April 2015

Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants.

Nat Commun 2015 Mar 11;6:6513. Epub 2015 Mar 11.

Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler, Suite 1309, Montreal, Quebec, Canada H3G 1Y6.

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http://dx.doi.org/10.1038/ncomms7513DOI Listing
March 2015

DNA methylation signature of childhood chronic physical aggression in T cells of both men and women.

PLoS One 2014 24;9(1):e86822. Epub 2014 Jan 24.

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada ; Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901708PMC
February 2015

Nongenetic inheritance and transgenerational epigenetics.

Authors:
Moshe Szyf

Trends Mol Med 2015 Feb 19;21(2):134-44. Epub 2014 Dec 19.

Department of Pharmacology and Therapeutics, McGill University Medical School, 3655 Sir William Osler Promenade #1309, Montreal, Quebec H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2014.12.004DOI Listing
February 2015

Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.

Carcinogenesis 2014 Nov 1;35(11):2436-46. Epub 2014 Sep 1.

Department of Pharmacology and Therapeutics, McGill University and Sackler Program for Epigenetics and Developmental Psychobiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada,

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http://dx.doi.org/10.1093/carcin/bgu181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216057PMC
November 2014

The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor.

Philos Trans R Soc Lond B Biol Sci 2014 Sep;369(1652)

Lumder Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Montréal, Québec, Canada H4H 1R3 Sackler Program for Epigenetics and Psychobiology at McGill University, Montréal, Québec, Canada H3A 0G4

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http://dx.doi.org/10.1098/rstb.2013.0513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142034PMC
September 2014

The dynamic nature of DNA methylation: a role in response to social and seasonal variation.

Integr Comp Biol 2014 Jul 10;54(1):68-76. Epub 2014 May 10.

*Stanford University, Gilbert Biology #314, 371 Serra Mall, Palo Alto CA 940305; Carleton University, Steacie Building #507, 1125 Colonel By Ottawa Ontario, K1S5B6; McGill University, McIntyre Medical Building #1309, 3655 Sir William Osler,Montreal, Quebec H3G1Y6*Stanford University, Gilbert Biology #314, 371 Serra Mall, Palo Alto CA 940305; Carleton University, Steacie Building #507, 1125 Colonel By Ottawa Ontario, K1S5B6; McGill University, McIntyre Medical Building #1309, 3655 Sir William Osler,Montreal, Quebec H3G1Y6.

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http://dx.doi.org/10.1093/icb/icu034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133575PMC
July 2014

Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets.

Clin Cancer Res 2014 Jun 24;20(12):3118-32. Epub 2014 Apr 24.

Authors' Affiliations: Departments of Pharmacology and Therapeutics and Medicine, McGill University Health Centre, Montreal; McGill Centre for Bioinformatics; and Sackler program for Psychobiology and Epigenetics at McGill University, Montreal, Quebec, Canada; Department of Nutrition Science, Purdue University, West Lafayette, Indiana; Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China; Department of Hepatology, Bangabandhu Sheikh Mujib Medical University; International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), Dhaka, Dhaka District, Bangladesh; Department of Medical Sciences, Toshiba General Hospital, Tokyo, Kanto, Japan; and Department of Pathology, Fatima Memorial Hospital College of Medicine and Dentistry Lahore, PakistanAuthors' Affiliations: Departments of Pharmacology and Therapeutics and Medicine, McGill University Health Centre, Montreal; McGill Centre for Bioinformatics; and Sackler program for Psychobiology and Epigenetics at McGill University, Montreal, Quebec, Canada; Department of Nutrition Science, Purdue University, West Lafayette, Indiana; Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China; Department of Hepatology, Bangabandhu Sheikh Mujib Medical University; International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), Dhaka, Dhaka District, Bangladesh; Department of Medical Sciences, Toshiba General Hospital, Tokyo, Kanto, Japan; and Department of Pathology, Fatima Memorial Hospital College of Medicine and Dentistry Lahore, Pakistan

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0283DOI Listing
June 2014

Childhood chronic physical aggression associates with adult cytokine levels in plasma.

PLoS One 2013 26;8(7):e69481. Epub 2013 Jul 26.

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724832PMC
April 2014

Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression.

PLoS One 2013 19;8(8):e71691. Epub 2013 Aug 19.

Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada ; Research Unit on Children's Psycho-Social Maladjustment and Ste-Justine Hospital Research Center, University of Montreal, Montreal, Quebec, Canada ; Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747262PMC
April 2014

Childhood abuse is associated with methylation of multiple loci in adult DNA.

BMC Med Genomics 2014 Mar 11;7:13. Epub 2014 Mar 11.

Sackler Program for Epigenetics & Developmental Psychobiology, McGill University, 3655 Promenade Sir William Osler, Montreal H3G 1Y6, QC, Canada.

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http://dx.doi.org/10.1186/1755-8794-7-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007631PMC
March 2014

Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation.

Chronobiol Int 2014 Feb 16;31(1):144-50. Epub 2013 Oct 16.

The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa , Mount Carmel, Haifa , Israel .

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http://dx.doi.org/10.3109/07420528.2013.842925DOI Listing
February 2014

Adult glucocorticoid exposure leads to transcriptional and DNA methylation changes in nuclear steroid receptors in the hippocampus and kidney of mouse male offspring.

Biol Reprod 2014 Feb 27;90(2):43. Epub 2014 Feb 27.

Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1095/biolreprod.113.115899DOI Listing
February 2014

Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine.

Carcinogenesis 2014 Jan 28;35(1):138-44. Epub 2013 Aug 28.

Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada and.

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http://dx.doi.org/10.1093/carcin/bgt284DOI Listing
January 2014

Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning.

Authors:
Moshe Szyf

Nat Neurosci 2014 Jan;17(1):2-4

Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nn.3603DOI Listing
January 2014

Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2.

Carcinogenesis 2013 Dec 16;34(12):2738-49. Epub 2013 Aug 16.

Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1093/carcin/bgt273DOI Listing
December 2013

The genome- and system-wide response of DNA methylation to early life adversity and its implication on mental health.

Authors:
Moshe Szyf

Can J Psychiatry 2013 Dec;58(12):697-704

Professor, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.

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http://dx.doi.org/10.1177/070674371305801208DOI Listing
December 2013

Effects of antenatal synthetic glucocorticoid on glucocorticoid receptor binding, DNA methylation, and genome-wide mRNA levels in the fetal male hippocampus.

Endocrinology 2013 Nov 12;154(11):4170-81. Epub 2013 Sep 12.

Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1210/en.2013-1484DOI Listing
November 2013

The dialogue between social environments and the genome.

Authors:
Moshe Szyf

Am J Public Health 2013 Oct 8;103 Suppl 1:S9-11. Epub 2013 Aug 8.

Moshe Szyf is with the Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec.

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http://dx.doi.org/10.2105/AJPH.2013.301533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786765PMC
October 2013

Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression.

Philos Trans R Soc Lond B Biol Sci 2013 25;368(1615):20120251. Epub 2013 Feb 25.

Sainte-Justine Hospital Research Center, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1098/rstb.2012.0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638384PMC
September 2013

DNA methylation, behavior and early life adversity.

Authors:
Moshe Szyf

J Genet Genomics 2013 Jul 25;40(7):331-8. Epub 2013 Jun 25.

Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1016/j.jgg.2013.06.004DOI Listing
July 2013

Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex.

Mol Pain 2013 Apr 18;9:21. Epub 2013 Apr 18.

Department of Pharmacology and Therapeutics, McGill University, Faculty of Medicine, 3655 Promenade Sir William Osler, Montréal, Québec H3G 1Y6, Canada.

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http://dx.doi.org/10.1186/1744-8069-9-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640958PMC
April 2013

Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex.

Mol Pain 2013 Apr 18;9:21. Epub 2013 Apr 18.

Department of Pharmacology and Therapeutics, McGill University, Faculty of Medicine, 3655 Promenade Sir William Osler, Montréal, Québec H3G 1Y6, Canada.

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http://dx.doi.org/10.1186/1744-8069-9-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640958PMC
April 2013

Glucocorticoid programming of the fetal male hippocampal epigenome.

Endocrinology 2013 Mar 6;154(3):1168-80. Epub 2013 Feb 6.

Department Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada H3G1Y6.

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http://dx.doi.org/10.1210/en.2012-1980DOI Listing
March 2013

How do environments talk to genes?

Authors:
Moshe Szyf

Nat Neurosci 2013 Jan;16(1):2-4

Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nn.3286DOI Listing
January 2013