Publications by authors named "Mortimer Poncz"

120Publications

Enhancing therapeutic efficacy of in vivo platelet-targeted gene therapy in hemophilia A mice.

Authors:
Xuefeng Wang Richard Y Fu Chong Li Chun-Yu Chen Jenni Firrman Barbara A Konkle Junping Zhang Lei Li Weidong Xiao Mortimer Poncz Carol H Miao

Blood Adv 2020 Nov;4(22):5722-5734

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.

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November 2020

Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes.

Authors:
Joseph H Oved Daria V Babushok Michele P Lambert Nicole Wolfset M Anna Kowalska Mortimer Poncz Konrad J Karczewski Timothy S Olson

Blood Adv 2020 Oct;4(20):5232-5245

Comprehensive Bone Marrow Failure Center, Division of Hematology, and.

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October 2020

Population based frequency of naturally occurring loss-of-function variants in genes associated with platelet disorders.

Authors:
Joseph H Oved Michele P Lambert M Anna Kowalska Mortimer Poncz Konrad J Karczewski

J Thromb Haemost 2021 Jan 23;19(1):248-254. Epub 2020 Oct 23.

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.

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January 2021

Neutrophils promote clearance of nuclear debris following acid-induced lung injury.

Authors:
Joseph Hai Oved Andrew James Paris Kandace Gollomp Ning Dai Kathryn Rubey Ping Wang Lynn Spruce Steven H Seeholzer Mortimer Poncz G Scott Worthen

Blood 2020 Sep 21. Epub 2020 Sep 21.

Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

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September 2020

RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.

Authors:
Daniel DeHelian Shuchi Gupta Jie Wu Chelsea Thorsheim Brian Estevez Matthew Cooper Kelly Litts Melissa M Lee-Sundlov Karin M Hoffmeister Mortimer Poncz Peisong Ma Lawrence F Brass

Blood 2020 Oct;136(15):1773-1782

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA.

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October 2020

FcRn augments induction of tissue factor activity by IgG-containing immune complexes.

Authors:
Douglas B Cines Sergei Zaitsev Lubica Rauova Ann H Rux Victoria Stepanova Sriram Krishnaswamy Amrita Sarkar M Anna Kowalska Guohua Zhao Alan E Mast Laurence J Blumberg Keith R McCrae Mortimer Poncz Jonathan J Hubbard Michal Pyzik Richard S Blumberg

Blood 2020 Jun;135(23):2085-2093

Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH.

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June 2020

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.

Authors:
Ian Johnston Amrita Sarkar Vincent Hayes Gavin T Koma Gowthami M Arepally Junmei Chen Dominic W Chung José A López Douglas B Cines Lubica Rauova Mortimer Poncz

Blood 2020 04;135(15):1270-1280

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA.

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April 2020

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis.

Authors:
Brian D Adair José L Alonso Johannes van Agthoven Vincent Hayes Hyun Sook Ahn I-Shing Yu Shu-Wha Lin Jian-Ping Xiong Mortimer Poncz M Amin Arnaout

Nat Commun 2020 01 21;11(1):398. Epub 2020 Jan 21.

Leukocyte Biology & Inflammation Program, and Structural Biology Program, Massachusetts General Hospital, Boston, MA, 02114, USA.

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January 2020

Pre-clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice.

Authors:
Ami Patel Cara Marie Clementelli Danuta Jarocha Gohar Mosoyan Cindy Else Manisha Kintali Helen Fong Jay Tong Ronald Gordon Virginia Gillespie Alla Keyzner Mortimer Poncz Ronald Hoffman Camelia Iancu-Rubin

Transfusion 2019 12 5;59(12):3698-3713. Epub 2019 Nov 5.

Division of Hematology and Medical Oncology, Tisch Cancer Institute and the Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

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December 2019

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.

Authors:
Kandace Gollomp Amrita Sarkar Sanjiv Harikumar Steven H Seeholzer Gowthami M Arepally Kristin Hudock Lubica Rauova M Anna Kowalska Mortimer Poncz

Blood 2020 03;135(10):743-754

Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.

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March 2020

Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A.

Authors:
Randolph B Lyde Hyun Sook Ahn Karen K Vo Danuta J Jarocha John Tkaczynski Elsa Treffeisen Spencer K Sullivan Rodney M Camire Denise E Sabatino Deborah L French Mortimer Poncz

Blood Adv 2019 05;3(9):1368-1378

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.

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May 2019

Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability.

Authors:
Vanessa M Scanlon Alexandra M Teixeira Tarun Tyagi Siying Zou Ping-Xia Zhang Carmen Jane Booth M Anna Kowalska Jialing Bao John Hwa Vincent Hayes Michael S Marks Mortimer Poncz Diane S Krause

Thromb Haemost 2019 May 12;119(5):744-757. Epub 2019 Mar 12.

Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States.

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May 2019

or : pick your poison.

Authors:
Kandace Gollomp Mortimer Poncz

Blood 2019 01;133(4):287-288

Children's Hospital of Philadelphia.

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January 2019

Platelets Can Soak It Up and Then Spit It Out.

Authors:
Kandace Gollomp David F Friedman Mortimer Poncz

Arterioscler Thromb Vasc Biol 2018 11;38(11):2544-2545

From the Division of Hematology, Children's Hospital of Philadelphia, PA (K.G., D.F.F., M.P.).

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November 2018

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Authors:
Sanjay Khandelwal Joann Ravi Lubica Rauova Alexandra Johnson Grace M Lee Jennifer B Gilner Sreenivasulu Gunti Abner L Notkins Maragatha Kuchibhatla Michael Frank Mortimer Poncz Douglas B Cines Gowthami M Arepally

Blood 2018 12 11;132(23):2431-2440. Epub 2018 Oct 11.

Division of Hematology, Duke University Medical Center, Durham, NC.

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December 2018

Neutrophil accumulation and NET release contribute to thrombosis in HIT.

Authors:
Kandace Gollomp Minna Kim Ian Johnston Vincent Hayes John Welsh Gowthami M Arepally Mark Kahn Michele P Lambert Adam Cuker Douglas B Cines Lubica Rauova M Anna Kowalska Mortimer Poncz

JCI Insight 2018 09 20;3(18). Epub 2018 Sep 20.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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September 2018

variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting.

Authors:
Shoshana Revel-Vilk Ela Shai Ernest Turro Nivin Jahshan Esti Hi-Am Galia Spectre Hagit Daum Yossef Kalish Karina Althaus Andreas Greinacher Chaim Kaplinsky Shai Izraeli Rutendo Mapeta Sri V V Deevi Danuta Jarocha Willem H Ouwehand Kate Downes Mortimer Poncz David Varon Michele P Lambert

Blood 2018 10 31;132(17):1851-1854. Epub 2018 Aug 31.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.

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October 2018

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

Authors:
Lubica Rauova Gowthami Arepally Mortimer Poncz Douglas B Cines

Autoimmun Rev 2018 10 10;17(10):1046-1052. Epub 2018 Aug 10.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, USA; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, USA. Electronic address:

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October 2018

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.

Authors:
Jing Dai Daria Madeeva Vincent Hayes Hyun Sook Ahn Valerie Tutwiler Gowthami M Arepally Douglas B Cines Mortimer Poncz Lubica Rauova

Blood 2018 08 18;132(7):727-734. Epub 2018 Jun 18.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.

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August 2018

Serpin functions in host-pathogen interactions.

Authors:
Jialing Bao Guoqing Pan Mortimer Poncz Junhong Wei Maoshuang Ran Zeyang Zhou

PeerJ 2018 5;6:e4557. Epub 2018 Apr 5.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.

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April 2018