Publications by authors named "Morteza Pourahmad"

13 Publications

  • Page 1 of 1

Protective effects of salep against isoniazid liver toxicity in wistar rats.

J Tradit Complement Med 2018 Jan 21;8(1):239-243. Epub 2017 Jun 21.

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid.

Materials And Methods: This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups.

Results: Significant lower serum levels of liver enzymes, billirubin, MDA and TOC; and significant higher levels of TAC and total proteins, were revealed in isoniazid/salep group in compare to isoniazid alone group.In addition, histological studies had not showed liver injury in isoniazid/salep group, while there was significant liver injury in isoniazid alone group.

Conclusions: Orchid extract (salep), probably because of its antioxidant properties, prevent the destructive effects of isoniazid on the liver.
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http://dx.doi.org/10.1016/j.jtcme.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756020PMC
January 2018

Type I, predominant genotype isolated from sheep in South of Iran.

Vet World 2017 Apr 7;10(4):386-392. Epub 2017 Apr 7.

Department of Biology, Basic Sciences Faculty, Islamic Azad University, Jahrom Branch, Jahrom, Iran.

Aim: This study was performed to determine the genetic diversity of in sheep using nested-polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in Southern Iran.

Materials And Methods: The tissue samples of diaphragm and heart from 125 sheep were collected from the main slaughterhouses of Jahrom district in South of Fars province, Iran, between Aprils and June 2013. The DNA were extracted and analyzed by nested-PCR using specific primers for SAG2 and GRA6 loci. RFLP was used to classify strains into one of the three major lineages of .

Results: Type I was predominant in this area. The data obtained from both loci demonstrated that the frequency of each genotype was 72% Type I, 2.4% Type III, 7.2% mixed Type I and II, 16.8% mixed Type I and III, 0.8% mixed Type II and III, and 0.8% mixed Type I, II and III.

Conclusions: Although the previously published data indicated that Type II is the predominant genotype in sheep in the other parts of the world, this study showed that genotype I is the dominant genotype of in the southern Iran; however, other genotypes were detected. High diversity of genotypes including mix genotypes in lambs is of importance for the public health. These studies depict a new mapping of genotypes pattern which could be very helpful in toxoplasmosis control and prevention.
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http://dx.doi.org/10.14202/vetworld.2017.386-392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422241PMC
April 2017

Molecular Survey on Detection of Leishmania Infection in Rodent Reservoirs in Jahrom District, Southern Iran.

J Arthropod Borne Dis 2014 Dec 9;8(2):139-46. Epub 2014 Apr 9.

Department of Internal Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Zoonotic Cutaneous Leishmaniasis (ZCL) is endemic in many parts of Iran. Recently its incidence is considerable in different parts of Jahrom district, in Fars Province, southern Iran. The aims of our study were to investigate the prevalence of leishmania infection, and identify and characterize the Leishmania species present, among the rodents by molecular methods in a new endemic focus of ZCL, in an urban and rural area of the Jahrom district, Fars Province, southern Iran.

Methods: From May to November 2010), 55 rodents in four regions of Jahrom focus were caught and checked for leishmania infection by the microscopical examination of liver, spleen, ears, and footpads' smears.

Results: Overall 18 Meriones persicus, 15 Tatera indica, 14 Mus musculus, and 8 Rattus rattus were caught. Totally, four (16.5%) and two (13.3%) of the Me. persicus and Ta. indica, but only one of Mu. musculus and Ra. rattus were found smear-positive for leishmania amastigotes, respectively. In the nested-PCR assay 8 (14.6%) smears were found positive for Leishmania major, none was found positive for any other Leishmania species. Sequencing based detection of Leishmania confirmed the microscopic and PCR findings. All positive specimens were shown 95-96% similarity with L. major Friedlin.

Conclusion: Tatera indica and Me. persicus are incriminated as the main 'reservoir' hosts of L. major in the rural area of Jahrom, moreover, Mu. musculus and Ra. rattus have the minor but remarkable role in the maintenance of the disease in the urban regions of Jahrom focus.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478425PMC
December 2014

Protective effect of salep on liver.

Hepat Mon 2015 Apr 25;15(4):e28137. Epub 2015 Apr 25.

Parasitology Department, Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, IR Iran.

Background: Salep is used for various purposes in food industries and traditional medicine. Therefore, evaluation of its effect on the liver seems to be necessary.

Objectives: The aim of this study was to assess salep effect on liver.

Materials And Methods: In this experimental study, various concentrations of Salep were intraperitoneally administered to five groups of Wistar rats (control, placebo and 20, 40 and 80 mg/kg salep). After one month, liver enzymes and liver tissue were evaluated and compared between different groups.

Results: Significant decreased level of liver enzymes, MDA (Malondialdehyde) and TOC (Total Oxidation Capacity) were found in various concentrations of salep administration. On the other hand, a significant increase was found in TAC (Total Antioxidant Capacity) level with various doses of salep.

Conclusions: Elevated level of total protein and albumin and decreased level of liver enzyme by salep extract were found in this study. Therefore, this plant may be a useful medicine for patients with liver diseases.
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http://dx.doi.org/10.5812/hepatmon.15(4)2015.28137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449893PMC
April 2015

Occult hepatitis B demonstrated by anti-HBc and HBV DNA in HIV-positive patients.

Rep Biochem Mol Biol 2014 Oct;3(1):38-42

Infectious disease Department, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: In patients who are hepatitis B virus (HBV) DNA-positive, but HBV surface antigen (HBsAg) -negative, the infection is referred to as occult hepatitis B infection (OBI). Occult HBV infection is harmful when other liver diseases are present, and can aggravate liver damage in in patients with chronic liver diseases. In human immunodeficiency virus (HIV) infection the suppression of viral replication by the immune system might be inactivated, and classical HBV infection in OBI patients may occur. Health care professionals should be aware of OBI in HIV patients. The routine test for HBV infection in Iran is the enzyme-linked immunosorbent assay for the HBV surface antigen (ELISA HBsAg); therefore, the aim of this study was to evaluate the prevalence of OBI in Iranian HIV patients.

Methods: This cross-sectional study was conducted in 2012 on sera from all the known and accessible HIV patients in Jahrom and Fassa, two cities in southern Iran. All samples were tested for the HBsAg, HBV core antibody (HBcAb). All the results were analyzed using SPSS.

Results: Of the 91 patients, seven (7.7%) were HBsAg-positive and forty-five (49.5%) were HBcAb-positive. In patients with negative HBsAg (84 patients), 39 (46.4%) were HBcAb positive and 53 (63%) were positive for HBV DNA.

Conclusion: The prevalence of HBV infection is relatively high in HIV patients, and more accurate tests than those presently in use should be used for diagnosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757087PMC
October 2014

Hepatitis E virus and serum level aminotransferases in blood donors.

Rep Biochem Mol Biol 2013 Oct;2(1):48-51

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran; Department of Internal Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Hepatitis E virus (HEV) infection is a self-limiting viral infection that can lead to severe complications and death. In different regions the epidemiology of this infection varies. In this study we evaluated the seroepidemiology of hepatitis E infection in Jahrom, a city in southern Iran.

Methods: This was a cross-sectional descriptive study of serum samples from 477 subjects, including 30 females and 447 males. HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) were measured by enzyme-linked immunosorbent assays (ELISA). Alanine transaminase (ALT) and aspartate transaminase (AST) levels were also determined. Four hundred forty-seven subjects were male and 30 were female. Subjects were classified by age and sex.

Results: One woman (3.3%) and 25 men (5.5%) were positive for HEV antibodies (IgG and/or IgM). There was found an association between serum level of aminotransferases and seropositivity for HEV.

Conclusion: The result of this study indicates that HEV is an etiological factor for hepatitis in this area of IRAN. The cost benefit of active immunization in endemic regions should be evaluated because an outbreak could have tragic consequences.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757067PMC
October 2013

Mucormycosis after scorpion sting: case report.

Mycoses 2013 Sep 18;56(5):589-91. Epub 2013 Mar 18.

Department of Infectious Disease, Jahrom University of Medical Sciences, Jahrom, Iran.

Mucor is a fungus, which give rise to opportunistic infection in immunocompromised patients. We described a 55-year-old immunocompetent woman with cutaneous mucormycosis after scorpion sting. Mucormycosis may happen in patients with intact immunity and is not allocated only to patients with immune deficiency.
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http://dx.doi.org/10.1111/myc.12066DOI Listing
September 2013

Evaluation of anti-varicella antibody in young women before their marriage: A sero-epidemiologic study in Iran.

J Clin Virol 2010 Aug 9;48(4):260-3. Epub 2010 Jun 9.

Department of Internal Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Chickenpox during pregnancy can cause severe complications in both the mother and her baby. However, no complications will occur in a mother with proper immunity. Therefore, physicians and health systems can make better decisions when they know the immunologic status of the women in a community.

Objectives: We conducted this study to clarify the Varicella zoster virus (VZV) immune status of engaged women in Iran.

Study Design: This cross-sectional descriptive study was carried out on 334 young women who intended to marry between 2006 and 2008. The subjects' VZV-immunoglobulin G (IgG) and demographic characteristics were evaluated.

Results: The mean age of the subjects was 20.5+/-4.9 years and their mean anti-varicella value was 86.22+/-71.05 U ml(-1). Of 333 young women studied, 242 (72.7%) were positive, 89 (26.7%) were negative for anti-varicella antibody and two were equivocal (0.6%). The rate of immunity increased with increasing age; all of the subjects over 35 years of age were immune to varicella. The positive predictive value (PPV) for self-reported history of chickenpox in subjects was estimated to be 79.5% and the negative predictive value (NPV) of a negative or uncertain disease history was 30.5%. A higher immune ratio was seen in women with more siblings.

Conclusions: The difference in the proportion of VZV-immune people in our country versus developed countries may be due to the introduction of varicella vaccine in developed nations. The mean age at first pregnancy in Iran is 25.7 years and the results of our study indicate that more than one-fourth of these women are not immune to varicella. We therefore recommend vaccination in women, especially those who are under 35 years of age. Number of siblings and positive history of varicella infection may be the indicators to determine the immunity level of a pregnant woman who has had contact with a patient with chickenpox.
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http://dx.doi.org/10.1016/j.jcv.2010.04.015DOI Listing
August 2010

Effects of camel thorn distillate on recurrent oral aphthous lesions.

J Dtsch Dermatol Ges 2010 May 3;8(5):348-52. Epub 2010 Feb 3.

Department of Internal Medicine, Jahrom University of Medical Sciences, Iran.

Background: Near 20 % of people suffer from recurrent oral aphthous ulcers. These painful ulcers are found on the oral mucosa. We conducted this study to evaluate the effect of the camel thorn distillate on this condition.

Patients And Methods: 93 patients with recurrent aphthous ulcers were selected and divided into two groups. One group was given a placebo (n = 44) and the other was given camel thorn distillate (n = 49). The diameter of the lesions and the severity of the pain were measured 3, 5, 7, 10 and 14 days after initiation of therapy. The lesion diameters and pain scores of the two groups were compared using the t-test.

Results: Complete resolution time ranged from 3 to 7 days (mean = 4.02) in the group treated with camel thorn distillate, whereas in the control group, complete resolution time ranged from 7 to 14 days (mean = 8.9, p < 0.001).

Conclusions: The efficacy of camel thorn distillate is comparable to that of other drugs used to treat oral aphthous ulcers. Its therapeutic effect may be due to the flavanones (alhagitin and alhagidin) that are present in this plant.
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http://dx.doi.org/10.1111/j.1610-0387.2010.07316.xDOI Listing
May 2010

Homocysteine level in Iranian patients with premature acute myocardial infarction.

Chin Med J (Engl) 2009 Aug;122(16):1952-4

Mohammad Shojaie Peymanieh Hospital, Jahrom University of Medical Sciences.

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August 2009

Fibrinogen as a risk factor for premature myocardial infarction in Iranian patients: a case control study.

Vasc Health Risk Manag 2009 20;5:673-6. Epub 2009 Aug 20.

Peymanieh Hospital, Internal Medicine Department, Jahrom University of Medical Sciences, Jahrom, Fars, Iran.

Background: Premature myocardial infarction with life-threatening complications may become epidemic in some Asian and African countries and especially Iran. Fibrinogen is considered as one of the probable risk factors of myocardial infarction. The aim of our study was to assess fibrinogen levels as an etiology of premature myocardial infarction in young Iranian men.

Findings: A case-control study was conducted between May 2005 and May 2007 to investigate the association between serum total fibrinogen level and myocardial infarction in men aged younger than 55 years admitted to the cardiac care units of Peymanieh and Motahari Hospitals affiliated to Jahrom University of Medical Sciences, Iran. The mean age of patients was 45.2 +/- 4 years in patients with premature myocardial infarction and 47.06 +/- 4.5 years in the control group (p = 0.085). There were no statistically significant relationships between the two groups in history of premature myocardial infarction in their first-degree relatives (p = 0.05), cigarette smoking (p = 0.46), diabetes (p = 0.49), or hypertension (p = 1). The mean plasma fibrinogen in patients (354.9 +/- 60 mg/dL) was elevated markedly compared with the control group (329 +/- 73 mg/dL). Hyperfibrinogenemia (>340 mg/dL) was detected in 81.8% of patients and 57.5% of controls (95% confidence interval, odds ratio = 3.3; p = 0.036).

Conclusion: This study introduced fibrinogen as a risk factor for premature coronary artery disease in Iranian men.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731065PMC
http://dx.doi.org/10.2147/vhrm.s6559DOI Listing
November 2009

Effect of honey on the common cold.

Arch Med Res 2009 Apr 9;40(3):224-5. Epub 2009 Mar 9.

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http://dx.doi.org/10.1016/j.arcmed.2009.01.001DOI Listing
April 2009

Cutaneous leishmaniasis associated with visceral leishmaniasis in a case of acquired immunodeficiency syndrome (AIDS).

Int J Dermatol 2009 Jan;48(1):59-61

Faculty of Medicine, Peymanieh Hospital, Jahrom, Iran.

Introduction: Leishmania/human immunodeficiency virus (HIV) coinfection is emerging as an increasingly frequent and extremely serious new disease. Although many reports have described the association of visceral leishmaniasis and AIDS, cutaneous leishmaniasis associated with AIDS is very uncommon.

Case Summary: We describe a case of visceral leishmaniasis/HIV coinfection associated with cutaneous Leishman body-positive lesions in a patient from Jahrom, a city in Fars province in Iran.

Conclusion: Our case demonstrated that it is better to evaluate the diagnosis of visceral leishmaniasis in patients who present with cutaneous leishmaniasis and HIV infection.
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http://dx.doi.org/10.1111/j.1365-4632.2009.03870.xDOI Listing
January 2009