Morten Olesen

Morten Olesen

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Morten Olesen

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Effect of diabetes duration on the relationship between glycaemic control and risk of death in older adults with type 2 diabetes.

Diabetes Obes Metab 2020 Feb 18;22(2):231-242. Epub 2019 Nov 18.

Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dom.13891DOI Listing
February 2020

Particulated Cartilage for Chondral and Osteochondral Repair: A Review.

Cartilage 2020 Feb 13:1947603520904757. Epub 2020 Feb 13.

Department of orthopedic surgery, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1177/1947603520904757DOI Listing
February 2020

No effect of platelet-rich plasma as adjuvant to bone marrow stimulation for the treatment of chondral defects in a large animal model.

Arch Orthop Trauma Surg 2020 Jan 29;140(1):77-84. Epub 2019 Oct 29.

Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.

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http://dx.doi.org/10.1007/s00402-019-03292-7DOI Listing
January 2020

Loss-of-Function Variants in Cytoskeletal Genes Are Associated with Early-Onset Atrial Fibrillation.

J Clin Med 2020 Jan 29;9(2). Epub 2020 Jan 29.

.Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.3390/jcm9020372DOI Listing
January 2020

Reevaluation of genetic variants previously associated with arrhythmogenic right ventricular cardiomyopathy integrating population-based cohorts and proteomics data.

Clin Genet 2019 Dec 19;96(6):506-514. Epub 2019 Aug 19.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark.

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http://dx.doi.org/10.1111/cge.13621DOI Listing
December 2019

Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation.

Ann Noninvasive Electrocardiol 2019 11 1;24(6):e12661. Epub 2019 Jun 1.

The Center for Integrative Electrocardiology, Arrhythmia Clinic Skåne University Hospital, Lund University (CIEL), Lund, Sweden.

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http://dx.doi.org/10.1111/anec.12661DOI Listing
November 2019

Early sarcomere and metabolic defects in a zebrafish cardiac arrhythmia model.

Proc Natl Acad Sci U S A 2019 Nov 8;116(48):24115-24121. Epub 2019 Nov 8.

Laboratory for Molecular Cardiology, Department of Cardiology, Vascular, Pulmonary and Infectious Diseases, University Hospital of Copenhagen, 2100 Copenhagen, Denmark;

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http://dx.doi.org/10.1073/pnas.1913905116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883774PMC
November 2019

Verification of threshold for image intensity ratio analyses of late gadolinium enhancement magnetic resonance imaging of left atrial fibrosis in 1.5T scans.

Int J Cardiovasc Imaging 2019 Nov 20. Epub 2019 Nov 20.

Department of Cardiology, Centre for Cardiac-, Vascular-, Pulmonary and Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s10554-019-01728-0DOI Listing
November 2019

Age-Dependent Systemic Effects of a Systemic Intermittent Hypoxic Therapy .

High Alt Med Biol 2019 Sep 1;20(3):221-230. Epub 2019 Jul 1.

Orthopaedic Research Laboratory, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1089/ham.2018.0113DOI Listing
September 2019

Visit-to-Visit Variability of Hemoglobin A in People Without Diabetes and Risk of Major Adverse Cardiovascular Events and All-Cause Mortality.

Diabetes Care 2019 01 23;42(1):134-141. Epub 2018 Oct 23.

Laboratory of Molecular Cardiology, Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-139
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http://dx.doi.org/10.2337/dc18-1396DOI Listing
January 2019

Clinical Outcomes and Failure Rates of Osteochondral Allograft Transplantation in the Knee: A Systematic Review.

Am J Sports Med 2018 12 17;46(14):3541-3549. Epub 2017 Oct 17.

Steadman Philippon Research Institute, Vail, Colorado, USA.

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http://dx.doi.org/10.1177/0363546517732531DOI Listing
December 2018

Multi-ethnic genome-wide association study for atrial fibrillation.

Authors:
Carolina Roselli Mark D Chaffin Lu-Chen Weng Stefanie Aeschbacher Gustav Ahlberg Christine M Albert Peter Almgren Alvaro Alonso Christopher D Anderson Krishna G Aragam Dan E Arking John Barnard Traci M Bartz Emelia J Benjamin Nathan A Bihlmeyer Joshua C Bis Heather L Bloom Eric Boerwinkle Erwin B Bottinger Jennifer A Brody Hugh Calkins Archie Campbell Thomas P Cappola John Carlquist Daniel I Chasman Lin Y Chen Yii-Der Ida Chen Eue-Keun Choi Seung Hoan Choi Ingrid E Christophersen Mina K Chung John W Cole David Conen James Cook Harry J Crijns Michael J Cutler Scott M Damrauer Brian R Daniels Dawood Darbar Graciela Delgado Joshua C Denny Martin Dichgans Marcus Dörr Elton A Dudink Samuel C Dudley Nada Esa Tonu Esko Markku Eskola Diane Fatkin Stephan B Felix Ian Ford Oscar H Franco Bastiaan Geelhoed Raji P Grewal Vilmundur Gudnason Xiuqing Guo Namrata Gupta Stefan Gustafsson Rebecca Gutmann Anders Hamsten Tamara B Harris Caroline Hayward Susan R Heckbert Jussi Hernesniemi Lynne J Hocking Albert Hofman Andrea R V R Horimoto Jie Huang Paul L Huang Jennifer Huffman Erik Ingelsson Esra Gucuk Ipek Kaoru Ito Jordi Jimenez-Conde Renee Johnson J Wouter Jukema Stefan Kääb Mika Kähönen Yoichiro Kamatani John P Kane Adnan Kastrati Sekar Kathiresan Petra Katschnig-Winter Maryam Kavousi Thorsten Kessler Bas L Kietselaer Paulus Kirchhof Marcus E Kleber Stacey Knight Jose E Krieger Michiaki Kubo Lenore J Launer Jari Laurikka Terho Lehtimäki Kirsten Leineweber Rozenn N Lemaitre Man Li Hong Euy Lim Henry J Lin Honghuang Lin Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Barry London Ruth J F Loos Siew-Kee Low Yingchang Lu Leo-Pekka Lyytikäinen Peter W Macfarlane Patrik K Magnusson Anubha Mahajan Rainer Malik Alfredo J Mansur Gregory M Marcus Lauren Margolin Kenneth B Margulies Winfried März David D McManus Olle Melander Sanghamitra Mohanty Jay A Montgomery Michael P Morley Andrew P Morris Martina Müller-Nurasyid Andrea Natale Saman Nazarian Benjamin Neumann Christopher Newton-Cheh Maartje N Niemeijer Kjell Nikus Peter Nilsson Raymond Noordam Heidi Oellers Morten S Olesen Marju Orho-Melander Sandosh Padmanabhan Hui-Nam Pak Guillaume Paré Nancy L Pedersen Joanna Pera Alexandre Pereira David Porteous Bruce M Psaty Sara L Pulit Clive R Pullinger Daniel J Rader Lena Refsgaard Marta Ribasés Paul M Ridker Michiel Rienstra Lorenz Risch Dan M Roden Jonathan Rosand Michael A Rosenberg Natalia Rost Jerome I Rotter Samir Saba Roopinder K Sandhu Renate B Schnabel Katharina Schramm Heribert Schunkert Claudia Schurman Stuart A Scott Ilkka Seppälä Christian Shaffer Svati Shah Alaa A Shalaby Jaemin Shim M Benjamin Shoemaker Joylene E Siland Juha Sinisalo Moritz F Sinner Agnieszka Slowik Albert V Smith Blair H Smith J Gustav Smith Jonathan D Smith Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Bruno H Stricker Albert Sun Han Sun Jesper H Svendsen Toshihiro Tanaka Kahraman Tanriverdi Kent D Taylor Maris Teder-Laving Alexander Teumer Sébastien Thériault Stella Trompet Nathan R Tucker Arnljot Tveit Andre G Uitterlinden Pim Van Der Harst Isabelle C Van Gelder David R Van Wagoner Niek Verweij Efthymia Vlachopoulou Uwe Völker Biqi Wang Peter E Weeke Bob Weijs Raul Weiss Stefan Weiss Quinn S Wells Kerri L Wiggins Jorge A Wong Daniel Woo Bradford B Worrall Pil-Sung Yang Jie Yao Zachary T Yoneda Tanja Zeller Lingyao Zeng Steven A Lubitz Kathryn L Lunetta Patrick T Ellinor

Nat Genet 2018 06 11;50(9):1225-1233. Epub 2018 Jun 11.

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41588-018-0133-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136836PMC
June 2018

Multifocal atrial and ventricular premature contractions with an increased risk of dilated cardiomyopathy caused by a Na1.5 gain-of-function mutation (G213D).

Int J Cardiol 2018 04;257:160-167

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.11.095DOI Listing
April 2018

Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation.

Per Med 2018 03 31;15(2):93-102. Epub 2018 Jan 31.

Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.2217/pme-2017-0076DOI Listing
March 2018

Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.

Am J Hum Genet 2018 01 28;102(1):103-115. Epub 2017 Dec 28.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777936PMC
January 2018

Analysis of 60 706 Exomes Questions the Role of De Novo Variants Previously Implicated in Cardiac Disease.

Circ Cardiovasc Genet 2017 Dec;10(6)

From the Laboratory for Molecular Cardiology, Institute for Biomedical Sciences, University of Copenhagen, Denmark (C.P.-M., G.A., J.G., J.H.S., S.H., M.S.O.); Laboratory for Molecular Cardiology, Department of Cardiology, Heart Centre at Rigshospitalet, Copenhagen University Hospital, Denmark (C.P.-M., G.A., J.G., J.H.S., S.H., M.S.O.); Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark (C.P.-M., G.A., J.G., J.H.S., S.H., M.S.O.); and Department of Clinical Medicine, University of Copenhagen, Denmark (J.H.S., S.H.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001878DOI Listing
December 2017

The role of common genetic variants in atrial fibrillation.

J Electrocardiol 2016 Nov - Dec;49(6):864-870. Epub 2016 Aug 26.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jelectrocard.2016.08.012DOI Listing
November 2017

Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants.

Heart Rhythm 2017 10 24;14(10):1531-1538. Epub 2017 May 24.

Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark; Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2017.05.027DOI Listing
October 2017

Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation.

Stem Cell Res 2017 10 10;24:29-32. Epub 2017 Aug 10.

Cellular Fate Reprogramming Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.08.009DOI Listing
October 2017

Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a PITX2 p.M200V mutation.

Stem Cell Res 2017 10 10;24:8-11. Epub 2017 Aug 10.

Cellular Fate Reprogramming Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.08.007DOI Listing
October 2017

Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics.

Adv Healthc Mater 2017 Sep 12;6(17). Epub 2017 Jul 12.

Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1002/adhm.201700385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590711PMC
September 2017

Autologous Cartilage Chip Transplantation Improves Repair Tissue Composition Compared With Marrow Stimulation.

Am J Sports Med 2017 Jun 20;45(7):1490-1496. Epub 2017 Mar 20.

Orthopaedic Research Laboratory, Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1177/0363546517694617DOI Listing
June 2017

Electrocardiographic Preexcitation and Risk of Cardiovascular Morbidity and Mortality: Results From the Copenhagen ECG Study.

Circ Arrhythm Electrophysiol 2017 Jun;10(6)

From the Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark (M.W.S., P.V.R., J.G., M.S.O., S.H., J.H.S., A.G.H., J.B.N.); Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (S.H., L.K., J.H.S.); Department of Health Science and Technology, Aalborg University, Denmark (S.M.H., C.G., C.T.-P.); Copenhagen General Practitioners' Laboratory, Denmark (A.P.); and Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (J.B.N.).

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http://dx.doi.org/10.1161/CIRCEP.116.004778DOI Listing
June 2017

Odense Pharmacoepidemiological Database: A Review of Use and Content.

Basic Clin Pharmacol Toxicol 2017 May 8;120(5):419-425. Epub 2017 Mar 8.

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense C, Denmark.

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http://dx.doi.org/10.1111/bcpt.12764DOI Listing
May 2017

Electrocardiographic PR Interval Duration and Cardiovascular Risk: Results From the Copenhagen ECG Study.

Can J Cardiol 2017 05 6;33(5):674-681. Epub 2017 Mar 6.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2017.02.015DOI Listing
May 2017

Analyses of more than 60,000 exomes questions the role of numerous genes previously associated with dilated cardiomyopathy.

Mol Genet Genomic Med 2016 Nov 17;4(6):617-623. Epub 2016 Sep 17.

Laboratory of Molecular Cardiology Department of Cardiology The Heart Centre University Hospital of Copenhagen Rigshospitalet Copenhagen Denmark.

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http://dx.doi.org/10.1002/mgg3.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118206PMC
November 2016

Association Between Heart Rate at Rest and Incident Atrial Fibrillation (from the Copenhagen Electrocardiographic Study).

Am J Cardiol 2016 09 14;118(5):708-13. Epub 2016 Jun 14.

Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.amjcard.2016.06.013DOI Listing
September 2016

KCNE1 G38S polymorphism is not the cause of long QT syndrome.

J Electrocardiol 2016 Mar-Apr;49(2):249-50. Epub 2015 Dec 12.

Dept. of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jelectrocard.2015.12.005DOI Listing
August 2016

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.

J Mol Cell Cardiol 2016 08 19;97:24-35. Epub 2016 Apr 19.

Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.04.006DOI Listing
August 2016

Genetic Misdiagnoses and the Potential for Health Disparities.

N Engl J Med 2016 Aug;375(7):655-65

From the Departments of Biomedical Informatics (A.K.M., D.M.M., I.S.K.), Pathology (B.H.F.), and Medicine (B.A.M., J.L.), Harvard Medical School, the Departments of Pathology, Massachusetts General Hospital (B.H.F.), and the Department of Pathology (H.L.R.), Division of Cardiovascular Medicine (B.A.M.), and Department of Medicine (B.A.M., J.L.), Brigham and Women's Hospital, Boston, and the Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology (MIT) (A.K.M., I.S.K.), the Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine (B.H.F., H.L.R.), and the Computer Science and Artificial Intelligence Laboratory, MIT (P.S.), Cambridge - all in Massachusetts; and the Laboratory of Molecular Cardiology, Department of Cardiology, the Heart Center, University Hospital of Copenhagen, Rigshospitalet, and the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen (M.S.O.) - both in Copenhagen.

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http://dx.doi.org/10.1056/NEJMsa1507092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292722PMC
August 2016

Implantation of Autologous Cartilage Chips Improves Cartilage Repair Tissue Quality in Osteochondral Defects: A Study in Göttingen Minipigs.

Am J Sports Med 2016 Jun 7;44(6):1597-604. Epub 2016 Mar 7.

Orthopedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark Department of Sports Traumatology, Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark.

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http://journals.sagepub.com/doi/10.1177/0363546516630977
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http://dx.doi.org/10.1177/0363546516630977DOI Listing
June 2016

Electrocardiographic Tpeak-Tend interval and risk of cardiovascular morbidity and mortality: Results from the Copenhagen ECG study.

Heart Rhythm 2016 Apr 18;13(4):915-24. Epub 2015 Dec 18.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2015.12.027DOI Listing
April 2016

Experimental articular cartilage repair in the Göttingen minipig: the influence of multiple defects per knee.

J Exp Orthop 2015 Dec 18;2(1):13. Epub 2015 Jun 18.

Department of Sports Traumatology, Department of orthopedic surgery, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1186/s40634-015-0031-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538720PMC
December 2015

P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study.

Heart Rhythm 2015 Sep 23;12(9):1887-95. Epub 2015 Apr 23.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2015.04.026DOI Listing
September 2015

Genetic aspects of lone atrial fibrillation: what do we know?

Curr Pharm Des 2015 ;21(5):667-78

Laboratory for Molecular Cardiology, Rigshospitalet, Juliane Mariesvej 9, 2100 Copenhagen Ø, Denmark.

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http://dx.doi.org/10.2174/1381612820666140825143610DOI Listing
August 2015

Chitosan-based nanoparticles for mucosal delivery of RNAi therapeutics.

Adv Genet 2014 ;88:325-52

Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark.

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http://dx.doi.org/10.1016/B978-0-12-800148-6.00011-0DOI Listing
July 2015

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation.

J Cardiovasc Electrophysiol 2015 Jul 4;26(7):715-23. Epub 2015 May 4.

Danish National Research Foundation Center for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/jce.12666DOI Listing
July 2015

The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.

Heart Rhythm 2015 Jun 7;12(6):1241-9. Epub 2015 Mar 7.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://ac.els-cdn.com/S1547527115002702/1-s2.0-S154752711500
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http://linkinghub.elsevier.com/retrieve/pii/S154752711500270
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http://dx.doi.org/10.1016/j.hrthm.2015.03.013DOI Listing
June 2015

Tunable CD44-specific cellular retargeting with hyaluronic acid nanoshells.

Pharm Res 2015 Apr 1;32(4):1462-74. Epub 2014 Nov 1.

Interdisciplinary Nanoscience Center (iNANO), University of Aarhus, Gustav Wieds Vej 14, Building 1593, room 329, 8000, Aarhus, Denmark.

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http://dx.doi.org/10.1007/s11095-014-1552-7DOI Listing
April 2015

Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

Circ Cardiovasc Genet 2015 Feb;8(1):64-73

From the The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Department of Biomedical Sciences (J.J., M.S.O., L.Y., J.B.N., B.L., N.N., M.G., S.H., A.G.H., J.H.S., T.J.), Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet (J.J., M.S.O., J.B.N., S.H., A.G.H., J.H.S.), and Department of Clinical Medicine (S.H., J.H.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA (M.V., P.T.E) and Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E); Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Rud, Norway (I.E.C.); Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Bispebjerg, Denmark (A.S.); and LuCamp, The Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care, Copenhagen, Denmark (S.H.).

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http://dx.doi.org/10.1161/HCG.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392342PMC
February 2015

Brugada syndrome risk loci seem protective against atrial fibrillation.

Eur J Hum Genet 2014 Dec 26;22(12):1357-61. Epub 2014 Mar 26.

1] Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark [2] Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ejhg.2014.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231412PMC
December 2014

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.

Cardiovasc Res 2014 Nov 22;104(2):355-63. Epub 2014 Jul 22.

Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1285A MRB IV, Nashville, TN 37323-6602, USA Division of Clinical Pharmacology, Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1285A MRB IV, Nashville, TN 37323-6602, USA

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http://dx.doi.org/10.1093/cvr/cvu170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271018PMC
November 2014

New population-based exome data question the pathogenicity of some genetic variants previously associated with Marfan syndrome.

BMC Genet 2014 Jun 18;15:74. Epub 2014 Jun 18.

Laboratory of Molecular Cardiology, Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1471-2156-15-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070351PMC
June 2014

Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population.

Eur Heart J 2014 May 6;35(20):1335-44. Epub 2014 Mar 6.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehu081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028611PMC
May 2014

Nationwide (Denmark) study of symptoms preceding sudden death due to arrhythmogenic right ventricular cardiomyopathy.

Am J Cardiol 2014 Apr 16;113(7):1250-4. Epub 2014 Jan 16.

The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark; Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.amjcard.2013.12.038DOI Listing
April 2014

Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada syndrome mutant.

Am J Physiol Heart Circ Physiol 2014 Apr 21;306(8):H1204-12. Epub 2014 Feb 21.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;

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http://www.physiology.org/doi/10.1152/ajpheart.00405.2013
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http://dx.doi.org/10.1152/ajpheart.00405.2013DOI Listing
April 2014

Atrial fibrillation: the role of common and rare genetic variants.

Eur J Hum Genet 2014 Mar 10;22(3):297-306. Epub 2013 Jul 10.

1] The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark [2] Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark [3] Department of Surgery and Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ejhg.2013.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925267PMC
March 2014

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation.

Heart Rhythm 2014 Feb 18;11(2):246-51. Epub 2013 Oct 18.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S15475271130120
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http://dx.doi.org/10.1016/j.hrthm.2013.10.034DOI Listing
February 2014

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.

J Mol Cell Cardiol 2014 Feb 27;67:69-76. Epub 2013 Dec 27.

Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.014DOI Listing
February 2014

The application of RNAi-based treatments for inflammatory bowel disease.

Drug Deliv Transl Res 2014 Feb;4(1):4-18

Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, University of Aarhus, Gustav Wieds Vej 14, 8000, Aarhus C, Denmark.

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http://dx.doi.org/10.1007/s13346-013-0156-9DOI Listing
February 2014

Genetic modifier of the QTc interval associated with early-onset atrial fibrillation.

Can J Cardiol 2013 Oct;29(10):1234-40

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark; Laboratory for Molecular Cardiology, Rigshospitalet, Copenhagen, Denmark; The Ion Channel Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2013.06.009DOI Listing
October 2013

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

Nat Genet 2013 Sep 21;45(9):1044-9. Epub 2013 Jul 21.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ng.2712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869788PMC
September 2013

The genetic component of Brugada syndrome.

Front Physiol 2013 15;4:179. Epub 2013 Jul 15.

The Danish National Research Foundation Centre for Cardiac Arrhythmia Copenhagen, Denmark ; Department of Cardiology, Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fphys.2013.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710955PMC
July 2013

Screening of the ito regulatory subunit klf15 in patients with early-onset lone atrial fibrillation.

Front Genet 2013 17;4:88. Epub 2013 May 17.

The Danish National Research Foundation Centre for Cardiac Arrhythmia Copenhagen, Denmark ; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fgene.2013.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656344PMC
June 2013

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation.

Eur Heart J 2013 May 21;34(20):1517-25. Epub 2012 Dec 21.

Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark.

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http://dx.doi.org/10.1093/eurheartj/ehs442DOI Listing
May 2013

Familial atrial fibrillation predicts increased risk of mortality: a study in Danish twins.

Circ Arrhythm Electrophysiol 2013 Feb 19;6(1):10-5. Epub 2012 Dec 19.

Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1161/CIRCEP.112.971580DOI Listing
February 2013

Rare variants in GJA5 are associated with early-onset lone atrial fibrillation.

Can J Cardiol 2013 Jan 2;29(1):111-6. Epub 2012 Oct 2.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2012.08.002DOI Listing
January 2013

A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation.

J Negat Results Biomed 2013 Jan 2;12. Epub 2013 Jan 2.

Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1477-5751-12-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554423PMC
January 2013

Mutation analysis of the candidate genes -, , and in patients with arrhythmogenic right ventricular cardiomyopathy.

Appl Transl Genom 2012 Dec 1;1:44-46. Epub 2012 Oct 1.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Blegdamsvej 3, 2200 Copenhagen N, Denmark; Laboratory for Molecular Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Juliane Maries Vej 20, 2100 Copenhagen O, Denmark; Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen O, Denmark.

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http://dx.doi.org/10.1016/j.atg.2012.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121199PMC
December 2012

Insights into the genome-wide association studies of the electrocardiographic early repolarization pattern.

Heart Rhythm 2012 Oct 1;9(10):1635-6. Epub 2012 Jul 1.

Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Juliane Mariesvej 20, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2012.06.037DOI Listing
October 2012

Familial aggregation of lone atrial fibrillation in young persons.

J Am Coll Cardiol 2012 Sep 20;60(10):917-21. Epub 2012 Jun 20.

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S073510971201499
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http://dx.doi.org/10.1016/j.jacc.2012.03.046DOI Listing
September 2012

High prevalence of genetic variants previously associated with LQT syndrome in new exome data.

Eur J Hum Genet 2012 Aug 29;20(8):905-8. Epub 2012 Feb 29.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://www.nature.com/articles/ejhg201223
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http://dx.doi.org/10.1038/ejhg.2012.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400735PMC
August 2012

Genetic loci on chromosomes 4q25, 7p31, and 12p12 are associated with onset of lone atrial fibrillation before the age of 40 years.

Can J Cardiol 2012 Mar-Apr;28(2):191-5. Epub 2012 Feb 14.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2011.11.016DOI Listing
July 2012

SCN1Bb R214Q found in 3 patients: 1 with Brugada syndrome and 2 with lone atrial fibrillation.

Heart Rhythm 2012 May 7;9(5):770-3. Epub 2011 Dec 7.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2011.12.005DOI Listing
May 2012

Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians.

Cardiology 2011 9;118(2):116-20. Epub 2011 May 9.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000323840DOI Listing
December 2011

Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients.

Scand Cardiovasc J 2011 Dec 27;45(6):324-6. Epub 2011 Jul 27.

Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark.

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http://dx.doi.org/10.3109/14017431.2011.594081DOI Listing
December 2011

A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.

Can J Cardiol 2011 Jul-Aug;27(4):523.e17-23. Epub 2011 May 28.

Department of Cardiology, Laboratory for Molecular Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1016/j.cjca.2011.01.003DOI Listing
September 2011

Screening of KCNN3 in patients with early-onset lone atrial fibrillation.

Europace 2011 Jul 11;13(7):963-7. Epub 2011 Mar 11.

The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/europace/eur007DOI Listing
July 2011