Morten Grunnet

Morten Grunnet

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Morten Grunnet

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Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model.

Europace 2019 Oct;21(10):1584-1593

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Norre Alle 14, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/europace/euz223DOI Listing
October 2019

Impact of arrhythmogenic calmodulin variants on small conductance Ca -activated K (SK3) channels.

Physiol Rep 2019 Oct;7(19):e14210

Laboratory of Cardiac Physiology, Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.14814/phy2.14210DOI Listing
October 2019

Pharmacological rescue of mutated K3.1 ion-channel linked to progressive myoclonus epilepsies.

Eur J Pharmacol 2018 Aug 9;833:255-262. Epub 2018 Jun 9.

University of Copenhagen, Faculty of Health Science, Department of Biomedical Sciences, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.ejphar.2018.06.015DOI Listing
August 2018

The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT receptor expressing interneurons: An in vitro study in rat hippocampus slices.

Brain Res 2018 06 21;1689:1-11. Epub 2017 Dec 21.

Brintellix Science Team, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Copenhagen, Denmark; Translational Neuropsychiatry Unit, Aarhus University, Skovagervej 2, DK-8240 Risskov, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.12.025DOI Listing
June 2018

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca-Activated K Channels in Pigs.

Circ Arrhythm Electrophysiol 2017 Oct;10(10)

From the Acesion Pharma, Copenhagen, Denmark (J.G.D., R.S.-V., C.C., D.R.P.S., S.H.B., U.S.S., M.G., B.H.B.); Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.S., J.L.S., P.L., D.R.P.S., S.-P.O., T.J., M.G., B.H.B.); and the Heart Centre, Rigshospitalet, Copenhagen, Denmark (J.H.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCEP.117.005125
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http://dx.doi.org/10.1161/CIRCEP.117.005125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647113PMC
October 2017

K3.1/K3.2 channel positive modulators enable faster activating kinetics and increase firing frequency in fast-spiking GABAergic interneurons.

Neuropharmacology 2017 05 24;118:102-112. Epub 2017 Feb 24.

Cardiac Physiology Laboratory, University of Copenhagen, Faculty of Health Sciences, Department of Biomedical Sciences, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.neuropharm.2017.02.024DOI Listing
May 2017

Effect of antiarrhythmic drugs on small conductance calcium - activated potassium channels.

Eur J Pharmacol 2017 May 18;803:118-123. Epub 2017 Mar 18.

Biomedical Institute, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark; Acesion Pharma, Ole Maaløes Vej 3, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.03.039DOI Listing
May 2017

Antiarrhythmic effect of the Ca-activated K (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation.

Pflugers Arch 2016 11 8;468(11-12):1853-1863. Epub 2016 Oct 8.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3A, 2200, Copenhagen N, Denmark.

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http://link.springer.com/10.1007/s00424-016-1883-9
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http://dx.doi.org/10.1007/s00424-016-1883-9DOI Listing
November 2016

Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family.

Scand J Clin Lab Invest 2015 24;75(8):699-709. Epub 2015 Sep 24.

a Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences , University of Copenhagen , Denmark.

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http://dx.doi.org/10.3109/00365513.2015.1091090DOI Listing
July 2016

pH-dependent inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts.

Pflugers Arch 2016 Apr 5;468(4):643-54. Epub 2016 Jan 5.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00424-015-1779-0DOI Listing
April 2016

Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.

J Cardiovasc Pharmacol 2015 Nov;66(5):441-8

*Acesion Pharma, Copenhagen, Denmark; Departments of †Biomedical Science; and ‡Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/FJC.0000000000000249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692285PMC
November 2015

Antiarrhythmic Effect of Either Negative Modulation or Blockade of Small Conductance Ca2+-activated K+ Channels on Ventricular Fibrillation in Guinea Pig Langendorff-perfused Heart.

J Cardiovasc Pharmacol 2015 Sep;66(3):294-9

*Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; †Acesion Pharma, Copenhagen, Denmark; ‡Lundbeck A/S, Copenhagen, Denmark; and §Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/FJC.0000000000000278DOI Listing
September 2015

Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A.

Circ J 2014 6;78(5):1136-43. Epub 2014 Mar 6.

Danish National Foundation Research Centre in Arrhythmias (DARC), Laboratory of Experimental Cardiology, Department of Biomedical Sciences.

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http://dx.doi.org/10.1253/circj.cj-13-1167DOI Listing
August 2015

Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium.

J Cardiovasc Pharmacol 2015 Aug;66(2):165-76

*Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; †Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China; and ‡Acesion Pharma, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/FJC.0000000000000259DOI Listing
August 2015

Biophysical characterization of KV3.1 potassium channel activating compounds.

Eur J Pharmacol 2015 Jul 3;758:164-70. Epub 2015 Apr 3.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.03.061DOI Listing
July 2015

Cardiac SK channels: Friend or foe?

Authors:
Morten Grunnet

Heart Rhythm 2015 May 9;12(5):1016-7. Epub 2015 Feb 9.

Acesion Pharma A/S and Institute for Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2015.02.007DOI Listing
May 2015

Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses.

Heart Rhythm 2015 Apr 24;12(4):825-35. Epub 2014 Dec 24.

Danish National Foundation Research Centre in Arrhythmias (DARC) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2014.12.028DOI Listing
April 2015

Targeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.

Basic Clin Pharmacol Toxicol 2015 Mar 29;116(3):187-200. Epub 2014 Dec 29.

Synaptic Transmission, H. Lundbeck A/S, Valby, Denmark.

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http://dx.doi.org/10.1111/bcpt.12361DOI Listing
March 2015

Synergistic antiarrhythmic effect of combining inhibition of Ca²⁺-activated K⁺ (SK) channels and voltage-gated Na⁺ channels in an isolated heart model of atrial fibrillation.

Heart Rhythm 2015 Feb 10;12(2):409-18. Epub 2014 Dec 10.

The Danish National Research Foundation, Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2014.12.010DOI Listing
February 2015

Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

Circ Cardiovasc Genet 2015 Feb;8(1):64-73

From the The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Department of Biomedical Sciences (J.J., M.S.O., L.Y., J.B.N., B.L., N.N., M.G., S.H., A.G.H., J.H.S., T.J.), Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet (J.J., M.S.O., J.B.N., S.H., A.G.H., J.H.S.), and Department of Clinical Medicine (S.H., J.H.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA (M.V., P.T.E) and Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E); Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Rud, Norway (I.E.C.); Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Bispebjerg, Denmark (A.S.); and LuCamp, The Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care, Copenhagen, Denmark (S.H.).

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http://dx.doi.org/10.1161/HCG.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392342PMC
February 2015

BK channel activators and their therapeutic perspectives.

Front Physiol 2014 9;5:389. Epub 2014 Oct 9.

Acesion Pharma Copenhagen, Denmark ; H. Lundbeck A/S Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fphys.2014.00389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191079PMC
October 2014

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

J Pharmacol Exp Ther 2014 Sep 20;350(3):520-30. Epub 2014 Jun 20.

NeuroSearch A/S, Ballerup, Denmark (F.R., S.J., A.N., M.P.G.K., C.H., W.D.B., T.D., D.S., S.-P.O., P.C., M.G., L.C.B.R.); University of Vermont, Department of Pharmacology, Burlington, Vermont (B.N., A.D.B., M.T.N.); and Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom (M.T.N.)

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http://dx.doi.org/10.1124/jpet.113.212662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152884PMC
September 2014

Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.

Cardiovasc Res 2014 Jul 9;103(1):156-67. Epub 2014 May 9.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://cardiovascres.oxfordjournals.org/cgi/doi/10.1093/cvr/
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http://dx.doi.org/10.1093/cvr/cvu121DOI Listing
July 2014

Structural insight into concealed long QT type 1.

Authors:
Morten Grunnet

Heart Rhythm 2014 Mar 7;11(3):469-70. Epub 2013 Dec 7.

Acesion Pharma, Copenhagen, Denmark; Lundbeck A/S, Valby, Denmark; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2013.12.006DOI Listing
March 2014

Therapeutic potential of Na(V)1.1 activators.

Trends Pharmacol Sci 2014 Mar 16;35(3):113-8. Epub 2014 Jan 16.

Neuroscience Drug Discovery, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.tips.2013.12.007DOI Listing
March 2014

Kv7 channels as targets for anti-epileptic and psychiatric drug-development.

Eur J Pharmacol 2014 Mar 20;726:133-7. Epub 2014 Jan 20.

Aniona Aps, Baltorpvej 154, Ballerup DK2750, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.01.017DOI Listing
March 2014

G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.

Cardiovasc Res 2014 Jan 22;101(1):175-84. Epub 2013 Oct 22.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 16.5.35, Copenhagen DK-2200N, Denmark.

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http://dx.doi.org/10.1093/cvr/cvt240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868351PMC
January 2014

Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog.

Circulation 2014 Jan 4;129(4):430-40. Epub 2013 Nov 4.

Research Center (X.-Y.Q., P.N., C.-T.W., H.H., M.H., M.A., S.N.), Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada; Cardiac and Circulatory Research Section (J.G.D., M.G.), Faculty of Health Sciences, University of Copenhagen and Acesion Pharma, Copenhagen, Denmark; Department of Clinical Pharmacology (B.J.J.M.B.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Division of Experimental Cardiology (X.-B.Z., D.D.), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Chang-Gung Memorial Hospital and University Taoyuan (C.-T.W.), Taoyuan, Taiwan, China; Institute of Pharmacology (D.D.), Faculty of Medicine, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.003019DOI Listing
January 2014

Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats.

Biochem Pharmacol 2013 Nov 16;86(10):1487-96. Epub 2013 Sep 16.

Department of Psychology and Neuroscience Program, University of Michigan, 530 Church Street, 4030 East Hall, Ann Arbor, MI 48109-1109, USA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark; NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915712PMC
November 2013

GIRK channel activation via adenosine or muscarinic receptors has similar effects on rat atrial electrophysiology.

J Cardiovasc Pharmacol 2013 Aug;62(2):192-8

Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/FJC.0b013e3182965221DOI Listing
August 2013

Cardiac ion channels and mechanisms for protection against atrial fibrillation.

Rev Physiol Biochem Pharmacol 2012 ;162:1-58

NeuroSearch A/S, Pederstrupvej 93, 2750, Ballerup, Denmark,

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http://dx.doi.org/10.1007/112_2011_3DOI Listing
March 2013

Functionally selective AT(1) receptor activation reduces ischemia reperfusion injury.

Cell Physiol Biochem 2012 30;30(3):642-52. Epub 2012 Jul 30.

Danish Arrhythmia Research Centre, Department of Biomedical Sciences, Faculty of Health, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000341445DOI Listing
December 2012

Keeping the rhythm -- pro-arrhythmic investigations in isolated Göttingen minipig hearts.

J Pharmacol Toxicol Methods 2011 Sep-Oct;64(2):134-44. Epub 2011 May 17.

H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.vascn.2011.05.001DOI Listing
August 2012

Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal.

Adv Pharmacol Sci 2011 17;2011:578273. Epub 2011 Nov 17.

NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

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http://dx.doi.org/10.1155/2011/578273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226329PMC
August 2012

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

Heart Rhythm 2012 Mar 22;9(3):440-8. Epub 2011 Oct 22.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2011.10.026DOI Listing
March 2012

Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure.

J Cardiovasc Pharmacol 2012 Feb;59(2):142-50

Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/FJC.0b013e318238727aDOI Listing
February 2012

The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na(+)/H(+) exchanger NHE1.

Cell Physiol Biochem 2011 16;28(1):13-24. Epub 2011 Aug 16.

Section for Cell and Developmental Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000331709DOI Listing
January 2012

Cardiac channelopathies and sudden infant death syndrome.

Cardiology 2011 16;119(1):21-33. Epub 2011 Jul 16.

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000329047DOI Listing
December 2011

Pharmacological treatment of atrial fibrillation: what does it take?

Authors:
Morten Grunnet

Heart Rhythm 2011 Dec 19;8(12):1940-1. Epub 2011 Aug 19.

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http://dx.doi.org/10.1016/j.hrthm.2011.08.019DOI Listing
December 2011

Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state.

Biophys J 2011 Aug;101(4):818-27

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bpj.2011.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175082PMC
August 2011

Characterization of cardiac repolarization in the Göttingen minipig.

J Pharmacol Toxicol Methods 2011 Mar-Apr;63(2):186-95. Epub 2010 Oct 15.

H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.vascn.2010.10.001DOI Listing
June 2011

Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition.

Hypertension 2011 Jun 18;57(6):1129-35. Epub 2011 Apr 18.

NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.170613DOI Listing
June 2011

Pathophysiological relevance of apical large-conductance Ca²+-activated potassium channels in pancreatic duct epithelial cells.

Gut 2011 Mar 12;60(3):361-9. Epub 2010 Oct 12.

Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.

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http://dx.doi.org/10.1136/gut.2010.214213DOI Listing
March 2011

Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Mol Pharmacol 2011 Jan 27;79(1):1-9. Epub 2010 Sep 27.

Department of Drug Discovery Portfolio Management, NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

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http://dx.doi.org/10.1124/mol.110.067728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014275PMC
January 2011

Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.

Neuropharmacology 2010 Sep 1;59(3):208-17. Epub 2010 Jun 1.

Department of Pharmacology, NeuroSearch A/S, 93 Pederstrupvej, DK-2750, Ballerup, Denmark.

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http://dx.doi.org/10.1016/j.neuropharm.2010.05.010DOI Listing
September 2010

Pharmacological activation of IKr impairs conduction in guinea pig hearts.

J Cardiovasc Electrophysiol 2010 Aug 16;21(8):923-9. Epub 2010 Feb 16.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1540-8167.2010.01733.xDOI Listing
August 2010

Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation.

Circ Arrhythm Electrophysiol 2010 Aug 19;3(4):380-90. Epub 2010 Jun 19.

NeuroSearch A/S, Pederstrupvej 93, Ballerup, Denmark.

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http://dx.doi.org/10.1161/CIRCEP.110.957407DOI Listing
August 2010

Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo.

Naunyn Schmiedebergs Arch Pharmacol 2010 Mar 2;381(3):271-83. Epub 2009 Oct 2.

Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00210-009-0456-2DOI Listing
March 2010

Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria.

Biochim Biophys Acta 2010 Jan 8;1797(1):71-80. Epub 2009 Sep 8.

The Johns Hopkins University, School of Medicine, Institute of Molecular Cardiobiology, 720 Rutland Ave., 1060 Ross Bldg., Baltimore, MD 21205-2195, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000527280900256
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http://dx.doi.org/10.1016/j.bbabio.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787855PMC
January 2010

Inherited cardiac diseases caused by mutations in the Nav1.5 sodium channel.

J Cardiovasc Electrophysiol 2010 Jan 20;21(1):107-15. Epub 2009 Oct 20.

The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1540-8167.2009.01633.xDOI Listing
January 2010

Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts.

Pflugers Arch 2009 Nov;459(1):11-23

The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00424-009-0718-3DOI Listing
November 2009

Functional properties of human neuronal Kv11 channels.

Pflugers Arch 2009 Aug 25;458(4):689-700. Epub 2009 Mar 25.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00424-009-0651-5DOI Listing
August 2009

Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes.

J Cardiovasc Pharmacol 2009 Aug;54(2):169-77

Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/FJC.0b013e3181af6db3DOI Listing
August 2009

hERG1 channel activators: a new anti-arrhythmic principle.

Prog Biophys Mol Biol 2008 Oct-Nov;98(2-3):347-62. Epub 2009 Jan 24.

NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

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http://dx.doi.org/10.1016/j.pbiomolbio.2009.01.002DOI Listing
May 2009

Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury.

Pflugers Arch 2009 Mar 2;457(5):979-88. Epub 2008 Sep 2.

Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00424-008-0583-5DOI Listing
March 2009

A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.

Cardiovasc Res 2009 Mar 10;81(4):686-94. Epub 2008 Dec 10.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences 12.5.10, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1093/cvr/cvn339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642600PMC
March 2009

Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function.

Cell Physiol Biochem 2008 9;22(5-6):611-24. Epub 2008 Dec 9.

NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

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http://dx.doi.org/10.1159/000185545DOI Listing
February 2009

Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro.

Br J Clin Pharmacol 2009 Feb 15;67(2):172-9. Epub 2008 Oct 15.

Department of Cardiology, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, Hvidovre, Denmark.

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http://dx.doi.org/10.1111/j.1365-2125.2008.03327.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670374PMC
February 2009

Antiarrhythmic effect of IKr activation in a cellular model of LQT3.

Heart Rhythm 2009 Jan 17;6(1):100-6. Epub 2008 Oct 17.

NeuroSearch A/S, Ballerup, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2008.10.020DOI Listing
January 2009

Single-copy insertion of transgenes in Caenorhabditis elegans.

Nat Genet 2008 Nov 26;40(11):1375-83. Epub 2008 Oct 26.

Department of Biology and Howard Hughes Medical Institute, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112, USA.

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http://www.nature.com/articles/ng.248
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http://dx.doi.org/10.1038/ng.248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749959PMC
November 2008

Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.

Pflugers Arch 2008 Sep 27;456(6):1137-48. Epub 2008 May 27.

The Danish National Research Foundation Center for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00424-008-0476-7DOI Listing
September 2008

Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.

Cardiovasc Res 2008 Jul 26;79(1):61-9. Epub 2008 Mar 26.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvn075DOI Listing
July 2008

Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.

Heart Rhythm 2008 May 4;5(5):734-41. Epub 2008 Mar 4.

Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2008.02.026DOI Listing
May 2008

Fetal arrhythmia caused by dysregulation of HERG channels.

Authors:
Morten Grunnet

Heart Rhythm 2008 Apr 7;5(4):562-4. Epub 2008 Feb 7.

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http://dx.doi.org/10.1016/j.hrthm.2008.02.003DOI Listing
April 2008

Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

Biochem Biophys Res Commun 2007 Dec 29;364(4):889-95. Epub 2007 Oct 29.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, 12.5.10, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.bbrc.2007.10.106DOI Listing
December 2007

The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

Mol Pharmacol 2007 Oct 16;72(4):1033-44. Epub 2007 Jul 16.

NeuroSearch A/S, Pederstrupvej 93, DK-2750 Ballerup, Denmark.

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http://dx.doi.org/10.1124/mol.107.038331DOI Listing
October 2007

Activation of ERG2 potassium channels by the diphenylurea NS1643.

Neuropharmacology 2007 Aug 21;53(2):283-94. Epub 2007 May 21.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S002839080700147
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August 2007

Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.

J Pharmacol Exp Ther 2007 Jun 26;321(3):996-1002. Epub 2007 Feb 26.

NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

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http://dx.doi.org/10.1124/jpet.106.118448DOI Listing
June 2007

KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

Biochim Biophys Acta 2007 Jun 14;1773(6):764-73. Epub 2007 Mar 14.

The Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedical Sciences, The Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.bbamcr.2007.02.008DOI Listing
June 2007

Modulation of ERG channels by XE991.

Basic Clin Pharmacol Toxicol 2007 May;100(5):316-22

Department of Medical Physiology, The Panum Institute, The University of Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1742-7843.2007.00048.xDOI Listing
May 2007

Inactivation as a new regulatory mechanism for neuronal Kv7 channels.

Biophys J 2007 Apr 19;92(8):2747-56. Epub 2007 Jan 19.

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Medical Physiology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1529/biophysj.106.101287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831682PMC
April 2007

Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.

Am J Physiol Cell Physiol 2006 Dec 21;291(6):C1377-87. Epub 2006 Jun 21.

Department of Molecular Biology, Institute of Clinical Medicine, University of Aarhus, Aarhus, Denmark.

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http://ajpcell.physiology.org/cgi/doi/10.1152/ajpcell.00015.
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http://dx.doi.org/10.1152/ajprenal.zh2-4590-corr.2006DOI Listing
December 2006

The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.

Neuropharmacology 2006 Nov 10;51(6):1068-77. Epub 2006 Aug 10.

The Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.neuropharm.2006.07.001DOI Listing
November 2006

Subtype-specific, bi-component inhibition of SK channels by low internal pH.

Biochem Biophys Res Commun 2006 May 20;343(3):943-9. Epub 2006 Mar 20.

Danish Arrhythmia Research Center, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.bbrc.2006.03.026DOI Listing
May 2006

Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels.

Biochem Biophys Res Commun 2006 May 23;343(4):1224-33. Epub 2006 Mar 23.

NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark.

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http://dx.doi.org/10.1016/j.bbrc.2006.03.072DOI Listing
May 2006

The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?

Biochem Biophys Res Commun 2006 Mar 24;341(4):979-88. Epub 2006 Jan 24.

Department of Medical Physiology and Danish Arrhythmia Research Centre, The Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0600110
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http://dx.doi.org/10.1016/j.bbrc.2006.01.046DOI Listing
March 2006

The KCNQ1 potassium channel: from gene to physiological function.

Physiology (Bethesda) 2005 Dec;20:408-16

Department of Medical Physiology, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1152/physiol.00031.2005DOI Listing
December 2005

Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.

Heart Rhythm 2005 Nov;2(11):1238-49

Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.hrthm.2005.07.025DOI Listing
November 2005