Morten A Karsdal

Morten A Karsdal

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Morten A Karsdal

Publications by authors named "Morten A Karsdal"

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Correlation between serological biomarkers of extracellular matrix turnover and lung fibrosis and pulmonary artery hypertension in patients with systemic sclerosis.

Int J Rheum Dis 2020 Feb 5. Epub 2020 Feb 5.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/1756-185X.13804DOI Listing
February 2020

Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?

Hepatology 2020 Jan 18;71(1):346-351. Epub 2019 Dec 18.

Institute of Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1002/hep.30969DOI Listing
January 2020

Recent advances in understanding the phenotypes of osteoarthritis.

F1000Res 2019 12;8. Epub 2019 Dec 12.

Division of Internal Medicine & Dermatology, Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.12688/f1000research.20575.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913225PMC
January 2020

Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice.

J Thromb Haemost 2019 Nov 9;17(11):1815-1826. Epub 2019 Aug 9.

Division of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1111/jth.14567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824926PMC
November 2019

Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program.

Aliment Pharmacol Ther 2019 Oct 25;50(8):930-939. Epub 2019 Jul 25.

Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/apt.15427DOI Listing
October 2019

Enhanced processing of von Willebrand factor reflects disease severity and discriminates severe portal hypertension in cirrhosis.

Eur J Gastroenterol Hepatol 2019 Aug;31(8):1040-1048

Clinical Physiology, Center of Functional Imaging and Research, Faculty of Health Sciences, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1097/MEG.0000000000001380DOI Listing
August 2019

Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.

Biochem Pharmacol 2019 07 29;165:91-98. Epub 2018 Jul 29.

Rheumatology, Nordic Bioscience, Herlev Hovedgade 207, DK-2730 Herlev, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.07.034DOI Listing
July 2019

Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study.

Transl Oncol 2019 May 9;12(5):693-698. Epub 2019 Mar 9.

Nordic Bioscience, Biomarkers and Research, DK-2730, Herlev, Denmark.

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http://dx.doi.org/10.1016/j.tranon.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411605PMC
May 2019

Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass.

J Clin Endocrinol Metab 2019 May 23. Epub 2019 May 23.

Section of Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital-Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1210/jc.2019-00505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656422PMC
May 2019

The message from the matrix-should we listen more closely?

J Thorac Dis 2019 Mar;11(Suppl 3):S230-S233

Nordic Bioscience A/S, Herlev Hovedgade, Herlev, Denmark.

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http://jtd.amegroups.com/article/view/27255/20198
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http://dx.doi.org/10.21037/jtd.2019.01.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424747PMC
March 2019

Protein biomarkers associated with pain mechanisms in osteoarthritis.

J Proteomics 2019 01 25;190:55-66. Epub 2018 Apr 25.

Nordic Bioscience A/S, Herlev, Denmark.

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http://dx.doi.org/10.1016/j.jprot.2018.04.030DOI Listing
January 2019

Assessment of liver fibrosis progression and regression by a serological collagen turnover profile.

Am J Physiol Gastrointest Liver Physiol 2019 01 30;316(1):G25-G31. Epub 2018 Aug 30.

Institute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Johannes Gutenberg University , Mainz , Germany.

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http://dx.doi.org/10.1152/ajpgi.00158.2018DOI Listing
January 2019

Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis.

BMC Rheumatol 2019 31;3. Epub 2019 Jan 31.

1Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 205-207, 2730 Herlev, Denmark.

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http://dx.doi.org/10.1186/s41927-019-0052-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390574PMC
January 2019

Assessment of extracellular matrix-related biomarkers in patients with lower extremity artery disease.

J Vasc Surg 2018 10 31;68(4):1135-1142.e6. Epub 2018 Mar 31.

Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2017.12.071DOI Listing
October 2018

Biomarkers for equine joint injury and osteoarthritis.

J Orthop Res 2018 03 24;36(3):823-831. Epub 2018 Jan 24.

Duke Molecular Physiology Institute and Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1002/jor.23738DOI Listing
March 2018

Weight change and risk of hyperglycaemia in elderly women.

Aging Clin Exp Res 2017 Dec 6;29(6):1095-1104. Epub 2017 Mar 6.

Nordic Bioscience A/S, Herlev Hovedgade 205-207, 2730, Herlev, Denmark.

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http://dx.doi.org/10.1007/s40520-016-0696-1DOI Listing
December 2017

Biomarkers of collagen turnover are related to annual change in FEV in patients with chronic obstructive pulmonary disease within the ECLIPSE study.

BMC Pulm Med 2017 Dec 4;17(1):164. Epub 2017 Dec 4.

Centre for Respiratory Medicine and Allergy, Manchester Academic Science Centre, The University of Manchester and University Hospital South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1186/s12890-017-0505-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716018PMC
December 2017

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo.

J Transl Med 2017 Dec 12;15(1):250. Epub 2017 Dec 12.

Biomarkers and Research Rheumatology, Nordic Bioscience A/S, Herlev Hovedgade 205-207, 2730, Herlev, Denmark.

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http://dx.doi.org/10.1186/s12967-017-1356-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727954PMC
December 2017

Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients.

Pain 2017 07;158(7):1254-1263

aNordic Bioscience Biomarkers & Research, Nordic Bioscience A/S, Herlev, Denmark bDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark cNeuroscience, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom dDepartment of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden eQuantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA fDepartment of Radiology, Hôpital Saint-Antoine, University Paris VI, Paris, France.

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http://dx.doi.org/10.1097/j.pain.0000000000000908DOI Listing
July 2017

The Dual Amylin- and Calcitonin-Receptor Agonist KBP-042 Works as Adjunct to Metformin on Fasting Hyperglycemia and HbA1c in a Rat Model of Type 2 Diabetes.

J Pharmacol Exp Ther 2017 07 24;362(1):24-30. Epub 2017 Apr 24.

Department of Musculoskeletal Diseases, Nordic Bioscience Biomarkers and Research, Herlev, Denmark.

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http://dx.doi.org/10.1124/jpet.117.241281DOI Listing
July 2017

Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes.

Diabetologia 2017 Jan 8;60(1):50-59. Epub 2016 Sep 8.

Institute of Translational Immunology and Research Center of Immune Therapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1007/s00125-016-4094-1DOI Listing
January 2017

Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy.

Am J Physiol Gastrointest Liver Physiol 2016 12 20;311(6):G1009-G1017. Epub 2016 Oct 20.

Institute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany; and.

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http://dx.doi.org/10.1152/ajpgi.00283.2016DOI Listing
December 2016

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.

Biomarkers 2015 5;20(8):557-64. Epub 2016 Feb 5.

a Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK .

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http://dx.doi.org/10.3109/1354750X.2015.1105498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819573PMC
November 2016

Characterization of serological neo-epitope biomarkers reflecting collagen remodeling in clinically stable chronic obstructive pulmonary disease.

Clin Biochem 2016 Oct 7;49(15):1144-1151. Epub 2016 Sep 7.

Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Section of Respiratory Medicine, Hvidovre Hospital, Hvidovre, Denmark.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.09.003DOI Listing
October 2016

High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD - results from the ECLIPSE study.

Respir Res 2016 10 4;17(1):125. Epub 2016 Oct 4.

Centre for Respiratory Medicine and Allergy, Manchester Academic Science Centre, The University of Manchester and University Hospital South Manchester NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1186/s12931-016-0440-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050854PMC
October 2016

Metabolic syndrome and subsequent risk of type 2 diabetes and cardiovascular disease in elderly women: Challenging the current definition.

Medicine (Baltimore) 2016 Sep;95(36):e4806

aNordic Bioscience A/S, Herlev bDTU Bioengineering, Technical University of Denmark, Kgs. Lyngby cOdense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1097/MD.0000000000004806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023917PMC
September 2016

Collagen and tissue turnover as a function of age: Implications for fibrosis.

J Hepatol 2016 Jan 22;64(1):103-9. Epub 2015 Aug 22.

Institute of Translational Immunology and Research Center for Immunotherapy, University Medical Center, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.jhep.2015.08.014DOI Listing
January 2016

Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study.

Arthritis Res Ther 2016 Jan 20;18:13. Epub 2016 Jan 20.

Biomarkers and Research, Nordic Bioscience, Herlev Hovedgade 207, 2730, Herlev, Denmark.

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http://dx.doi.org/10.1186/s13075-015-0913-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719735PMC
January 2016

KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration.

Eur J Pharmacol 2015 Sep 28;762:229-38. Epub 2015 May 28.

Nordic Bioscience, Herlev Hovedgade 207, DK-2730 Herlev, Denmark.

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http://dx.doi.org/10.1016/j.ejphar.2015.05.051DOI Listing
September 2015

Biomarkers of cartilage and surrounding joint tissue.

Biomark Med 2014 ;8(5):713-31

Nordic Bioscience, Biomarkers & Research, Herlev Hovedgade 207, Herlev DK-2730, Denmark.

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http://dx.doi.org/10.2217/bmm.13.144DOI Listing
August 2015

Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases.

Nephrol Dial Transplant 2015 Jul 16;30(7):1112-21. Epub 2015 Mar 16.

Institute of Pathology, RWTH University of Aachen, Aachen, NRW, Germany Department of Nephrology, RWTH University of Aachen, Aachen, NRW, Germany.

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http://dx.doi.org/10.1093/ndt/gfv063DOI Listing
July 2015

Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD.

Chest 2015 Jul;148(1):16-23

Respiratory and Allergy Research Group, Manchester Academic Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, England.

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http://dx.doi.org/10.1378/chest.15-0296DOI Listing
July 2015

Association of versican turnover with all-cause mortality in patients on haemodialysis.

PLoS One 2014 29;9(10):e111134. Epub 2014 Oct 29.

Odense University Hospital, Department of Nephrology, Institute for Molecular Medicine, Cardiovascular and Renal Research, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111134PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212982PMC
June 2015

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study.

Lancet Respir Med 2015 Jun 12;3(6):462-72. Epub 2015 Mar 12.

National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton Hospital, London, UK; National Heart and Lung Institute, Imperial College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(15)00048-XDOI Listing
June 2015

Accelerated extracellular matrix turnover during exacerbations of COPD.

Respir Res 2015 Jun 11;16:69. Epub 2015 Jun 11.

Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK.

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http://respiratory-research.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12931-015-0225-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491243PMC
June 2015

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.

Am J Physiol Gastrointest Liver Physiol 2015 May 12;308(10):G807-30. Epub 2015 Mar 12.

Institute of Translational Immunology and Research Center for Immunotherapy, University of Mainz Medical Center, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1152/ajpgi.00447.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437019PMC
May 2015

Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C.

Liver Int 2015 Feb 29;35(2):429-37. Epub 2014 Oct 29.

Nordic Bioscience A/S, Herlev, Denmark; Faculty of Health Science, University of Southern Denmark, Odense, Denmark.

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http://doi.wiley.com/10.1111/liv.12700
Publisher Site
http://dx.doi.org/10.1111/liv.12700DOI Listing
February 2015

Serological biomarkers of joint tissue turnover predict tocilizumab response at baseline.

J Clin Rheumatol 2014 Sep;20(6):332-5

From the *Nordic Bioscience, Herlev Hovedgade, Herlev, Denmark; and †Roche Products Ltd, Welwyn Garden City, United Kingdom.

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http://dx.doi.org/10.1097/RHU.0000000000000150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154839PMC
September 2014